54 results about "Metacresol" patented technology

The invention relates to a tazobactam synthesis method which comprises the steps of: with 6-APA(Amino Penicillanic Acid) as raw material, preparing a key intermediate 6,6-dihydro penam sulphoxide acid diphenylcarbinol ester through successive reactions of esterification, oxidation, reduetive debromination and the like without separation; then, reacting with 2-triphenyl silicon-1,2,3-triazole; introducing a triazole ring; and finally obtaining the final product of tazobactam through potassium permanganate oxidation and metacresol deprotection. The tazobactam synthesis method is mainly characterized in that a phase transfer catalyst is introduced in the first step, therefore, the reaction rate and the product purity are improved; since an environment-friendly hydrogen peroxide-cobalt acetate catalytic oxidation system is adopted in the third step, the characteristics of good reaction selectivity, high yield, catalyst recyclability and the like are achieved; a method for synthesizing 2 alpha-methyl-2 beta-(1,2,3- triazole-1- radical) methyl penam-3 alpha-carboxylic acid diphenylcarbinol ester by using 2-triphenyl silicon-1,2,3-triazole is adopted in the fifth step, and the tazobactamsynthesis method is simple and convenient to operate, is safe and reliable, shortens the reaction route and improves the total yield. Compared with the traditional process, the tazobactam synthesis method greatly reduces the production cost and the environment pollution and has greater implementation value and economic benefits.

The invention relates to a preparation method of a covalent-ion cross-linked film of sulfonated polyimide containing imidazolyl. The preparation method comprises the following steps: 1, 4, 5, 8-naphthoic tetracarboxylic dianhydride, sulfonated diamine, common non-sulfonated diamine and diamine containing imidazolyl are added into a metacresol medium, the sulfonated polyimide containing imidazolyl is obtained by copolycondensation under the presence of triethylamine and benzoic acid and the protection of nitrogen; a solution casting method and proton exchange are adopted to prepare non-covalent cross-linked sulfonated polyimide film containing imidazolyl which is then processed by methane-sulfonic acid/phosphorus pentoxide solution or phosphoric acid solution or polyphosphoric acid containing phosphorus petoxide so as to prepare the covalent-ion cross-linked film of sulfonated polyimide containing imidazolyl. The covalent-ion cross-linked film obtained by the preparation method has anti-free radical oxidation susceptibility which is far better than the common sulfonated polyimide or non-covalent cross-linked film without containing imidazolyl and has potential application prospect in the fields of fuel cells and the like.

The invention provides a technology for complexing, crystallizing, separating and purifying metacresol, belonging to the field of separation and purification in a chemical industry. The technology comprises the steps of dissolving urea in mixed phenol: adding the mixed phenol into a reactor, wherein the mixed phenol comprises 10.907wt% of o-cresol, 34.276wt% of p-cresol, 53.176wt% of m-cresol and 1.641% of dimethyl phenol; adding the urea into the reactor, wherein the mole ratio of the urea to the m-cresol is 1.0-1.8; heating and rising the temperature to be 85-105DEG C in a water bath or an oil bath for 40-80min, so that the urea is completely dissolved in the mixed phenol; cooling, adding normal hexane under the temperature of 60DEG C, and crystallizing for 1-2h under the temperature from -10DEG C to -20DEG C; transporting crystallized serous fluid into a filter to separate solid from liquid; recovering filter liquor in a rectifying way, adding water into crystalline solid, and hydrolyzing during heating at 40DEG C to obtain water phase and organic phase; and recovering the water phase, so that the organic phase is the m-cresol. In the technology, methylbenzene is replaced by normal hexane to be taken as a dissolvent for complexing and crystallizing reaction, so that the technology is higher in the yield of the cresol, the usage amount of the dissolvent can be reduced by one third, and the dissolvent can be covered by less energy consumption.

