1166 results about "Coupling reaction" patented technology

The invention discloses a DNA synthesis method which comprises the following steps: processing an initial substrate according to a preset strategy to obtain a target substrate with a Mark pattern and a plurality of reaction sites, and adjusting the positions of the target substrate and an ink-jet printing device through the Mark pattern, so that the working directions of a reaction unit array and the device are consistent, and the subsequent operation accuracy is ensured; deprotecting the reaction sites to generate active groups; sequentially spraying a target monomer solution and an activator solution into the reaction sites of the preset area after deprotection treatment through an ink-jet printing device, and carrying out a coupling reaction with the active groups to obtain a mixed solution containing a nucleotide chain; carrying out cleaning, oxidation, capping and deprotection treatment on the mixed solution to obtain a single-layer base product; according to the target base sequence, determining a corresponding target monomer solution, and circularly carrying out a reaction to obtain a mixed solution containing a nucleotide chain; and obtaining the synthesized DNA according to the mixed solution. According to the method, high-throughput, high-quality and high-efficiency DNA synthesis can be realized.

The invention discloses a preparation method of a carbon shell confinement type nickel-bismuth-titanium composite catalyst and application of the carbon shell confinement type nickel-bismuth-titanium composite catalyst in high alcohol synthesis, and belongs to the technical field of catalysts. The preparation method of the carbon shell confinement type nickel-bismuth-titanium composite catalyst comprises the following steps: dissolving nickel salt, titanium dioxide and citric acid in water to form a homogeneous solution; adding bismuth salt into the homogeneous solution, and drying to obtain a precursor; and roasting the precursor to obtain the carbon shell confinement type nickel bismuth titanium composite catalyst. The carbon shell confinement type nickel-bismuth-titanium composite catalyst provided by the invention shows excellent catalytic performance in a reaction system for synthesizing high-carbon alcohol through carbon-carbon coupling of water-phase alcohol molecules. According to the catalyst, the high-carbon alcohol yield can reach 45.04% while high organic phase selectivity is maintained, and compared with a traditional nickel-bismuth-based catalyst, the high-carbon alcohol yield is remarkably improved.

The invention discloses a metal modified molecular sieve catalyst and a preparation method and application thereof. The catalyst is a metal-loaded molecular sieve which is modified by post-treatment after a metal component is loaded on the molecular sieve; the molecular sieve is selected from at least one of H-ZSM-5, H-Beta, H-ZSM-35, H-MOR, H-MCM-22, H-ZSM-11 and H-ZSM-22, and the molecular sieve is selected from at least one of H-ZSM-5, H-Beta, the metal is loaded on the molecular sieve through ion exchange and / or impregnation; the post-treatment modification is selected from at least one of heating treatment, water vapor treatment and silanization treatment. The metal component of the catalyst can catalyze dehydrogenation reaction and carbon dioxide activation, the molecular sieve component provides a substance diffusion channel and an acid center, and post-treatment modification can regulate the distribution of the molecular sieve acid center and improve the hydrothermal stability of the catalyst. The catalyst can efficiently promote the coupling reaction of cycloalkane and carbon dioxide, the selectivity of aromatic hydrocarbon reaches 90% or above, and the conversion rate of carbon dioxide reaches 20% or above.

The invention discloses a synthesis method of oxyalkyl isourea and application of the oxyalkyl isourea as a free radical alkylation reagent. According to the synthesis method, cheap and rich alcohol compounds and carbodiimide are used as raw materials, oxygen alkyl isourea is synthesized in one step under the mild condition of metal catalysis, the synthesis process is simple and convenient, the yield is high, and hectogram-level large-scale preparation can be achieved. The synthesized oxyalkyl isourea can be used as a free radical alkylation reagent to be applied to a coupling reaction of metal catalysis, so that different alkylate products rich in saturated carbon sequence structures are prepared, and the method has a good application prospect.

