2769results about "Amino-hyroxy compound preparation" patented technology

This invention discloses a fluorene-based organic small molecule hole transport material and its applications. The general structural formula of the fluorene-based organic small molecule hole transport material is as follows: where n = 1-4, and R represents the hole transport capacity. This fluorene-based organic small molecule hole transport material is used as an undoped hole transport material in perovskite solar cell devices. By introducing dicarboxylic acid groups onto the fluorene-based organic small molecule hole transport material, when used in an inverted perovskite solar cell device, it can form chemical bonds with the hydroxyl groups of the glass conductive substrate, forming a directionally aligned self-assembled layer on the surface of the glass conductive substrate. This effectively improves the charge transport capability at the interface and increases the photoelectric conversion efficiency of the perovskite solar cell device. Furthermore, since this perovskite solar cell device does not contain lithium salts, it exhibits high water and oxygen stability. In addition, the synthesis process of this fluorene-based organic small molecule hole transport material is simple, and the raw materials are inexpensive and readily available, making it highly valuable for practical applications.

The invention provides a rapidly metabolized lipid compound, and particularly relates to a compound as shown in formula (I), or pharmaceutically acceptable salt, isotope variant, tautomer or stereoisomer thereof. The invention also provides nanoparticle pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions thereof in delivery of nucleic acids. # imgabs0 #

The invention relates to the technical field of chemical synthesis, in particular to a preparation method of 3, 4 '-diaminodiphenyl ether.The preparation method comprises the steps that m-dinitrobenzene is dissolved with alcohol, and selective hydrogenation is conducted in a high-temperature and high-pressure reaction kettle with a palladium catalyst; and co-heating and refluxing the product after selective hydrogenation, a strong alkali aqueous solution, a first solvent and a phase transfer catalyst to obtain the m-aminophenol salt. M-aminophenol salt, p-nitroiodobenzene, alkali and a second solvent are subjected to a co-heating reaction, and then 3-amino-4 '-nitrodiphenyl ether is obtained through post-treatment; the method comprises the following steps: dissolving 3-amino-4 '-nitrodiphenyl ether with alcohol, carrying out hydrogenation reduction with a palladium catalyst, and carrying out post-treatment purification to obtain 3, 4'-diaminodiphenyl ether. According to the method, common m-dinitrobenzene is used as a raw material, m-nitroaniline is obtained through selective hydrogenation, m-aminophenol salt is prepared through the m-nitroaniline, then etherification reaction is carried out, the reaction yield is higher, the purity is better, and side reactions are few.

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

The invention belongs to the technical field of oilfield chemistry, and discloses a cross-linking agent for degradable gel and a preparation method and application thereof.The preparation method comprises the steps that a compound A is dissolved in an organic solvent and stirred to be uniform, and a first solution is obtained; adding a polymerization inhibitor and a compound B into the first solution, and uniformly stirring at room temperature to obtain a second solution; the second solution is sequentially subjected to heating stirring, diethyl ether washing, ethanol recrystallization, suction filtration and drying, and the cross-linking agent for gel is obtained. According to the invention, a non-conjugated aromatic system is added into a cross-linking agent structure, so that the prepared gel can be automatically degraded under a certain temperature condition; ammonium ions and halide ions are added into a cross-linking agent structure, so that the anti-pollution performance of the gel is enhanced, and the problems that existing gel is difficult to degrade and poor in anti-pollution performance are solved.

The invention relates to the technical field of organic chemical synthesis, in particular to a preparation method of 3, 4 '-diaminodiphenyl ether.The preparation method comprises the steps that S1, under inert gas and in a first solvent, m-dinitrobenzene and p-acetamidophenol are subjected to a heating reaction under the condition of a weak base catalyst, and 3-nitro-4-acetamido diphenyl ether is prepared; s2, in a second solvent, the 3-nitro-4-acetamido diphenyl ether is subjected to a hydrogenation reduction reaction, and 3-amino-4-acetamido diphenyl ether is prepared; and S3, dissolving the 3-amino-4-acetaminodiphenyl ether in an alcohol solvent system, adding an aqueous solution of alkali, controlling the reaction temperature, carrying out a hydrolysis reaction, and after the reaction is finished, carrying out post-treatment to obtain the 3, 4 '-diaminodiphenyl ether. The preparation method provided by the invention has the advantages of easily available raw materials, low price, good selectivity and high product yield, and is more suitable for industrial production by comprehensively considering economical efficiency and safety.

