80 results about "Triphenylethylene" patented technology

Triphenylethylene compounds of formula (I) are provided. The compounds are particularly useful for selective estrogen receptor modulation.

The present invention provides novel pharmaceutical compositions containing triphenylethylene derivative compounds, and methods of using the composition for treatment of symptoms associated with atrophic vaginitis. The pharmaceutical compositions are prepared for the vaginal administration of triphenylethylene derivative compounds in single or combination therapies. Preferably, the triphenylethylene derivative is tamoxifen.

Triphenylethylene compounds of formula (I) are provided. The compounds are particularly useful for selective estrogen receptor modulation.

Triphenylethylene compounds of formula (I) are provided. The compounds are particularly useful for selective estrogen receptor modulation.

The invention belongs to the technical field of organic light emitting materials, and discloses an aggregation-induced light emitting material simultaneously containing a triphenylethylene structure and a tetraphenylethylene structure. During synthesis, a triphenylethylene intermediate containing a functional group and a tetraphenylethylene intermediate containing a functional group are connected together by coupling reaction. A synthesis method of the invention has the advantages of simple process and convenient purification; and the synthesized organic light emitting material simultaneously containing the triphenylethylene structure and the tetraphenylethylene structure has the advantages of obvious aggregation-induced light emitting performance, high thermal stability, high glass-transition temperature and high luminous intensity and is suitable for preparing a light emitting layer material in an organic electroluminescent material device.

The invention discloses a novel diamine compound, and a preparation method and an application thereof. The preparation method of the novel functional diamine compound comprises the following steps: a large conjugate structure comprising benzophenone carbonyl group is obtained; the ketone carbonyl group is subjected to a Wittig or Wittig-Horner reaction, such that a large conjugate system with a triphenylethylene / tetraphenylethylene structure and comprising a halogen atom is obtained; the halogen atom is further subjected to a Suzuki reaction or a plurality steps of reactions, such that a monoamine compound comprising a triphenylethylene / tetraphenylethylene large conjugate system is obtained; the monoamine compound is subjected to a reaction with halogenated nitrobenzene, such that a dinitro monomer comprising triphenylamine and the triphenylethylene / tetraphenylethylene large conjugate system is obtained; and the dinitro monomer is reduced into the novel diamine compound, such that the novel functional diamine compound comprising triphenylamine and a triphenylethylene / tetraphenylethylene structure is obtained. The synthesis method provided by the invention is simple. Purification is easy. The method is suitable for industrial productions. The synthesized diamine compound has a significant aggregation-induced emission property, and can be used for synthesizing high-performance and functional polymers such as polyamide, polyimide, polyamideimide, polyesterimide, and the like.

The invention discloses a benzothiazole derivative containing a triphenylethylene or tetraphenylethylene structure and having aggregation-induced emission property and a preparation method and application thereof. The preparation method comprises the following steps: with 2-amino-6-methoxybenzothiazole as a start raw material, performing a ring-opening reaction under an alkaline condition to generate 2-amino-5-methoxythiophenol; performing a ring-closing reaction with an aromatic aldehyde compound containing a triphenylethylene or tetraphenylethylene structure to obtain a methoxy-containing benzothiazole derivative, or performing demethylation to obtain a hydroxyl-containing benzothiazole derivative, wherein the compound also can be modified through a group substitution reaction to generate a benzothiazole derivative containing other functional groups. The benzothiazole derivative disclosed by the invention has relatively low luminous intensity in a solution, emits strong fluorescence in an aggregation state or solid state, and belongs to good aggregation-induced emission materials; the synthesis is relatively simple, and the cost of the raw materials is low, so that large-scale commercial production is easy to realize; the benzothiazole derivative plays an important role in the fields of electroluminescent devices, fluorescent probes, fluorescent switches, organism imaging and the like.

The invention discloses polyimide with low dielectric properties, and a preparation method and an application thereof. The polyimide provided by the invention is prepared through an imidization method by using the raw materials of aromatic diamine comprising triphenylamine and with large side group comprising triphenylethylene / tetraphenylethylene, and various tetra-dianhydrides. The polyimide provided by the invention has ultra-low dielectric constant, relatively low dielectric loss, excellent solubility, relatively high glass transition temperature, relatively high thermal stability, excellent mechanical performances, excellent photo-luminescent performance, and the like. The synthesis method of the polyimide is simple and diverse, and is suitable for industrial productions. The polyimide provided by the invention can be used for preparing low dielectric materials, and can be widely applied in high-tech industry fields such as electronics, microelectronics, information, luminescent materials, aeronautics and astronautics, and specially very large scale integrated circuits.

