36 results about "Methanesulfonic acid" patented technology

This invention relates to the field of electrochemical energy storage technology, specifically disclosing a locally high-concentration electrolyte and its preparation method. The electrolyte uses methoxytrimethylsilane and 2,2,2-trifluoroethyl methanesulfonate as the base solvent, ethoxy(pentafluoro)cyclotriphosphazene or 1,1,1,3,3,3-hexafluoroisopropyl methyl ether as the functional diluent, and is compounded with specific proportions of sodium bis(trifluoromethanesulfonyl)imide, sodium hexafluorophosphate as the main salt, and vinyl sulfate and siloxane polymer additives. Through the synergistic effect between the components, while ensuring high ionic conductivity and excellent wettability, it also significantly improves the stability of the negative electrode interface, providing key material support for the development of high-energy-density negative electrode-free sodium metal batteries, and showing broad application prospects in large-scale energy storage, portable electronic devices, and other fields.

The disclosure belongs to a field of environmentally friendly new materials, specifically relating to a modified covalent organic framework for simultaneous adsorption of multiple heavy metal ions, along with its preparation method and applications. The preparation steps for the material are as follows. 1,3,5-tris(4-aminophenyl)benzene and 2,5-dihydroxyterephthalaldehyde are dissolved in a mixed solvent and allowed to stand and react at room temperature to obtain a mixed solution. Scandium trifluoromethanesulfonate is added to the obtained mixed solution, and allowed to stand and react at the room temperature. After completion of the reaction, the insoluble matter is separated from the reaction solution, and the insoluble matter is washed and dried to obtain a covalent organic framework substrate. A neutral solution is used to perform an ultrasonic modification treatment on the covalent organic framework substrate prepared, and then the modified substrate is washed and dried to obtain a modified covalent organic framework.

The application discloses a synthesis method of 2-aryl-4-phosphoryl-4H-chromene compounds, which comprises the following steps: dissolving 2-hydroxychalcone, diaryl phosphine oxide and mercury triflate in an organic solvent, and reacting at 80-100 DEG C; after the reaction is completed, 2-aryl-4-phosphoryl-4H-chromene compounds are obtained through separation and purification; the synthesis method is simple, the reaction condition is mild, and the operation is convenient; the raw materials are easy to prepare; the reaction byproduct is water; and the method has the advantages of high atomic economy, green environmental protection and the like.

The invention discloses a synthesis method of a trifluoromethanesulfonate radical promoted amidino nickel complex. The preparation method comprises the following steps: reacting N, N '-dialkyl substituted amidino alkali metal salt with a nickel precursor, adding trifluoromethanesulfonate as an accelerant, and regulating the reaction rate and selectivity by utilizing the coordination effect of trifluoromethanesulfonate so as to efficiently prepare the amidino nickel complex. In the process, an ether compound is used as a solvent, the reaction is carried out at 0-70 DEG C for 1-48 hours, the reaction yield can reach 90% at most, and the product purity is gt; and 98%. The method has the characteristics of easily available raw materials, simplicity and convenience in operation, mild reaction conditions, good target product selectivity, high synthesis efficiency, convenience in post-treatment and the like, and has industrial application prospects.

This invention provides a manufacturing method that can produce high-purity quaternary ammonium salts with high yield. [Solution] A reaction step to obtain an ammonium halide compound by reacting a tertiary amine with a (substituted) benzyl halide compound, and the halide ions contained in the ammonium halide compound obtained in the reaction step are (C6F5)4B - SbF6 - PF6 - (CF3CF2)3PF3 - (C6F5)4Ga - A method for producing quaternary ammonium salts is used, which includes a salt exchange step in which the salt is exchanged in a solvent with at least one ion selected from the group consisting of trifluoromethanesulfonate anion and p-toluenesulfonate anion, and the entire process from the reaction step to the salt exchange step is carried out using a continuous production facility.