The invention provides a novel method for synthesizing a fluoroalkyl substituted 4, 4 '-diaminodiphenylmethane compound, which comprises the following steps: under the action of a catalyst, reacting an amine compound with a fluorine-containing aldehyde compound in an organic solvent, and after the reaction is finished, carrying out post-treatment to obtain the fluoroalkyl substituted 4, 4'-diaminodiphenylmethane compound. The method has the advantages of mild reaction conditions, simple operation, high reaction efficiency, cheap and easily available raw materials, good atom economy, no generation of wastes, and large-scale application prospects. In addition, the fluoroalcohol solvent is recycled through simple distillation operation, the cost of a large amount of solvent is effectively saved, the process safety is improved, and efficient and green industrial production is facilitated.

The invention discloses a synthesis method of dialkyl amino alcohol. The dialkyl amino alcohol is obtained by reacting dialkyl amino ester with a Grignard reagent. According to the synthetic route provided by the invention, the overall synthesis condition is mild, the used raw materials are easy to obtain, and the toxicity is relatively low.

The invention provides a synthesis method of bis (hydroxyethyl) amino propyl hydroxyethyl oleylamine, which comprises the following steps: taking N-tert-butyloxycarbonyl-1, 3-propane diamine and ethylene oxide according to a set proportion, and reacting in a first organic solvent to obtain a first intermediate; reacting the first intermediate with a hydrochloric acid solution according to a set ratio to obtain a second intermediate; and taking the second intermediate, 1-bromo-cis-9-octadecene and alkali according to a set ratio to react in a second organic solvent to obtain a compound bis (hydroxyethyl) amino propyl hydroxyethyl oleylamine, and synthesizing the bis (hydroxyethyl) amino propyl hydroxyethyl oleylamine by adopting a green and environment-friendly method.

The invention provides a preparation method and intermediates of alasset hydrochloride, which comprises the following steps: reacting an initial raw material as shown in a formula 1, which is protected by bare phenolic hydroxyl groups or different protecting groups, with bis (pinacolato) diboron to obtain an intermediate as shown in a formula 2, carrying out coupling reaction on the intermediate and a compound as shown in a formula 3 to obtain a corresponding hydroxyl-protected intermediate as shown in a formula 4, and separating and purifying the intermediate to obtain the alasset hydrochloride. The preparation method comprises the following steps: carrying out catalyst pressurized hydrogenation, carrying out asymmetric chiral hydrogenation to obtain an intermediate as shown in a formula 5, carrying out substitution or reductive amination to obtain an intermediate as shown in a formula 6, carrying out nucleophilic substitution on the intermediate as shown in a formula 7 to obtain an intermediate as shown in a formula 8, and carrying out deprotection to obtain a target product as shown in a formula I. According to the invention, a chiral resolution link in the existing preparation technology is avoided, and a chiral group is introduced through asymmetric hydrogenation, so that the yield is greatly improved, the production cost is greatly reduced, the tedious and tedious synthesis steps in the original process are shortened, and the post-treatment is simpler and more controllable.

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

The present invention discloses a method for preparing a supported carbon-wrapped bimetallic catalyst, the preparation method comprising: (1) weighing the supported bimetallic catalyst, mixing it with water, adding an aqueous solution of a soluble sugar carbon source compound and an aqueous solution of hydroxyethyl cellulose, soaking at room temperature for 0.5 to 10 hours, and vacuum drying until the water is dried to obtain a dry product; (2) then calcining the dried product at 400 to 1000° C. for 2 to 20 hours in an inert atmosphere, a hydrogen atmosphere or a vacuum state to obtain a calcined product; (3) then reducing the temperature to 100 to 180° C., treating the calcined product in an air atmosphere for 4 to 10 hours to obtain a supported carbon-wrapped bimetallic catalyst. The catalyst prepared by the present invention has a complete carbon layer with a suitable structure and thickness to wrap the metal active component, is used for hydrogenation and rearrangement of nitrobenzene compounds to prepare alkoxy-substituted or phenolic hydroxyl-substituted aniline compounds, and has high stability and high selectivity for target products.

