168results about How to "High reaction yield" patented technology

The invention relates to a synthetic method for agomelatine. The method comprises the following steps: reacting 7-methoxy-1-tetralone (2) serving as a raw material with acetonitrile under the action of n-butyl lithium to obtain 1-hydroxy-7-methoxy-1,2,3,4-tetralin-1-naphthyl acetonitrile (3); then uniformly mixing the compound (3) and acetic acid solvent or toluene, adding dichloro dicyano benzoquinone into the mixture for reacting at the temperature of between 50 and 150 DEG C for 4 to 20 hours to obtain a compound (4); adding the compound (4) into uniformly mixed solution of lithium aluminum hydride and tetrahydrofuran for reacting at the temperature of between 0 and 60 DEG C for 5 to 24 hours to obtain (7-methoxy-1-naphthyl) ethylamine (5); and finally uniformly mixing the compound (5)and triethylamine or naphthyridine, and adding acetylchloride into the mixture for reacting at the temperature of between 0 and 25 DEG C for 1 to 5 hours to obtain the agomelatine (1). The synthetic method for the agomelatine of the invention has the advantages of high yield, low cost, high controllability, simple processing after the reaction and environment protection and is suitable for industrial production of the melatonin antidepressant.

The invention discloses a synthesis method of sulfobutyl ether-beta-cyclodextrin with a specific average substitution degree. The synthesis method comprises the following steps: (1) dissolving beta-cyclodextrin into NaOH solution while stirring, wherein the use amount of NaOH solution is 1.6-6.5 times as much as the molar quantity of beta-cyclodextrin; (2) dropwise adding 1,4-butyl sultone and performing reflux etherification; when pH value drops to 8.8, adding NaOH solution to adjust the pH value to be between 8.80-9.70 until the pH value does not change; and then adding all residual NaOH aqueous solution into a reaction container from a sample injector; and (3) when detecting that the mass of residual beta-cyclodextrin in the reaction container is 1% or below, adding NaOH solution, wherein the use amount of NaOH solution is 0.4-1.5 times as much as the molar quantity of beta-cyclodextrin. By the synthesis method, a sulfobutyl ether-beta-cyclodextrin product with a specific average substitution degree can be obtained and the yield is high; in addition, the specific average substitution degree range of the synthesis product is concentrated and the composition of the product is in strict normal distribution; the reaction conditions are mild and post-treatment is simple.

Disclosed herein are a reaction method and a production method of an organic compound which are capable of achieving high reaction selectivity according to the purpose and a high production rate of a target substance. The methods include at least two fluids, wherein at least one kind of the fluids is a fluid containing at least one organic compound and at least one kind of the fluids other than the above fluid is a fluid containing at least one reactant in the form of a liquid or solution, and the respective fluids join together in a thin film fluid foamed between processing surfaces arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, whereby an organic reaction is performed in the thin film fluid.

The invention relates to a clean production process of a dicamba synthesis midbody, and provides a clean production method of 2,5-dichlorophenol. The clean production process comprises the following steps: stirring 30-70% of dilute sulfuric acid and 2,5-dichloroaniline in a backflow state for 1-2hours, wherein the weight ratio of the dilute sulfuric acid to the 2,5-dichloroaniline is (6:1)-(9:1); after the reaction, cooling the reaction liquid to 0-5 DEG C, and dropping 10-60% nitroso-sulfuric acid and stirring for 2 hours to obtain diazonium liquid, wherein the molar ratio of the 2,5-dichloroaniline to the nitroso-sulfuric acid is 1:(1.0-1.5); carrying out pyrohydrolysis on the synthesized diazonium liquid at 140-170 DEG C to obtain 2,5-dichlorophenol; and carrying out diazotization synthesis on part of the hydrolyzed dilute sulfuric acid subjected to recovery processing as batch charging of dilute sulfuric acid, and synthesizing the other part of the dilute sulfuric with SO2 to be 10-60% nitroso-sulfuric acid, and then applying to diazotization synthesis. According to the synthesis process, no waste salt or phenolic wastewater are generated during diazotization reaction, the reaction yield is as high as 95%, and diazonium liquid is subjected to pyrohydrolysis and the dilute sulfuric acid can be recycled, so that the cycle use of the two can be achieved. The clean production process belongs to a clean and environment-friendly production process.