This invention belongs to the field of wastewater treatment technology, specifically a waste liquid treatment device for an alkaline washing tower used in methanesulfonic acid processing. It includes a support frame with a waste liquid treatment structure at its top. The top of the waste liquid treatment structure is connected to an external waste liquid pipeline, and the bottom of the structure is connected to an external suction pump. This invention uses the waste liquid treatment structure to transport the waste liquid to the top of a separator. The separator filters out old salt particles from the waste liquid, preventing them from entering the evaporator. This avoids the old salt particles affecting the evaporation rate and reduces the workload of the friction mechanism, thus increasing the evaporation and concentration rates. The evaporator concentrates the filtered waste liquid, separating the salt by utilizing the difference in solubility of alkali and salt in water. Both salt and alkali can be reused, reducing alkali consumption and lowering treatment costs. The discharged steam is pollution-free, truly achieving pollution-free emissions, making it more environmentally friendly and meeting long-term stable environmental emission requirements.

The application relates to the field of pharmaceutical chemistry. The application relates to a hydrate crystal form of lazertinib monomethanesulfonate and a preparation method and application thereof. The hydrate crystal form of lazertinib monomethanesulfonate provided by the application has at least one of the following advantages: good stability, good solubility, good dissolution, low hygroscopicity, uniform particle size distribution, good morphology, good fluidity, good crystallinity, stable storage, avoidance of degradation, impurity increase, appearance change and crystal transformation during development and storage, simple and reliable preparation method, and great development value.

An electrochemically mediated, hydrometallurgical method is provided for extraction of nickel, zinc, lead, silver, molybdenum, and / or copper from sulfide minerals. These metal concentrates, such as pentlandite, pyrrhotite, pyrite, sphalerite, galena, Ag2S, MoS2, etc., are contacted with nitric acid and cerium(IV) nitrates, cerium(IV) methanesulfonate, and / or cerium(IV) sulfate, as oxidative leaching agents to preferentially leach the target metals contained therein. The strong oxidizing capacity of cerium(IV) enables rapid dissolution of metal sulfides under ambient conditions. Cerium(IV) can be electrochemically regenerated and recycled for treatment of additional sulfide minerals. Target metal products can be extracted via processes such as solvent extraction and precipitation, enabling complete recovery, e.g., of nickel from pentlandite.

The present application relates to the technical field of chemical synthesis, and particularly relates to a preparation method of 4,4'-difluorobenzophenone and a method for synthesizing polyether ether ketone by two steps of carbon tetrachloride. The preparation method of 4,4'-difluorobenzophenone comprises the following steps: under the condition that trifluoromethanesulfonic acid and N-methyl pyrrolidone exist, CCl4 and fluorobenzene are reacted, and the product is hydrolyzed to obtain 4,4'-difluorobenzophenone. The present application solves the problems of high cost, poor environmental protection and performance that cannot meet market requirements of PEEK by innovating raw material route, catalytic system and process parameters, realizes low-cost, green and high-performance synthesis of PEEK, the purity of the prepared DFBP monomer can reach >=99.99%, and the PEEK molecular weight distribution (PDI<=1.9) can be narrowed, and the method is suitable for industrialized production of PEEK materials used in high-end fields such as aerospace, medical devices and electronic and electrical appliances.

This invention relates to the field of battery technology, and more particularly to a non-aqueous electrolyte, a lithium-ion battery, a battery module, a battery pack, and an electrical device. The non-aqueous electrolyte comprises a lithium salt, a non-aqueous organic solvent, and functional additives. The functional additives include compounds with the structure shown in Formula I and other additives; R1 and R2 are each independently selected from carbonyl, amide, and dimethylacetamide groups; R3, R4, R5, and R6 are each independently selected from hydrogen and fluorine; n is selected from 1 to 3; other additives are selected from one or more combinations of lithium difluorosulfonylimide, lithium trifluoromethanesulfonate, lithium fluorosulfonate, 2-propynyl methanesulfonate, methanedisulfonate methylene, fluoroethylene carbonate, spiroethylene sulfate, vinylene carbonate, and 1,3-propanesulfonate lactone. This invention, through the synergistic effect of compounds with the structure shown in Formula I and other additives, improves the low-temperature performance, rate performance, and cycle performance of lithium batteries.

