Production of multiple unsaturated fatty acid phytosterin ester

A technology of unsaturated fatty acid and phytosterol ester, applied in the field of preparation of food additives, can solve the problems of harsh operating conditions, difficult industrialized production and the like, and achieves the effects of low requirements on reaction conditions, simple process, high content and reaction yield

Inactive Publication Date: 2007-06-20
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Generally speaking, most of the existing processes use organic solvents that are toxic and harmful in the food industry, or the operating conditions are harsh, and it is not easy for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the preparation of fatty acid methyl ester

[0040] Take 100kg of sunflower oil (in which linoleic acid: 69%, oleic acid: 21%) mixed with 200kg of methanol, heat up to reflux at 70°C, add 50kg of sodium methoxide dropwise, and complete the dropwise addition within 30min. The reaction was maintained at this temperature for 3hr. Use TLC to monitor the degree of completion of the reaction during the reaction. After the reaction is completed, add 300kg of deionized water, leave it to separate after slight stirring, remove the lower hydration layer, and then wash with 300kg of deionized water to neutrality. The washed oil layer was degassed and dried under vacuum conditions to obtain 85.1 kg of fatty acid methyl esters with a conversion rate of 98% and a yield of 95%. The fatty acid composition was analyzed by GC. The specific results are shown in Table 1.

Embodiment 2

[0041] Embodiment 2: the preparation of crude polyunsaturated fatty acid phytosterol ester

[0042] Get 10kg phytosterol (beta-sitosterol: 48.2%, stigmasterol: 25.7%, campesterol: 24.0%, brassicasterol: 1.5%) and the fatty acid methyl ester of 40kg above-mentioned preparations are mixed and be warmed up to 110 ℃, dissolve phytosterol , after heating up, the reactant was vacuum-dried, and the vacuum degree reached -0.09Mpa, and kept for 1hr. After the dehydration was completed, 12 kg of 35% sodium methoxide solution was added dropwise. The mixture was maintained at 130° C. for 3.5 hours under a vacuum of 30 Pa until the reaction was complete. The degree of completion of the reaction could be monitored by TLC. The methanol produced during the reaction could be recovered and concentrated. After the reaction was completed, the temperature of the reaction solution was lowered to 80°C, the vacuum was broken, the catalyst was quenched with 40kg of deionized water, and the reaction s...

Embodiment 3

[0044] Embodiment 3: the refining of polyunsaturated fatty acid phytosterol ester

[0045] Heat 17.0kg of the yellow crude phytosterol fatty acid ester obtained above to melt at 100°C, add 150g of activated clay and 150g of activated carbon, vacuumize and stir for 1.0hr, then filter, then put the filtered product into the reaction kettle, and add After 150g of activated clay, 150g of diatomaceous earth, and 100g of activated carbon, keep a vacuum of -0.08MPa, stir at 110°C for 0.5hr, and obtain 15.8kg of light yellow to white plants with phytosterol esters obtained after filtration through conventional deodorization steps. Sterol fatty acid esters that are free-flowing fluids above 35°C. The content of various sterols and fatty acids can be analyzed by gas chromatography, and the specific results are shown in Table 1.

[0046] Fatty acid and sterol composition analysis in table 1 starting reactant and product

[0047] linseed oil

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Abstract

Production of unsaturated fatty acid plant sterol ester is carried out by alcoholysis reacting for glycerin trilaurate of vegetable oil under action of methanol and catalyst to obtain fatty acid methyl ester, ester exchange reacting for fatty acid methyl ester and plant sterol under action of catalyst, removing un-reacted methanol and fatty acid methyl ester to obtain crude unsaturated fatty acid plant sterol ester, de-coloring and deodorizing to obtain the refined final product. It's cheap, harmless and non-toxic and can be used in food-industry production.

Description

technical field [0001] The invention relates to a method for preparing food additives, in particular to a method for preparing polyunsaturated fatty acid phytosterol esters. Background technique [0002] As we all know, excessive intake of cholesterol is the main cause of cardiovascular disease. In order to reduce the incidence of cardiovascular disease, it is necessary to reduce the intake of cholesterol, or take some measures to reduce the absorption of cholesterol and increase its consumption, but these methods may It is difficult to achieve, and it may also bring unexpected side effects and damage human health. In recent years, it is a more effective way to reduce the cholesterol level in human serum by ingesting lignin, phytosterols, chitin and other substances, and among them, phytosterols have a better cholesterol-lowering effect and have increasingly attracted people's attention. Pay attention to. Since the structure of phytosterols is similar to that of cholestero...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00C07J75/00
Inventor 许新德邵斌吕良伟赵全健俞亚宏
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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