The invention relates to a preparation method of a temperature and pH sensitive shell cross-linked polymeric micelle, characterized by synthesizing a temperature and pH sensitive diblock copolymer by reversible addition-fragmentation chain transfer (RAFT) polymerization, and then using small-molecule dialdehyde or diacid to carry out part crosslinking on the shell structure of a self-assembled polymeric micelle. The method has the characteristics of simpleness, convenience, high preparation yield, no environmental pollution, and the like. The prepared diblock copolymer has the advantages of strong functionality and narrow molecular weight distribution. By using small-molecule cross-linking agent to carry out part crosslinking on the micelle shell structure, under the precondition of guaranteeing the stability of the polymeric micelle, the preparation method has the characteristics of strong feasibility and simple operation, and can reutilize micelles, etc. The obtained temperature and pH sensitive shell cross-linked polymeric micelle has excellent drug loading performance, can rapidly and efficiently adsorb readily degradable or indissoluble drugs under different concentration conditions, is a new generation high performance drug loaded product, and can be applied in the medicine fields of in vivo transfer, gene vectors, and the like.

The invention provides laurinol alkyl ether, which has a structure as shown in a formula I, wherein R is alkyl having the number of carbon atoms of 1-10. The invention further provides a method for preparing laurinol alkyl ether, which comprises the following steps: enabling laurinol, alkyl reagent and alkaline compound to react in the presence of a catalyst to obtain the laurinol alkyl ether. A drilling fluid is prepared from the laurinol alkyl ether by adopting the technical scheme. The laurinol alkyl ether has excellent inhibition, low viscosity, strong temperature resistance, hydrolytic stability and biodegradability, and can be used as a basic fluid for synthetic base drilling fluid. The preparation method has high reaction yield and good product quality, is simple in process and mild in condition, has a non-toxic, efficient and environment-friendly preparation process, and can be popularized and applied to catalytic esterification reactions.

The invention relates to a new technology for producing acrylamide by using a ceramic membrane bioreactor. The new technology comprises the following steps of: (1) putting nitrile hydratase thallus fermentation liquor into a ceramic membrane filter for separating and washing thalli; (2) discharging the penetrating liquid of a ceramic microfiltration membrane filter, adding a concentrated and washed nitrile hydratase containing thallus solution serving as a bio-enzyme catalytic agent to an acrylonitrile hydration reaction kettle for catalyzing the hydration reaction of acrylonitrile; and separating and removing an acrylamide product through a ceramic ultrafiltration membrane in the reaction process, and returning the nitrile hydratase containing thallus serving as the bio-enzyme catalytic agent to the reaction kettle for reuse. The new technology has the advantages that the ceramic membranes can remove impurities in the acrylamide product in high precision and timely move away the acrylamide product and can also achieve the purpose of effectively separating thalli and residues of the fermentation liquor, thereby greatly increasing the recovery rate of fermentation liquor thalli and the selectivity and purity of objective products of the following process.

The invention relates to a method for producing tryptamine ketones and the derivatives shown in formula (I), wherein the compounds are obtained through reaction between indole quinines or the derivatives and isatoic anhydrides or the derivatives. The invention is characterized in that the solvent is selected from lower alcohols, chloroform, carbon tetrachloride, 1, 2-dichloroethane, tetrahydrofuran, dioxane, toluene, xylene, DMF and DMSO of C2-C5; the catalyst is inorganic base or organic base; R1, and R2 is selected from hydrogen, hydroxyl and alkoxy, amino of C1-C6, halogen, alkyla, amide, substituted aminomethyl C1-C8 or amide methyl.

The present invention relates to anticoccidial medicine for animal, and is especially preparation process of methyl triazone as one anticoccidial medicine for animal. The preparation process includes the following steps: 1. reacting phenol and trifluoro monochloro methanethiol in the presence of organic base to prepare p-trifluoro methylthio phenol; 2. diazotizing red color base RL and chloric substitution reaction to prepare 2-methyl-4-nitrochlorobenzene; 3. catalytically synthesizing methyl carbamide with urea and methylamine; 4. reacting p-trifluoro methylthio phenol and 2-methyl-4-nitrochlorobenzene to prepare 3-methyl-4-(4- trifluoro methylthio phenoxy)-nitrobenzene; and 5. reducing 3-methyl-4-(4- trifluoro methylthio phenoxy)-nitrobenzene with nitrogen, acylating with nitrogen, condensating, cyclizing and other reaction to prepare final product methyl triazone. The process has low cost and is perfected.