An Aspergillus niger mutant strain designated MTCC 25759 derived from parent strain Aspergillus niger ATCC 9142 through chemical mutagenesis using ethyl methane sulfonate at 1 mg / mL for 30 to 60 minutes demonstrates enhanced production capabilities for both citric acid and gluconic acid. The mutant strain exhibits genetic modifications at 47 specific sequence positions that contribute to improved metabolic pathways, enhanced substrate utilization efficiency, and increased tolerance to acidic fermentation conditions. The mutant strain achieves gluconic acid production of 198.836 g / L representing a 66% improvement over the parent strain's 119.776 g / L yield, and citric acid production reaching 0.415 g / L with consistent late-phase productivity. The enhanced production capabilities provide economic advantages through improved substrate conversion rates, reduced raw material costs, and increased production capacity within existing fermentation infrastructure while maintaining the Generally Regarded As Safe (GRAS) status for commercial applications.

This invention belongs to the field of polyolefins, and particularly relates to a method for reducing the ash content of polypropylene and the application of imidazolium ionic liquids. The method provided by this invention includes the following steps: mixing imidazolium ionic liquid with crude polypropylene, filtering, and washing to obtain low-ash polypropylene; the imidazolium ionic liquid has the structure of formula (I); in formula (I), R... ‑ The ash is derived from one or more of chloride, bromide, iodide, hydroxide, acetate, thiocyanate, nitrate, methanesulfonate, tetrafluoroborate, and hexafluorophosphate ions. This invention uses an imidazolium ionic liquid with a specific chemical structure as an ash removal agent for polypropylene. This imidazolium ionic liquid can interact with the metallic ash in polypropylene, thereby significantly reducing the ash content in the washed polypropylene product.

Fezolinetant preparation procedure. The present invention relates to a process for obtaining fezolinetant that allows for the production of said product with high purity and enantiomeric excess through the use of trifluoromethanesulfonic acid. The present invention also relates to the trifluoromethanesulfonic acid salt of fezolinetant and to the use of said salt in the production of fezolinetant.

The present invention provides: a novel additive containing an ionic liquid that can be used for a composition for forming a cathode catalyst layer of a polymer electrolyte fuel cell; a novel composition for forming a cathode catalyst; and a novel cathode catalyst layer formed using the same.　The present invention relates to a composition for forming a cathode catalyst layer of a polymer electrolyte fuel cell, the composition containing an ionic liquid represented by formula (1). In the formula, X represents an atomic group containing a nitrogen atom or a phosphorus atom; Y represents a hydrogen atom, a carboxy group, or a sulfonic acid group; Z-represents a hydrogen sulfate anion, a trifluoromethanesulfonate anion, a bis(trifluoromethylsulfonyl)imide anion, a halogen anion, a tetrafluoroborate anion, a hexafluorophosphate anion, a bis(fluorosulfonyl)imide anion, or a nonafluorobutanesulfonate anion; and n represents an integer of 2-4.

This invention discloses a method and its application for creating stress-resistant mutants of common bean using chemical mutagenesis. The main steps include: determining the screening concentration of hydroxyproline (Hyp), determining the median lethal dose of ethyl methanesulfonate (EMS), and subculturing the stress-resistant mutants. After 3-5 subcultures, the stress-resistant mutants screened by this invention ultimately yielded 31 cotyledonary nodes of common bean resistant to hydroxyproline (Hyp), with a mutation rate of 8.16%. This invention can induce mutagenesis and directionally screen for stress-resistant common bean mutants, providing material support for stress-resistant breeding of common bean.

