141 results about "Plant sterol ester" patented technology

The invention refers to a process for the preparation of a fat composition containing fatty acid sterol esters, free sterols and glycerides, which process can be characterized as a one pot direct interesterification of sterols with tri-glycerides. The invention also refers to the fat composition obtained by said process, and to the use thereof in a food, cosmetic or pharmaceutical product.

A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and / or pharmacokinetic profile of a lipophilic therapeutic agent by formulation with sterols and / or sterol esters, resulting in higher bioavailability of a therapeutic agent administered to a subject in need of such therapeutic agent. The formulation contains a therapeutic agent and a sterol or sterol ester, and can, optionally, further contain a solubilizer and / or an enhancing agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold (“HPPS”) nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a-helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.

Production of unsaturated fatty acid plant sterol ester is carried out by alcoholysis reacting for glycerin trilaurate of vegetable oil under action of methanol and catalyst to obtain fatty acid methyl ester, ester exchange reacting for fatty acid methyl ester and plant sterol under action of catalyst, removing un-reacted methanol and fatty acid methyl ester to obtain crude unsaturated fatty acid plant sterol ester, de-coloring and deodorizing to obtain the refined final product. It's cheap, harmless and non-toxic and can be used in food-industry production.

A process for separating VE, sterol and sterolester from the deodored distillate of plant oil features that the sterol is separated out by directly dynamic crystallizing, the lipase is used to convert the fatty acid in oil and the neutral oil to methylester of fatty acid, and the molecular distillation is used to separate high-purity methylester of fatty acid and VE.

Personal care compositions containing at an alpha-glucan and / or beta-glucan; at least one additional skin and / or hair care active selected from the group consisting of sugar amine, vitamin B3, retinoids, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), menthyl anthranilate, cetyl pyridinium chloride, ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, tetrahydrocurcumin, their derivatives, their precursors, and combinations thereof; and a dermatologically acceptable carrier.

Antiperspirant compositions herein comprise an antiperspirant active, a carrier and a structurant for the carrier which comprises an effective concentration of a combination of at least one sterol and at least one sterol ester, to form a solid or a soft solid. The compositions can be anhydrous and in the form of a suspension of antiperspirant active, or can comprise aqueous emulsions.A particularly suitable sterol comprises beta sitosterol and a particularly preferred sterol ester comprises oryzanol. Preferably the mole ratio of sterol to sterol ester is in the range of 3:1 to 1:2.

The invention discloses a method wwhich extracts phytosterol from vegetable oil asphaltum, the technology of this method is simple, and the material is cheap and facile, the productivity of product is high, the cost of product is low. The method of this invention is translating the free fatty acid of material into fatty acid ester by using esterification, getting oil phase containing much sterol ester by wash, then getting the product via the alcoholysis of free fatty acid in material by organic solvent, forming a fire-new process flow, realizing the of natural sterol.

Compositions in powder form of sterols or stanol esters, and milk powder and / or proteins are disclosed. A process of making the compositions is also disclosed. The suitability of incorporation of the compositions in powder form in food products, for example beverages and milk products, is also disclosed.

Compositions containing extracts of Aloe which are suitable for dietary supplements and / or functional food products are disclosed. The compositions which further comprise extracts of other plants are also disclosed. The compositions of extracts of Aloe in combination with chitosans, fatty acids, sterols and / or sterol esters are additionally disclosed. The compositions disclosed induce satiety and / or reduce the appetite.

The invention provides morinda citrifolia enzyme skin whitening sunscreen cream and a preparation method thereof. The morinda citrifolia enzyme skin whitening sunscreen cream, in percentage by weight, comprises the following components: stearin, hexadecyl / octadecyl natural fatty alcohol, caprylic / capric triglyceride, isononyl isononanoate, jojoba oil, polydimethylsiloxane, sterol ester, vitamin E, methylparaben, propylparaben, glycerol, an amino acid moisturizer, allantoin, lauryl alcohol ether, morinda citrifolia enzyme and deionized water. The morinda citrifolia enzyme skin whitening sunscreen cream provided by the invention has obvious free radical scavenging capability, can effectively inhibit growth of melanin and has good ultraviolet absorption effect and realizes skin whitening, sunscreen and skin protection effects, the preparation method is simple and easy to operate, and production cost is relatively low.

The invention discloses functional camellia oil, which is obtained by mixing, stirring and filtering raw materials comprising the following ingredients in parts by mass: 928.8 to 989.3 parts of camellia oleifera seed oil, 10 to 70 parts of plant sterol ester, 0.1 to 0.7 part of rosemary and 0.1 to 1 part of vitamin E. The functional camellia oil has the advantages that the stability is good, the shelf life is long, the effect of obviously reducing blood cholesterol, triglyceride and low-density lipoprotein cholesterin is realized, the cardiovascular and cerebrovascular diseases can be effectively prevented, and good stability is realized during high-temperature cooking.

