2043results about "Amino-hyroxy compound preparation" patented technology

This invention discloses a fluorene-based organic small molecule hole transport material and its applications. The general structural formula of the fluorene-based organic small molecule hole transport material is as follows: where n = 1-4, and R represents the hole transport capacity. This fluorene-based organic small molecule hole transport material is used as an undoped hole transport material in perovskite solar cell devices. By introducing dicarboxylic acid groups onto the fluorene-based organic small molecule hole transport material, when used in an inverted perovskite solar cell device, it can form chemical bonds with the hydroxyl groups of the glass conductive substrate, forming a directionally aligned self-assembled layer on the surface of the glass conductive substrate. This effectively improves the charge transport capability at the interface and increases the photoelectric conversion efficiency of the perovskite solar cell device. Furthermore, since this perovskite solar cell device does not contain lithium salts, it exhibits high water and oxygen stability. In addition, the synthesis process of this fluorene-based organic small molecule hole transport material is simple, and the raw materials are inexpensive and readily available, making it highly valuable for practical applications.

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

The invention belongs to the technical field of oilfield chemistry, and discloses a cross-linking agent for degradable gel and a preparation method and application thereof.The preparation method comprises the steps that a compound A is dissolved in an organic solvent and stirred to be uniform, and a first solution is obtained; adding a polymerization inhibitor and a compound B into the first solution, and uniformly stirring at room temperature to obtain a second solution; the second solution is sequentially subjected to heating stirring, diethyl ether washing, ethanol recrystallization, suction filtration and drying, and the cross-linking agent for gel is obtained. According to the invention, a non-conjugated aromatic system is added into a cross-linking agent structure, so that the prepared gel can be automatically degraded under a certain temperature condition; ammonium ions and halide ions are added into a cross-linking agent structure, so that the anti-pollution performance of the gel is enhanced, and the problems that existing gel is difficult to degrade and poor in anti-pollution performance are solved.

The invention relates to the technical field of organic chemical synthesis, in particular to a preparation method of 3, 4 '-diaminodiphenyl ether.The preparation method comprises the steps that S1, under inert gas and in a first solvent, m-dinitrobenzene and p-acetamidophenol are subjected to a heating reaction under the condition of a weak base catalyst, and 3-nitro-4-acetamido diphenyl ether is prepared; s2, in a second solvent, the 3-nitro-4-acetamido diphenyl ether is subjected to a hydrogenation reduction reaction, and 3-amino-4-acetamido diphenyl ether is prepared; and S3, dissolving the 3-amino-4-acetaminodiphenyl ether in an alcohol solvent system, adding an aqueous solution of alkali, controlling the reaction temperature, carrying out a hydrolysis reaction, and after the reaction is finished, carrying out post-treatment to obtain the 3, 4 '-diaminodiphenyl ether. The preparation method provided by the invention has the advantages of easily available raw materials, low price, good selectivity and high product yield, and is more suitable for industrial production by comprehensively considering economical efficiency and safety.

The invention provides a novel method for synthesizing a fluoroalkyl substituted 4, 4 '-diaminodiphenylmethane compound, which comprises the following steps: under the action of a catalyst, reacting an amine compound with a fluorine-containing aldehyde compound in an organic solvent, and after the reaction is finished, carrying out post-treatment to obtain the fluoroalkyl substituted 4, 4'-diaminodiphenylmethane compound. The method has the advantages of mild reaction conditions, simple operation, high reaction efficiency, cheap and easily available raw materials, good atom economy, no generation of wastes, and large-scale application prospects. In addition, the fluoroalcohol solvent is recycled through simple distillation operation, the cost of a large amount of solvent is effectively saved, the process safety is improved, and efficient and green industrial production is facilitated.

The invention discloses a synthesis method of dialkyl amino alcohol. The dialkyl amino alcohol is obtained by reacting dialkyl amino ester with a Grignard reagent. According to the synthetic route provided by the invention, the overall synthesis condition is mild, the used raw materials are easy to obtain, and the toxicity is relatively low.