The invention discloses a method for synthesizing a 5, 7-diene steroidal compound as shown in a formula (I), which comprises the following steps of allowing a hydrazone as shown in a formula (II) to react with an alkali as shown in a formula (III) in an organic solvent for 0 to 6 hours at the temperature of between minus 20 and 50 DEG C, then heating to 25 and 150 DEG C, preserving the temperature to react for 0.5 to 6 hours, de-protecting the reaction solution, recycling the solvent to obtain a crude product, and recystallizing the crude product to obtain the finished product 5, 7-diene steroidal compound. The method has mild reaction conditions, high reaction yield (generally more than 85 percent, and even more than 95 percent), low production cost and good selectivity, and therefore is an advanced technique route.

The invention discloses a dikaryotic cobalt complex and a preparation method thereof. The dikaryotic cobalt complex consists of a dikaryotic cobalt complex crystal, wherein the chemical formula of the dikaryotic cobalt complex crystal is Co2(H2O)4(C12H9N3)4(C8H4O4)2.2H2O. The dikaryotic cobalt complex crystal belongs to a triclinic crystal system, and the space group is P-1. The dikaryotic cobalt complex is prepared by adopting a hydrothermal synthesis method by the following steps: mixing cobalt chloride hexahydrate, 2-(3-pyridyl)benzimidazole, 1,3-phthalic acid and water by stirring; placing the mixture into an enclosed container and reacting for at least one hour at the reaction temperature of at least 150 DEG C; performing solid-liquid separation. The dikaryotic cobalt complex crystal emits strong fluorescent light at the central wavelength of 450 nanometers under the excitation of ultraviolet light of which the wavelength is 380 nanometers, indicating that the dikaryotic cobalt complex crystal has high fluorescence characteristic.

The invention relates to a synthetic method of compound blocked polyisocyanates by using multiple sealants to compound and block terminal groups, which is characterized in that 300-600 parts of polyisocyanate ( by mass part, the same below), 50-350 parts of active methylene compound and 290-335 parts of solvent are stirred for 1-3 hours at a temperature of 50-90 DEG C; 50-350 parts of another active methylene compound is added to be stirred for 1-2 hours at a temperature of 50-90 DEG C; 20-130 parts of pyrazole derivative compound is added to be stirred at a temperature of 50-85 DEG C in batches until NCO groups can not be detected or NCO% is not higher than 0.2% (about 0.5-2 hours). Compared with the prior art, the invention has improved technology and obvious advantages.

The invention discloses a method for chemical synthesis of 2, 3, 4, 5-tetrafluorobenzoyl chloride. The method comprises the following steps: 2, 3, 4, 5-tetrafluorobenzoic acid reacts with bis(trichloromethyl) carbonate in an organic solvent under the action of an organic amine catalyst at the temperature of 20-100 DEG C for 1-10h, and the 2, 3, 4, 5-tetrafluorobenzoyl chloride is obtained after post treatment; and the organic amine catalyst is tertiary amine containing N-formoxyl group or solid-phase supported tertiary amine containing the N-formoxyl group. The method has the advantages of mild reaction conditions, high reaction yield and less three wastes, and has greater implementation values, social benefits and economic benefits.

The invention discloses a method for synthesizing a medicine intermediate 2,3,5-trimethylhydroquinone diester. The conventional methods are not environment-friendly, or difficultly realize industrial production due to high production cost. The method is characterized by comprising the following steps of: 1) reacting carboxylic acid anhydride serving as an acylating agent with alpha-isophorone in the presence of a catalyst to obtain the enol isomer esterification product of isophorone; 2) adding a solvent dimethyl sulfoxide (DMSO), a heteropolyacid catalyst and alkali into the enol isomer esterification product, blowing air, and reacting to obtain the monoesterification product of ketoisophorone; and 3) recycling the solvent in the monoesterification product, and reacting in the presence of the carboxylic acid anhydride and the catalyst to obtain the 2,3,5-trimethylhydroquinone diester. By changing the molecular structure of the alpha-isophorone, reaction activity is improved, reaction yield is high, the method is easy and convenient to operate, environment-friendly and low in production cost, and the industrial production is easy to realize.