The invention discloses an aggregation-induced emission-based copper ion detection probe and a preparation method and application thereof. The structure of the fluorescent probe is as shown in a formula I, and the fluorescent probe is prepared through formylating hydroxytetrstyrene as a raw material and forming triphenylethylene-based salicylaldehyde azine together with hydrazine hydrate. The probe is stable in optical property, high in copper ion detection sensitivity and low in lower detection limit, the detection limit is 30.9nM and the response range is 0.5-7.5muM; the probe is good in selectivity and free of response to cations such as a silver ion, a barium ion, a calcium ion, a lithium ion, a magnesium ion, an ammonium ion, a nickel ion, a zinc ion, a mercury ion, a cobalt ion and a lead ion; and the probe is simple in synthesis, mild in condition and high in yield. The fluorescent molecular probe has practical application value in the field of copper ion detection in biochemistry and environmental chemistry.

The invention discloses a water-soluble aggregation-induced emission quinoxaline compound, a preparation method thereof and an application of the compound. According to the method, 1, 4-dibromo-2, 3-diaminobenzene and o-diketone with an equal molar weight react to obtain 1, 4-dibromo-quinoxaline, the 1, 4-dibromo-quinoxaline is sequentially subjected to Suzuki reaction with triphenyl ethylene boric acid ester and pyridine boronic acid to obtain a quinoxaline neutral compound containing triphenylethylene and pyridine components, and the quinoxaline neutral compound further reacts with a nucleophilic reagent containing active methylene to obtain the pyridinium salt functionalized water-soluble aggregation-induced emission quinoxaline compound. The prepared water-soluble aggregation-induced emission quinoxaline compound can be dissolved in mixed solvents of water / organic solvents with the water volume percent content of 95%-60%. The compound has excellent aggregation-induced emission performance and water solubility and can be used as a fluorescent probe and a solid light-emitting material.

The invention discloses a bispyribac-sodium salt suspending agent comprising the following components by weight percent: 10-40 percent of bispyribac-sodium salt original medicine, 0.5-5 percent of wetting agent, 1-10 percent of dispersing agent, 0.1-5 percent of thickening agent, 0.1-2 percent of antifoaming agent, 1-10 percent of anti-freezing agent, 0.1-1 percent of preservative, 1-10 percent of stabilizing agent and the balance of water. The dispersing agent is one or two of triphenylethyl phenol polyoxyethylene ether phosphate benzilate, styrene-acrylic acid copolymer, triphenylethylene phenol polyoxyethylene ether and triphenylethylene phenol polyoxyethylene propene ether, and the wetting agent is fatty alcohol-polyoxyethylene ether and / or alkylphenol polyoxyethylene succinate sulfonate. The suspending agent has good dispersity and liquidity as well as high suspensibility, can be directly sprayed or sprayed after being mixed with water by any proportion, is convenient to use and has no pollution to the environment.

The invention relates to an emulsion breaker for dehydration of crude oil extracted from an acidified oil well, which is applied to the treatment of crude oil in the oil extraction field. The emulsion breaker comprises the following components by weight percent: 3.5 to 4.5% of triphenylethylene phenol polyoxypropylene (7) polyoxyethylene (30) ether, 3.0 to 3.5% of phenethyl phenyl polyoxypropylene polyoxyethylene ether, 6.7 to 7.4% of toluene diisocynate polyether crosslinked product, 5.0 to 6.5% of nonylphenol polyoxyethylene (30) ether, 1.5 to 2.0% of dodecyl primary amine polyoxyethylene (10) ether, 35.5 to 38.0% of rosin amine polyoxypropylene polyoxyethylene ether, 0.25 to 0.3% of sodium hydroxide, 0.12 to 0.20% of urotropine, 0.05 to 0.065% of vitamin C, 15 to 17% of methyl alcohol and the balance of water, wherein the sum of the weight percentage of all the components is of one hundred percent. The emulsion breaker has the beneficial effects that: in the condition of dosage of 50 to 80mg / l, after the crude oil is dehydrated, the water content is less than 0.5% and the oil content is less than 300mg / I; and water is clear. The emulsion breaker reaches the industry regulation standard.

