404 results about "Picolinic acid" patented technology

Disclosed are novel compounds useful for prevention or control of diseases derived from fungi, a process for producing the same, and novel antifungal agents using the novel compounds. The compounds useful for prevention and treatment of diseases derived from fungi according to the present invention include novel compounds represented by formula (I). The compounds represented by formula (I) have potent antifungal activity against diseases derived from fungi, and do not have phytotoxicity to mammals and agricultural and garden plants, from which diseases should be eliminated, and, even when applied to agricultural and garden plants, have high photostability.whereinR1 represents isobutyryl, tigloyl, isovaleryl, or 2-methylbutanoyl;R2 represents a hydrogen atom, an aromatic carboxylic acid residue, or a protective group of amino; and R3 represents a hydrogen atom, nitro, amino, acylamino, or N,N-dialkylamino, excluding the case where, when R1 represents isobutyryl, tigloyl, isovaleryl, or 2-methylbutanoyl with R3 representing a hydrogen atom, R2 represents a 3-hydroxypicolinic acid residue, 3-hydroxy-4-methoxypicolinic acid residue, or a 3,4-dimethoxypicolinic acid residue.

The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.

An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid, analogs or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes and enzymes required for growth, replication or inflammatory response. The preparations can be administered systemically or topically. The products can be used to reduce systemic levels of metals in disease states such as Wilson's disease, iron or lead toxicity. The preparations have antineoplastic, antiviral, antiinflammatory, analgesic antiangiogenic and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, cancers, sunburn, inflammatory responses, untoward angiogenesis and other diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS.

4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

The invention relates to a preparation method of an anionic aqueous polyurethane dispersoid for fabric coating and decoration. The preparation method is operated according to the following steps that: (a) polyether polyol, polyester polyol and diisocyanate are subjected to polymerization reaction for 2 to 4 hours at 70 to 90 DEG C under the effect of catalysts; (b) acetone solvents and diamine hydrophilic chain extenders containing picolinic acid structures are added for taking reaction for 5 to 30 minutes at 40 to 65 DEG C, and polyurethane prepolymers are prepared; (c) the temperature is lowered to 20 to 40 DEG C, low-molecular-weight chain extenders and water are added and are emulsified through being stirred at high speed; (d) the acetone solvents are removed through reduced pressure distillation, and the anionic aqueous polyurethane dispersoid for fabric coating and decoration is obtained. Because diamine containing the picolinic acid structures is used as hydrophilic chain extenders, the regular pyridine ring structure is contained, the crystallization performance and the initial bonding intensity can be improved, meanwhile, a pyridine ring is an electron deficiency system, the color deepening caused by oxidation cannot easily occur, and the product has the yellowing resistance performance.

Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

Methods of treating and / or preventing surface infections, such as acne, in an animal, such as a human being, using antibiotics incorporating borinic acid complexes, especially picolinic acid derivatives, are disclosed, along with compositions of these antibiotics.

An herbicidal composition containing (a) an herbicidal chloroacetanilide component and (b) an herbicidal picolinic acid component provides synergistic control of selected broadleaf weeds.

Synergistic compositions and methods are disclosed for using cruciferous indoles with iron / zinc chelators in the treatment of papillomavirus-related conditions. These synergistic compositions of diindolylymethane (DIM), related trimeric derivatives, and related indole derivatives include combinations with deferoxamine, deferiprone, bipyridyl, Desferri-exochelin, picolinic acid, 3-hydroxypicolinic acid, and sodium butyrate as iron / zinc chelators. The methods described comprise more effective therapies for common cutaneous warts (verrucae) and related dysplasias of the oropharynx, genitalia, and uterine cervix.