The invention relates to a pyridino-quinazolinone compound and a preparation method thereof. The structural formula of the compound is shown in the specification, wherein R1=-Ome or H; and R2=-H, -Me, -Ph, -CO2Et, or-Br. The substituted pyridino-quinazolinone compound disclosed by the invention is an important pharmaceutical molecular active skeleton and organically synthesized intermediate, and plays an important role in pharmaceutical chemistry. According to the method, raw materials are available, the reaction yield is high, and the applicable scope of a substrate is wide. Conventional solvents are used in reaction, the operation is simple, the conditions are mild, the reaction is environment-friendly, and the reaction yield is up to 95%, and therefore, the pyridine-quinazolinone compound and the preparation method thereof disclosed by the invention are extremely suitable for industrial production.

The invention discloses a preparation method for buflomedil, which adopts a 4-fluoro-1-(2, 4, 6-trimethoxybenzene) butanone and a pentazane as raw materials. In an organic solvent cyclohexane, a sodium iodide is adopted as a catalyst to derive a buflomedil with a reaction temperature from 20 DEG C to a boiling point of a solvent system. The preparation method for buflomedil of the invention has the advantages of safety, reliability, shorter reaction time, ideal yield and product purity.

The invention discloses a method for regenerating a zinc oxide desulfurization waste agent. The method comprises the following steps: reacting a zinc oxide desulfurization waste agent and deionized water in a hydrothermal reaction kettle at the temperature of 150-250 DEG C for 12-48 hours, wherein a mass ratio of the zinc oxide desulfurization waste agent to the deionized water is 1 to 70, filtering a reaction solution after the reaction is ended, collecting filter residues, washing the filter residues, and drying to obtain the regenerated zinc oxide desulfurization agent. Because the reaction is performed in a high-temperature high-pressure closed environment, refractory zinc oxide materials in the zinc oxide desulfurization waste agent are in full contact with the deionized water to carry out a chemical reaction, and the regenerated zinc oxide desulfurization agent can be obtained through a one-step reaction only. Therefore, the regeneration method of the zinc oxide desulfurization agent are simple and short in steps, low in energy consumption, time/labor-saving and convenient to operate, the regeneration cost of the zinc oxide desulfurization waste agent is greatly reduced, and industrial production is facilitated.

The invention relates to a method for preparing 2,5-acetonyl acetone from raw biomass, paper products, cotton products and lignocellulose platform chemical compounds. A reaction system is an acid water solution and organic solvent two-phase system; a catalyst is a supported noble metal catalyst; under the conditions of certain temperature and hydrogen gas pressure, the raw biomass, the paper products, the cotton products and the lignocellulose platform chemical compounds can be used for preparing 2,5-acetonyl acetone products with high yield in one step. The method has the characteristics of mild reaction temperature and high product selectivity; an effective path for preparing the 2,5-acetonyl acetone from biomass is provided.

The invention discloses a mixed fluid stirring mechanism and a tubular reactor. A main shaft is provided with a forward stirring structure and a reverse stirring structure, and paddle blades of the forward stirring structure and the reverse stirring structure are spirally arranged on the main shaft; the acting force generated by the forward stirring structure and the acting force generated by reverse stirring structure are opposite in direction. A relatively strong mixing effect can be achieved under the condition of low energy consumption, the problem that materials are conveyed in the reactor can be well solved, and the technical situation that the effect is not good during internal conveying of the reactor is made up for.

The present invention discloses a method for preparing graphene nano-belt through sealed oxidation. According to the method, multi-walled carbon nano-tubes, potassium permanganate and concentrated sulfuric acid are subjected to a pressurization oxidation reaction in a sealed polytetrafluoroethylene lining reaction kettle to improve the longitudinal multi-walled carbon nano-tube cutting efficiency so as to obtain the high quality graphene nano-belt. Compared with the conventional method, the method of the present invention has characteristics of less preparation steps, short reaction time, environmental protection, safety, and easy large-scale production achieving. The graphene nano-belt prepared through the method of the present invention has advantages of less structure defects, good water solubility, high yield, and the like.