The invention provides a preparation method and intermediates of alasset hydrochloride, which comprises the following steps: reacting an initial raw material as shown in a formula 1, which is protected by bare phenolic hydroxyl groups or different protecting groups, with bis (pinacolato) diboron to obtain an intermediate as shown in a formula 2, carrying out coupling reaction on the intermediate and a compound as shown in a formula 3 to obtain a corresponding hydroxyl-protected intermediate as shown in a formula 4, and separating and purifying the intermediate to obtain the alasset hydrochloride. The preparation method comprises the following steps: carrying out catalyst pressurized hydrogenation, carrying out asymmetric chiral hydrogenation to obtain an intermediate as shown in a formula 5, carrying out substitution or reductive amination to obtain an intermediate as shown in a formula 6, carrying out nucleophilic substitution on the intermediate as shown in a formula 7 to obtain an intermediate as shown in a formula 8, and carrying out deprotection to obtain a target product as shown in a formula I. According to the invention, a chiral resolution link in the existing preparation technology is avoided, and a chiral group is introduced through asymmetric hydrogenation, so that the yield is greatly improved, the production cost is greatly reduced, the tedious and tedious synthesis steps in the original process are shortened, and the post-treatment is simpler and more controllable.

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

The present invention provides a method for synthesizing alacastran, comprising reacting an amino compound of formula V with a chiral intermediate of formula VI, reducing the resulting product with a reducing agent capable of providing an ethyl group to produce a compound of formula VII, and then deprotecting the compound to obtain alacastran, as shown in the following reaction formula. The method for synthesizing alacastran of the present invention avoids the low yield caused by amide reduction and the risk of substrate racemization, has a high yield, low material cost, safe operation, and is suitable for industrial production.

The invention discloses a quaternary ammonium salt modified linalool derivative as well as preparation and application thereof. The structure of the quaternary ammonium salt modified linalool derivative is shown as a formula (I). The quaternary ammonium salt modified linalool derivative is prepared by carrying out nucleophilic substitution reaction on linalool and benzyltrimethylammonium chloride. The derivative can be applied to water-based disinfectants or antibacterial daily necessities. The derivative has good water solubility and bactericidal activity. Through the synergistic interaction of the quaternary ammonium salt group and the linalool mother nucleus, the disinfection and sterilization capacity of the linalool derivative is remarkably improved compared with that of independent quaternary ammonium salt or linalool, and the linalool derivative particularly has a better disinfection and killing effect on pathogens of a quaternary ammonium salt-resistant disinfectant. # imgabs0 #

The invention provides a method for preparing high-purity phosphatidylserine by a batch enzyme catalysis method based on dynamic choline removal, and belongs to the technical field of enzymatic reaction. According to the method disclosed by the invention, in a reaction system for preparing phosphatidylserine, a byproduct choline is selectively adsorbed by adopting resin. Choline in a reaction system is removed in real time through the integrated adsorption separation module, the enzyme inhibition problem is solved, and meanwhile, the PC conversion rate is larger than or equal to 98% and the PS purity is larger than or equal to 96% in combination with the immobilized enzyme circulation technology; the enzyme can be reused for more than or equal to 20 times (activity retention is more than or equal to 90%); and the choline residual concentration is less than or equal to 0.5 mM (an inhibition threshold value or less).

The invention discloses a functional cross-linking agent and a preparation method and application thereof, and relates to the technical field of oilfield chemistry and application, the structure of the functional cross-linking agent comprises a quaternary ammonium salt structure, an ester group and a conjugated non-planar central nucleus, no additional conditions such as illumination, acidic conditions or alkaline conditions are needed, and the functional cross-linking agent has good stability. The self-degradation can be realized under a certain temperature condition. The method is simple and reliable in technology, high in yield and suitable for large-scale industrial production. A three-dimensional network structure is formed through chemical crosslinking, weak bonds in the functional crosslinking agent are broken and the three-dimensional network structure is disintegrated under the action of a built-in catalyst, generated linear low-molecular-weight water-soluble polymers are dissolved in formation water to form low-viscosity fluid, flowback is not needed, and subsequent water injection is not affected; and temporary plugging maintenance and the like of a low-temperature oil field well can be realized.