The invention relates to preparation of a multi-channel Ni / CM ceramic catalytic membrane, and belongs to the technical field of membrane catalysis. According to the preparation method, Ni-BTC grows in situ on the surface and in the pore channels of the multi-channel ceramic membrane through a hydrothermal method and is calcined in a reducing atmosphere to prepare the catalytic membrane, and the preparation process is simple. The prepared catalytic membrane has high catalytic activity and stability, meanwhile, separation of a catalyst and a product is avoided, and recovery and reutilization of the catalyst are facilitated.

The present invention provides a method for synthesizing alacastran, comprising reacting an amino compound of formula V with a chiral intermediate of formula VI, reducing the resulting product with a reducing agent capable of providing an ethyl group to produce a compound of formula VII, and then deprotecting the compound to obtain alacastran, as shown in the following reaction formula. The method for synthesizing alacastran of the present invention avoids the low yield caused by amide reduction and the risk of substrate racemization, has a high yield, low material cost, safe operation, and is suitable for industrial production.

The invention discloses a quaternary ammonium salt modified linalool derivative as well as preparation and application thereof. The structure of the quaternary ammonium salt modified linalool derivative is shown as a formula (I). The quaternary ammonium salt modified linalool derivative is prepared by carrying out nucleophilic substitution reaction on linalool and benzyltrimethylammonium chloride. The derivative can be applied to water-based disinfectants or antibacterial daily necessities. The derivative has good water solubility and bactericidal activity. Through the synergistic interaction of the quaternary ammonium salt group and the linalool mother nucleus, the disinfection and sterilization capacity of the linalool derivative is remarkably improved compared with that of independent quaternary ammonium salt or linalool, and the linalool derivative particularly has a better disinfection and killing effect on pathogens of a quaternary ammonium salt-resistant disinfectant. # imgabs0 #

The invention relates to the technical field of catalysts, and particularly discloses a carbon-loaded nickel-molybdenum alloy catalyst, a preparation method thereof and application of the carbon-loaded nickel-molybdenum alloy catalyst in synthesis of amine compounds by selective reduction of nitro compounds. According to the carbon-loaded nickel-molybdenum alloy catalyst, Ni4Mo is used as an active site, and conductive carbon black is used as a carrier. The catalyst can be used for chemically and selectively hydrogenating nitro compounds into corresponding amine compounds under mild conditions (20-30 DEG C, 10 bar H2). The preparation method of the catalyst is simple, and the catalyst has good catalytic activity in selective reduction of nitro compounds. According to the catalyst, the activity and selectivity of a non-noble metal catalyst are adjusted through intermetallic alloying, and some insights can be provided for subsequent development of cost-effective catalysts.

The invention discloses a system and a method for separating ammonia, ethanolamine and water, which belong to the technical field of ammonia still separation, and are characterized in that a shell-and-tube heater is arranged in a flash tank, a reactor a and a reactor b are respectively arranged on two sides of the flash tank, the reactor a is communicated with the flash tank through a pipeline a, the reactor b is communicated with the flash tank through a pipeline b, and the reactor b is communicated with the flash tank through a pipeline b. The problems that separation is difficult, the separation cost is high and the operation period is short are solved, the problems that an existing plate tower is low in separation efficiency and high in energy consumption, silk screen filler is prone to corrosion and the operation period is short are solved, and the device is mainly applied to separation of ammonia, ethanolamine and water.

The invention provides a method for preparing high-purity phosphatidylserine by a batch enzyme catalysis method based on dynamic choline removal, and belongs to the technical field of enzymatic reaction. According to the method disclosed by the invention, in a reaction system for preparing phosphatidylserine, a byproduct choline is selectively adsorbed by adopting resin. Choline in a reaction system is removed in real time through the integrated adsorption separation module, the enzyme inhibition problem is solved, and meanwhile, the PC conversion rate is larger than or equal to 98% and the PS purity is larger than or equal to 96% in combination with the immobilized enzyme circulation technology; the enzyme can be reused for more than or equal to 20 times (activity retention is more than or equal to 90%); and the choline residual concentration is less than or equal to 0.5 mM (an inhibition threshold value or less).

