157 results about "Picolinic acid" patented technology

The invention relates to the technical field of adhesives, and particularly discloses an electrogenerated viscosity-reducing adhesive as well as a preparation method and application thereof. The electrogenerated viscosity-reducing glue is prepared from the following raw materials in parts by weight: 100 to 150 parts of polyacrylate, 30 to 50 parts of polyvinyl alcohol, 20 to 40 parts of functional monomer, 1 to 5 parts of conductive agent, 2 to 6 parts of alkenyl-containing ionic liquid, 1 to 5 parts of lithium salt, 1 to 5 parts of tackifier, 1 to 2 parts of dispersant, 0.1 to 2 parts of initiator and 60 to 100 parts of organic solvent, and the conductive agent is obtained by synergistically modifying hydroxylated carbon nanotubes with 2-thiophenecarboxylic acid and 2-picolinic acid. The electrogenerated viscosity-reducing adhesive is applied to the electrogenerated viscosity-reducing adhesive tape, and the obtained adhesive tape is excellent in peel strength and shear strength, high in power-on viscosity-reducing efficiency, free of adhesive residue during peeling, reusable and wide in application prospect.

The invention provides an improved preparation method of Oxazosulfyl. The improved preparation method of Oxazosulfyl comprises the following step: enabling 3-ethylsulfonyl pyridine-2-formic acid, 2-amino-4-(trifluoromethyl) mercaptophenol and anhydrous zinc chloride to react in a pressure reaction kettle, so as to obtain Oxazosulfyl. The method is short in process route, simple to operate and suitable for industrial production.

A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A1) a 4-pyrone-based compound represented by General Formula (1) below, and a pH is 5.0 or more. A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A2) a picolinic acid compound, and a pH is 5.0 or more.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

The invention relates to a preparation method of 4-hydroxybutyl acrylate, which is characterized in that acrylic acid and tetrahydrofuran are used as raw materials, in the presence of a polymerization inhibitor and a compound catalyst, the 4-hydroxybutyl acrylate is prepared, the compound catalyst comprises concentrated sulfuric acid and metal salt, and the concentrated sulfuric acid and the metal salt are mixed to prepare the 4-hydroxybutyl acrylate. The metal salt is selected from one or more of ferric trichloride, ferric formate, ferric acetate, ferric acrylate, ferric methacrylate, chromium trichloride, chromium acrylate, chromium methacrylate, chromium acetylacetonate, ferric acetylacetonate, chromium picolinate, chromium formate and chromium acetate. According to the method disclosed by the invention, the 4-hydroxybutyl acrylate can be prepared with high selectivity under a mild condition.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 5-bromopyridine-2-carboxylic acid methyl ester, which specifically comprises the following steps: 1) reacting 3-butyric acid-2-oxo-methyl ester with 2-bromoethylamine to synthesize 6-amino-5-bromo-3, 5-diene-2-ketone; (2) enabling the 6-amino-5-bromine-3, 5-diene-2-ketone prepared in the step (1) to react with glacial acetic acid, and synthesizing 5-bromine-2-methylpyridine; (3) reacting the 5-bromo-2-methylpyridine prepared in the step (2) with potassium permanganate to synthesize 5-bromopicolinic acid; 4) reacting the 5-bromopicolinic acid prepared in the step 3) with methanol and concentrated hydrochloric acid to synthesize the 5-bromopyridine-2-carboxylic acid methyl ester.The preparation method of the 5-bromopyridine-2-carboxylic acid methyl ester.The preparation method of the 5-bromopyridine-2-carboxylic acid methyl ester.The preparation method of the 5-bromopyridine-2-carboxylic acid methyl esterhas the advantages that the total reaction yield is high, the prepared 5-bromopyridine-2-carboxylic acid methyl esteris high in purity, reaction conditions are mild, cyanide does not need to participate in the reaction, and operation is easy.