The invention relates to the technical field of silicon dioxide surface modification, in particular to a silicon dioxide hollow sphere with an MOF composite layer, a manufacturing method and a dielectric loss prediction method. The silicon dioxide hollow sphere comprises a hollow spherical structure formed by silicon dioxide, an amino silane layer grafted on the surface of an inner core layer through a covalent bond, a ZIF-8 crystal layer growing in situ by taking amino as a nucleation site, and thiol groups distributed on the outer surface of an MOF crystal. According to the silicon dioxide hollow sphere with the MOF composite layer, the manufacturing method and the dielectric loss prediction method, the silicon dioxide hollow sphere with the MOF composite layer has good compatibility and stability in an LCP matrix, the dielectric loss is small, and the performance of a high-frequency FPC is effectively improved.

The application belongs to the technical field of functional resin, and particularly relates to a novel modified phenolic resin with high heat resistance, preparation and application thereof. The thermoplastic phenolic resin is modified by 4,4'-diaminodiphenyl methane (MDA) to improve the heat resistance of the phenolic resin. The obtained modified phenolic resin has excellent heat resistance, and when the modified phenolic resin is applied to a friction material as a binder, the wear rate of the friction material at high temperature is greatly reduced, and the service life of the friction material is prolonged.

The invention discloses a method for preparing ethylenediamine and piperazine from ethylene glycol, which comprises the following steps: in a system containing ethylene glycol, ammonia gas, hydrogen, a solvent and a catalyst, carrying out dehydrogenation, amination and hydrogenation on ethylene glycol and ammonia gas under the action of the catalyst to generate ethanolamine; the ethanolamine is further aminated to generate ethidene diamine; and further reacting ethylene glycol, ethanolamine and ethylenediamine to generate piperazine. According to the present invention, the solubility of ethanolamine and ethylenediamine is increased by introducing the solvent with the high polarity into the reaction system, such that the high ethylene glycol conversion rate is achieved under the mild reaction conditions (180-220 DEG C, 4-5 MPa), and the selectivity of ethylenediamine and piperazine is significantly improved. Wherein the selectivity of ethylene glycol can reach 74.1%, the sum of the selectivity of ethanediamine and piperazine can reach 85.5%, and the selectivity of piperazine can reach 73.3%.

The present invention provides a method for preparing an elastostrat intermediate and its derivatives, and relates to the field of organic chemical synthesis, specifically, to the field of asymmetric catalytic hydrogenation of organic compounds. The method for preparing an elastostrat intermediate and its derivatives is as follows: Compound 1 and compound SM1 are coupled by palladium catalysis to obtain compound 2; Compound 2 is subjected to asymmetric hydrogenation reduction of the carbonyl group to obtain compound 3; and compound 3 is hydrogenated to obtain compound 4. The preparation method of the present invention is simple, shortens the preparation steps, and is conducive to scale-up production; at the same time, the present invention shortens the reaction route, reduces the price of starting materials, and saves costs.

The invention discloses a titanium-doped lamellar FER molecular sieve and application thereof in a rutin electrochemical sensing detector, and belongs to the technical field of molecular sieve synthesis and electrochemical sensor detection. The titanium-doped lamellar FER molecular sieve is prepared by taking an organic compound as a template agent through a hydrothermal method. The structural formula of the organic compound is NH2-C2H4-NH-(CH2) n-O-(p-C6H4) 2-O-(CH2) n-NH-C2H4-NH2, and the structural formula of the organic compound is NH2-C2H4-NH-CH2. Wherein n ranges from 10 to 16. The preparation method comprises the following steps: immobilizing chitosan on a titanium-doped lamellar FER molecular sieve to obtain a composite material, and modifying an electrode by adopting the obtained composite material to construct an electrochemical sensor; the obtained electrochemical sensor is used for detecting and analyzing rutin. The rutin detection concentration linear range of the obtained electrochemical sensor reaches 0.1-10 [mu] mol / L, the concentration detection range is wide, the detection sensitivity, accuracy, repeatability and selectivity are high, the detection lower limit is low, and the stability is good.

A process for the hydrogenation of carbonyl compounds consisting of the following steps: (a) providing hydrogen with a molar share of deuterium ≤ 100 ppm, based on the total hydrogen content, by electrolysis of water using electrical power generated at least in part from non-fossil energy, (b) hydrogenating a carbonyl compound using the hydrogen provided in step (a) to form the corresponding hydrogenation product, wherein at least one carbonyl group of the carbonyl compound is hydrogenated.

