64 results about "Picolinic acid" patented technology

A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A1) a 4-pyrone-based compound represented by General Formula (1) below, and a pH is 5.0 or more. A polishing liquid for CMP, containing: abrasive grains; an additive; and water, in which the abrasive grains include cerium-based particles, a zeta potential of the abrasive grains is negative, the additive includes (A2) a picolinic acid compound, and a pH is 5.0 or more.[In the formula, X11, X12, and X13 are each independently a hydrogen atom or a monovalent substituent.]

The invention provides a reactive dye with a high fixation rate and a preparation method thereof. The reactive dye is prepared from the following raw materials in parts by mass: 25 parts of modified reactive dye, 0.3-0.7 part of a metal ion agent and 60-80 parts of water, wherein the modified reactive dye is obtained by inclusion of reactive dye molecules with beta-cyclodextrin-pyridine carboxylic acid, and beta-cyclodextrin and pyridine carboxylic acid in the beta-cyclodextrin-pyridine carboxylic acid are connected through an alkyl chain; metal ions provided by the metal ion agent can be chelated with the picolinic acid. Reactive dye molecules and beta-cyclodextrin-pyridine carboxylic acid form an inclusion structure, the hydrolysis probability of active groups is reduced, and an alkyl chain regulates steric hindrance and molecular spacing, so that pyridine nitrogen and carboxylic acid more efficiently form a more stable chelate with metal ions and further form coordinate bonds with hydroxyl groups on the fiber surface, and the fixation rate of the reactive dye is improved.

The invention discloses a synthesis method and application of nitrogen-doped carbon-coated Co porous spheres, cobalt nitrate hexahydrate and 4-picolinic acid are dissolved in a mixed solution, the mixed solution comprises dimethylformamide and absolute ethyl alcohol, then the mixed solution is transferred into a reaction kettle for heating reaction, and after the reaction is finished, centrifugal drying is performed to obtain a Co coordination compound precursor; and calcining the precursor in an argon hydrogen atmosphere, and selecting and setting a proper heating rate, a proper calcining temperature and a proper calcining time to obtain the nitrogen-doped carbon-coated Co porous ball. The obtained nitrogen-doped carbon-coated Co porous ball is used as the air cathode of the zinc-air battery, so that high power density and excellent charge-discharge cycle stability are realized.

The invention discloses a preparation method of 3-quinuclidinone hydrochloride, which comprises the following steps: carrying out temperature control reaction on 4-picolinic acid and chloroacetic acid under alkaline water conditions to obtain an aqueous solution of a compound a, and directly entering the next reaction without post-treatment after the reaction is finished; adding a reducing agent alkaline water system into the aqueous solution of the compound a, controlling the temperature to react, controlling the temperature to adjust the pH value to 5-5.5 after the reaction is finished, extracting with n-butyl alcohol, and drying to obtain an n-butyl alcohol solution of a compound b, and directly entering the next reaction step; wherein the reducing agent is one of sodium borohydride and potassium borohydride; dropwise adding thionyl chloride into an n-butyl alcohol solution of the compound b, controlling the temperature to react after dropwise adding is ended, and concentrating to remove the solvent and unreacted thionyl chloride after the reaction is ended, so as to obtain a compound c; carrying out Dieckmann condensation reaction on the compound c at controlled temperature under the condition of organic alkali by using toluene as a solvent, carrying out hydrochloric acid quenching reaction after the reaction is finished, and directly carrying out next-step reaction after extracting and removing impurities from a water phase containing a hydrochloride solution of a compound d by using toluene; and carrying out a decarboxylation reaction on the compound d in a hydrochloric acid aqueous solution at controlled temperature, after the reaction is finished, adjusting the pH value to 10-13, extracting, and salifying to obtain a target compound TM, namely 3-quinuclidinone hydrochloride. The preparation method of 3-quinuclidinone hydrochloride provided by the invention has the advantages of economical and easily available raw materials, mild reaction conditions, efficient reaction, simple operation and low cost, and is suitable for industrial application.