The invention provides a reactive dye with a high fixation rate and a preparation method thereof. The reactive dye is prepared from the following raw materials in parts by mass: 25 parts of modified reactive dye, 0.3-0.7 part of a metal ion agent and 60-80 parts of water, wherein the modified reactive dye is obtained by inclusion of reactive dye molecules with beta-cyclodextrin-pyridine carboxylic acid, and beta-cyclodextrin and pyridine carboxylic acid in the beta-cyclodextrin-pyridine carboxylic acid are connected through an alkyl chain; metal ions provided by the metal ion agent can be chelated with the picolinic acid. Reactive dye molecules and beta-cyclodextrin-pyridine carboxylic acid form an inclusion structure, the hydrolysis probability of active groups is reduced, and an alkyl chain regulates steric hindrance and molecular spacing, so that pyridine nitrogen and carboxylic acid more efficiently form a more stable chelate with metal ions and further form coordinate bonds with hydroxyl groups on the fiber surface, and the fixation rate of the reactive dye is improved.

The invention provides a diagnostic marker for metabolic syndrome and preclinical stage thereof, and the diagnostic marker or a plasma small molecule metabolism biomarker consists of the following substances: pyrimidine, (S)-beta-aminoisobutyric acid, 3-hydroxybutyric acid, L-serine, guanidine acetic acid, 3-hydroxyisovaleric acid, L-homoserine, L-cysteine, piperidine acid, hypotaurine and creatinine. The beverage is prepared from phenylacetic acid, erythritol, picolinic acid, taurine, pyroglutamic acid, lemonic acid, malic acid, tyramine, isonicotinic acid, o-phosphoethanolamine, L-glutamine, salicylic acid and D-glucose. The invention also provides a kit for detecting the plasma small molecule metabolism biomarker composition, the spectrum peak intensity of the obtained plasma small molecule metabolism biomarker is detected, the risk score of whether each subject is MetS or pre-MetS is calculated, and then whether the subject is MetS or pre-MetS is predicted. According to the invention, efficient and rapid diagnosis of the metabolic syndrome and the preclinical stage thereof is realized.

The invention discloses a synthesis method and application of nitrogen-doped carbon-coated Co porous spheres, cobalt nitrate hexahydrate and 4-picolinic acid are dissolved in a mixed solution, the mixed solution comprises dimethylformamide and absolute ethyl alcohol, then the mixed solution is transferred into a reaction kettle for heating reaction, and after the reaction is finished, centrifugal drying is performed to obtain a Co coordination compound precursor; and calcining the precursor in an argon hydrogen atmosphere, and selecting and setting a proper heating rate, a proper calcining temperature and a proper calcining time to obtain the nitrogen-doped carbon-coated Co porous ball. The obtained nitrogen-doped carbon-coated Co porous ball is used as the air cathode of the zinc-air battery, so that high power density and excellent charge-discharge cycle stability are realized.

The invention discloses a preparation method of 3-quinuclidinone hydrochloride, which comprises the following steps: carrying out temperature control reaction on 4-picolinic acid and chloroacetic acid under alkaline water conditions to obtain an aqueous solution of a compound a, and directly entering the next reaction without post-treatment after the reaction is finished; adding a reducing agent alkaline water system into the aqueous solution of the compound a, controlling the temperature to react, controlling the temperature to adjust the pH value to 5-5.5 after the reaction is finished, extracting with n-butyl alcohol, and drying to obtain an n-butyl alcohol solution of a compound b, and directly entering the next reaction step; wherein the reducing agent is one of sodium borohydride and potassium borohydride; dropwise adding thionyl chloride into an n-butyl alcohol solution of the compound b, controlling the temperature to react after dropwise adding is ended, and concentrating to remove the solvent and unreacted thionyl chloride after the reaction is ended, so as to obtain a compound c; carrying out Dieckmann condensation reaction on the compound c at controlled temperature under the condition of organic alkali by using toluene as a solvent, carrying out hydrochloric acid quenching reaction after the reaction is finished, and directly carrying out next-step reaction after extracting and removing impurities from a water phase containing a hydrochloride solution of a compound d by using toluene; and carrying out a decarboxylation reaction on the compound d in a hydrochloric acid aqueous solution at controlled temperature, after the reaction is finished, adjusting the pH value to 10-13, extracting, and salifying to obtain a target compound TM, namely 3-quinuclidinone hydrochloride. The preparation method of 3-quinuclidinone hydrochloride provided by the invention has the advantages of economical and easily available raw materials, mild reaction conditions, efficient reaction, simple operation and low cost, and is suitable for industrial application.

