76 results about "Bis triazole" patented technology

The invention discloses a phenyl bistriazole compound, and a preparation method and application thereof, and particularly relates to a 1-[4-(1H-1,2,4-triazole-1-yl)phenyl]-1H-1,2,4-triazole single crystal and a preparation method of 1-[4-(1H-1,2,4-triazole-1-yl)phenyl]-1H-1,2,4-triazole. The organic compound is prepared by heating ethylenediamine, 1H-1,2,4-triazole, potassium carbonate, 1,4-diiodobenzene and cuprous iodide through a one-pot method. The preparation method disclosed by the invention has the characteristics simple process operation, low production cost and less environmental pollution, and is suitable for large-scale industrial production. The 1-[4-(1H-1,2,4-triazole-1-yl)phenyl]-1H-1,2,4-triazole single crystal prepared by the invention can be used in the aspect of photoelectric materials, especially dye and luminescent agents.

The invention relates to a copper coordination polymer as well as a preparation method and application of the copper coordination polymer. The copper coordination polymer is a nano-hole-containing Cu (II)-anthracenecyclo bistriazole two-dimensional coordination polymer having ion exchange and solvent exchange functions and is a complex having the following chemical formula, namely, {[Cu(tatrz)2(NO3)2].(CH3OH).4H2O} (1), wherein tatrz is 1-[9-(1H-1,2,4-triazole-1-yl) anthracene-10-yl]-1H-1,2,4-triazole. When NaClO4 is added into aqueous and methanol solutions of the complex, ClO4<-> can replace NO3<-> which is involved in the coordination to obtain the complex {[Cu(tatrz)2(H2O)2](ClO4)2.4CH3OH} (1a). When the complex (1) is immersed in methanol, water molecules in the complex are partially replaced by methanol molecules to obtain the complex {[Cu (tatrz)2 (NO3)2].4.4CH3OH.0.6H2O} (1c). The complex as an ion exchange and solvent exchange agent has great application value in the field of material science.

The invention relates to a method for preparing a 4,5-diaryl-2H-1,2,3-triazole compound. The method specifically comprises steps as shown in the description, wherein a compound of formula II as shownin the description is reacted with R2CN to generate a compound of formula I as shown in the description under the action of an alkali in an organic solvent; R1 and R2 are respectively and independently selected from C5-C10 aryl which are optionally substituted by halogen, alkoxy, alkyl and chloroalkyl; the alkali is selected from t-BuOK and NaHMDS; the mole ratio of the compound of formula II as shown in the description to R2CN to the alkali is 1:(1.0-1.2):(2.5-3.0); the organic solvent is optimally selected from methylbenzene, xylene, DMF (Dimethyl Formamide), dioxane, polyethyleneglycol dimethyl ether, methyl tertiary butyl ether and N-methyl pyrrolidone; a reaction temperature is optimally 60-100 DEG C, and further optimally 60-80 DEG C; the reaction time is optimally 3-4 hours.

The invention discloses a preparation method of 1,2,3-bis-triazole ligands and an application of the 1,2,3-bis-triazole ligands in a CuAAC reaction. With cheap and easily available glycine methyl ester hydrochloride as a base raw material, and through derivation and conversion of functional groups, a diyne compound with glycine as a structure is obtained; then under a condition of room temperature and with organic azide as a raw material and copper iodide as a catalyst, 1,2,3-bis-triazole seven-membered-ring compounds are synthesized; and with the bis-triazole compounds and derivatives thereof as substrates, a series of methods for synthesis of the 1,2,3-bis-triazole derivatives are developed. A variety of novel, highly efficient, simple and easily available ligand catalysts are provided for a click reaction, and the 1,2,3-bis-triazole ligands have obvious effect on accelerating the reaction when used as the ligands and have quite practical application.