The application discloses a method for removing trace sulfonamidochrysoidine in water by activating peracetic acid through complexation of manganese sulfate and 2-picolinic acid, wherein, (1) a homogeneous Mn(II)-PICA complex solution is prepared by mixing and stirring a manganese sulfate solution and a 2-picolinic acid solution; (2) peracetic acid solution and the homogeneous Mn(II)-PICA complex solution are added into water containing sulfonamidochrysoidine, and the mixture is fully stirred, and in the reaction process, high-valence manganese active species Mn(V)=O is generated; the system mainly adopts a non-radical oxidation path, has high selectivity to sulfonamidochrysoidine, and realizes degradation of the sulfonamidochrysoidine. The method has high activation efficiency and fast degradation speed, and the complex system significantly improves the activation efficiency of PAA, and the removal rate of sulfonamidochrysoidine can reach more than 90 % within 10 min, which is much higher than that of a single activation system.

This invention provides a chemical mechanical polishing (CMP) slurry and its application. The CMP slurry comprises: a catalyst, a stabilizer, an oxidant, a pH adjuster, abrasive particles, a corrosion inhibitor, and water. The corrosion inhibitor is a nitrogen-containing heterocyclic carboxylic acid compound, wherein the nitrogen-containing heterocyclic carboxylic acid compound includes at least one selected from nicotinic acid, isonicotinic acid, pyridinecarboxylic acid, imidazocarboxylic acid, pyrazolecarboxylic acid, 3-pyridineacetic acid, 3-pyridinepropionic acid, 3-methyl-2-pyridinecarboxylic acid, and L-piperidine acid. The CMP slurry provided by this invention can simultaneously polish tungsten and silicon oxide, and can also control the polishing rate of silicon oxide while inhibiting tungsten corrosion, thus making it suitable for different application scenarios. In addition, the CMP slurry has good stability and can maintain its performance even after long-term standing.

The application relates to a reagent combination for detecting depression, a manufacturing method, a detection system and application thereof, and belongs to the technical field of instrument detection. The reagent combination for detecting depression comprises a calibrator, a quality control sample and an extraction solution of a to-be-detected compound serving as a biomarker; wherein the to-be-detected compound is at least three kinds selected from 5-hydroxyanthranilic acid, methionine, gamma-aminobutyric acid, 3,4-dihydroxyphenylacetic acid, 2-picolinic acid, quinolinic acid, kynurenine, 5-hydroxytryptamine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, dopamine and norepinephrine. The reagent combination for detecting depression and the detection system can significantly improve the accuracy of diagnosis, are convenient to detect, have good repeatability of detection data, are high in specificity, and are accurate in clinical diagnosis results.

The present application relates to the field of organic synthesis, in particular to a preparation method of tetrachloropyridine carboxylic acid, which comprises: putting tetrachloro-2-cyanopyridine and water into a reactor, and then adding a catalyst to react, wherein the catalyst comprises a metal oxide catalyst manganese dioxide and a metal inorganic salt catalyst sodium tungstate, the mass ratio of tetrachloro-2-cyanopyridine and water is 1:(1-2.5). The preparation method provided by the present application has a product content of tetrachloropyridine carboxylic acid greater than 98%, a product yield greater than 97%, and the preparation raw material does not include acid or alkali, thereby reducing the pollution to the environment.

The invention discloses a primer for selectively detecting bacillus and a preparation method of the primer. The primer comprises noble metal nanoparticles of a bipyramid structure and a metal organic framework doped with lanthanide metal ions, and the metal organic framework doped with lanthanide metal ions grows in situ in a bipyramid tip area of the noble metal nanoparticles. According to the primer for selectively detecting the bacillus, disclosed by the invention, a marker picolinic acid of the bacillus can be selectively adsorbed in a complex sample, so that interference of environmental factors on detection is effectively avoided, and the detection accuracy of an SERS spectrum on the bacillus in a complex environment is greatly improved; besides, when the primer selectively adsorbs the marker picolinic acid, the Raman signal of the picolinic acid can be effectively enhanced by the electromagnetic fields generated by the two tips of the bipyramidal noble metal nanoparticles, so that the ultra-sensitive detection of the marker is realized.