The invention discloses a functional cross-linking agent and a preparation method and application thereof, and relates to the technical field of oilfield chemistry and application, the structure of the functional cross-linking agent comprises a quaternary ammonium salt structure, an ester group and a conjugated non-planar central nucleus, no additional conditions such as illumination, acidic conditions or alkaline conditions are needed, and the functional cross-linking agent has good stability. The self-degradation can be realized under a certain temperature condition. The method is simple and reliable in technology, high in yield and suitable for large-scale industrial production. A three-dimensional network structure is formed through chemical crosslinking, weak bonds in the functional crosslinking agent are broken and the three-dimensional network structure is disintegrated under the action of a built-in catalyst, generated linear low-molecular-weight water-soluble polymers are dissolved in formation water to form low-viscosity fluid, flowback is not needed, and subsequent water injection is not affected; and temporary plugging maintenance and the like of a low-temperature oil field well can be realized.

The invention relates to the technical field of silicon dioxide surface modification, in particular to a silicon dioxide hollow sphere with an MOF composite layer, a manufacturing method and a dielectric loss prediction method. The silicon dioxide hollow sphere comprises a hollow spherical structure formed by silicon dioxide, an amino silane layer grafted on the surface of an inner core layer through a covalent bond, a ZIF-8 crystal layer growing in situ by taking amino as a nucleation site, and thiol groups distributed on the outer surface of an MOF crystal. According to the silicon dioxide hollow sphere with the MOF composite layer, the manufacturing method and the dielectric loss prediction method, the silicon dioxide hollow sphere with the MOF composite layer has good compatibility and stability in an LCP matrix, the dielectric loss is small, and the performance of a high-frequency FPC is effectively improved.

The invention discloses a refining method of a norepinephrine bitartrate intermediate. The refining method of the norepinephrine bitartrate intermediate comprises the following steps: S1, reacting a crude product of the norepinephrine bitartrate intermediate 3 with inorganic acid in an organic solvent to obtain inorganic acid salt of the norepinephrine bitartrate intermediate 3; s2, in the presence of an antioxidant, enabling the inorganic acid salt of the norepinephrine bitartrate intermediate 3 to react with inorganic alkali in water to obtain a refined product of the norepinephrine bitartrate intermediate 3; the structural formula of the norepinephrine bitartrate intermediate 3 is as shown in formula I in the specification. # imgabs0 #

The invention discloses an ammonia distillation, dehydration and refining system for alcohol amine products. The system comprises an ammonia distillation device, a dehydration device, a vacuum device, a tail gas absorption device, a first ethyl rectification device, a second ethyl rectification device and a third ethyl rectification device. By optimizing the production process and adopting advanced production equipment, efficient, energy-saving and environment-friendly production of the alcohol amine product is realized.

The application belongs to the technical field of functional resin, and particularly relates to a novel modified phenolic resin with high heat resistance, preparation and application thereof. The thermoplastic phenolic resin is modified by 4,4'-diaminodiphenyl methane (MDA) to improve the heat resistance of the phenolic resin. The obtained modified phenolic resin has excellent heat resistance, and when the modified phenolic resin is applied to a friction material as a binder, the wear rate of the friction material at high temperature is greatly reduced, and the service life of the friction material is prolonged.

The invention discloses a method for preparing ethylenediamine and piperazine from ethylene glycol, which comprises the following steps: in a system containing ethylene glycol, ammonia gas, hydrogen, a solvent and a catalyst, carrying out dehydrogenation, amination and hydrogenation on ethylene glycol and ammonia gas under the action of the catalyst to generate ethanolamine; the ethanolamine is further aminated to generate ethidene diamine; and further reacting ethylene glycol, ethanolamine and ethylenediamine to generate piperazine. According to the present invention, the solubility of ethanolamine and ethylenediamine is increased by introducing the solvent with the high polarity into the reaction system, such that the high ethylene glycol conversion rate is achieved under the mild reaction conditions (180-220 DEG C, 4-5 MPa), and the selectivity of ethylenediamine and piperazine is significantly improved. Wherein the selectivity of ethylene glycol can reach 74.1%, the sum of the selectivity of ethanediamine and piperazine can reach 85.5%, and the selectivity of piperazine can reach 73.3%.

The present invention provides a method for preparing an elastostrat intermediate and its derivatives, and relates to the field of organic chemical synthesis, specifically, to the field of asymmetric catalytic hydrogenation of organic compounds. The method for preparing an elastostrat intermediate and its derivatives is as follows: Compound 1 and compound SM1 are coupled by palladium catalysis to obtain compound 2; Compound 2 is subjected to asymmetric hydrogenation reduction of the carbonyl group to obtain compound 3; and compound 3 is hydrogenated to obtain compound 4. The preparation method of the present invention is simple, shortens the preparation steps, and is conducive to scale-up production; at the same time, the present invention shortens the reaction route, reduces the price of starting materials, and saves costs.