The invention provides a garbage pyrolysis gasification multi-stage directional regulation-gas-solid phase reforming synergistic hydrogen production treatment process which comprises the following steps: first-stage regulation: pretreatment and graded feeding: crushing, sorting, drying and catalytic coating treatment are performed on garbage through a physical-chemical directional means; second-stage regulation and control: performing low-temperature pyrolysis directional dechlorination, and performing thermochemical directional conversion on plastic and biomass garbage at 350-450 DEG C; third-stage regulation and control: gasifying and melting are coordinated and oriented, and a gas-solid phase coupling reaction is realized in double fluidized beds at 800-900 DEG C; four-stage regulation and control: multi-stage gas-solid phase reforming is carried out, and the hydrogen yield is increased through catalysis-adsorption synergistic effect in a 700 DEG C moving bed; and five-stage regulation and control: deep purification and hydrogen purification, wherein the synthesis gas is selectively oxidized by utilizing chemical looping combustion to release hydrogen with the purity being greater than or equal to 99.99%. According to the invention, the molten ash is used as a catalytic carrier, and the Fe-Ce active sites of the molten ash are utilized to synchronously realize tar cracking and synthesis gas reforming, so that the conversion rate of tar is effectively improved.

The invention discloses a method for simulating reaction migration of metal in a xanthate-loaded porous medium. On the basis of a coupling reaction mechanism of metal and an organic complexing agent (xanthogenate) in a porous medium, a multi-surface morphology complexing model (MSM) containing soil native components and xanthogenate is constructed and is combined with a reactive migration numerical model (a coupling water flow and solute migration equation); according to the method, through model calibration and experimental verification, the dynamic migration process of each metal component and the competitive retention distribution of the metal component on different solid-phase components can be accurately simulated and quantitatively analyzed under the complex condition that metal and xanthate coexist.

The invention provides a preparation method of a Joule heat-assisted super-wetting metal net, a metal net with super-hydrophilic performance and a metal net with super-hydrophobic performance. According to the material, carbon nanotubes are firmly adhered to the surface of a metal net through polydopamine mediation to construct a micro-nano coarse structure, a hydrophobic alkyl compound is grafted through a sulfenyl three-component coupling reaction to reduce surface energy, and a super-hydrophilic / underwater super-oleophobic metal net and a super-hydrophobic metal net are prepared respectively. The Joule heating effect of the material is remarkably enhanced by introducing the carbon nanotubes, so that the temperature of the material can be rapidly increased to 100 DEG C or above within 20 seconds under the ultralow voltage of 2.0 V. The characteristic can be effectively used for in-situ heating viscosity reduction of high-viscosity crude oil, continuous and efficient oil-water separation is achieved in a double-channel separation device, the crude oil flux reaches up to about 3985 L.m <-2 >. H <-1 >, and the separation efficiency exceeds 98.6%. The method is also suitable for stainless steel meshes with micron-sized apertures, and can realize efficient separation of various crude oil emulsions.

The invention discloses a method for preparing high-value chemicals through photocatalytic driving of beta-O-4 lignin depolymerization and coupling cascade reaction, and belongs to the technical field of photocatalytic biomass resource conversion. The method comprises the following steps: (1) dispersing a beta-O-4 lignin raw material into a solvent containing a photocatalyst; (2) introducing a normal-temperature chemically stable gas to replace air in a reaction system; and (3) carrying out a depolymerization reaction of beta-O-4 bonds and an in-situ C-C bond coupling reaction under an illumination condition to generate a target product. And (4) separating and purifying the product and recovering the catalyst. Through photocatalytic cascade reaction design, the defects of harsh reaction conditions and multi-step separation in a traditional method are avoided, the method has the advantages of mild reaction conditions, high atom utilization rate, high product selectivity and environmental friendliness, and a new way is provided for high-value utilization of lignin.