The invention discloses a chromium picolinate preparation method, which comprises: placing 2-picolinic acid, a chromium source and a solvent in a container, and carrying out a complexation reaction at a temperature of 30-100 DEG C to prepare a first solution; keeping the temperature at 30-100 DEG C, adding a reducing agent into the first solution, adding an alkaline regulator, regulating the pH value to 5-7, and stirring and dispersing to obtain a second solution; and pulping the second solution to obtain a solid product and a mother solution, and drying the solid product to obtain chromium picolinate crystal particles. The synthesis is simple, and the product purity, yield and yield are high; the reducing agent is added to treat hexavalent chromium generated in the reaction, so that the content of hexavalent chromium in the product is greatly reduced, and the product is safer and more reliable; the mother liquor can be recycled, no wastewater and sewage treatment station needs to be built, the energy consumption is low, and the method has remarkable cost advantage and economic benefit and is suitable for large-scale production.

The invention belongs to the technical field of synthesis and application of complexes, and provides a metal carbonyl Mn complex taking a 2-picolinic acid derivative as a ligand as well as a preparation method and application of the metal carbonyl Mn complex. The chemical formula of the complex is [Mn (CO) 3 (L) Br], L is 2-picolinic acid, 5-Cl-2-picolinic acid, 5-Br-2-pyridylaldehyde or 6-Br-2-picolinic acid methyl ester, and the complex with four different substituent groups has high water solubility and has an obvious effect on improving the water solubility of CORM. The four complexes can realize CO controllable release under different illumination wavelengths, and can be applied to preparation of donors capable of realizing CO controllable release in visible light or near-infrared light. The compound can be combined with human serum protein to prepare a serum protein complex, and can be applied to metabolism regulation and cell targeting carrying of the complex. The growth of human cervical cancer HeLa cells is obviously inhibited, and the compound can be applied to screening and preparation of lead compounds of anti-tumor drugs.

The application discloses a method for removing trace sulfonamidochrysoidine in water by activating peracetic acid through complexation of manganese sulfate and 2-picolinic acid, wherein, (1) a homogeneous Mn(II)-PICA complex solution is prepared by mixing and stirring a manganese sulfate solution and a 2-picolinic acid solution; (2) peracetic acid solution and the homogeneous Mn(II)-PICA complex solution are added into water containing sulfonamidochrysoidine, and the mixture is fully stirred, and in the reaction process, high-valence manganese active species Mn(V)=O is generated; the system mainly adopts a non-radical oxidation path, has high selectivity to sulfonamidochrysoidine, and realizes degradation of the sulfonamidochrysoidine. The method has high activation efficiency and fast degradation speed, and the complex system significantly improves the activation efficiency of PAA, and the removal rate of sulfonamidochrysoidine can reach more than 90 % within 10 min, which is much higher than that of a single activation system.

This invention provides a chemical mechanical polishing (CMP) slurry and its application. The CMP slurry comprises: a catalyst, a stabilizer, an oxidant, a pH adjuster, abrasive particles, a corrosion inhibitor, and water. The corrosion inhibitor is a nitrogen-containing heterocyclic carboxylic acid compound, wherein the nitrogen-containing heterocyclic carboxylic acid compound includes at least one selected from nicotinic acid, isonicotinic acid, pyridinecarboxylic acid, imidazocarboxylic acid, pyrazolecarboxylic acid, 3-pyridineacetic acid, 3-pyridinepropionic acid, 3-methyl-2-pyridinecarboxylic acid, and L-piperidine acid. The CMP slurry provided by this invention can simultaneously polish tungsten and silicon oxide, and can also control the polishing rate of silicon oxide while inhibiting tungsten corrosion, thus making it suitable for different application scenarios. In addition, the CMP slurry has good stability and can maintain its performance even after long-term standing.

The application relates to a reagent combination for detecting depression, a manufacturing method, a detection system and application thereof, and belongs to the technical field of instrument detection. The reagent combination for detecting depression comprises a calibrator, a quality control sample and an extraction solution of a to-be-detected compound serving as a biomarker; wherein the to-be-detected compound is at least three kinds selected from 5-hydroxyanthranilic acid, methionine, gamma-aminobutyric acid, 3,4-dihydroxyphenylacetic acid, 2-picolinic acid, quinolinic acid, kynurenine, 5-hydroxytryptamine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, dopamine and norepinephrine. The reagent combination for detecting depression and the detection system can significantly improve the accuracy of diagnosis, are convenient to detect, have good repeatability of detection data, are high in specificity, and are accurate in clinical diagnosis results.