The invention discloses a glufosinate-picolinic acid herbicide weeding composition. The glufosinate-picolinic acid herbicide weeding composition comprises glufosinate and a picolinic acid herbicide as active ingredients, and the balance pesticide assistants. A weight ratio of glufosinate to the picolinic acid herbicide in the glufosinate-picolinic acid herbicide weeding composition is in a range of (20: 1) to (1: 10). The glufosinate-picolinic acid herbicide weeding composition comprises 10 to 80wt% of glufosinate and the picolinic acid herbicide. The glufosinate-picolinic acid herbicide weeding composition can be used for preventing and removing weeds in bare places, orchards and farmlands, has effects superior to effects of a single picolinic acid herbicide or glufosinate, reduces a use amount of a pesticide, reduces the adverse influence produced by a pesticide on the ecological environment, and effectively solves the problem of weed resistance to pesticides.

The invention discloses a selective electrochemical reduction method of halogenated picolinic acid or salt compounds of the halogenated picolinic acid, and the method is as follows: using an acidic solution as a reaction medium, adding the halogenated picolinic acid or a salt compound of the halogenated picolinic acid, which is shown as formula (II) into the acidic solution to obtain an electrolytic reaction liquid for electrolytic reaction in an electrolytic tank using a chemistry inert material as a positive pole and a metallic material as a negative pole, and after the electrolytic reaction is completed, acidifying the electrolytic reaction liquid to recover a selective reduction product shown as formula (I); according to the method, high selective reduction removal of 6-halogen of multiple halogenated picolinic acid can be realized by the electrolytic reaction in the presence of a 3-and 5-or 3-halogen substituent group.

An electrolytic synthesis method of 3,6-matrigon takes alkaline aqueous solution as the reacting medium, which comprises the following step: dissolving 3,4,5,6-tetrachloropicolinic acid or the salt of the 3,4,5,6-tetrachloropicolinic acid in the alkaline aqueous solution, proceeding the electrolytic reducing reaction, obtaining target compound (II) after the electrolytic reaction and the acidification, wherein, firstly, proceeding the electrolytic reaction in the alkaline aqueous solution system with pH value 8.5-11, secondly, continuingly completing the electrolytic reaction under condition of the alkaline range is between pH value 13 and pH value 13.5 after obtaining trichloropyridine formate intermediate compound (I). The method has the advantages of easy operation, safety, friendly to the environment, the reaction temperature of the first stage can reach over 80 DEG C, the dissolvability of the reactant is efficiently improved, the reaction velocity is quickened, the batch output of the products is increased, and the spurging and the hydroxylating secondary reaction are efficiently avoided.

The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.

Compositions and methods for inhibiting the growth of lens epithelial cells are provided. The compositions provided include a chelating agent in an amount sufficient for inhibiting the growth of lens epithelial cells. The compositions and methods provided may also be used for the treatment of disorders of the eye, especially in the treatment of presbyopia.

The present invention provides novel 5-substituted picolinic acid compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are independently H, C2-C6 acyl or halo-substituted benzoyl; and R3 is -C(O)O-C1-C6 alkyl, C(O)OH, CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, with the proviso that when R2 is acetyl and R3 is methoxycarbonyl, R1 is not H; and that when R3 is CN, CONH2, CONHCH3, CON(CH3)2, 1-methyltetrazole or 2-methyltetrazole, R1 and R2 are H. The present invention also relates to a pharmaceutical composition comprising compound of the present invention, which is useful in the treatment of IL-1 and TNF mediated diseases or the like. The present invention further relates to a process for producing the compounds of the formula (I).

Compositions and methods for inhibiting the growth of lens epithelial cells are provided. The compositions provided include a chelating agent in an amount sufficient for inhibiting the growth of lens epithelial cells. The compositions and methods provided may also be used for the treatment of disorders of the eye, especially in the treatment of presbyopia.

The invention discloses a synthesizing method of new-typed herbicide 4-amino-3, 5, 6-trichloropyridine-2-aminic acid, which is characterized by the following: adopting 3, 4, 5, 6-tetrachloropyridine formate or tetrachloropyridine formic acid as original raw material; ammonifying; acidifying; making the total receiving rate at 75-91%.