The invention provides a synthesis method of flomoxef sodium. The synthesis method comprises steps as follows: a, (6R,7R)-3-chloro-7-(2-((difluoromethyl) sulfenyl) acetamido)-7-methoxy-8-oxo-5-oxa-1-azabicyalo[4.2.0] octan-2-ene-2-(benzhydryl) carboxylate ester and metacresol are added to a reaction bottle and subjected to a reaction at the temperature of 65-70 DEG C; after the reaction ends, the mixture is cooled, a solvent is added for follow-up treatment, and a flomoxef acid solution is obtained; b, triethylamine is added to the flomoxef acid solution, solids are separated out, filtration and drying are performed, and flomoxef triethylamine salt is obtained; c, the flomoxef triethylamine salt is added to the reaction bottle, an organic solvent is added for dissolution, the temperature is reduced to subzero 25 DEG C to subzero 20 DEG C, sodium salt and an organic solvent are continuously dropwise added, then, crystal growing, filtration, washing and drying are performed after adding, and flomoxef sodium is obtained.

The invention provides a 4, 6-diphenyl-1, 9-anthralin compound luminescent material, a preparation method and application thereof. In the invention, 4, 6-dibenzoyl-1, 3-m-phenylenediamine and p-alkyl hypnone, p-acetyl biphenyl, p-acetyl diphenyl ether, 2-acetamidofluorene, 3-acetyl carbazole and mono-acetyl compounds substituted by alkyl thereof are used as raw materials, polyphosphoric acid is adopted as a catalyst, metacresol is employed as solvent, and a Friedlander condensation reaction is performed to obtain a series of 4, 6-diphenyl-1, 9-anthralin compounds which can be used as a luminous layer or an electron transport layer of an organic light emitting diode.

The invention provides a polyphenol mixture recycling purification technology which comprises the steps of alkalization and phase splitting: heating a polyphenol mixture to react with a sodium carbonate solution to general phenol sodium salt, conveying reaction liquid into an alkalization and phase splitting tower for continuous reaction to generate the phenol sodium salt and phase splitting and obtaining a water phase rich in the phenol sodium salt and an organic light component, acidification, water washing and phenol extraction: conveying the water phase into an acidification tower for acidification, allowing an organic phase on the upper layer in the acidification tower to overflow into a water washing tower for washing treatment, ethanol crystallization mixing and adding the organic phase after the water washing and ethanol into a crystallizer for crystallization to form 2,3-dimethyl phenol, and rectification and separation: continuously conveying primary mother liquid into a primary rectification tower for rectification till a metacresol finished product with a content greater than 98% is generated continuously in the primary rectification tower, and conveying kettle liquid with a 3,5-dimethyl phenol content greater than 80% from the primary rectifying tower into a secondary rectification tower for continuous rectification and purification to form a product with the 3,5-dimethyl phenol content greater than 98%.

The invention discloses a method for preparing 2,3,6-trimethylphenol, and the 2,3,6-trimethylphenol is an important intermediate of vitamin E. The method comprises the following steps of: enabling a mixture of metacresol, methanol and water to pass a fixed bed reactor containing an o-position methylation catalyst in a liquid space velocity of 0.4-10 h<-1>, and preparing the 2,3,6-trimethylphenol by carrying out a gas solid phase catalytic reaction under a temperature of 280-450 DEG C and a pressure of 0-10 MPa, wherein the o-position methylation catalyst consists of iron oxide, silicon dioxide and alkali metal oxide, and in the oxides, the metal ion molar ratio of iron, silicon, aluminum and alkali metal is equal to 100:(0.1-10):(0.2-5):(0-1). According to a catalyst for synthesizing the 2,3,6-trimethylphenol and a preparation method thereof, the conversion rate of the metacresol for compounding the 2,3,6-trimethylphenol is 100%, the yield of the 2,3,6-trimethylphenol is above 99.9%, and the service life of the catalyst is longer than 3000 hours.