The invention relates to the field of organic chemistry, and particularly discloses a synthetic method of berberine hydrochloride. The synthesis method of berberine hydrochloride comprises the following steps: S1, carrying out reductive amination reaction on bromohomopiperony lamine and o-veratraldehyde to synthesize an intermediate II; s2, carrying out Suzuki coupling reaction on the intermediate II and an organic boron compound under the catalysis of a palladium metal organic matter to synthesize an intermediate III; s3, the intermediate III and organic chloride are subjected to an amino chlorination reaction, and an intermediate IV is synthesized; s4, carrying out intramolecular atom transfer radical addition and intramolecular Friedel-Crafts alkylation cascade reaction on the intermediate IV in a mixed solvent under the catalysis of a copper catalyst to synthesize an intermediate V; and S5, carrying out oxidative aromatization reaction on the intermediate V and iodine under the catalysis of alkali to synthesize berberine hydrochloride. The synthesis process is simpler, reaction conditions are easier to control, the yield is high, and the method is suitable for industrial production.

The invention provides a preparation method of bicyclobutane, and belongs to the technical field of aerospace fuels. According to the method, the bicyclobutane fuel is efficiently synthesized through nickel-catalyzed bromocyclobutane coupling reaction, and according to the method, nickel chloride serves as a catalyst, a reducing agent manganese powder is added, and the debromination self-coupling reaction of halogenated cyclobutane is promoted. The reduction coupling fuel synthesis strategy shows high efficiency, and the conversion number (TON) of the nickel catalyst can reach 44. The reaction can be carried out in an open system at the temperature of 40 DEG C, a water-free and oxygen-free environment is not needed, the yield of the bicyclobutane fuel is 88%, and the purity of the bicyclobutane fuel is 99% or above. Fuel performance tests show that bicyclobutane has excellent physical and chemical properties, the density is 0.82 g.mL <-1 >, the combustion net heat value is 44.39 MJ.kg <-1 >, and bicyclobutane is a high-energy aerospace fuel with great potential.

The invention provides a synthesis method of tigoraz and an intermediate thereof and a new intermediate thereof, and particularly provides a preparation method of a compound shown as a formula V. The preparation method comprises the following steps: in the presence of a solvent, alkali and a catalyst, carrying out intramolecular coupling reaction on a compound shown as a formula IV to obtain the compound shown as the formula V; the preparation method provided by the invention has one or more of the following advantages: (1) the raw materials are cheap and easily available; (2) the reaction conditions are mild; (3) the yield is high; (4) the product purity is high; (5) the process operation is simple and convenient; and (6) industrial production is facilitated.

The invention discloses a preparation method of 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine as an elinnetin intermediate, and belongs to the technical field of medicine synthesis. According to the invention, cheap and easily available 3-nitro-4-hydroxypyridine is used as an initial raw material, and the 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine is synthesized at low cost and high yield through the steps of halogenation, coupling, hydroxylation, reduction, condensation and the like. The raw materials used in the whole process are simple and easy to obtain, the reaction conditions are milder, and the reaction route is short. According to the invention, the Suzuki coupling reaction is firstly carried out, and then the hydroxylation of the pyridine 2 position is carried out, so that the use of an anhydrous reagent and harsh anhydrous reaction conditions are effectively avoided, and the reaction cost is remarkably reduced. In addition, the method is easy and convenient to operate, good in stability, high in total yield and suitable for industrial large-scale production.

The invention belongs to the technical field of preparation of transition metal organic photocatalysts, and particularly relates to design and a preparation method of a carbazole terpyridyl nickel catalyst. The invention aims to design and synthesize a carbazole terpyridyl nickel catalyst with light / nickel synergistic catalytic activity. The preparation method comprises the following specific synthesis steps: reacting different types of alpha-pyridone pyridinium and alpha, beta-unsaturated ketone in methanol, and carrying out suction filtration, washing, drying and other operations to obtain the corresponding carbazole terpyridyl ligand. The carbazole terpyridyl ligand and anhydrous nickel bromide are subjected to a heating reflux reaction in a tetrahydrofuran solution, and the corresponding carbazole terpyridyl nickel catalyst is obtained through methanol washing, suction filtration, drying and other operations. The terpyridyl nickel catalyst has high catalytic activity in a C-N, C-O and C-S coupling reaction promoted by visible light.