The invention provides a cationic antistatic agent containing hydroxyl and ether bonds and a preparation method thereof, and belongs to the technical field of cationic antistatic agents. The preparation method comprises the following steps: carrying out neutralization reaction on amine substances and acid in a solvent to obtain an intermediate product; and reacting the intermediate product with glycidyl ether under the action of a catalyst to obtain the cationic antistatic agent. According to the prepared cationic antistatic agent, hydroxyl and ether bonds are introduced into the molecular structure, the hygroscopicity of the antistatic agent can be remarkably improved due to the existence of the hydroxyl, a conductive water film is formed, and therefore the conductivity and the antistatic performance of the surface of a material are enhanced; ether bonds can be combined with water molecules in air through hydrogen bonds to form a conductive channel, so that the antistatic effect is further improved. The antistatic agent prepared by the invention not only has excellent antistatic property, but also shows good smoothness, softness, water cleaning property, washing resistance and compatibility, and is suitable for various application scenes needing antistatic treatment.

The invention discloses a titanium-doped lamellar FER molecular sieve and application thereof in a rutin electrochemical sensing detector, and belongs to the technical field of molecular sieve synthesis and electrochemical sensor detection. The titanium-doped lamellar FER molecular sieve is prepared by taking an organic compound as a template agent through a hydrothermal method. The structural formula of the organic compound is NH2-C2H4-NH-(CH2) n-O-(p-C6H4) 2-O-(CH2) n-NH-C2H4-NH2, and the structural formula of the organic compound is NH2-C2H4-NH-CH2. Wherein n ranges from 10 to 16. The preparation method comprises the following steps: immobilizing chitosan on a titanium-doped lamellar FER molecular sieve to obtain a composite material, and modifying an electrode by adopting the obtained composite material to construct an electrochemical sensor; the obtained electrochemical sensor is used for detecting and analyzing rutin. The rutin detection concentration linear range of the obtained electrochemical sensor reaches 0.1-10 [mu] mol / L, the concentration detection range is wide, the detection sensitivity, accuracy, repeatability and selectivity are high, the detection lower limit is low, and the stability is good.

A process for the hydrogenation of carbonyl compounds consisting of the following steps: (a) providing hydrogen with a molar share of deuterium ≤ 100 ppm, based on the total hydrogen content, by electrolysis of water using electrical power generated at least in part from non-fossil energy, (b) hydrogenating a carbonyl compound using the hydrogen provided in step (a) to form the corresponding hydrogenation product, wherein at least one carbonyl group of the carbonyl compound is hydrogenated.

The invention relates to sterile bispentadol sebacate, a preparation method thereof and medical application of a medicinal preparation containing the sterile bispentadol sebacate. Wherein the particle size D50 of the sterile bis (tapentadol) sebacate is 0.5 to 10 [mu] m. The invention also provides application of the bispentadol sebacate in preparation of various acute and chronic pain medicines, and the bispentadol sebacate has the characteristic of remarkable long-acting effect.

The invention relates to the technical field of plastic packaging bottles, and discloses a degradable environment-friendly material cosmetic packaging bottle and a preparation method thereof.The degradable environment-friendly material is prepared from, by weight, 60-75 parts of polyethylene resin, 25-40 parts of hydroxyl quaternary ammonium salt grafted polylactic acid, 1.6-3 parts of maleic anhydride grafted polyethylene and 0.3-0.6 part of antioxidant; the maleic anhydride grafted polyethylene disclosed by the invention can be used as a compatilizer to improve the compatibility between the hydroxyl quaternary ammonium salt grafted polylactic acid and polyethylene resin, the obtained degradable environment-friendly material has higher mechanical properties, and the hydroxyl quaternary ammonium salt grafted polylactic acid contains biquaternary ammonium salt antibacterial groups, so that the antibacterial property of the degradable environment-friendly material is improved. Therefore, the degradable environment-friendly material shows good antibacterial performance. The degradable environment-friendly material disclosed by the invention contains a degradable polylactic acid component, is green, environment-friendly, degradable and good in antibacterial property, and has good application in the aspects of cosmetic packaging bottles and the like.