The invention discloses a polymerizable organic strong acid / sulfuric acid composite curing agent and a foamable phenolic resin combination thereof. The combination comprises 100 parts of liquid A-stage phenolic resin, 7-9 parts of foaming agents, 2-6 parts of foam stabilizer, and 6-10 parts of polymerizable organic strong acid / sulfuric acid composite curing agents. The polymerizable organic strong acid / sulfuric acid composite curing agents are obtained through phenol or metacresol sulfonated in slightly excessive concentrated sulfuric acid, postprocessing processes of separation and the like are not needed, preparation processes are simple, and cost in low. The polymerizable organic strong acid / sulfuric acid composite curing agent can be chemically bonded with phenolic resin and directly brought in structure of foams, the polymerizable organic strong acid / sulfuric acid composite curing agent is not easy to permeate, small in corrosivity of base materials due to the fact that the potential of hydrogen (PH) value of the obtained foams reaches up to 5.8, rapid in foaming speed, and free from foam collapse and foam contraction.

The invention discloses a preparation method for thymol. Metacresol and isopropanol are used as reaction raw materials. The preparation method comprises the following preparation steps of stirring the metacresol and the isopropanol to be uniform; adding a catalyst in a mixture of the metacresol and the isopropanol and stirring to be uniform again to obtain a reaction mass; reacting the reaction mass at the reaction temperature of 100-200DEG C under the radiation of microwave with the power of 200 to 1,000W for 0.1 to 60 minutes to obtain the thymol as a target product, wherein the amount ratio of the metacresol to the isopropanol is 1:(0.01-10), and the dose of the catalyst is 1 to 30 percent of the mass sum of the metacresol and the isopropanol. According to the preparation method for the thymol, disclosed by the invention, the reaction temperature is 100 to 200DEG C and is greatly lower than the preparation temperature of the thymol by using an existing friedel-crafts alkylation reaction; the reaction time is shorter, and is only 0.1 to 60 minutes.

The invention provides a method for measuring the content of seven harmful phenol in the mainstream flue gas by high efficiency liquid chromatography, comprising the steps of mainstream flue gas collection, flue gas sample preparation and high efficiency liquid chromatography fluorescence detection. Firstly, the fluorescence detection spectrum data output by a high efficiency liquid chromatographyfluorescence detector of different mixed concentration sample is processed with a partial least square method, and a mathematical model is built, and then the fluorescence detection spectrum data ofthe metacresol and the paracresol in high efficiency liquid chromatography fluorescence detection data of the flue gas sample is input into the mathematical model to obtain the concentration of the metacresol and the paracresol. The method can be used for simultaneously analyzing the content of seven harmful phenol compounds in the mainstream flue gas and realizes the measurement of the metacresolcompound and the paracresol compound with a chemometrics method without adopting any other instrument, equipment or reagent, has accurate mausruing result, simple measure process and rapid calculation speed.

The invention discloses a method for preparing 3-methoxyl-4-tert-butyl toluene. Under the existence of quaternary ammonium salt type phase transfer catalysts, 6-tert-butyl metacresol reacts with dimethyl sulphate and water solution of hydroxides or carbonates of alkali metals at 20-50 DEG C, and 3-methoxyl-4-tert-butyl toluene can be produced with high yield. Post treatment of the reaction mixture is very simple and 3-methoxyl-4-tert-butyl toluene with a content of higher than 99.2 percent can be obtained after only two water washing operations. The method has the advantages of simple process, easy product quality control, low cost, low environment pollution and safe production and is suitable for industrialized application.

The present invention discloses a synthesis method for 2-methoxy-4-methylbenzylamine. The method comprises the following three steps that: 1, metacresol and formaldehyde are mixed in a solvent A, the resulting solution is subjected to a carbonylation reaction under an alkaline condition through a catalytic action of a Lewis acid catalyst to generate 2-hydroxy-4-methyl-benzaldehyde; 2, the 2-hydroxy-4-methyl-benzaldehyde and a methylating regent are subjected to heating reflux in a solvent B to carry out a methylation reaction to generate 2-methoxy-4-methyl-benzaldehyde; 3, the 2-methoxy-4-methyl-benzaldehyde and ammonium formate are subjected to a reductive amination reaction under a heating condition to generate the 2-methoxy-4-methylbenzylamine. According to the synthesis method provided by the present invention, the used raw materials are mass industrial products, such that the production cost is low; in the third step of the reductive amination reaction, a hazardous reducing agentof lithium aluminum hydride is prevented from using; the reaction conditions are mild, the operation is safe and convenient; the yield of the final product is high, the generated three waste are less, and the method is applicable for the industrial production.