The present invention relates to herbicidal compound of Arylalkyl ester of 4—aminopicolinic acid and 6-amino-4-pyrimidinecarboxylate compound of formula 1 B wherein X represents H or F; Y represents halogen, Ci-C8 alkyl, C3-C6 cycloalkyl, or phenyl substituted with 1 - 4 substituents independently selected from halogen. Ci-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 haloalkoxy, cyano, nitro, NRlR2, or where two adjacent substituents are taken together as —0 (CH2)nO— or —0 (CH2)n— wherein n=l or 2; Z represents halogen or C2-C4 alkenyl; R1 and R2 independently represent H, Ci-Ce alkyl, or C1-C6 acyl; R3 represents unsubstituted or substituted C7Cnarylalkyl; are herbicide for control of weeds especially those species common to rice and wheat cropping system and in pasture management program.

The invention belongs to the technical field of compound purification, and particularly relates to a purification method of chromium 2-picolinate. The purification method of chromium 2-picolinate provided by the invention comprises the following steps: mixing a chromium 2-picolinate crude product with water and ethanol, adjusting the pH value of the system to 3.5-4.5, then carrying out heating and heat preservation, then carrying out heating reflux, extracting fractions, then stopping heating, and filtering, washing and drying the residual materials after the fractions are extracted to obtain the chromium 2-picolinate. The purified 2-chromium picolinate is obtained. According to the method, the purity of the chromium 2-picolinate can be effectively improved by utilizing a specific acid environment and ethanol, so that a new strategy can be provided for purification of the chromium 2-picolinate, and the method is particularly suitable for pure product preparation and product quality control of the chromium 2-picolinate.

The invention relates to a method for preparing 3, 4, 5, 6-tetrachloropicolinic acid from picloram solid residues. The method comprises the following steps: dissolving picloram solid residues which take 6-amino-3, 4, 5-trichloropicolinic acid and 4-amino-3, 5, 6-trichloropicolinic acid as main components as raw materials in 1, 4-dioxane or other solvents, adding concentrated nitric acid to carry out N-amino nitration, then adding thionyl chloride to carry out sealed heating chlorination, and carrying out post-treatment to obtain 3, 4, 5, 6-tetrachloropicolinic acid. According to the method, picloram solid residues are converted into production raw materials with practical application value, diazotization operation in a traditional method is avoided, and the method has the advantages of being safe and mild in reaction, easy to operate, green and economical.

The invention discloses a synthesis method of a halauxifen-methyl intermediate, which comprises the following steps: by taking 4-amino-3, 5, 6-trichloropyridine-2-carboxylic acid methyl ester as a raw material, carrying out acylation, fluorination, bromination, hydrolysis and other reactions to obtain 4-amino-6-bromo-3-chloro-5-fluoropicolinic acid with the total yield of 67.13%. The method is simple to operate, stable in process and environment-friendly, and the obtained halauxifen-methyl intermediate is high in purity and suitable for industrial mass production.

The application discloses a method for directional construction of eugenol-based supramolecular co-crystal system and application of the product, and belongs to the field of agricultural chemistry and supramolecular crystal engineering technology. The method comprises the following steps: selecting eugenol as a hydrogen bond donor molecule through rational molecular design, selecting nicotinamide or 2-pyridinecarboxylic acid as a co-crystal ligand according to the quantitative screening standards of hydrogen bond acceptor strength (pKa value), molecular geometric length and specific functional groups, dissolving the two in a mixed solvent with a specific dielectric constant range at a 1:1 molar ratio, and obtaining a supramolecular co-crystal product with a clear structure through programmed temperature uniform cooling crystallization, aging and drying. The product has stable crystal structure, pH-responsive release characteristics and slow-release performance better than that of a physical mixture. The product is added to urea at an addition amount of 0.5% to 5.0%. The application realizes directional construction of co-crystals from empirical screening to rational design, structure control and performance prediction, and provides a reliable material platform for nitrogen fertilizer efficiency.