The present invention describes the gold-catalyzed construction of geminocyano-substituted tricyclic [4.4.0.0] 1,5 The method for synthesizing the decane skeleton belongs to the field of organic synthesis technology. Compound 1 is added to an organic solvent, and the reaction is carried out at 25℃-80℃ for 3 hours in the presence of a gold catalyst and additives to obtain product compound 2. The gold catalyst is selected from triphenylphosphine monochloride, triphenylphosphine gold(I) 3-methylbenzotriazole salt, and triphenylphosphine gold(I) trifluoromethanesulfonate. The additive is selected from silver trifluoromethanesulfonate, silver fluoroantimonate, and silver bis(trifluoromethanesulfonylimide). The synthetic method described in this invention is simple to operate, low in cost, highly efficient, and widely applicable, possessing practical application value. Substrate 1 in this invention can be flexibly derivatized by adjusting the structure of its synthetic raw materials or through subsequent functionalization modifications, providing greater convenience for skeleton modification. This invention utilizes the properties of gold catalysts to achieve rapid and convenient synthesis of fused-ring skeletons containing three-membered rings that are difficult to synthesize under other conditions.

This invention discloses a method for preparing benzyl 3-methyl-5-oxopiperidin-1-carboxylic acid ester and its intermediates. The method uses ethyl acetoacetate as a starting material, proceeding through trifluoromethanesulfonation to generate an enol trifluoromethanesulfonate intermediate, palladium-catalyzed cyanation, catalytic hydrogenation, reduction-cyclization transformation under a borohydride / transition metal salt system, nitrogen carbonyl protection, and sulfonium ylide-mediated transformation to obtain the intermediate. The intermediate is further rearranged / cyclized to obtain the target compound. Compared with existing routes, this invention avoids the use of malodorous / high-risk thiol reagents and highly corrosive acids, thus enabling the preparation of the target compound.

This disclosure provides a method for preparing a compound represented by formula (I). The method comprises reacting a first starting material represented by formula (II) and a second starting material represented by formula (III) in a reaction mixture under Negishi conditions to form a compound of formula (I). R is an amine protecting group; Y is Cl, Br, or I; and Z is a trifluoromethanesulfonate, Cl, Br, or I.

The application discloses a preparation method of a naphthomostat mesylate impurity standard substance, and specifically comprises the following steps: firstly, reacting m-aminobenzoic acid with a hydrochloric acid solution to obtain an m-aminobenzoic acid hydrochloride solution; then, adding a magnetic solid acid catalyst and a 20-30% mass concentration cyanamide aqueous solution, and stirring and reacting at room temperature under a pulse magnetic field to obtain 3-guanidinobenzoic acid hydrochloride; then, adding 3-guanidinobenzoic acid hydrochloride, 6-amidino-2-naphthol mesylate, N,N'-dicyclohexyl carbodiimide and a supported catalyst into pyridine, stirring and reacting at room temperature to obtain 6-amidino-2-naphthyl-3-guanidinobenzoic acid ester; and finally, salifying to obtain 6-amidino-2-naphthyl-3-guanidinobenzoic acid ester mesylate. The 6-amidino-2-naphthyl-3-guanidinobenzoic acid ester mesylate with high purity and high yield obtained by the application is of great significance for the quality research of naphthomostat mesylate.

The invention relates to the technical field of photoresist, in particular to photoresist for a capacitive touch sensor and a preparation process of the photoresist. The invention discloses a preparation process of photoresist for a capacitive touch sensor. The preparation process comprises the following steps: preparing a modified photoreaction agent; preparing modified polyimide resin powder; preparing silicon dioxide hollow carbon spheres and nano titanium dioxide hybrid particles; and preparing the photoresist. The preparation method comprises the following steps: firstly carrying out nitration reaction on 4-tert-butylphenol, then reducing nitryl into amino to obtain amino substituted 4-tert-butylphenol, protecting the amino by di-tert-butyl dicarbonate ester, then oxidizing iodobenzene into a high-valence iodine active intermediate by taking m-chloroperoxybenzoic acid as an oxidizing agent, and reacting with Boc-amino substituted 4-tert-butylphenol to obtain the high-valence iodine-substituted 4-tert-butylphenol. And finally, carrying out a replacement reaction with silver trifluoromethanesulfonate, carrying out deprotection to obtain a modified photoreaction agent, and carrying out a condensation polymerization reaction on the modified photoreaction agent, 4, 4 '-hexafluoroisopropyl phthalic anhydride and the like to generate a polyamic acid prepolymer, so that the photoetching resolution can be greatly improved.