The invention discloses a method for preparing 3, 4-difluorobenzaldehyde, and relates to the technical field of organic synthesis. The method includes carrying out Grignard exchange reaction on 3, 4-difluoro bromobenzene, tetrahydrofuran and a Grignard reagent to obtain first reaction products; carrying out reaction on the first reaction products and N, N-dimethylformamide to obtain second reaction products; treating the second reaction products to obtain the 3, 4-difluorobenzaldehyde. The 3, 4-difluoro bromobenzene is used as a raw material, and the tetrahydrofuran is used as a solvent. The method has the advantages that the Grignard exchange reaction is carried out on the 3, 4-difluoro bromobenzene and the freshly prepared Grignard reagent which is isopropylmagnesium chloride, and accordingly the problem of large quantities of generated byproducts due to excessively high reaction temperatures when 3, 4-difluoro bromobenzene and a Grignard reagent which is metal magnesium can be solved; the reaction is carried out on the N, N-dimethylformamide and the products already subjected to Grignard exchange, so that the 3, 4-difluorobenzaldehyde can be prepared, and the reaction yield can be increased.

The invention discloses a method for preparing aromatic aldehyde by selective catalytic oxidation of a toluene compound through a transition metal modified MFI molecular sieve. The method comprises the following steps: under the catalytic action of the transition metal modified MFI molecular sieve, with bromide or molecular bromine as an initiator and with oxygen or air as an oxygen source, performing reaction on a substrate toluene compound, and adding a polar organic solvent in the reaction system. The preparation method of the aromatic aldehyde by catalytic oxidation has the advantages that the percent conversions of reactants are high and the selectivity of a target product is high. In addition, a catalyst is simple to prepare, easy to separate and long in service life; the reaction conditions are mild and environmental friendly, and the application prospect is good.

The invention relates to a high-efficiency, constant-pressure synthesizing method of alkoxyl alkyl substituted phenol, comprising R1 and R2: H, C1-C10 alkyls, C6-C9 cycloalkyls, or C7-C12 aromatic alkyls; R3: C1-C10 alkyls or C6-C9 cycloalkyls; and R4: H or C1-C10 alkyls. And it can act as oxidation inhibitor, and antiseptic, importantly acting as key raw material of synthesizing other compounds, and especially used to synthesize high-molecular weight, anti-migration, anti-extraction, high-efficiency, long-effect oxidation inhibitor. And the synthesizing method comprises: the alkyl substituted phenol, alcohol and aldehyde make constant pressure refluxing reaction to make it under the action of the mixed catalyst of secondary amine and tertiary amine, or of cyclo secondary amine and tertiary amine.

The invention relates to a method for preparing isoproterenol hydrochloride. The method comprises the following steps: (1) preparation of 2-amino-1-(3, 4-dihydroxy phenyl)-ethanone; (2) preparation of isoproterenol ketone hydrochloride; and (3) preparation of isoproterenol hydrochloride. The method disclosed by the invention adopts a reaction system of glycine and zinc chloride instead of a reaction system of monochloro acetic acid and phosphorus oxychloride, so that the method has the advantages that the environmental protection cost is reduced; the reaction yield is increased; the industrial production is benefited; the reaction condition is mild; the catalyst quantity is little; and the process is simple. Compared with conventional synthetic processes, the method disclosed by the invention has obvious economic benefit and environmental benefit.

The invention discloses a method for synthesizing nitromethane, and relates to the technical field of synthesis of compounds with nitryl connected to a saturated noncyclic carbon atom. The method comprises the following steps: stirring and dissolving raw materials sodium nitrite; dripping a raw material dimethyl sulfate in a stirring state, and reacting; filtering the reaction liquid under a stirring state in the post-treatment, separating solid and liquid phases, decompressing and distilling the liquid phase to obtain a nitromethane coarse product, and rectifying to obtain a nitromethane finished product; adding a solvent and a phase transfer catalyst before the raw material dimethyl sulfate is dripped, wherein the boiling point of the solvent is lower than 100 DEG C, the solvent is used for controlling the reaction temperature, and the reaction temperature is 20-60 DEG C. According to the method, the reaction temperature can be easily controlled, the generation of a side product methyl nitrite can be reduced, the reaction yield can be improved, and spark generated in the rectifying process can be reduced, potential safety hazard can be reduced, and the product purity can be increased.