The present invention relates to new macrocyclic ligands substituted by at least one picolinic ester group, to radioactive complexes thereof and to their use in medical imaging and / or therapy, in particular in interventional radiology. The present invention also relates to new processes for the preparation of the ligands according to the invention, and also to intermediates in the preparation thereof.

The invention discloses an efficient synthesis method of 2-acetamido-pyridine-3-formic acid, which comprises the following steps: taking 2-amino-3-methylpyridine as a raw material, firstly reacting with acetic anhydride in a micro-channel reactor, and carrying out post-treatment to obtain 2-acetamido-3-methylpyridine; and then, carrying out catalytic oxidation on the intermediate in a water-ethanol system in an oxygen environment by taking iridium trichloride, copper 2-picolinate, N-hydroxyphthalimide and iodobenzene as a catalytic system. And filtering out and recovering the catalyst after the reaction, and carrying out two-step programmed cooling crystallization and activated carbon decoloration refining on mother liquor to obtain a high-purity target product. The method has the advantages of cheap raw materials, adoption of a green solvent and oxygen as oxidants, mild reaction conditions, high product yield and purity, few three wastes, recoverable catalyst, and facilitation of industrial production.

The present invention relates to use of a personal care composition comprising a heteroaromatic compound selected from nicotinic acid, picolinic acid, niacin, niacinamide, picolinamide and mixtures thereof, a retinoic acid precursor selected from retinyl esters, retinol, retinal, retinoic acid and mixtures thereof, a resorcinol compound; and an oil-soluble sunscreen, for improving the barrier function of skin.

The invention discloses crystalline pyridyl polyester and a preparation method thereof. The crystalline pyridyl polyester is prepared by taking picolinic acid and aliphatic dihydric alcohol with a certain chain length as raw materials and combining a specific melt polymerization process. The obtained pyridyl polyester is simple in structure and high in crystallinity, the preparation process is simple and convenient, industrial production is easy, and a new thought is provided for preparation of high-performance bio-based polyester.

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases, particularly in plants.

The invention discloses a synthesis method of 2-chloro-3-picolinic acid, which comprises the following steps: adding hydrogen peroxide into a mixed solution of 3-cyanopyridine and acetic anhydride, and reacting to obtain an oxidized crude product; adding bis (trichloromethyl) carbonate into the oxidized crude product, and reacting to obtain a chlorinated intermediate product; and carrying out alkaline hydrolysis on the chlorination intermediate product, and acidifying to obtain the 2-chloro-3-picolinic acid. According to the synthesis method, acetic anhydride is added into the raw materials, oxidation reaction is promoted, an acid environment for maintaining system reaction is provided, and the reaction yield is increased; the whole reaction does not have an intermediate product discharging link, all reactions can be carried out in the same reaction container, the procedures of solid discharging, drying and the like in a traditional method are omitted, the technological process is simplified, solid feeding operation is avoided, and the manpower and material resource cost is saved; the method avoids phosphorus-containing wastewater difficult to treat produced by the traditional chlorination reaction, greatly reduces the treatment difficulty of three wastes, and has a remarkable environmental protection effect.

The invention relates to the field of MOFs materials, in particular to a preparation method and application of an ultrahigh ammonia adsorption MOFs material, an organic ligand of the MOFs material is 3-aminopyridine-4-formic acid, a metal source of the MOFs material is manganous nitrate tetrahydrate, the preparation method comprises the steps that S1, the manganous nitrate tetrahydrate and the 3-aminopyridine-4-formic acid are dissolved in absolute ethyl alcohol, then sealing is conducted, and a precursor is obtained; performing continuous ultrasonic treatment for 10-20 minutes to obtain a mixed solution; s2, heating the mixed solution in an environment of 75-85 DEG C for 65-80 hours, and then cooling to room temperature to obtain a reaction solution; s3, washing the reaction liquid obtained in the step S2 with absolute ethyl alcohol, and then filtering and separating to obtain the MOFs material. The adsorption capacity of the prepared MOFs material on ammonia gas exceeds that of other MOFs materials, and meanwhile the MOFs material still has good adsorption capacity on ammonia gas after multiple times of adsorption and desorption.