The present invention relates to picolinic acid derivatives which can be used to treat fungal diseases, especially plant fungal diseases.

The present invention provides an improved method for preparing Oxazosulfyl, which comprises reacting 3-ethylsulfonylpyridine-2-carboxylic acid, 2-amino-4-(trifluoromethyl) mercaptophenol and anhydrous zinc chloride in a pressure reactor to obtain Oxazosulfyl. The process route of the present invention is short and the operation is simple, which is suitable for industrial production.

The present application relates to the field of organic synthesis, in particular to a preparation method of tetrachloropyridine carboxylic acid, which comprises: putting tetrachloro-2-cyanopyridine and water into a reactor, and then adding a catalyst to react, wherein the catalyst comprises a metal oxide catalyst manganese dioxide and a metal inorganic salt catalyst sodium tungstate, the mass ratio of tetrachloro-2-cyanopyridine and water is 1:(1-2.5). The preparation method provided by the present application has a product content of tetrachloropyridine carboxylic acid greater than 98%, a product yield greater than 97%, and the preparation raw material does not include acid or alkali, thereby reducing the pollution to the environment.

The invention discloses an indan picolinamide compound as well as a preparation method and application thereof. The structural formula of the indane picolinamide compound is as shown in # imgabs0 #, and the preparation method comprises the following steps: reacting 4-(trifluoromethyl)-pyridine-3-formic acid with thionyl chloride to generate 4-(trifluoromethyl)-pyridine-3-formyl chloride, reacting the 4-(trifluoromethyl)-pyridine-3-formyl chloride with 7-fluoro-1, 1, 2, 3-tetracarboxylic acid under the catalysis of organic alkali or inorganic alkali to generate 4-(trifluoromethyl)-pyridine-3-formyl chloride, and reacting the 4-(trifluoromethyl)-pyridine-3-formyl chloride with 7-fluoro-1, 1, 2, 3-tetracarboxylic acid under the catalysis of organic alkali or inorganic alkali to generate 4-(trifluoromethyl)-pyridine-3-formyl chloride. According to the present invention, the target product N-(7-fluoro-1, 1, 3-trimethyl-4-indanyl)-4-trifluoromethylpyridine-3-formamide is generated through the reaction of 2, 3-difluoro-1, 1, 3-trimethyl-4-aminoindane, and the N-(7-fluoro-1, 1, 3-trimethyl-4-indanyl)-4-trifluoromethylpyridine-3-formamide has bactericidal activity, can be used for preventing and treating plant fungal diseases, and has good application prospects.

The invention belongs to the technical field of health-care food, and particularly relates to a composition for improving immunity and regulating blood sugar and application of the composition. The raw materials of the composition comprise active substances, the active substances comprise ginsenoside Rg2, notoginsenoside R1, ginsenoside Rh1, ginsenoside Rb2 and chromium picolinate, and the mass ratio of the ginsenoside Rg2 to the notoginsenoside R1 to the ginsenoside Rh1 to the ginsenoside Rb2 to the chromium picolinate is (5-15): (2-6): (2-6): (1-5): (0.1-0.2). The composition obtained by compounding the ginsenoside Rg2, the notoginsenoside R1, the ginsenoside Rh1, the ginsenoside Rb2 and the chromium picolinate has good effects of improving the immunity and reducing the blood sugar.

The present invention discloses a UV / blue light enhanced rare earth nanocomposite, a preparation method thereof, and an application thereof in acrylate photopolymerization. The rare earth nanocomposite includes rare earth nanomaterials and an organic coordination molecular layer disposed on the surface of the rare earth nanomaterials; the rare earth nanomaterials include a light emitting layer and a first energy capture layer disposed outside the light emitting layer, and an energy transfer channel is formed between the first energy capture layer and the light emitting layer; the main component of the organic coordination molecular layer is picolinic acid. In the rare earth nanocomposite of the present invention, the light emitting layer is used to capture energy and emit light, and the first energy capture layer is used to additionally obtain excitation energy and transfer it to the light emitting layer, thereby improving the excitation light energy capture ability, increasing the light emission intensity, promoting the photopolymerization reaction, and achieving the purpose of improving the photopolymerization reaction effect. Picolinic acid is used to protect the surface of the rare earth nanocomposite and promote energy transfer, thereby enhancing the photopolymerization reaction effect.