This invention discloses a cellulose acetate-based 1,8-naphthalenedimide fluorescent probe for detecting hydrazine, its preparation method, and its application. The invention uses 4-bromo-1,8-naphthalenedimide as a raw material, which undergoes a condensation reaction with 4-aminobutyric acid to obtain 4-(4-bromo-1,8-naphthalenedimide)butyric acid (BNA-B); BNA-B undergoes a coupling reaction with 4-formylphenylboronic acid to obtain 4-(4-(4-formylphenyl)-1,8-naphthalenedimide)butyric acid (FNA-B); compound FNA-B then undergoes an esterification reaction with cellulose acetate (CA) to obtain the cellulose acetate-based 1,8-naphthalenedimide fluorescent probe FNA-B-CA. This compound specifically recognizes hydrazine. Under 365 nm ultraviolet light irradiation, the addition of hydrazine to a DMF / H2O solution of FNA-B-CA changes the fluorescence color of the solution from bright blue to colorless, indicating a detection limit of 8.4 × 10⁻⁶ for hydrazine. ‑8 M has promising applications as a fluorescent probe for the detection of hydrazine.

The present application relates to the technical field of resin preparation, and relates to a preparation method of an anticoagulant superabsorbent resin, which comprises the following steps: combining hydrolyzed tannic acid and nanocellulose through an oxidative coupling reaction, loading citric acid to obtain an anticoagulant compound; dissolving acrylic acid, sulfonated lignin, the anticoagulant compound, polylactic acid-diacrylate, azodicarboxamide, nanosilica and a photoinitiator in water to obtain a mixed solution; injecting the mixed solution into a microchannel reactor to perform a polymerization reaction under irradiation of pulsed ultraviolet light, so as to obtain a superabsorbent resin gel; immersing the superabsorbent resin gel in a polylactic acid-diacrylate solution, performing surface crosslinking through ultraviolet light irradiation, drying and grinding, so as to obtain anticoagulant superabsorbent resin particles; and the present application can inhibit platelet aggregation, delay the start of the coagulation cascade reaction, block the activation of coagulation factors, effectively prolong the blood clotting time, and provide a more sufficient liquid absorption window for the superabsorbent resin.

The invention discloses an oligonucleotide synthesis process of a sulfo-PMO structure. In the oligonucleotide synthesis process of the sulfo-PMO structure, the molecular structural formula of sulfo-PMO is shown in the specification. According to the invention, the molecular structure of thio-PMO is specifically limited, and the synthesis of nucleotide phosphate amide and (thio) phosphoric acid amide in the solid-phase synthesis oligonucleotide is carried out along the direction from 5'to 3 ', that is, in each cycle period, the O5'or O6' position of the nucleotide phosphate amide and (thio) phosphoric acid amide monomer is firstly subjected to coupling reaction, and then the protecting group is removed at the O3 'or N3' position, so that the oligonucleotide phosphate amide and (thio) phosphoric acid amide are obtained. And releasing active hydroxyl or amino / amido to enter the next cycle. The protecting group adopted by the sulfo-PMO molecule is consistent with the protecting groups of other nucleotides, so that the conversion rate of each step of coupling reaction can be conveniently detected on line.