The invention provides a tetraphenylethylene blue-fluorescence organic compound and a preparation method for an organic electroluminescence device thereof. A structure of the tetraphenylethylene blue-fluorescence organic compound is as shown in formula (I): wherein Ar is a naphthyl. The compound is capable of enabling the naphthyl and a triphenylethylene group to be connected with anthracene, using the anthracene as a fundamental luminescence group, and using triphenylethylene and naphthalene as modification for transforming a structure or a group of the anthracene, wherein the triphenylethylene and the anthracene form a structure similar to tetraphenyl ethylene. Because the tetraphenyl ethylene structure can produce an aggregation-induced emission (AIE) effect, a phenomenon of exciton annihilation can be effectively inhibited, so a molecule has the stronger fluorescence emission in a high-concentration aggregation state than that in a low-concentration. In addition, because a relativemolecular weight of the compound is larger, an aromatic structure and an ethylene structure have a conjugate condition, the finally prepared compound is good in heat stability, and has the high luminance brightness, and the prepared device is good in performance.

The invention discloses an <18>F-labeled aggregation-induced emission (AIE) fluorescent / positron emission tomography (PET) dual-mode probe, and a preparation method and application thereof. The compound is denoted as <18>F-TPE-TEG, and has a following structure. The synthesis method of a labelled precursor of the compound comprises the following steps: firstly, adding 2-bromo-1,1,2-triphenylethylene, 4-hydroxyphenylboronic acid and tetrabutylammonium bromide into tetrahydrofuran, and taking K2CO3 and tetrakis(triphenylphosphine)palladium as catalysts to carry out a reaction to obtain 4-hydroxytetraphenylethylene; then dissolving triethylene glycol, triethylamine and p-toluenesulfonyl chloride in dichloromethane, and carrying out a reaction to obtain 8-p-toluenesulfonyloxy-3,6-dioxyoctanol;adding the 4-hydroxytetraphenylethylene, K2CO3, the 8-p-toluenesulfonyloxy-3,6-dioxyoctanol into acetonitrile, and carrying out a reaction to obtain 8-tetraphenylethyleneoxy-3,6-dioxyoctanol; and finally, dissolving the 8-tetraphenylethyleneoxy-3,6-dioxyoctanol, p-toluenesulfonyl chloride and triethylamine in dichloromethane, and carrying out a reaction to obtain the labelled precursor. The <18>F-labeled compound can be used as an AIE fluorescent / PET dual-mode probe to be applied to tumor imaging research.

The invention discloses a preparation method of a triphenylethylene derivative luminescent film. The preparation method comprises the following steps of: (1), dissolving carbazole triphenylethylene derivative monomer with an aggregation-induced emission effect in an electrolyte solution of an electrolytic tank; (2), starting up the electrolytic tank for carrying out electrolysis, so that the monomer is polymerized into a film, wherein in the electrolysis process, the voltage range of positive potential of a working electrode is 0.8V-1.6V, the range of the negative potential is (-)1.0V-0V; and the signal waveform is sine wave or triangular wave; (3), taking out the film after electrolytic polymerization is completed, cleaning and drying to obtain the luminescent film. The luminescent film which is prepared by the preparation method disclosed by the invention has a smooth surface, surface roughness of smaller than 3nm and can be used for solving a problem that the conventional electro-polymerization film is extremely large in surface roughness; and the obtained film has good thermal stability, the initial decomposition temperature of 376 DEG C and higher luminous efficiency. The preparation method of the triphenylethylene derivative luminescent film disclosed by the invention is simple to operate, not only capable of effectively removing impurity components, but also lower in production cost.

The invention discloses a suspending agent of tebuthiuron. The suspending agent of tebuthiuron comprises the following components in percentage by weight: 20 to 50 percent of raw medicament of tebuthiuron, 0.5 to 5 percent of wetting agent, 1 to 10 percent of dispersing agent, 0.1 to 5 percent of thickening agent, 0.1 to 2 percent of defoaming agent, 1 to 10 percent of preservative, and the balance of water, wherein the dispersing agent is one or two of triphenyl ethylphenol polyethenoxy ether phosphate ester triethoxide, alkylphenol polyethenoxy ether sodium sulfonate, triphenylethylene phenol polyethenoxy ether, triphenylethylene phenol polyoxyethylene polyoxy propylene ether; and the wetting agent is fatty alcohol polyethenoxy ether and / or alkylphenol polyoxyethylene succinate sulfonate. The suspending agent is good in dispersibility and fluidity and high in suspension rate and can be directly sprayed or mixed with water in any ratio and then sprayed, so that the suspending agent is conveniently used and does not pollute the environment.