This invention belongs to the field of pharmaceutical technology and discloses a cocrystal of dihydroquercetin and pyridinecarboxylic acid, its preparation method, composition, and uses. Specifically, this invention discloses a novel dihydroquercetin and pyridinecarboxylic acid cocrystal using dihydroquercetin (as shown in formula a) as the active pharmaceutical ingredient and pyridinecarboxylic acid (as shown in formula b) as the cocrystal ligand; a method for preparing the dihydroquercetin and pyridinecarboxylic acid cocrystal; and the application of the dihydroquercetin and pyridinecarboxylic acid cocrystal as the active pharmaceutical ingredient in the preparation of antioxidants, free radical scavengers, cell protectants, and antivirals.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of an edoxaban intermediate. The method takes 2,5-dimethyl-4,5,6,7-tetrahydrothiazole[5,4-c]pyridine (compound 1) as raw material, and first performs an oxidation reaction with an oxidant to obtain 5-methyl-4,5,6,7-tetrahydrothiazole[5,4-c]pyridine-2-methanal (compound 2), then performs a reaction with chlorite to obtain 5-methyl-4,5,6,7-tetrahydrothiazole[5,4-c]pyridine-2-carboxylic acid (compound 3), and finally performs a salt formation in an organic solution of hydrochloric acid to obtain the edoxaban intermediate (compound 4). The reaction route of the application is short, the material is cheap and easy to obtain, the reaction condition is mild, the atomic economy is high, the obtained product has high purity, the product quality can meet the subsequent requirements, and the yield is high.

The invention belongs to the technical field of disease treatment, and particularly relates to a composition for regulating blood sugar and microvascular homeostasis and a preparation method thereof. The composition for regulating the blood sugar and the microvascular homeostasis is prepared from the following components in parts by mass: 380 to 520 parts of peony seed oil, 260 to 440 parts of dihydromyricetin and 0.025 to 0.062 part of chromium picolinate. The composition for regulating blood sugar and microvascular homeostasis can be used for protecting microvessels, regulating blood sugar, improving microcirculation of the whole body and preventing diabetic complications, and is suitable for preventing and treating diseases such as hyperglycemia, hyperlipidemia and glycolipid metabolism syndrome. Experiments on vascular endothelial dysfunction of obese rats show that the composition disclosed by the invention can be used for remarkably improving microvascular endothelial functions of the obese rats and effectively delaying rise of arterial blood pressure. Experiments on mouse diabetic cardiomyopathy find that the composition has a definite myocardial protection effect on DCM mice.

This invention provides a cerium oxide-based polishing slurry for STI structures. The slurry comprises, by total mass, 0.05 wt%–5 wt% nano-cerium dioxide abrasive, 0.02 wt%–0.2 wt% hydroquinone, 0.05 wt%–0.25 wt% pyridinecarboxylic acid, 0.01 wt%–0.5 wt% D-sorbitol, and 0.001 wt%–0.01 wt% 1,2-benzisothiazolin-3-one, with a pH of 3–5. The cerium oxide-based polishing slurry provided by this invention, by adding a reducing agent to gently fine-tune the CeO2 surface activity to increase the Ce3+ content, promotes the removal rate of TEOS. Through the synergistic effect of other inhibitors and passivators, a high TEOS:Si3N4 selectivity ratio is obtained. Inhibiting the removal rate of Si3N4 indirectly avoids excessive grinding of oxides in the trenches, resulting in better wafer surface planarization efficiency.