The invention discloses a fluorine atom modified (benzene-thiophene) derivative conjugated polymer, and relates to an organic photoelectric material. A thiophene derivative monomer 1 is prepared through a coupling reaction, then the thiophene derivative monomer 1 and a fluorine-atom-modified (benzene-thiophene) derivative monomer 2 are subjected to electrochemical copolymerization, the fluorine-atom-modified (benzene-thiophene) derivative conjugated polymer is obtained, the transmittance, coloring efficiency, response time and other properties of the polymer are optimized, and the photoelectric conversion efficiency of the polymer is improved. The preparation method has important guiding significance on electrochromic application of the polymer. The invention discloses a preparation method of a fluorine atom modified (benzene-thiophene) derivative conjugated polymer, the polymer material is prepared by an electrochemical method, the structural formula of the polymer material is shown in the specification, and n is a natural number of 1-10000. According to the series of conjugated polymers, the content of fluorine atoms is adjusted, so that the optical contrast and coloring efficiency of electrochromism are improved, and the conjugated polymers are novel electrochromism functional layer materials.

The invention discloses a 96-hole preassembled plate fat-soluble vitamin pretreatment kit, and belongs to the technical field of in-vitro diagnostic reagents. Comprising magnetic bead suspension liquid, equilibrium liquid, leacheate 1, leacheate 2 and eluent which are carried on a preassembled plate, and the magnetic bead suspension liquid comprises absolute ethyl alcohol and magnetic beads; the preparation process of the magnetic beads comprises the following steps: activating carboxyl of the carboxyl magnetic beads through EDC and NHS; then nitrochlorobenzene and triethylamine are added for a coupling reaction; mixing the coupling reaction product with pyrrolidone, ammonium persulfate and a pore-foaming agent to obtain target magnetic beads; the magnetic beads can be specifically combined with fat-soluble vitamins in human serum or plasma, efficient separation and release of an object to be detected are achieved through a magnetic separation technology, and the magnetic beads are suitable for follow-up mass spectrum quantitative analysis. The kit disclosed by the invention has the characteristics of simplicity and convenience in operation, high extraction efficiency and good stability, the pretreatment time can be remarkably shortened, the detection accuracy is improved, and an efficient solution is provided for clinical detection of fat-soluble vitamins.

The invention discloses a synthesis method of a mono / dibromo pyridine derivative, which comprises the following steps: reacting a pyridine derivative with dimethyl butynedioate and methyl pyruvate at room temperature by using acetonitrile as a solvent to generate a dearomatized heteroaromatic compound; in an oxygen environment, copper bromide is used for brominating the dearomatized heteroaromatic compound to realize dibromination, and if potassium carbonate is additionally added in the reaction, monobromination is realized; and finally, respectively generating mono / dibromopyridine derivatives under hydrochloric acid hydrolysis. A carbon halogen bond of bromopyridine has very high activity, and various reactions such as Suzuki coupling, Sonogashira coupling, Heck reaction, amination reaction and the like can be carried out. On the basis, the polysubstituted bromopyridine can be subjected to selective reaction, and many new ideas can be provided for organic synthesis. The method disclosed by the invention is simple and safe to operate and environment-friendly, the cost is lower by using the copper bromide, and the required reaction conditions are simple.

The invention provides a method for constructing an aryl C-P bond through a reaction of an Ar-F compound of a nickel catalysis electron donating group, which comprises the following steps: in the presence of a nickel catalyst, an additive and alkali, carrying out a coupling reaction on a substituted aryl compound in a formula B and a compound in a formula C diphenylphosphine oxide in an organic solvent to generate an aryl phosphine oxide compound in a formula A, the reaction formula is shown in the specification, Ar is or, and R is an electron-donating group. The method disclosed by the invention has the effects that the substrate has universality, the operation is simple, the condition is mild, a noble metal catalyst and a phosphine ligand are not needed, the cost is low, and the yield is high.

The present disclosure provides uses of type II and variant type I and type II inorganic pyrophosphatases under nonnatural conditions present in industrial applications. In another aspect, the present disclosure describes compositions and methods of using inorganic pyrophosphatases with nucleoside triphosphates and in coupled reactions with a second enzyme.