The application provides a synthesis method of metrafenone, and belongs to the technical field of organic synthesis, and comprises the following steps: firstly, subjecting 5-hydroxy-1-methyl-3-(trifluoromethyl)-1H-pyrazole to a hydroxymethylation reaction to obtain 4-(hydroxymethyl)-5-hydroxy-1-methyl-3-(trifluoromethyl)-1H-pyrazole; then, reacting with difluorobromoacetic acid to obtain 4-(hydroxymethyl)-5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole; then, subjecting to a mesylation reaction to obtain a mesylate intermediate; simultaneously, preparing 3-acetylthio-5,5-dimethyl-4,5-dihydroisoxazole from 3-chloro-5,5-dimethyl-4,5-dihydroisoxazole; then, subjecting the intermediate to a thioetherization reaction with the mesylate intermediate to obtain a thioether coupling intermediate; finally, performing an oxidation reaction in the presence of a catalyst to obtain metrafenone. By adopting the mesylate activated intermediate and combining a continuous flow fixed bed oxidation process, the method is favorable for improving the purity and total yield of the target product and reducing the tungsten residue in the product.

This invention provides a purification method for compound I, a key intermediate of capecitabine. The crude compound I is dissolved in an organic solvent, stirred at a first temperature, and primary tar is removed. Water is added at room temperature, and the pH is adjusted to alkaline with alkali to remove secondary tar. The organic phase is then concentrated and recrystallized. Compared to existing technologies or traditional column chromatography processes, the purification method provided by this invention significantly improves product purity, removes tar-like substances and impurities of similar polarity generated during preparation, ensuring that the content of the toxic impurity methyl methanesulfonate in the intermediate is less than 1.0 ppm, yielding a white solid compound I with a purity ≥99%. This method is suitable for large-scale industrial production, avoids column chromatography separation, is low-cost, and environmentally friendly.

The application relates to the technical field of petroleum additives, in particular to a shear-resistant crude oil drag reducer and a preparation method thereof. The shear-resistant crude oil drag reducer prepared by the application is a polymer with diphenylmethane 4,4'-diisocyanate, 2-(dimethylamino) ethyl acrylate, methylsulfonic acid-2-propargyl-1-alcohol, vinyl acetate, acryloyl chloride and methyl methacrylate as polymerization monomers. The polymer system has a hyperbranched structure by introducing a terminal hydroxyl polyether ester polyol. Compared with conventional crude oil drag reducers, the shear-resistant crude oil drag reducer has the advantages of strong shear resistance, low use concentration and better drag reduction effect. In addition, the preparation method adopts a solidification-first and hydrolysis-later process, and the product has stable performance.

The present application relates to the technical field of organic synthesis, in particular to a synthesis method of 2,2,2-triphenylacetophenone, steps comprising: 1) preparing mesoporous SiO2 supported triflic anhydride catalyst, realizing solid-liquid separation and circulation of the catalyst; 2) adding pyridine in a segmented temperature control (0-5℃ initial drop, 15-20℃ subsequent drop) mode, reacting with the supported catalyst and benzopinacol in dichloromethane at 20℃ for 2h to avoid local overheating to generate byproducts; 3) after reaction, the catalyst is recovered by filtration, the mother liquor is washed with water, dried, concentrated to obtain a crude product, and then recrystallized with petroleum ether-ethyl acetate (volume ratio 8:1) double solvent to improve the purity to the pharmaceutical grade; 4) dichloromethane is recovered by a three-stage process of "calcium chloride water removal-normal pressure distillation-molecular sieve dehydration-precision filtration", and the recovery rate is ≥90%; 5) the byproduct pyridinium triflate is converted into pyridine and triflic acid by alkaline hydrolysis-acidification, and is reused in the catalytic system.