The invention relates to an N2-substituted 1,2,3-triazole derivative for a Cu (I) ligand as well as a preparation method and an application of the N2-substituted 1,2,3-triazole derivative. The derivative has the structural general formula as shown in the specification, wherein R is alkyl or aryl, R' is H atom, alkyl or aryl, and X is CH or N atom. The preparation method comprises the following steps: mixing NH-1,2,3-triazole, halogenated hydrocarbon and K2CO3, stirring, reacting, extracting and drying after the reaction is ended, and filtering and concentrating to obtain a coarse product; separating and purifying through thin-layer column chromatography on silica gel, thus obtaining the product; or mixing NH-1,2,3-triazole, halogenated aromatic hydrocarbon, CuX and K2CO3, by taking DMF as a solvent, heating, reacting, extracting and drying after the reaction is ended, filtering and concentrating to obtain a coarse product, separating and purifying through thin-layer column chromatography on silica gel, thus obtaining the product. The invention has the advantages that the N2-substituted 1,2,3-triazole derivative is simple in synthesis and stable in property and has the characteristics of small catalyst amount, mild reaction conditions, high product yield and high substrate adaptability.

The invention relates to a copper coordination polymer as well as a preparation method and application of the copper coordination polymer. The copper coordination polymer is a nano-hole-containing Cu (II)-anthracenecyclo bistriazole two-dimensional coordination polymer having ion exchange and solvent exchange functions and is a complex having the following chemical formula, namely, {[Cu(tatrz)2(H2O)2](BF4)2} (1), wherein tatrz is 1-[9-(1H-1,2,4-triazole-1-yl) anthranyl-10-yl]-1H-1,2,4-triazole. When NaClO4 is added into aqueous and methanol solutions of the complex, ClO4<-> can replace BF4<-> in holes to obtain the complex {[Cu(tatrz)2(H2O)2](ClO4)2.5.56H2O} (1a). When the complex (1) is immersed in a mixed solvent of water and methanol of NaF, ClO4<-> cannot be replaced by F<->, which indicates that the complex has selective ion exchange property and has great application value in the field of material science.

The invention discloses a preparation method of [Cu(L)2(NO3) 2] (1) (L=1-(4-(4-(1H-1,2,4-triazole-1-methyl) phenoxy) phenyl)-1H-1,2,4-triazole) and potential application value as catalyst for a 4- tert-butylphenylboronic acid coupling reaction. A normal temperature evaporation method is employed that Cu(NO3)2 and L react at ambient temperature under stirring volatilization condition to prepare the complex. The invention further discloses application of [Cu(L)2(NO3)2] (1) (L=1-(4-(4-(1H-1, 2, 4-triazole-1-methyl) phenoxy) phenyl)-1H-1,2,4-triazole) as catalyst for the 4-tert-butylphenylboronic acid coupling reaction.

The invention discloses a preparation method of {[Cu(tatrz)2(H2O)2](ClO4)2*4CH3OH}( 1 )(tatrz=1-[9-(1H-1,2,4-triazole-1-yl)anthracene-10-yl]-1H-1,2,4-triazole) and a potential application value in catalyzing a phenylboronic acid coupled reaction. The complex is prepared by using a room temperature volatilization method, namly stirring and volatilizing Cu(ClO4)2 and tatrz at room temperature. The invention further discloses an application of the {[Cu(tatrz)2(H2O)2](ClO4)2*4CH3OH}( 1 )(tatrz=1-[9-(1H-1,2,4-triazole-1-yl)anthracene-10-yl]-1H-1,2,4-triazole) in a factor of a coupled reaction catalyst of phenylboronic acid.

The invention relates to a synthesis method of novel triazolone, triadimenol compounds, namely novel triazolone compound is obtained by subjecting phenyl or substituted phenyl, as raw material, to Friedel-Crafts acylation, triazole alkylation and halogenated benzylation; and novel triadimenol compound is obtained by carbonyl reduction of the triazolone compound. The invention further relates to uses of the novel triazolone and triadimenol compounds as medicines and agricultural chemicals.

The invention discloses a 3-gem methyl dinitro-1,2,4-triazole compound. The structural formula of the 3-gem methyl dinitro-1,2,4-triazole compound is shown as (I), and please see the formula in the specification. The 3-gem methyl dinitro-1,2,4-triazole compound is mainly used in the explosive field.

