19 results about "Plant sterol ester" patented technology

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention discloses a genetically engineered bacterium and an application of the genetically engineered bacterium in production of farnesene. The genetically engineered bacterium takes saccharomyces cerevisiae as a chassis strain; an exogenous beta-farnesene synthase gene is integrated, an ERG9 gene is knocked out, a promoter of a truncated HMG1 gene is replaced with an ANB1 promoter, an exogenous transhydrogenase gene is integrated and driven by a glucose sensitive promoter, beta-farnesene synthase is mutated and fused with a transmembrane structural domain of ABC transporter protein PDR10, and then a chimeric expression unit is constructed. According to the present invention, the chassis bacteria are modified by at least one of the steps of overexpression of phosphatidylcholine synthetase, knockout of sterol ester synthetase and introduction of exogenous alkyl glycerol monooxygenase, and the obtained engineering bacteria are combined with the optimized fermentation process so as to significantly improve the farnesene synthesis efficiency and the production economy; therefore, the genetically engineered bacterium and the fermentation method provided by the invention have good application prospects.

This film-forming composition for skin contains the following components (A) to (E). A phospholipid (A) A sterol ester (B) A C10-24 higher alcohol (C) Water (D) Water-insoluble fibers (E) having an average fiber diameter of 0.3 μm to 5 μm and an average fiber length of 20 μm to 300 μm In the film-forming composition for skin, the mass ratio (B) / (E) of component (B) to component (E) is 1 to 15. The water-insoluble fibers of component (E) preferably have a variation coefficient value of the fiber length of 40% to 100%.

The object of this invention is to provide Labyrinthula microorganisms that have high sterol ester production capacity. [Solution] A Labyrinthull microorganism modified to have reduced or lost activity of sterol 24-C-methyltransferase (SMT1) compared to an unmodified strain, wherein the Labyrinthull microorganism is modified to express a modified diacylglycerol acyltransferase 2C (modified DGAT2C) gene, and the modified diacylglycerol acyltransferase 2C (modified DGAT2C) is modified to have a defect in presumed transmembrane regions 1 to 8 of the presumed transmembrane regions 1 to 12 in diacylglycerol acyltransferase 2C (DGAT2C).

The present application relates to the technical field of microbial feed additive, and discloses a feed lactic acid bacteria additive and a preparation method thereof.The preparation method comprises the following steps: taking Lactobacillus plantarum and / or Enterococcus faecalis as a bacterial strain to activate and expand culture, taking agricultural and sideline product waste as a substrate to obtain mature fermentation liquor through deep liquid fermentation; mixing the mature fermentation liquor with a composite protective agent containing double essential oil, chitosan, theabrownin and porous silicon dioxide to obtain a semi-dry granule core through granulation and low-temperature pre-drying; and coating the semi-dry granule core with a κ-carrageenan / konjac glucomannan / plant sterol ester composite gel, and drying and packaging to obtain a finished product.The double essential oil, chitosan and theabrownin jointly form a full-spectrum active antibacterial system; the elastic composite gel outer layer realizes dual protection of liquid water and water vapor; the porous silicon dioxide actively maintains low water activity of the granule to prevent the lactic acid bacteria from recovering in advance; and the product has high viable count, strong heat and acid resistance, and excellent storage stability.

The present application relates to the field of cosmetic technology, and discloses an anti-inflammatory soothing cosmetic composition, which comprises the following components in percentage by weight: a barrier repair component: 0.5-4%, an immunomodulatory component: 0.5-3%, a nerve soothing component: 0.3-2.5%, an anti-inflammatory plant complex: 0.3-3%, a moisturizing soothing enhancer: 1-10%, and a balance of auxiliary materials. The above components significantly enhance anti-inflammatory soothing and barrier repair through a five-dimensional synergistic mechanism of 'barrier repair-immune tolerance-nerve desensitization-anti-inflammatory itching-moisturizing stability maintenance'; the introduction of ceramides, rare ginsenosides, plant sterol esters, and free fatty acids synergistically constructs 'bionic liposomes', which are closer to the lipid composition of human stratum corneum, enhance transdermal absorption and stability, and significantly improve repair efficiency; the synergistic effect of dipotassium glycyrrhizinate, tamarix flower extract, spilanthes extract, dinoxanthin, and baicalin suppresses rapid anti-inflammatory itching, strengthens barrier repair, and is suitable for highly sensitive skin.

The invention discloses amino acid sterol ester and a preparation method thereof. Belongs to the technical field of natural grease product structure modification. The preparation method comprises the following steps: by taking amino acid and sterol as reaction raw materials, adding a reaction solvent and a molecular sieve, fully stirring at normal temperature, then adding lipase and providing microwave to assist an esterification reaction, thereby obtaining the amino acid sterol ester. The method is rapid, efficient and simple and convenient to operate, and the obtained amino acid sterol ester does not need to be further purified and has the advantages of high bioavailability and the like.

The present invention discloses a composition with hair growth and hair strengthening functions, a preparation method and an application, belonging to the technical field of hair growth and hair strengthening. The raw materials of the composition include, by weight: main components, including 1020 - 3050 parts of protein and 22.4 - 140 parts of nutritional fortifier; efficacy components, including 20 - 200 parts of powdered plant sterol ester, 100 - 500 parts of millet extract, 100 - 500 parts of polygonatum sibiricum powder, 100 - 400 parts of mulberry powder and 100 - 500 parts of aronia melanocarpa fruit powder; auxiliary components, including 200 - 1800 parts of flavoring agent. The composition of the present invention has no toxic and side effects, can promote the metabolism and proliferation of hair follicle cells, can effectively promote the formation of melanin in hair follicles, shorten the time for hair follicles to enter the growth phase from the resting phase and grow hair, and can strengthen the tightness of hair on the scalp, thereby achieving the effect of preventing hair loss and strengthening hair.