The invention relates to a composite synergistic wetting agent and a preparation method thereof. The components comprise 30-50 % of tristyrylphenol ethoxylates phosphate; 20-30 % of maleic acid-acrylic acid copolymer sodium salt; 10-20 % of tristyrylphenol ethoxylates succinic acid monoester sodium sulfonate; and 10-20 % of propylene glycol block polyether. The composite synergistic wetting agenthas excellent wetting and dispersing performance, and the combination of the auxiliary agent components of the invention is adopted to provide surface energy for original drug particles, the particlesare wrapped to form steric hindrance, electrostatic repulsion and to destroy the hydrogen bond combination of the compound and water. The invention further provides the application of the composite synergistic wetting agent in pymetrozine and a composite aqueous suspending agent combined with pymetrozine and other original drugs (clothianidin), which has good universality for the original drug ofthe pymetrozine produced by different processes, and the obtained preparation agent has good stability.

The invention discloses a multifunctional aggregation-induced luminescence enhancement compound, a method for preparing the same and application of the multifunctional aggregation-induced luminescenceenhancement compound. The multifunctional aggregation-induced luminescence enhancement compound comprises anthracene-triphenylethylene carbazole structures with alkyl chains. The multifunctional aggregation-induced luminescence enhancement compound, the method and the application have the advantages that the multifunctional aggregation-induced luminescence enhancement compound has the aggregation-induced luminescence enhancement performance and is high in luminescence efficiency and strength and excellent in solubility, and high-quality thin film materials can be easily prepared from the multifunctional aggregation-induced luminescence enhancement compound; the method for preparing the multifunctional aggregation-induced luminescence enhancement compound is simple and is excellent in repeatability, and purification can be facilitated; the multifunctional aggregation-induced luminescence enhancement compound can be used for luminescent layers of organic electroluminescence devices, fluorescent sensing, Fe3+ ion detection and nitroaromatic explosive substance detection.

The invention relates to a fluorescent probe based on a tetraphenylethylene derivative, and a preparation method and application thereof, belonging to the technical field of fluorescence spectrum analysis. The fluorescent probe is one of 2-(4-(2-(2-(2-methoxyethoxy)ethoxy)phenyl)-1,1,2-triphenylethylene, (E)-1,2-bis-(4-(2-(2-(2-(2-methoxyethoxy)ethoxy)phenyl)-1,2-toluylene and (Z)-1,2-bis(4-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)1,2-toluylene. The synthesis method has the advantages of simple steps, convenient purification and good product stability. The fluorescent probe can be used for detecting the viscosity of the fluid, and has high sensitivity, good optical stability and specific response to the viscosity.

The invention discloses a piperazine-modified tetraphenylethylene derivative which has a structural formula as shown in formula I, and discloses a preparation method of the piperazine-modified tetraphenylethylene derivative. The preparation method comprises the following steps: coupling 1-(4'-bromophenyl)-1, 2, 2-triphenylethylene with 4-(4'-carbonate-1-piperazinyl) phenylboronic acid pinacol ester by a Suzuki reaction; and then performing concentration, extraction, drying, column chromatography and other separation and purification treatments to finally obtain the piperazine-modified tetraphenylethylene derivative. The invention further provides application of the piperazine-modified tetraphenylethylene derivative as a fluorescence detection medium for detecting aromatic nitro-explosive TNP in a dispersion system for a mixed solvent of organic solvent / water; and a minimum detection limit of the TNP can reach a level of 1*10<-6> M.

The invention discloses a biimidazole derivatives modified modified by triphenylethylene and preparation and application of the biimidazole derivatives. The biimidazole derivatives is 1,1'-di-normal propyl-5,5'-double (1,2,2-triphenylethylene)-1H, 1'H-2,2'-biimidazole or 1,1'-bi-normal dodecyl-5,5'-double (1,2,2-triphenylethylene)-1H,1'H-2,2'-biimidazole. The biimidazole derivatives modified modified by the triphenylethylene is used as a fluorescent probe, and obvious fluorescence emission is achieved in a green-yellow light area (450-600 nm). A THF solution of the biimidazole derivatives modified modified by the triphenylethylene is transferred into a water solution, then, nitro class explosive is added, with the concentration increasing of the nitro class explosive, the fluorescent weakening degree of the fluorescent probe is enhanced, and the fluorescent strength is inversely proportional to the concentration of the nitro class explosive. A detection range of the biimidazole derivatives modified modified by the triphenylethylene for 2,4,6-trinitrophenol is from 0 to 10<-4>M, the detection range is wide, and the accuracy degree deviation is lower than + / -0.8%.