The present invention provides a copper surface chemical silver plating solution, comprising 0.1-100 g / L of silver (II) pyridine-2-carboxylate, 0.1-10 g / L of a complexing agent, 0.1-100 mL / L of an organic acid, 0.5-10 g / L of a surfactant, 0.2-8 g / L of an accelerator, 5-100 g / L of a corrosion inhibitor, and water. The present invention improves the chemical silver plating solution formula and adopts divalent silver ions Ag. 2+ It has a higher redox potential and a fast oxidation deposition speed, which makes the silver ion deposition rate fast and the silver plating layer can be deposited thicker. At the same time, the deposition rate is fast, and the attack on the circuit side corrosion position is small, which can avoid side corrosion. By combining with other additives, the deposition rate of silver ions can be further accelerated, the deposition thickness can be increased, and side corrosion can be avoided, thereby solving the side corrosion problems of thin silver thickness and strong acid corrosion of copper surface in chemical silver plating in the existing technology.

The invention discloses a primer for selectively detecting bacillus and a preparation method of the primer. The primer comprises noble metal nanoparticles of a bipyramid structure and a metal organic framework doped with lanthanide metal ions, and the metal organic framework doped with lanthanide metal ions grows in situ in a bipyramid tip area of the noble metal nanoparticles. According to the primer for selectively detecting the bacillus, disclosed by the invention, a marker picolinic acid of the bacillus can be selectively adsorbed in a complex sample, so that interference of environmental factors on detection is effectively avoided, and the detection accuracy of an SERS spectrum on the bacillus in a complex environment is greatly improved; besides, when the primer selectively adsorbs the marker picolinic acid, the Raman signal of the picolinic acid can be effectively enhanced by the electromagnetic fields generated by the two tips of the bipyramidal noble metal nanoparticles, so that the ultra-sensitive detection of the marker is realized.

The present invention relates to herbicidal compound of Arylalkyl ester of 4—aminopicolinic acid and 6-amino-4-pyrimidinecarboxylate compound of formula 1 B wherein X represents H or F; Y represents halogen, Ci-C8 alkyl, C3-C6 cycloalkyl, or phenyl substituted with 1 - 4 substituents independently selected from halogen. Ci-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 haloalkoxy, cyano, nitro, NRlR2, or where two adjacent substituents are taken together as —0 (CH2)nO— or —0 (CH2)n— wherein n=l or 2; Z represents halogen or C2-C4 alkenyl; R1 and R2 independently represent H, Ci-Ce alkyl, or C1-C6 acyl; R3 represents unsubstituted or substituted C7Cnarylalkyl; are herbicide for control of weeds especially those species common to rice and wheat cropping system and in pasture management program.

The invention belongs to the technical field of compound purification, and particularly relates to a purification method of chromium 2-picolinate. The purification method of chromium 2-picolinate provided by the invention comprises the following steps: mixing a chromium 2-picolinate crude product with water and ethanol, adjusting the pH value of the system to 3.5-4.5, then carrying out heating and heat preservation, then carrying out heating reflux, extracting fractions, then stopping heating, and filtering, washing and drying the residual materials after the fractions are extracted to obtain the chromium 2-picolinate. The purified 2-chromium picolinate is obtained. According to the method, the purity of the chromium 2-picolinate can be effectively improved by utilizing a specific acid environment and ethanol, so that a new strategy can be provided for purification of the chromium 2-picolinate, and the method is particularly suitable for pure product preparation and product quality control of the chromium 2-picolinate.

The invention relates to a method for preparing 3, 4, 5, 6-tetrachloropicolinic acid from picloram solid residues. The method comprises the following steps: dissolving picloram solid residues which take 6-amino-3, 4, 5-trichloropicolinic acid and 4-amino-3, 5, 6-trichloropicolinic acid as main components as raw materials in 1, 4-dioxane or other solvents, adding concentrated nitric acid to carry out N-amino nitration, then adding thionyl chloride to carry out sealed heating chlorination, and carrying out post-treatment to obtain 3, 4, 5, 6-tetrachloropicolinic acid. According to the method, picloram solid residues are converted into production raw materials with practical application value, diazotization operation in a traditional method is avoided, and the method has the advantages of being safe and mild in reaction, easy to operate, green and economical.

