33 results about "Glycine methyl ester hydrochloride" patented technology

The invention discloses a synthesis method of N-(2-Fmoc-aminoethyl) glycine methyl ester hydrochloride, comprising the following steps: reacting ethylenediamine with haloacetic acid, and recrystallizing with DMSO to obtain N-(2- Aminoethyl)glycine (WT13003Fa); N-(2-aminoethyl)glycine is used as raw material, and methanol is reacted with the participation of thionyl chloride to prepare N-(2-aminoethyl)glycine methyl ester (WT13003Fb2); Then react N-(2-aminoethyl) glycine methyl ester with Fmoc-osu to prepare N-(2-Fmoc-aminoethyl) glycine methyl ester hydrochloride (WT13003Fc). The purity of N-(2-Fmoc-aminoethyl) glycine methyl ester hydrochloride prepared by the synthetic method of the present invention reaches 97%, and the yield is 47%.

The invention provides a preparation method of D-phenylglycine methyl ester hydrochloride / D-dihydrophenylglycine methyl ester hydrochloride, comprising the following steps: (a) mixing D-phenylglycine or D-dihydrobenzene Glycine and methanol were added to the reaction tank at a ratio of 1g: 3~5mL, and after stirring evenly, slowly added thionyl chloride; (b) reflux reaction after the addition of thionyl chloride; (c) vacuum distillation, Then cool down and crystallize, centrifuge and dry to obtain a white product; (d) recover the reaction mother liquor, concentrate the mother liquor in a vacuum, cool down and crystallize, and centrifuge to obtain a yellow recovered product; (e) wash the yellow recovered product with an organic reagent, and dry it in a vacuum to obtain White recycled product; (f) Apply the white recycled product to the reaction tank, and then follow steps (a)~(c) to prepare the next batch of products. The invention proposes a new way of applying the mother liquor, so that the product quality is more stable, the purity is high, and the color grade and turbidity are excellent.

A method for preparing 2-amino-dimethyl acetamide hydrochloride. An initial raw material is selected from commercialized raw material or easily prepared glycine methyl ester hydrochloride and is prepared into 2-amino-dimethyl acetamide hydrochloride by amino protection, aminolysis and deprotection. The invention has advantages of cheap and easily available raw material, mild reaction conditions, stable technology, a stable overall yield at 78-84%, a stable object product purity higher than 99%, and intermediates obtained by direct separation with a purity higher than 98%. Meanwhile operations of the whole production process are simple and without generation of three wastes (waste gas, waste water and industrial residue) so as to save production costs substantially. The method is suitable for large scale production and provides a new thinking and approach for preparation of 2-amino-dimethyl acetamide hydrochloride.

The invention relates to a preparation method of a compound of formula (i). The compound of formula i is prepared by using glycine methyl ester or its hydrochloride as a starting material, through protection of benzaldehyde, alkylation of benzyl chloride, and deprotection. The starting material of the invention is easy to obtain and low in price, and the intermediates involved in the reaction process do not need to be separated and purified, the operation is simple, the reaction conditions are mild, and the method is suitable for large-scale industrial production.

The invention discloses a preparation method of 1,2,3-bis-triazole ligands and an application of the 1,2,3-bis-triazole ligands in a CuAAC reaction. With cheap and easily available glycine methyl ester hydrochloride as a base raw material, and through derivation and conversion of functional groups, a diyne compound with glycine as a structure is obtained; then under a condition of room temperature and with organic azide as a raw material and copper iodide as a catalyst, 1,2,3-bis-triazole seven-membered-ring compounds are synthesized; and with the bis-triazole compounds and derivatives thereof as substrates, a series of methods for synthesis of the 1,2,3-bis-triazole derivatives are developed. A variety of novel, highly efficient, simple and easily available ligand catalysts are provided for a click reaction, and the 1,2,3-bis-triazole ligands have obvious effect on accelerating the reaction when used as the ligands and have quite practical application.

The invention discloses a new synthetic method of sivelestat sodium hydrate, comprising the following steps: successively pouring acyl chloride, a nonpolar organic solvent, an alkaline acid-binding agent, glycine methyl ester hydrochloride and an amide-type catalyst into a reactor so as to react, pouring reaction products into diluted hydrochloric acid, removing an organic layer, adjusting pH of a water layer to neutral with diluted alkali, filtering, drying, recystalizing, drying to obtain N-benzoyloxycarbonylmethyl-2-aminobenzamideglycine; successively pouring N-benzoyloxycarbonylmethyl-2-aminobenzamideglycine, 4-pivaloyloxybenzenesulfonyl choride, the nonpolar organic solvent, the alkaline acid-binding agent and the amide-type catalyst into a reaction vessel to react, pouring reaction products into diluted hydrochloric acid, standing and removing an organic layer, pouring sodium hydroxide into a water layer, cooling reaction products after the end of the reaction, filtering out crystals, dissolving and decolouring to obtain sivelestat sodium hydrate. By the new synthetic method of sivelestat sodium hydrate, synthetic process route is greatly shortened. The synthetic method is easy to operate. Reaction conditions are mild, and industrial production safety coefficient is raised.

The invention discloses an aromatic substitution spiro indolyl diketopiperazine compound and a synthesis method thereof. Glycine is used as a raw material and subjected to esterification reaction with methyl alcohol and thionyl chloride to obtain methyl glycinate hydrochloride, methyl glycinate hydrochloride and aromatic aldehyde are subjected to condensation reaction to obtain Schiff base, isatin is used as a raw material and subjected to reduction reaction under the action of hydrazine hydrate to obtain indoline-2-ketone, indoline-2-ketone and benzaldehyde are subjected to Knoevenagel reaction under piperidine catalysis to obtain 3-phenylidene-1,3-dihydro-2H-indol-2 ketone, 3-phenylidene-1,3-dihydro-2H-indol-2 ketone and Schiff base are subjected to 1,3-dipole cycloaddition reaction under catalysis of chiral ligand (S)-TF-BiphamPhos / AgoAc to obtain spiro pyrrolidine, and protecting group removal and ring closure are carried out on spiro pyrrolidine and N-(9-fluorene methoxycarbonyl)-L-prolyl chloride through base catalysis to obtain the target product. The method has the advantages of being simple in path, high in yield, high in diastereoselectivity and single in product spatial configuration, and the raw materials are low in price and easy to obtain.

The invention relates to a preparation method of a tadalafil related substance F, wherein the method takes heliotropin and glycine methyl ester hydrochloride as starting materials, and through a seven-step reaction and then through column chromatography separation, the tadalafil related substance F meeting the requirements of Pharmacopoeia is obtained with high purity.