Anthracycline bitriazole and copper fluoroborate complex with 4-pyridinylphenylboronic acid catalyzing effect and preparation method of anthracycline bitriazole and copper fluoroborate complex

A technology of anthracycline bistriazole copper and copper complexes, which is applied in the field of inorganic synthesis, can solve the problems of expensive palladium catalysts, and achieve the effects of being suitable for large-scale production, high reaction yield, and high purity

Inactive Publication Date: 2015-04-08
TIANJIN NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the palladium catalyst is relatively expensive. If the expensive palladium catalyst can be replaced by a cheap

Method used

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  • Anthracycline bitriazole and copper fluoroborate complex with 4-pyridinylphenylboronic acid catalyzing effect and preparation method of anthracycline bitriazole and copper fluoroborate complex
  • Anthracycline bitriazole and copper fluoroborate complex with 4-pyridinylphenylboronic acid catalyzing effect and preparation method of anthracycline bitriazole and copper fluoroborate complex
  • Anthracycline bitriazole and copper fluoroborate complex with 4-pyridinylphenylboronic acid catalyzing effect and preparation method of anthracycline bitriazole and copper fluoroborate complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of 1-[9-(1H-1,2,4-triazol-1-yl)anthracen-10-yl]-1H-1,2,4-triazole (tatrz) ligand

[0029] Using the "one-pot method", the organic compound was prepared by heating 9,10-dibromoanthracene, triazole, potassium carbonate and copper oxide in DMF polar solvent; wherein 9,10-dibromoanthracene: three Azole: potassium carbonate: the molar ratio of copper oxide is 2:10:30:1;

[0030]

[0031] The reaction temperature is 1500°C, and the reaction time is 18 hours.

Embodiment 2

[0033] Cu(BF 4 ) 2 and 1-[9-(1H-1,2,4-triazol-1-yl)anthracen-10-yl]-1H-1,2,4-triazole (tatrz) in a molar ratio of 1: 1;

[0034] tatrz (0.0624 g, 0.2 mmol) and Cu(BF 4 ) 2 (0.0691 g, 0.2 mmol) in H 2 O (6 mL) and CH3 CN (4 mL) was stirred in a mixed solvent at room temperature for half an hour and then filtered, and the filtrate was volatilized at room temperature to form yellow rod-shaped crystals analyzed by X-ray single crystal diffraction. Yield: 35% (calculated based on tatrz). Elemental analysis (C 36 h 28 B 2 CuF 8 N 12 o 2 ) Theoretical value (%): C, 48.16; H, 3.14; N, 18.72. Found: C, 48.15; H, 3.16; N, 18.69.

Embodiment 3

[0036] The crystal structure was determined using an APEX II CCD single crystal diffractometer, using graphite monochromatized Mokα rays (λ = 0.71073 ?) as the incident radiation. ω -2 θ Diffraction points are collected by scanning, and the unit cell parameters are obtained by least square method correction. The crystal structure is solved by software from the difference Fourier electron density map, and corrected by Lorentz and polarization effects. All H atoms were synthesized by difference Fourier transform and determined by ideal position calculation. The detailed crystal determination data are shown in Table 1. Structural primitives see figure 1 , the three-dimensional structure of the complex see figure 2 .

[0037] Table 1. Crystallographic data of complex 1

[0038]

[0039] Example 3

[0040] Cu(BF 4 ) 2 and 1-[9-(1H-1,2,4-triazol-1-yl)anthracen-10-yl]-1H-1,2,4-triazole (tatrz) in a molar ratio of 1: 1;

[0041] We also tried other ratios such as Cu(...

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Abstract

The invention discloses a preparation method of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) and a potential application value of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) for catalyzing coupled reaction of 4-pyridinylphenylboronic acid. The complex is prepared by using a normal-temperature volatilization method comprising the step of volatilizing by stirring Cu(BF4)2 and tatrz at normal temperature. The invention further discloses application of {[Cu(tatrz)2(H2O)2] (BF4)2} (1) (tatrz=1-[9-(1H-1, 2, 4-triazole-1-yl)anthracene-10-yl]-1H-1, 2, 4-triazole) as a catalyst for coupled reaction of 4-pyridinylphenylboronic acid.

Description

[0001] The present invention has been funded by the National Natural Science Foundation of China (21471113), the Tianjin Municipal Education Commission project (20140506), the Tianjin Normal University academic innovation promotion project for young and middle-aged teachers, and the Tianjin Higher Education Innovation Team Training Program (TD12-5038). technical field [0002] The invention belongs to the technical field of inorganic synthesis and relates to copper complex {[Cu(tatrz) 2 (H 2 O) 2 ](BF 4 ) 2} (1) Preparation of (tatrz = 1-[9-(1H-1,2,4-triazol-1-yl)anthracene-10-yl]-1H-1,2,4-triazole) Method and application as catalyst for coupling reaction of 4-pyridinephenylboronic acid. Background technique [0003] The study of highly selective synthesis catalyzed by transition metal complexes has been an active field. Reactions that are difficult to achieve with common synthetic means can sometimes be completed in one step using transition metal complexes under mild ...

Claims

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Application Information

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IPC IPC(8): C07F1/08B01J31/22C07D213/22C07D213/127
CPCB01J31/1815B01J2231/4205C07B2200/13C07D213/127C07D213/22C07D249/08C07F1/08
Inventor 王英
Owner TIANJIN NORMAL UNIVERSITY
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