The invention belongs to the field of material synthesis catalysis, and discloses a novel metal organic framework supported catalyst, a preparation method and application thereof in photocatalytic CO2 reduction. A Zn-MOF carrier is synthesized through terephthalic acid, zinc nitrate hexahydrate and 3, 5-diamino-1, 2, 4-triazole, an amide type N, N bidentate coordination site is constructed through covalent modification of picolinic acid ligands, then a metal precursor is loaded, a novel metal organic framework supported catalyst is synthesized, and the novel metal organic framework supported catalyst is applied to photocatalytic CO2 reduction. The Zn-MOF carrier and the catalyst both have the advantage of being simple and convenient to prepare, the catalyst is novel in structure and excellent in catalytic performance, compounding of photo-induced electrons and holes is effectively inhibited through precise loading of Ir metal, directional movement of electrons in a frame is promoted, efficient reaction is achieved with Ir as a CO2 reduction catalytic center, and the catalyst is suitable for large-scale industrial production. The utilization rate of visible light and the efficiency of preparing formic acid by reducing CO2 through photocatalysis are improved.

The invention discloses a fireproof and corrosion-resistant coating for a metal box body of a compressed garbage truck and a preparation method of the fireproof and corrosion-resistant coating, and belongs to the technical field of fireproof coatings. The fireproof and corrosion-resistant coating for the metal box body of the compressed garbage truck is obtained by coating the surface of the treated metal box body of the compressed garbage truck with fireproof and corrosion-resistant paint and curing the fireproof and corrosion-resistant paint, wherein the fireproof corrosion-resistant coating is prepared from the following raw material components in parts by mass: 28 to 42 parts of epoxy resin, 12 to 18 parts of reactive diluent, 2.5 to 5 parts of modified filler, 8 to 20 parts of flame retardant, 0.1 to 1 part of defoaming agent, 0.1 to 1 part of dispersing agent, 0.1 to 1 part of flatting agent and 8 to 12 parts of curing agent; wherein the curing agent comprises a polyamide curing agent which is obtained by reacting a diamine monomer with a dicarboxylic acid monomer and then reacting with 6-acetylpyridine-2-formic acid for end capping; the diacid monomer comprises 1H-pyrrole-3, 4-dicarboxylic acid; the prepared fireproof and corrosion-resistant coating for the metal box body of the compression garbage truck is good in fireproof and corrosion-resistant performance.

Mass spectrometry is performed on a nucleic acid contained in a sample with a matrix-assisted laser desorption / ionization mass spectrometer using a mixed matrix containing 3-hydroxypicolinic acid and 2,4-dihydroxyacetophenone or a mixed matrix containing 3-hydroxypicolinic acid and 2,4,6-trihydroxyacetophenone monohydrate. This makes it possible to detect [M+H]+ or [M−H]− of the nucleic acid and fragment ions generated by dissociation of the ions with high sensitivity.

A method for preparing high-purity chromic oxide and by-product sodium 3-picolinate by recycling chromium-containing waste comprises the following steps: adding chromium-containing waste residues and chromium-containing sodium hydrogen sulfate into water, stirring, adding 3-methylpyridine, stirring to obtain a mixed material, adding the mixed material into a reaction kettle, stirring, and heating for reaction; recovering unreacted azeotrope of 3-methylpyridine and water after the reaction is finished, condensing the recovered material to obtain 3-methylpyridine, returning the 3-methylpyridine, cooling the reaction kettle after the recovery is finished, and pressing the material into a reaction liquid storage tank by using compressed air; filtering the feed liquid in the reaction liquid storage tank to obtain a filtrate and a filter cake, washing and filtering the filter cake to obtain hydrated chromium hydroxide, and recycling the washing liquid as recycled water; and calcining the hydrated chromium hydroxide at high temperature to obtain chromium oxide. The chromium-containing waste is adopted as the raw material, discharge of the chromium-containing waste is reduced, and the method has important economic and environment-friendly significance. The product in the process can be recycled, so that the method is more environment-friendly.