The invention provides a colorimetric recognition method for uranyl ions. According to the recognition method, 5-(diethylamine)-2-((5-(4-(1,2,3-triphenylethylene) phenyl)-2-pyridine) diazonium) phenol is adopted as a chemical sensor for analyzing and recognizing the uranyl ions. Colorimetric recognition of the uranyl ions can be effectively achieved among multiple metals through 5-(diethylamine)-2-((5-(4-(1,2,3-triphenylethylene) phenyl)-2-pyridine) diazonium) phenol in a mixed solution of dimethyl sulfoxide and water. Recognition of 5-(diethylamine)-2-((5-(4-(1,2,3-triphenylethylene) phenyl)-2-pyridine) diazonium) phenol on the uranyl ions has good selectivity, sensitivity and anti-jamming capability.

The invention provides simetryn, oxyfluorfen and butachlor complex missible oil and a preparation method thereof, and relates to the technical field of prevention of annual weed in rice transplantation fields. The oil is prepared from 12 parts of simetryn, 8 parts of oxyfluorfen, 40 parts of butachlor, 3.75 parts of triphenylethylene-based phenol polyoxyethylene ether, 3.75 parts of toluylene-based phenol-formaldehyde condensate polyoxyethylene ether, 7.5 parts of calcium dodecylbenzene sulfona and 25 parts of xylene. Simetryn, oxyfluorfen and butachlor are added to xylene to be stirred and completely dissolved, the rest of the raw materials are then added, the mixture is evenly mixed by conducting stirring in a reaction kettle, sampling is conducted to analyze the content, standing, filtering and packaging are conducted after the content is qualified, sampling is conducted again to analyze the content, and storage is conducted after the content is qualified. The simetryn, oxyfluorfen and butachlor complex missible oil which is compounded by conducting blending according to the ratio of 3:2:10 and the content is 60%, the obvious synergism range can be achieved, and the obvious synergism effect can not be achieved through other preparations blended according to other ratios.

The invention provides a triphenylethylene compound containing cyanogen. An electron repulsive group comprising bis-phenylamino and alkoxy and an electron withdrawing group comprising the cyanogen are led to a triphenyl ethane conjugated system to form to two electron transfer channels opposite to each other. The triphenylethylene compound provided by the invention has obvious intramolecular charge transfer property. Due to the influence of the three phenyl, four bis-phenylamino and two alkoxyl steric clashes in the triphenylethylene compound, the molecular space structure of the triphenylethylene compound containing the cyanogen provided by the invention is of a curved petal shape of orchid, and having gathered auxoflorence property.

The invention discloses a low-cost novel cleaning agent. The cleaning agent is prepared from the following raw materials in parts by weight: 4.3-6.2 parts of ferrous lactate, 5.1-7.3 parts of sodium propionate, 3.4-5.3 parts of cocamide propyl amine oxide, 4.4-7.5 parts of tristyryl phenol polyoxyethylene ether, 7.3-10.4 parts of dodecyl dimethyl benzyl ammonium chloride, 2.3-4.2 parts of a surfactant and 3.7-5.4 parts of a mixture of ethanolamine and triethanolamine. The cleaning agent has the beneficial effects that the cleaning agent has an economical and efficient cleaning effect, belongs to concentrated products and can be used in a low-concentration diluted manner; all ingredients generate an excellent synergistic enhancement effect through effective combination, so that the cleaning agent has good degreasing, deoiling and antirust effects, and the average cleaning cost is low; the cleaning agent is good in safety performance and does not pollute the environment; energy sources are saved, and the cleaning cost is low; the cleaning agent does not damage metallic equipment during cleaning and does not corrode the metallic equipment after cleaning.

The invention relates to an aggregation-induced luminescence material of tristyryl-substituted phenanthroimidazole derivatives and its application in the preparation of organic electroluminescent devices, belonging to the technical field of organic electroluminescence. The structural formula of the luminescent material is as follows. Its outstanding feature is that the phenanthroimidazole group and the triphenylethylene group are connected together through a benzene ring. This type of molecule not only inherits the good thermal stability of phenanthroimidazole, but also has a high It has the advantages of electron mobility and high fluorescence quantum efficiency, and also inherits the property of triphenylethylene group aggregation-induced luminescence, which overcomes the problem of fluorescence quenching caused by aggregation. At the same time, the molecule has a large twisted structure, which can ensure that the compound has a high fluorescence quantum efficiency in the solid state. The electroluminescent device prepared by using this type of material as the light-emitting layer has excellent performance. The electroluminescent device is used for Prepare an illumination source or a flat panel display.