The invention relates to an anthracycline bis-triazole-copper tetrafluoroborate complex for catalyzing phenylboronic acid and a preparation method thereof, and discloses a preparation method of {[Cu(tatrz)2(H2O)2](BF4)2} (1) (tatrz=1-[9-(1H-1,2,4-triazole-1-yl) anthracene-10-yl]-1H-1,2,4-triazole), and the {[Cu(tatrz)2(H2O)2](BF4)2} (1) (tatrz=1-[9-(1H-1,2,4-triazole-1-yl) anthracene-10-yl]-1H-1,2,4-triazole) has a potential application value of catalyzing a coupling reaction of phenylboronic acid. A normal temperature evaporation method is adopted, namely, the complex is prepared from Cu(BF4)2 and tatrz under a normal temperature stirring volatilization condition. The invention further discloses an application of the {[Cu(tatrz)2(H2O)2](BF4)2} (1) (tatrz=1-[9-(1H-1,2,4-triazole-1-yl) anthracene-10-yl]-1H-1,2,4-triazole) serving as a coupling reaction catalyst of the phenylboronic acid.

The invention discloses a preparation method and application of an m-phenyl-4-substituted-bitriazole compound, and particularly discloses a preparation method of 4-(3-(4H-1, 2, 4-triazole-4-yl)phenyl)-4H-1, 2, 4-triazole. The organic compound is prepared by using a one-pot method, namely heating m-phenylenediamine and diformylhydrazine. The preparation method disclosed by the invention has the characteristics of simple technological operation, low production cost and little environmental pollution and is suitable for large-scale industrial production. The 4-(3-(4H-1, 2, 4-triazole-4-yl)phenyl)-4H-1, 2, 4-triazole prepared by using the preparation method can be applied to the aspects of photoelectric materials and luminescent agents.

The invention relates to a method for preparing 4-aryl-NH-1,2,3-triazole by the aid of aldehyde and sodium bisulfite adduct. The method is characterized by comprising steps as follows: the aldehyde and sodium bisulfite adduct, a nitrocompound, sodium azide, a solvent and an additive react at the temperature of 60-150 DEG C for 1-10 h with a one-pot method, after the reaction ends, aftertreament is performed, and 4-aryl-NH-1,2,3-triazole can be prepared. The cheap and easy-to-obtain aldehyde and sodium bisulfite adduct, nitrocompound and sodium azide are taken as raw materials, and 4-aryl-NH-1,2,3-triazole compounds can be conveniently prepared from the three components. Compared with existing methods, the method has the advantages that the raw materials are low in cost and simple and easy to obtain, the operation is convenient, and the reaction efficiency is high.

The invention discloses a method for synthesizing azaconazole bactericide through reaction between bromo ketal and 1H-1,2,3-triazole. The method comprises partial steps: putting 1.15g of sodium (0.05mol) into a 250 ml three-neck flask containing 60 ml of methyl alcohol, adding 3.45g (0.05 mol) of 1H-1,2,4-triazole after reaction is completed, stirring for 30 minutes under the room temperature, adding 75 ml of N,N-dimethyl formamide and evaporating to remove the methyl alcohol under the normal pressure until a temperature in the flask reaches 130 DEG C. The method disclosed by the invention has the advantages that azaconazole novel bactericide development successfully fills a gap in China, synthesis researches of similar derivatives based on the azaconazole bactericide will be in the ascendant, and successful development and industrial implementation of varieties of novel bactericides have a far-reaching influence on national economy development. The method disclosed by the invention is a novel azaconazole synthesizing method.

The invention relates to an anthracycline bitriazole and copper fluoroborate complex with a 4-methoxyphenylboronic acid catalysis effect and a preparation method of the anthracycline bitriazole and copper fluoroborate complex, and discloses a preparation method of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) and a potential application value of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) for catalyzing coupled reaction of 4-methoxyphenylboronic acid. The complex is prepared by using a normal-temperature volatilization method comprising the step of volatilizing by stirring Cu(BF4)2 and tatrz at normal temperature. The invention further discloses application of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) as a 4-methoxyphenylboronic acid coupled reaction catalyst.