The invention relates to sterile bispentadol sebacate, a preparation method thereof and medical application of a medicinal preparation containing the sterile bispentadol sebacate. Wherein the particle size D50 of the sterile bis (tapentadol) sebacate is 0.5 to 10 [mu] m. The invention also provides application of the bispentadol sebacate in preparation of various acute and chronic pain medicines, and the bispentadol sebacate has the characteristic of remarkable long-acting effect.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The invention belongs to the technical field of hydrogel sensors, and particularly relates to quaternary ammonium salt containing a carbamate structure as well as a preparation method and application of the quaternary ammonium salt. The structural formula of the quaternary ammonium salt is # imgabs0 #; wherein n comprises an integer from 7 to 17; m comprises an integer of 2-4; x comprises Cl, Br, I and F; the quaternary ammonium salt contains a carbamate group and can form a hydrogen bond, so that the quaternary ammonium salt and the generated hydrogel have excellent hydrophilicity and water-retaining property; the hydrogel participating in preparation has excellent fatigue resistance, tensile hysteresis, biocompatibility and antibacterial property.

The invention relates to the technical field of synthesis of metal organic complexes, in particular to a preparation method of a metal organic complex, and aims to solve the problems that the metal organic complex is tedious to prepare, low in yield, high in cost, incapable of meeting industrial production requirements and the like in the prior art. The preparation method of the metal organic complex comprises the following steps: carrying out Grignard reaction on a Grignard reagent and (dimethylamino) acetone to prepare a first product; wherein the Grignard reagent comprises R-MgX, R is selected from any one of C1-C2 alkyl groups, and X is selected from any one of chlorine, bromine and iodine; the general formula of the first product is as shown in the following formula (I): # imgabs0 # (I); carrying out a complexation reaction on the first product and a salt of a first metal M to prepare a metal organic complex; the general formula of the metal organic complex is as shown in the following formula (II): # imgabs1 # (II); m is selected from any one of copper and nickel.

The invention discloses a method for preparing a perovskite solar cell by passivating the surface of pure-phase two-dimensional perovskite, and belongs to the technical field of perovskite solar cells. The method comprises the following steps: synthesizing a pure-phase two-dimensional material by using an amine / ammonium compound, dissolving the pure-phase two-dimensional material in an organic solution, dynamically spin-coating the pure-phase two-dimensional material on the surface of three-dimensional perovskite, and annealing to form a pure-phase two-dimensional perovskite passivation layer. The pure-phase two-dimensional perovskite passivation layer with a wide band gap is applied to the top of the three-dimensional perovskite, so that energy level alignment between the perovskite layer and the charge transport layer can be improved, and electrons are effectively prevented from penetrating through the perovskite and a hole transport layer interface; meanwhile, the pure-phase two-dimensional perovskite passivation layer can effectively passivate surface defects of the three-dimensional perovskite thin film; the two-dimensional material has good hydrophobicity, degradation of the perovskite material caused by moisture can be reduced, and the long-term stability of the device can be improved. According to the method, the photovoltaic performance of the cell can be effectively improved, and the efficient and stable perovskite solar cell is obtained.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of metaraminol bitartrate. The preparation method comprises the following steps: reacting benzyloxycarbonyl-L-alanine serving as a raw material with dimethylhydroxylamine hydrochloride, then reacting with 3-benzyloxybromobenzene, then carrying out one-step hydrogenation reaction to obtain m-hydroxylamine, and finally salifying to obtain the metaraminol bitartrate. The method adopts a one-step hydrogenation method to simultaneously realize dual effects of reduction and deprotection, reduces operation steps and material consumption, saves material cost, and reduces generation of reaction wastes; in the preparation process, reaction conditions are mild, safety and reliability are achieved, operation is easy, and the obtained target product is high in yield, good in selectivity and suitable for large-scale production.