The invention discloses long-acting high-dynamic hydrazone bond hydrogel as well as a preparation method and application thereof, and particularly relates to the technical field of biomedical materials. The preparation method comprises the following steps: taking 1-adamantane acetic acid and adipic dihydrazide modified sodium hyaluronate and benzaldehyde-terminated eight-arm polyethylene glycol as carrier raw materials; the hydrazone bond hydrogel with relatively high stability is prepared through a coupling reaction of an aldehyde group of benzaldehyde-terminated eight-arm polyethylene glycol and a hydrazide group of 1-adamantane acetic acid and adipic dihydrazide modified sodium hyaluronate. The beta-cyclodextrin modified m-phenylenediamine catalyst is dynamically combined into the carrier through reversible host-guest complexation between beta-cyclodextrin and 1-adamantane acetic acid, so that the long-acting high-dynamic hydrazone bond hydrogel is obtained, and the requirement of three-dimensional culture of stem cells on mechanical properties can be met; and network dynamics can be maintained for a long time, so that stem cell spreading is supported, mechanical signal transduction is activated, osteogenesis-related gene expression is promoted, and stem cell osteogenesis differentiation capability is enhanced.

The present disclosure provides an electrocatalytic reactor and method of electrochemical conversion of carbon dioxide (CO2) into value-added products (VAPs) The electrocatalytic reactor includes Stainless Steel (SS), or Copper (Cu) or Copper alloy (Cu-alloy) electrodes, wherein one or more anode is an SS electrode, wherein the electrodes act as electrocatalyst, and acidified deionised water (H3O+) is used as electrolyte for generation of H2 gas through bulk electrocatalysis, wherein a catalyst initiator that includes 80% by weight of metal carbonates or bicarbonates of Mg or Na with 20% by weight of MgO is used to facilitate the reaction of the short-lived cation radical intermediates formed by C- C coupling reactions on the cathode surface leading to hydrolysis and VAPs formation with high specificity and selectivity.

The application belongs to the field of organic synthesis, and particularly relates to a synthesis method of 2-(3,3-dimethylbutyl)pyridine. 2-vinylpyridine, brominated tertiary butane, a mixed solution of dimethyl ether and isopropyl ether as a reaction system solvent, nickel iodide as a nickel salt, bipyridine as a ligand, dicyclohexylmethylamine as a base in the system, 2,6-dimethyl-3,5-diethyl-1,4-dihydropyridine as a reducing agent, a photocatalyst 2,4,5,6-tetrakis(9 ‑ Carbazole) - m-phenylenedinitrile, under the condition of room temperature and nitrogen atmosphere, a reduction cross-coupling reaction is used to synthesize 2-(3,3-dimethylbutyl)pyridine. The application uses inexpensive nickel metal as a catalyst, constructs a cross-coupling reaction of carbon-carbon bond, and has the advantages of mild reaction condition, high economy and the like.

The application discloses a synthesis method of nitrogen-doped carbon-coated In2O3-CdSe hexagonal nanorod, and comprises the following steps: dissolving indium nitrate tetrahydrate and terephthalic acid in an organic solvent, transferring the mixture into a reaction kettle after ultrasonic treatment for 10 minutes, heating the mixture for a period of time, centrifuging and collecting the product after the reaction is completed, cleaning the product with ethanol, and drying the product to obtain a MIL-68-In precursor with a hexagonal nanorod structure; dispersing the MIL-68-In precursor in an organic solvent containing dissolved cadmium acetate, transferring the mixture into a reaction kettle after ultrasonic treatment for 10 minutes, heating the mixture for a period of time, centrifuging and collecting the product after the reaction is completed, cleaning the product with ethanol for several times, drying the product, and using the product for further use, and then calcining the synthesized sample and selenium powder in a tube furnace to obtain In2O3-CdSe@N-C. The application synthesizes the In2O3-CdSe@N-C hexagonal nanorod photocatalyst through a solvothermal and calcination method, and the synthesized photocatalyst has higher photocatalytic activity than the MIL-68-In.