The invention provides a preparation method of 1-substituted-4-carbamoyl-1,2,4-triazol-5-one derivatives, which is low in cost and high in yield and purity and is represented as the following formula (I). The method is characterized in that in the presence of quaternary ammonium salt or salt, 1-substituted-1,2,4-triazol-5-one derivative reacts with an alkali metal hydroxide in aromatic hydrocarbon solvent and the byproduct water is simultaneously removed by azeotropic distillation. Then the obtained reaction mixture is added with amidogen formoxyl chloride for further reaction. In formula (I), x represents a halogen atom or a lower alkyl group, y represents a halogen atom, r represents lower alkyls, n and m independently represent an integer of 0 to 5.

The invention relates to an anthracene-ring bitriazol-cupric tetrafluoroborate complex capable of catalyzing 4-tert-butyl phenylboronic acid and a preparation method thereof and discloses a preparation method of {[Cu(tatrz)2(H2O)2](BF4)2} (1) (tatrz=1-[9-(1H-1,2,4-triazol-1-yl)anthracen-10-yl]-1H-1,2,4-triazole) and a potential application value thereof in the catalysis of coupling reaction of 4-tert-butyl phenylboronic acid. According to the method, a normal-temperature volatilization method is adopted, namely the complex is prepared from Cu(BF4)2 and tatrz under the conditions of stirring and volatilizing at normal temperature. The invention further discloses application of {[Cu(tatrz)2(H2O)2](BF4)2} (1) (tatrz=1-[9-(1H-1,2,4-triazol-1-yl)anthracen-10-yl]-1H-1,2,4-triazole) as a coupling reaction catalyst of 4-tert-butyl phenylboronic acid.

The invention relates to an anthracycline bitriazole and copper fluoroborate complex with a 4-methylbenzeneboronic acid catalyzing effect and a preparation method of the anthracycline bitriazole and copper fluoroborate complex, and discloses a preparation method of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) and a potential application value of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) for catalyzing coupled reaction of 4-methylbenzeneboronic acid. The complex is prepared by using a normal-temperature volatilization method comprising the step of volatilizing by stirring Cu(BF4)2 and tatrz at normal temperature. The invention further discloses application of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) as a catalyst for coupled reaction of 4-methylbenzeneboronic acid.

The invention discloses a double-triazole substituted ethoxy benzene compound and a preparation method and application thereof. The organic compound is prepared by conducting reflux reaction on 1,4-bis (bromomethyl)-2,5-diethoxy benzene with 3-(1H-1,2,4-triazole-1-yl) propionitrile in acetonitrile, and then conducting basic hydrolysis. The preparation method of the present invention has the characteristics of simple operation, low production cost and little environmental pollution, and is applicable to large scale industrialization production. The compound prepared by the invention can be applied to the research on bactericide. The experimental results confirm that the double-triazole substituted ethoxy benzene compound has certain sterilization activity on Escherichia coli and Staphylococcus aureus, especially significant bactericidal activity against Staphylococcus aureus.

The invention discloses a preparation method of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) and a potential application value of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) for catalyzing coupled reaction of 4-pyridinylphenylboronic acid. The complex is prepared by using a normal-temperature volatilization method comprising the step of volatilizing by stirring Cu(BF4)2 and tatrz at normal temperature. The invention further discloses application of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) as a catalyst for coupled reaction of 4-pyridinylphenylboronic acid.

The invention discloses an oxygen ether dual-triazole copper complex capable of catalyzing p-fluorophenylboronic acid and a preparation method of the oxygen ether dual-triazole copper complex. The complex is prepared from Cu(NO3)2 and L by adopting a 'normal temperature volatilization method' under normal temperature stirring and volatilization conditions. The invention further discloses application of (Cu(L)2(NO3)2)(1)(L=1-(4-(4-(1H-1, 2, 4-triazole-1-yl) phenoxy) phenyl)-1H-1, 2, 4-triazole) as a coupling reaction catalyst of p-fluorophenylboronic acid.