The invention belongs to the technical field of organic synthesis, and in particular to a method for preparing 2-methyl-4-methoxydiphenylamine. Steps: (1) adding o-nitrotoluene, a metal catalyst, methanol and sulfuric acid to a reaction kettle, maintaining a hydrogen pressure of 0.03-0.05 MPa, obtaining a crude 2-methyl-4-methoxyaniline product, and separating a solid 3-methyl-4-aminophenol product; (2) adding 3-methyl-4-aminophenol to a reactor, adding a NaOH solution, adding DMAC and pure water, adding dimethyl carbonate dropwise, and washing with alkali to obtain a crude 2-methyl-4-methoxyaniline product; (3) adding solvent pure water, Na2CO3 and o-chlorobenzoic acid to the reactor, the crude 2-methyl-4-methoxyaniline product is put into the reactor, adding a dispersant and a catalyst ligand, and adding a CuCl catalyst at the same time, acid precipitation, filtering to obtain an MMD intermediate; (4) mixing the obtained intermediate with an organic solvent, decarboxylating, and purifying to obtain 2-methyl-4-methoxydiphenylamine. The by-products can be recovered, and the yield is increased by 6-7% compared with the original process, which reduces the requirements for process conditions.

The present invention discloses three choline ionic liquids, which are composed of any one or more compounds represented by the following structural formulas:. The present invention also provides a method for synthesizing the above choline ionic liquids and their application as electrolyte additives for magnesium-air batteries. By adding the above choline ionic liquids to the electrolyte, the discharge voltage and specific energy of the magnesium-air battery with high-purity magnesium as the anode are greatly improved. In addition, it is also suitable for magnesium-air battery systems with AM50, AZ31 and ZK61 as the anode, and has good universality. The choline ionic liquid proposed by the present invention has low pollution and a simple synthesis method, can significantly improve the discharge performance of the magnesium-air battery, and has good application prospects.

The invention relates to a preparation method of oxilafluorine, which comprises the following steps: by taking a fat alkane compound and a hydroxyethyl reagent as raw materials, carrying out tank closing reaction, then reacting under the action of an alkaline reagent, and finally salifying to obtain the target product oxilafluorine. According to the method, the tank closing reaction is directly carried out, other auxiliaries are not needed, the amino compound serves as a reaction raw material and also serves as an acid-binding agent, use of other organic reagents can be reduced, and the method is more environmentally friendly. Meanwhile, the synthesis method provided by the invention is novel, good in reaction selectivity, simple and convenient in route and high in yield.

The invention discloses a migration-resistant macromolecular anti-aging agent as well as a preparation method and application thereof, and belongs to the technical field of anti-aging agents. The preparation method comprises the following steps: putting p-aminodiphenylamine into a reaction container; heating the reaction container, and stirring the interior of the reaction container by using a stirrer; dropwise adding glycidyl methacrylate into the reaction container; performing constant-temperature reaction for a period of time to obtain a reaction material; adding white carbon black, pouring reaction materials into a barrel of a high-speed stirring dispersion machine, and stirring and mixing; and taking out the powdery product to obtain the migration-resistant macromolecular anti-aging agent. According to the migration-resistant macromolecular anti-aging agent, p-aminodiphenylamine and glycidyl methacrylate serve as raw materials, the macromolecular anti-aging agent containing double bonds and hydroxyl is prepared through amino ring-opening epoxy reaction, the migration resistance of the anti-aging agent can be greatly improved through combination of the carbon-carbon double bonds and the structure on the surface of rubber, meanwhile, the hydroxyl can capture free radicals, and the migration resistance of the anti-aging agent is improved. The aging process of the rubber is delayed and the service life is prolonged.

The present disclosure provides derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized to form a compound that is surface-active and have advantageous surfactant characteristics. The compounds of the present disclosure have low critical micelle concentrations (CMC) as well as superior ability to lower the surface tension of a liquid.

The invention relates to the technical field of isotope separation, and particularly discloses a functionalized ionic liquid as well as a preparation method and application thereof in separation of boron isotopes. The ionic liquid prepared from halogenated ether, a nitrogen-containing compound and fluorine-containing inorganic salt is used as a complexing agent for boron isotope separation. The ionic liquid has good chemical stability and thermal stability and can be kept stable in the long-time separation process of boron isotopes; the ionic liquid has unique selectivity, has different affinity and complexing stability to 10B and 11B, and is convenient to realize accurate separation of 10B and 11B; the boron isotope separation agent also has excellent solubility and flowability, can fully contact and react with boron isotopes, improves the separation efficiency, reduces equipment blockage and energy consumption, and provides convenient conditions for large-scale industrial boron isotope separation; in addition, the ionic liquid has better environmental friendliness, better meets the development requirements of green chemistry, and has huge application potential in the field of boron isotope separation.