The invention discloses a synthesis method of a halauxifen-methyl intermediate, which comprises the following steps: by taking 4-amino-3, 5, 6-trichloropyridine-2-carboxylic acid methyl ester as a raw material, carrying out acylation, fluorination, bromination, hydrolysis and other reactions to obtain 4-amino-6-bromo-3-chloro-5-fluoropicolinic acid with the total yield of 67.13%. The method is simple to operate, stable in process and environment-friendly, and the obtained halauxifen-methyl intermediate is high in purity and suitable for industrial mass production.

The application discloses a method for directional construction of eugenol-based supramolecular co-crystal system and application of the product, and belongs to the field of agricultural chemistry and supramolecular crystal engineering technology. The method comprises the following steps: selecting eugenol as a hydrogen bond donor molecule through rational molecular design, selecting nicotinamide or 2-pyridinecarboxylic acid as a co-crystal ligand according to the quantitative screening standards of hydrogen bond acceptor strength (pKa value), molecular geometric length and specific functional groups, dissolving the two in a mixed solvent with a specific dielectric constant range at a 1:1 molar ratio, and obtaining a supramolecular co-crystal product with a clear structure through programmed temperature uniform cooling crystallization, aging and drying. The product has stable crystal structure, pH-responsive release characteristics and slow-release performance better than that of a physical mixture. The product is added to urea at an addition amount of 0.5% to 5.0%. The application realizes directional construction of co-crystals from empirical screening to rational design, structure control and performance prediction, and provides a reliable material platform for nitrogen fertilizer efficiency.

The present invention relates to new macrocyclic ligands substituted by at least one picolinic ester group, to radioactive complexes thereof and to their use in medical imaging and / or therapy, in particular in interventional radiology. The present invention also relates to new processes for the preparation of the ligands according to the invention, and also to intermediates in the preparation thereof.

The invention discloses efficient light-controlled drug release nanoparticles based on a reversible TTET mechanism and a preparation method, and belongs to the technical field of light-controlled drug release. The preparation method comprises the following steps: adding ethyl 4-chloroacetoacetate into methanesulfonic acid dissolved with 4-bromoresorcinol, and stirring; then obtaining a compound 1; the preparation method comprises the following steps: mixing a compound 1, a drug molecule with carboxyl, K2CO3 and ultra-dry DMF, and carrying out a heating reaction in the presence of nitrogen to obtain a prodrug Cu-Dug; the preparation method comprises the following steps: mixing 2-(2, 4-difluorophenyl)-pyridine and IrCl3. 3H2O, adding a mixed solvent in the presence of nitrogen, carrying out a heating reflux reaction, cooling, carrying out suction filtration, washing, drying, mixing with a pyridine-2-formic acid derivative and Na2CO3, adding glycol ether in the presence of nitrogen, and carrying out a heating reaction; then distilling, extracting, drying and purifying to obtain the photosensitizer Ir complex; the preparation method comprises the following steps: adding a co-block polymer, a prodrug Cu-Dug and a photosensitizer Ir complex into THF (tetrahydrofuran), and mixing to obtain a mixed solution; and adding the mixed solution into deionized water, stirring, dialyzing, and filtering to obtain a nanoparticle aqueous solution.

The invention relates to the field of separation, in particular to a poly (2-vinylpyridine) evaporative crystallization device and method.The poly (2-vinylpyridine) evaporative crystallization device comprises a reaction kettle, and an evaporative crystallization assembly for conducting evaporative crystallization treatment on poly (2-vinylpyridine) is arranged in the reaction kettle; through cooperation of the reaction kettle, the pretreater and the separator, the evaporative crystallization extraction effect on the organic phase in the poly (2-vinylpyridine) kettle residue is achieved, a high-value picolinic acid product is prepared, economic benefits are improved while waste is avoided, the economic benefits are guaranteed, and the production cost is reduced. And carbon emission reduction is realized, and the concept of green sustainable development is met.