The invention relates to a compound of formula (I)Wherein R1, R2, R3 and R4 are defined as in the description and in the claims. The said compounds of the invention are preferential agoniste of the Carsonabinocid Receptor 2 and thus useful as medicaments and may be used in treatment of chronic pain, atherosclerosis, ischemic / reperfusion injury and other related diseases.A representative compound of this invention is 6-cyclopropylmethoxy-5-(tetrahydro-pyradine-2-carboxglic acid [1-methyl-1-(5-methyl-(1,2,4]oxadiazol-3-yl)-ethyl)-amide.

The invention relates to micro-electronic multilayer metal film etching liquid and application thereof. The micro-electronic multilayer metal film etching liquid comprises, by weight percentage, 5%-25% of hydrogen peroxide, 3%-10% of auxiliary acid, 2%-10% of a hydrogen peroxide stabilizer, 0.001%-1% of a taper angle control agent, 0.1%-1% of an additive and the balance ultrapure water. The auxiliary acid is an acidic material capable of providing H+; the hydrogen peroxide stabilizer is a combination of three kinds of bis-phosphonic acid tetrasodium, 8-hydroxyquinoline, citric acid, dipicolinic acid, aminoethanol phosphoric acid, picolinic acid and polyacrylamide; and the taper angle control agent is an organic compound containing amidogens, and the carbon chain length of the taper angle control agent ranges from 1 to 10. According to the micro-electronic multilayer metal film etching liquid, the special hydrogen peroxide stabilizer is selected, the additive in the etching liquid is used in a matched manner, and therefore the long-period stored etching liquid can be obtained; and meanwhile, the etching capacity of the etching liquid is stabilized.

The invention discloses a synthesis method of Vadadustat. The method 3,5-dichloro-2-picolinic acid and glycine methyl ester hydrochloride carry out condensation reaction; the obtained N-(3,5-dichloropyridine-2-carbonyl) glycine methyl ester and 3-chlorobenzene Boronic acid is carried out catalytic coupling reaction; The N-[5-(3-chlorophenyl)-3-chloropyridine-2-carbonyl] glycine methyl ester obtained and sodium methylate are carried out methoxy substitution reaction; The obtained N- [5-(3-chlorophenyl)-3-methoxypyridine-2-carbonyl]glycine is hydrolyzed to obtain finished product Vadadustat. The synthesis method has short route steps, simplified operation and low cost, is a green and environment-friendly method, and is suitable for industrial production.

Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

The invention relates to a novel metal complex and application thereof in an organic luminescent device. The structural general formula of the metal iridium complex for near infrared luminescence is LnIrX(3-n), wherein X is selected from acetylacetone, dibenzoylmethane, dipivaloylmethane or picolinic acid; n is selected from 1, 2 or 3; L is selected from the following structural formula L1, L2 or L3; R1-R9 are independently selected from H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkylamino, carbazolyl, F, trifluoromethyl and C5-18 aryl respectively; and Ar represents C5-18 aryl and C5-18 heterocyclic aryl. The metal complex has the advantages of short luminescence life and high luminescence efficiency; and an organic luminescent device prepared from the luminescent material has the characteristic of high luminescence efficiency under high current density. The structural formula L1, the structural formula L2 and the structural formula L3 are shown in the specification.

The present invention provides a method of removing silicon nitride in preference to silicon dioxide by CMP. The method utilizes a polishing slurry that includes colloidal silica abrasive particles dispersed in water and an additive that suppresses the silicon dioxide removal rate but enhances the silicon nitride removal rate. In one embodiment of the invention, the additive is lysine, which is effective at a pH of about 9, or arginine, which is effective at a pH of about 8. In another embodiment of the invention, the additive is lysine mono hydrochloride in combination with picolinic acid, which is effective at a pH of about 8, or arginine in combination with picolinic acid, which is effective at a pH of about 9.