A confectionery chew for lowering serum cholesterol in an animal in need thereof including a carbohydrate, a seeding agent, which can be a fondant, a structuring agent, which can be a protein, a starch, a hydrocolloid, and mixtures thereof, and cholesterol lowering agent selected from a sterol, a sterol ester, a stanol, a stanol ester, and mixtures thereof.

Processes are provided for preparing ready-to-eat health bars such as chocolate granola bars and chocolate confectioneries such as dark or milk chocolate chews. The bars and confectioneries contain sterol ester(s) and / or stanol esters and cocoa solids having a high cocoa procyanidin content. The cocoa solids are pretreated with the sterol / stanol ester(s) or other edible oils or fats during the preparation of the products to prevent the loss of cocoa procyanidins. Other particulate antioxidants can be pretreated with food grade fats and / or oils or emulsifiers such as lecithin to conserve their effectiveness.

The invention discloses a phytosterol and sterol ester preparing method. The preparing method includes the steps that vegetable oil deodorized distillate is used as a raw material and is heated and filtered to remove impurities; the reaction material and low-carbon monohydric alcohol are fully mixed and heated and pass through a cationic resin column; the low-carbon monohydric alcohol and water are removed in a pressure reduction mode; crystallization is carried out, and coarse solid phase plant phytosterol and a liquid phase substance are obtained through filtering and separating; secondary crystallization is carried out, and refined solid phase plant phytosterol is obtained through filtering and separating; the obtained solid phase plant phytosterol is dried to obtain phytosterol; phytosterol and fatty acid methyl ester are mixed and heated to 85 DEG C to be fully dissolved; a catalyst sodium methylate is put, the temperature is raised to 135-150 DEG C for pressure-reduction reaction; the reaction liquid is cooled to 80 DEG C and washed to be neutral; after washing, the reaction liquid is subjected to molecular distillation to obtain phytosterol. The preparing method has the advantages of being low in production cost, stable in process index and high in product yield.

The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold (''HPPS'') nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a- helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.

The invention relates to a preparation method of a magnetic immobilized enzyme for producing a plant sterol ester, belonging to the field of catalytic materials and chemical synthesis. The preparation method of the magnetic immobilized enzyme for producing the plant sterol ester is characterized by comprising the following steps: 1) carrying out chemical modification on a magnetic substrate with vinylphosphonic acid to introduce a carbon-carbon double bond with reactivity onto the surface of the magnetic substrate; 2) wrapping the surfaces of the modified magnetic particles with polymer layers containing epoxy or sulfonate radical groups to obtain magnetic polymer microspheres; and 3) in a buffer solution, immobilizing an enzyme on the surfaces of the magnetic polymer microspheres by an epoxy ring-opening or electrostatic adsorption method to obtain the magnetic immobilized enzyme for producing the plant sterol ester. The obtained magnetic immobilized enzyme has the characteristics of high catalytic activity, good reuse performance and is simple in separation and recovery.

The invention relates to a method for the production of oxidation-stable sterol formulations, wherein catechins and / or the derivatives thereof are added to the sterols or sterol esters, and to the formulations produced according to said method. The catechins are preferably used in an amount of 20 to 1000 ppm, based on the sterol or on the sterol ester. Green tea extract may be incorporated as the catechin formulation. The formulations containing sterols produced according to said method have very high oxidative stability and have no displeasing aftertaste.

The invention belongs to the field of cosmetics and discloses a hair conditioner comprising olive oil and derivatives of the olive oil and a preparation method of the hair conditioner. The hair conditioner comprises the following raw material components in percentage by mass: 1 to 3 percent of olivamidopropyl trimethylammonium chloride, 1 to 10 percent of olive (OLEAEUROPAEA) fruit oil, 1 to 5 percent of sorbitan olivate, 1 to 5 percent of polydimethyl siloxane, 1 to 8 percent of PEG-7 olivate, 0.1 to 1 percent of plant sterol ester, 1 to 10 percent of an olive leaf extract, 0.1 to 1 percent of a preservative, 0.05 to 1 percent of essence, 0.01 to 0.5 percent of pH regulator and the balance of deionized water. Over 90 percent of components in the formula are naturally sourced components, the product is natural, mild and almost nonirritant, can be used for a long time, can be used for nursing dry and damaged hair and can be used for daily care.

Personal care composition including a first skin and / or hair care active cetyl pyridinium chloride; and at least one additional skin and / or hair care active selected from the group consisting of tetrahydrocurcumin, sugar amine, vitamin B3, retinoids, hydroquinone, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, idebenone, dehydroacetic acid, Licohalcone A, creatine, creatinine, feverfew extract, yeast extract, beta glucans, alpha glucans, their salts, their derivatives, their precursors, and / or combinations thereof; and a dermatologically acceptable carrier. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the personal care composition of the invention.