The invention relates to a carbon/carbon composite material preform. The carbon/carbon composite material preform comprises 40-70wt% of short carbon fibers, and the balance of a carbon nano-adhesive. The invention provides a preparation method of the preform. The method comprises the following steps: dispersing the short carbon fibers in a polyoxyethylene and hydroxypropyl methyl cellulose ether dispersed aqueous solution; standing the obtained solution, and removing a supernatant; heating and drying the obtained material to obtain a carbon fiber preform; carrying out vacuum impregnation to make a n-propanol solution of phenol-metacresol-furfural-acetyl chloride be impregnated into the carbon fiber preform, heating the obtained carbon fiber preform to carry out in situ polymerization in order to form a phenolic aldehyde-based nano-adhesive, and drying the phenolic aldehyde-based nano-adhesive to volatilize n-propanol in order to obtain a phenolic resin nano-adhesive reinforced carbon fiber preform; and carbonizing the phenolic resin nano-adhesive reinforced carbon fiber preform to obtain the carbon nano-adhesive reinforced short carbon fiber preform. The preparation method has the advantages of no need of expensive long carbon fibers, no need of a complex knitting technology, convenient operation, short period, low cost, excellent performances and easy industrial production.

The invention discloses DOT6 boric acid ester type braking fluid, which is prepared from the following ingredients in percentage by mass: 3 to 16 percent of polyethylene glycol ether, 82 to 95 percentof tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl]orthoborate, 0.05 to 0.15 percent of 6-methyl-2-mercaptobenzothiazole, 0.05 to 0.15 percent of methylbenzotriazole, 0.5 to 1.0 percent of N-methylmonoethanolamine, 0.05 to 0.1 percent of antioxidants 1010, 0.04 to 0.2 percent of acrylic acid 2-ethylhexyl acrylate, 0.01 to 0.05 percent of 4,4'-butylidene bis-(6-tertiary butyl metacresol), 0.01 to 0.05 percent of paraben, 0.01 to 0.05 percent of dodecencylsuccinic acid (T746) and 0.5 to 1.0 percent of alkalinity regulators. The tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl]orthoborate obtained through optimizing the esterification process can effectively solve the problem of high dry and wet boiling point requirements of DOT6; meanwhile, the excellent low-temperature driving performance is realized; thebraking is more sensitive.

The invention discloses a stable insulin glargine injection and a preparation method thereof. The stable insulin glargine injection comprises the following components: 100IU/mL of insulin glargine, 10-100 mu g/mL of zinc, 1.5-3.5 mg/mL of metacresol, 0.7-1.8 mg/mL of phenol, 15-20 mg/mL of glycerin, and hydrochloric acid and/or sodium hydroxide and injection water, the pH value is 3.8-4.2. By means of modifying the raw material components and the preparation process of the insulin glargine injection, the stability of the insulin glargine injection is increased and the quality of the preparation is improved, and the insulin glargine injection does not have allergic reactions and the safety is good.

The invention relates to a pharmaceutical raw material hexafluoroacetone synthesis method, which mainly comprises: adding 3 mol 2,3-dihydroxy-hexafluoroisopentane and 4-6 mol N-methylpropionamide solution to a reaction container, increasing the temperature of the solution to 70-80 DEG C, maintaining for 60-80 min, adding 2-3 mol bismuth molybdate, continuously carrying out the reaction for 50-70 min, reducing the temperature to 40-50 DEG C, carrying out pressure reducing distillation, collecting the distillate at a temperature of 80-89 DEG C, washing with a metacresol solution, washing with am-chloroaniline solution, and re-crystallizing with a methoxytoluene solution to obtain the crystal hexafluoroacetone.