The synthesis process of chromium 2-picolinate includes oxidizing 2-picoline into 2-picolinic acid, separating side product chromium oxide and mirabilite, and complexing with trivalent chromium salt to produce chromium 2-picolinate. The synthesis process of the present invention has simple operate, cheap material, high additional value of the side product, mild reaction condition, short reaction time, low power consumption, low cost, high yield and easy application in production.

A homologeous catalyst system for the hydroxylation reaction of methanol to obtain acetic acid or the carbonylating reaction of methyl acetate to obtain ethylanhydride is composed of the primary catalyst (rhodium acetate (or nitrate) as coordination center and potassium), cocatalyst (iodomethane), additive (lithium iodide, potassium iodide, or lithium acetate), and polar solvent (acetic acid, ethylanhydride, methyl acetate, or water). Its preparing process includes dissolving picolinic acid and hydrated potassium in methanol or water to obtain organic potassium ligand, dissolving in water or methanol solution, and dripping rhodium solution.

The invention relates to an anti-stress feed additive which takes Chinese herbal medicaments and organic chromium as core components and a preparation method of the anti-stress feed additive. The feed additive consists of the following components in parts by mass: 10 to 20 parts of astragalus membranaceus, 10 to 20 parts of scutellaria baicalensis, 10 to 20 parts of mint, 10 to 20 parts of spina date seeds, 20 to 40 parts of glucose, 2*10<-7> to 3*10<-7> parts of chromium picolinate, 1 to 5 parts of KCl, and 1 to 5 parts of NaHCO3. The anti-stress feed additive can be obtained by mixing, crushing, grinding and drying the components. By using the anti-stress feed additive, the anti-stress capacity of livestock and poultry can be enhanced; the anti-stress feed additive is particularly suitable for the livestock and the poultry during long-distance transport in dry and hot weathers, can relieve and treat transport stress, and can also rapidly supplement electrolyte loss caused by livestock and poultry dehydration and rapidly recover cell osmotic pressure and regulate in-vivo acid-base balance; the meat quality of the livestock and the poultry is improved; the selected Chinese herbal medicaments are easily absorbed and digested by the livestock and the poultry; the harm to human health caused by residues of the Chinese herbal medicaments in the livestock and the poultry is avoided.

The invention discloses a disinfectant for cleaning and disinfecting a hemodialysis machine. The disinfectant contains the following components by weight percent: 0.5%-1.0% of peracetic acid, 2.0%-5.0% of hydrogen peroxide, 0.1%-0.5% of pyridine-2-formic acid, 0.01%-0.05% of sodium citrate, 0.2%-2.0% of sodium dichloroisocyanurate, 0.05%-1.0% of sulfamic acid and the balance being water. A preparation technology of the disinfectant is simple, the disinfectant is convenient to use, the technological conditions are easy to achieve and the product stability is good.

The invention relates to a preparation method and an application of an N-heterocyclic carbine palladium compound containing a pyridyl-2-formate or pyridyl-2,6-diformate ligand. The N-heterocyclic carbine palladium compound containing the pyridyl-2-formate or pyridyl-2,6-diformate ligand is generated by reacting initial raw materials of a substituted imidazolium or imidazolium salt, palladium chloride and 2-picolinic acid or 2,6-dipicolinic acid, or the N-heterocyclic carbine palladium compound is generated in a high yield manner by using a corresponding N-heterocyclic carbine palladium chloride dipolymer and 2-picolinic acid or 2,6-dipicolinic acid as initial raw materials. The N-heterocyclic carbine palladium compound of the invention has a very high catalytic activity when being used in a C-N cross-coupling reaction of a halogenated arene and an organic amine as a catalyst. The chemical structural formula of the N-heterocyclic carbine palladium compound containing the pyridyl-2-formate or pyridyl-2,6-diformate ligand is shown in the specification. In the chemical structural formula, m is 0-4, and n is 0-3; and carbon numbers of R<1>, R<2>, R<3>, R<4> and R<5> are defined in the claim 1.