The invention relates to a compound of formula I or II (I), (II), A- being a counteranion selected from the following ions: chloride, bromide, iodide, acetate, methane sulfonate, benzene sulfonate, camphosulfonate, tartrate, dibenzoate, ascorbate, fumarate, citrate, phosphate, salicylate, oxalate, bromohydrate, tosylate, and X being a 3-carbon alkyl group. The invention also relates to this compound for its use as a medicinal product, particularly in the treatment of neuropsychiatric disorders. Figure to be published with the abstract: Figure 1

This invention discloses a method for preparing lanamivir I. The method includes: starting with N-acetylneuraminic acid, esterification to obtain II, followed by acetylation and cyclization without separation to obtain III; then deacetylation to obtain IV, followed by carbonate esterification to obtain V; etherification to obtain VI, followed by azide ring-opening to obtain VII; azide reduction to obtain VIII, followed by guanidinolation to obtain IX; then ester hydrolysis to obtain X; and finally deprotection of the Boc protecting group to obtain lanamivir I, with an overall yield of 25-46%. This invention uses thionyl chloride to catalyze methyl esterification, ensuring complete reaction without separation and allowing direct use in the next step; it utilizes trimethylsilyl trifluoromethanesulfonate as a catalyst to achieve a one-step acetylation and cyclization reaction, simplifying the operation; the azide ring-opening reaction conditions are mild, requiring no strict temperature control, and the yield can reach 88.9%; simultaneously, a crystallization purification step is introduced after guanidinolation, making the intermediate quality controllable, and the final product yield can reach over 85%.

The application discloses a trifluoromethanesulfonic acid rare earth solid carrier catalyst and a preparation method and application thereof, and belongs to the technical field of hydrofining catalyst preparation. The technical problems to be solved are that the reaction rate of a hydrofining catalyst system in a refining process is easily affected, PAHs are competitively adsorbed, and the catalyst is deactivated by initial carbon deposition. The technical solution is that a trifluoromethanesulfonic acid type rare earth complex is introduced into a Ni-Mo / Al2O3 metal system, so that the rare earth element and the metal precursor form a stable and highly dispersed composite system in a solution, and cooperatively participate in the structural evolution of a NiMoS active phase in a continuous process of impregnation, calcination and sulfidation, a solid carrier catalyst is prepared, and a rare earth reinforced NiMoS composite system with high metal dispersion, strong electronic regulation capacity and low deactivation kinetic constant is constructed, so that the deep hydrofining effect, the aromatic hydrocarbon saturation degree, the HDS efficiency and the operation stability are improved, and the application value is important.

The application belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of nafamostat mesylate. The compound 4-((tert-butoxycarbonyl)amino)benzoic acid is used as a starting material, the compound 6-hydroxy-2-naphthalene formamidine is reacted with the compound 4-((tert-butoxycarbonyl)amino)benzoic acid through esterification, and then the target product nafamostat mesylate is prepared by reacting with aminooxyacetic acid to form a salt. The process can effectively avoid the use of acyl chloride which is toxic and irritating, and the operation is safer.

3,3'-carbonyl bis(7-diethylaminocoumarin) compound preparation method, including: (1) in inert gas environment, compound 1 with compound 2 mikhailov acid, compound 3 methanesulfonic anhydride in the first reaction solvent, under the action of metal catalyst, the reaction temperature is 0~150 DEG C, reaction, after reaction is completed, compound 4 is obtained;(2) compound 4 and compound 5 in the second reaction solvent, under the action of catalyst, the reaction temperature is-20~200 DEG C, reaction, after reaction is completed, compound 6 3,3'-carbonyl bis(7-diethylaminocoumarin) is obtained.The key raw material of the application is cheap and easy to obtain;The reaction condition is relatively mild, and the operator is friendly, the reaction yield is high, the product purity is high, the production cost is greatly reduced, and the demand of product ton level production can be fully met.