The invention relates to a preparation method of a compound 5,6-dihydroxy indoline and halogen acid salts thereof. Phenylethylamine SM-0 sold in the market is used as a raw material and firstly reactswith acyl chloride to obtain amide SM-1; amide SM-1 reacts with halogen to obtain a compound as shown in the formula III; the compound as shown in the formula III undergoes intramolecular cyclizationunder the catalysis of copper oxalate to generate a compound as shown in the formula IV; and the compound as shown in the formula IV reacts with halogen acids to respectively obtain the expected target compounds as shown in the formula I and formula II. The invention has the following beneficial effects: 1) cheap copper oxalate is used as a catalyst of the cyclization, raw materials are cheap andeasily available, and the method for preparing the compound as shown in the formula IV from the compound as shown in the formula III has advantages of high reaction yield and less side reaction and is suitable for industrial production; and 2) the whole process is simple to operate, and the products obtained have high purity and good stability and are easy to store and use for a long time.

The invention provides a preparation method of sugammadex sodium. The method comprises the following steps: performing a reaction on perhalogenated gamma-cyclodextrin with a sulfo reagent to generatean intermediate I persulfydryl gamma-cyclodextrin, performing a reaction on the persulfydryl gamma-cyclodextrin with halogenated propionate to generate an intermediate II, and finally, carrying out hydrolysis salifying reaction to obtain sugammadex sodium. Compared with the prior art, the preparation method is simple to operate, mild in reaction condition, high in product yield, high in purity, less in pollution and suitable for industrial production.

The invention discloses a method for combined production of 1,1,2-trifluorotrichloroethane and 1,1,1-trifluorodichloroethane. The method comprises the following steps: adding reaction raw materials comprising hydrofluoric acid, hexachloroethane and tetrachloroethylene into a reaction autoclave according to a molar ratio of (10-40):(0.8-2.5):(1.2-3.6), reacting, adding a catalyst for catalysis, reacting at 30-250DEG C under 0.3-3.0Mpa for 2-12h, washing with water, washing with an alkali, and carrying out rectifying purification to obtain the products 1,1,2-trifluorotrichloroethane and 1,1,1-trifluorodichloroethane, wherein the catalyst can be metal fluoride or metal chloride, the metal fluoride comprises AlF3, SbF3, SbF5 and ZnF2, and the metal chloride comprises SbCl5. The synthetic method has the advantages of abundant sources and low price of the raw materials, high reaction yield, easy reaction feeding, easy separation and extraction of the generated products, and realization of industrial continuous production.

The invention relates to a novel synthetic method for tofacitinib intermediate (3R,4R)-N,4-dimethyl-1-benzyl-3-piperidinamine and oxalate hydrates of (3R,4R)-N,4-dimethyl-1-benzyl-3-piperidinamine. The method comprises the following steps: 3-amino-4-methylpyridine is taken as a starting material, amino of 3-amino-4-methylpyridine is subjected to a reaction with ortho-formate, imino formate is generated, and after simple concentration, an N-methyl derivative is obtained by reduction with metal borohydride; after Boc protection, quaternary ammonium salt is generated from a product and benzyl halide and reduced by metal borohydride, a product is subjected to selective hydrogenation with an Rh catalyst, a compound with rich (3R,4R-rel-) configuration is formed, deprotection, salifying and resolution are performed by a hydrochloric acid/alcohol system for removing a (3R,4S-rel-) isomer pair, an obtained (3R,4R-rel-) configuration product is subjected to free treatment and resolved by L-DTTA, and a 3R,4R- configuration product is obtained; after free treatment of salt obtained after resolution, oxalate is formed and purified, a small quantity of remaining 3S,4S-isomers are further removed, and corresponding (3R,4R)-N,4-dimethyl-1-benzyl-3-piperidinamine with high purity and high optical purity is obtained. Through the adoption of the method, safe, simple and industrial large-scale preparation of the tofacitinib intermediate (3R,4R)-N,4-dimethyl-1-benzyl-3-piperidinamine oxalate hydrates is better facilitated.

The invention discloses a synthesis device and method of a gaseous extinguishing agent. The synthesis device is characterized in that a reaction still is connected with an agitator, a trifluoropropene storage tank, a liquid bromine storage tank, an alkali liquor storage tank and a fractional distillation tube, the tail end of a branch tube of the fractional distillation tube goes into a collecting bottle, the adding order of raw materials can be controlled through a plurality of switching valves, and halon is synthesized by one step to substitute for a clean gaseous extinguishing agent. Three operation steps of addition, elimination and fractionation can be performed in the synthesis device, and the whole synthesis flow is free from transferring of any intermediate product from the step of feeding materials to the step of obtaining the target product, so that the material loss is avoided, the reaction yield is improved, the reaction time is saved, and the reaction efficiency is improved.