The present invention discloses a method and system for producing hexafluorobutadiene, which includes the following steps: In step (1), an organic solution of bromotrifluoroethylene and zinc powder are respectively introduced into a first reactor containing an initiator, zinc powder, and an organic solvent, followed by a second reactor, and reacted to obtain a trifluorovinylzinc bromide solution. The reaction solution is then introduced into a precipitator to separate excess zinc powder, resulting in a zinc-free trifluorovinylzinc bromide solution. The excess zinc powder is then filtered and reused. In step (2), the trifluorovinylzinc bromide solution obtained above and a pre-prepared composite catalyst solution are introduced into a third reactor and subjected to a coupling reaction to obtain crude hexafluorobutadiene. In step (3), the crude hexafluorobutadiene obtained above is purified to obtain a product with a purity of ≥ 99.9%.

The invention belongs to the technical field of material science, and relates to a preparation method and application of an unsaturated bond extended tetraphenyl ethylene siloxane compound. An unsaturated bond is introduced into a siloxane group, and the siloxane group containing the unsaturated bond and a tetraphenyl ethylene derivative are subjected to a coupling reaction. The coupling reaction is carried out in an inert atmosphere, the temperature is 90-150 DEG C, and the time is 6-24 hours. And purifying the product by silica gel column chromatography to obtain the target compound. Unsaturated bonds are introduced into a tetraphenyl ethylene structure, so that the adjustability of the photochromic wavelength is realized, the performance of the compound is remarkably improved, the application range of the compound is remarkably widened, and a new thought and a new method are provided for development of photochromic materials.

The application discloses a kind of high level dipole orientation tetraphenyl benzene derivatives and its preparation method and application, the tetraphenyl benzene derivative has structure shown in formula (I):In formula (I), any two of R1, R2, R3, R4 Four groups are each independently selected from N-containing electron-donating group, and the other two are each independently selected from electron-withdrawing group.The tetraphenyl benzene derivative is prepared using two-step suzuki coupling reaction.The tetraphenyl benzene derivative of the application has excellent solid-state light emitting efficiency and high molecular level dipole orientation, and can be used as non-doped light-emitting layer to prepare non-doped blue light organic electroluminescent device with high efficiency, low degree of efficiency roll-off, low start voltage, with maximum external quantum efficiency reaching 8.32%, which is greatly improved compared with prior art, and has wide application prospect in the field of organic optoelectronics.

The invention provides a hydrogen sensor as well as a preparation method and application thereof, and particularly relates to the technical field of sensors. The hydrogen sensor comprises a ceramic substrate electrode and a gas-sensitive layer, the gas-sensitive layer is arranged on the surface of the ceramic substrate electrode, the gas-sensitive layer comprises a composite material formed by doping a semiconductor material with precious metal, the surface of the composite material is coated with a hydrophobic membrane, and the surface of the hydrophobic membrane is coated with a metal layer. The hydrophobic membrane is formed by chemical coupling reaction of hydrophobic silane and hydroxyl groups. According to the hydrogen sensor, by adopting the specific semiconductor sensing material and the hydrophobic membrane, the adaptability and the stability of the hydrogen sensor in a high-temperature alkali liquor corrosion environment are greatly improved, the hydrogen sensor can reliably work for a long time in a severe environment, the replacement frequency of the sensor is reduced, and the use cost is reduced.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of 4, 4 '-[oxygen bis (methylene)] bis [5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole]. The invention provides a preparation method of 4, 4 '-(oxybis (methylene)) bis (5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole, which comprises the following steps: dissolving a compound shown in a formula IV and a compound shown in a formula V in a solvent, adding alkali, carrying out coupling reaction to obtain a reaction solution, and carrying out post-treatment to obtain a compound shown in a formula VI, namely 4, 4'-(oxybis (methylene)) bis (5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole. The compound is 4, 4 '-(oxybis (methylene)) bis (5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole). The preparation method disclosed by the invention is simple and easy to implement, mild in condition, high in safety, suitable for preparing reference substances in laboratories, and beneficial to product quality control and production process development.