The invention provides a method for degumming with magnetic immobilized phospholipase A2. The method comprises the steps of adding magnetic immobilized PLA2 (phospholipase A2) into soybean raw oil for degumming, and recycling magnetic immobilized enzyme with a magnetic field after a reaction is finished. For determination of a phosphorus content after the degumming, oil yield and recycling times of immobilized PLA2, the obtained minimum phosphorus content after the degumming is 20ppm, and the relative activity of the immobilized enzyme keeps around 80% after the oil yield is increased by 1.2%, and magnetic immobilized PLA2 is continuously utilized for eight lots. After magnetic immobilized PLA2, phospholipid formation in degumming oil can be increased; separation of an oil phase and a gum phase is improved; formation of free fatty acid in the degumming oil can be controlled; and sterol can be re-esterified with free fatty acid to form sterol ester to become a part of edible oil. Therefore, physical refining is realized, and the yield of the degumming oil can be increased. The high quality degumming oil with a low phosphorus content can be produced, and the degumming oil contains higher-content functional plant sterol ester at the same time.

This invention pertains to the preparation of a sterol ester-enriched food ingredient utilizing a base-catalyzed tranesterification of free sterol with fatty acyl glyceride. Phytosterols are subject to transesterification with fatty acyl glyceride from vegetable oils in the presence of an alkali catalyst. The reaction is performed under vacuum in the range of 0.01-1 Torr. Following an initial period of transesterification, the reaction mixture is distilled to remove glycerol to enhance the formation of sterol esters. A sterol ester-rich fraction can be isolated from the reaction mixture using organic solvents in combination with aqueous washes.

The invention relates to a method for preparing plant sterol ester-containing functional health-care grease. The method for preparing plant sterol ester-containing functional health-care grease is characterized in that: the plant sterol ester-containing functional health-care grease is obtained by realizing ester exchange between grease and plant sterol ester with a biological enzyme method; and the highest transformation rate can be up to 86 percent. In the method, a plant sterol ester-containing product is developed by adopting an enzymatic ester exchange technology. The method comprises the advantages of mild reaction condition, high efficiency, specificity, environmental friendliness, small quantity of by-products, good product quality, and the like. Compared with a chemical method, the method has the advantages of small investment, simple equipment, low energy consumption, low production cost, environmental friendliness and contribution to environmental protection.

A method for preparing a fat composition by reacting a sterol raw material with a triglyceride raw material to create the fat composition.

The invention relates to a process for isolating sterols and tocopherols from mixtures of fats and fatty derivatives and from residues left after they have been worked up. After splitting of the glycerides by hydrolysis and subsequent removal of the free fatty acids by distillation, the sterol esters still present are largely split into free sterols by an additional hydrolysis step.

The invention relates to a novel preparation method for efficiently synthesizing fatty acid plant sterol esters by using micelle catalysts. The used technical scheme of the invention comprises the following steps of: firstly adding a certain amount of fatty acid into a reaction bottle fitted with stirring, oil bath and temperature control functions, and inletting nitrogen gas and heating; then adding a certain amount of plant sterol esters and the micelle catalysts with 0.5-3.0 mol percent, regulating a reaction temperature to be 80-160 DEG C and reacting for 2-6 hours; and preparing the fatty acid plant sterol esters by separating and purifying. The method provided by the invention has the advantages of simple process, high efficiency and convenience for mass production.

The application relates to a method for extracting phytosterol from oil slick asphaltum and a preparation method of sterol ester. The method comprises the following steps: carrying out saponification on tall oil pitch to obtain a crude sterol product; leaching the crude sterol product to obtain a sterol product with the purity of 70-90%; distilling to remove fatty alcohol in the sterol product; crystallizing the obtained product, wherein the purity of the crystal is larger than or equal to 98%. The method in the invention can be used for effectively removing the content of the fatty alcohol in a phytosterol product, improving the purity of the finial product of phytosterol; the steps are simple and easy to operate, and are suitable for industrial production.

The process for recovery of plant sterols and tocopherols from deodorization distillates formed during chemical or physical refining of vegetable oils consists of the following steps: free fatty acids are removed from the deodorization distillate by vacuum distillation or by continuation solvent saponification, after the removal of free fatty acids, the received material is reacted with an aromatic carboxylic acid anhydride at a temperature of 50-150° C., under reduced pressure, after the treatment with anhydride, tocopherols are removed from the mixture, and crystalline free sterols are recovered from the distillation residue containing sterol esters, di- and triglycerides by transesterification.

Disclosed is a method for enzymatically producing sterol fatty acid ester for food, this method comprises: reaction for synthesizing the sterol fatty acid ester by deodorizing scum oil, in the presence of the enzyme which is active in fat decomposing as a catalyst, an enzyme deactivation treatment, dehydration treatment and enzymatic protein removal treatment, the impurity is removed by molecular distillation treatment, adsorbent treatment, and steam distillation treatment, thus obtaining the sterol fatty acid ester for foods excellent in terms of both appearance and safety.