The utility model relates to the technical field of reactors, and discloses a lipase reactor for efficiently preparing sterol ester, which comprises a reaction box, the top of the reaction box is provided with an open slot, both sides of the open slot are provided with fixing columns, adjacent sides of the two fixing columns are provided with sliding chutes, sliding plates are fixedly connected in the two sliding chutes, and the sliding plates are arranged in the open slot. A motor is fixedly connected to the top of the sliding plate, the output end of the motor penetrates through the sliding plate to be fixedly connected with a stirring rod, a gear is fixedly connected to the outer portion of the upper portion of the stirring rod, electric heating plates are arranged in the two sides of the reaction box, and electric push rods are fixedly connected to the front and rear portions of the top of the reaction box; the output end of the electric push rod is fixedly connected with a cleaning assembly. According to the reaction kettle disclosed by the utility model, the fixed column, the sliding groove, the sliding plate, the motor, the gear, the stirring rod and the rack are matched to work, the motor drives the stirring rod to rotate so as to stir a reaction solution, and the stirring rod can move while stirring, so that the stirring effect is better.

The present application relates to the technical field of health food and soft capsule preparation, in particular to a kind of full sea-buckthorn oil sterol ester soft capsule and low-temperature homogenization preparation method thereof.The content of the soft capsule is composed of sea-buckthorn seed oil 41.7%, phytosterol 33.3% and sea-buckthorn fruit oil 22% by weight percentage, wherein, sea-buckthorn fruit oil completely replaces soybean oil and chemical synthesis suspending agent, as functional excipient and physical stabilizer, when preparing, high-quality sea-buckthorn oil is extracted at 38±0.5 ℃ subcritical low temperature, and the raw and auxiliary materials are mixed at 38±0.5 ℃ constant temperature;then, pill is pressed at 22-24 ℃ environment, and the accurate temperature difference of 14-16 ℃ is used to stimulate micro-phase rearrangement and viscosity improvement of oil liquid.The present application realizes instantaneous physical homogenization and long-term stable non-layering of content under the condition of zero addition of stabilizer, and realizes efficient comprehensive utilization of sea-buckthorn resources.

The invention belongs to the quality standard and detection technology field of health food, and is specifically related to a detection method for measuring the total amount of multiple free sterols and sterol esters in a kind of plant sterol ester. The present invention utilizes C18 solid phase extraction cartridge purification technology, separates and removes other components, enriches target component, utilizes reversed-phase liquid chromatography, first quantitatively detects the free sterol content originally present in four kinds of raw materials of stigmasterol, campesterol, β-sitosterol, and rapeseed sterol; Then weigh the sample and carry out saponification to convert sterol ester into sterol, with methanol-water-phosphoric acid mixed solvent as mobile phase A, methanol-isopropanol mixed solvent as mobile phase B, methanol as mobile phase C, gradient elution is carried out through reversed-phase C18 analytical column, the total amount of sterols in the determination sample (including the free sterols originally present and the sterols obtained by saponification and hydrolysis) is determined, so as to convert the content of plant sterol ester in raw material.

The invention belongs to the technical field of edible oil and enzymes, and discloses medium-chain and long-chain fatty acid edible oil with a reasonable fatty acid proportion and a preparation method, the edible oil simultaneously meets the requirements that the mass percentage content of medium-chain and long-chain fatty acid triglyceride is 45%-65%, the proportion of saturated fatty acid to monounsaturated fatty acid to polyunsaturated fatty acid is (1-1.5): 2: 1, and the content of fatty acid is 1-1.5%. The polyunsaturated fatty acid is composed of n-6 polyunsaturated fatty acid and n-3 polyunsaturated fatty acid, and the ratio of the n-6 polyunsaturated fatty acid to the n-3 polyunsaturated fatty acid is (4-6): 1; the edible oil contains phytosterol ester with the final mass concentration of 0.5%-1.5%. The edible oil contains a certain amount of MLCT, the proportion of various fatty acid components is reasonable, and the proportion of n-6 polyunsaturated fatty acid to n-3 polyunsaturated fatty acid also meets the health requirements of human bodies.

The invention discloses targeted prebiotic plant extraction dietary powder for conditioning hyperlipidemia and a preparation process of the targeted prebiotic plant extraction dietary powder. In the invention, patent strains such as lactobacillus plantarum LP-12, bifidobacterium longum BL-08 and the like in the formula can regulate intestinal flora balance and inhibit activity of liver cholesterol synthesis key enzymes, so that generation of endogenous cholesterol is reduced from the source; natural monacolin K and phytosterol ester in the red yeast rice powder respectively inhibit cholesterol synthesis and competitively block exogenous cholesterol absorption to form a bidirectional regulation mechanism. Meanwhile, the oat beta-glucan forms an adhesive layer in the intestinal tract, so that part of lipid absorption is physically blocked; and prebiotics such as resistant dextrin and fructo-oligosaccharide provide nutrients for probiotics, promote secretion of short-chain fatty acids and further activate lipid metabolism related pathways. The components cooperate with one another to cover the whole chain of cholesterol synthesis, absorption and metabolism, so that the multi-dimensional lipid-lowering effect of'source inhibition-process blocking-metabolic regulation 'is realized.

The invention discloses a construction and identification method for a neutral loss triggering prediction database of phytosterol ester in vegetable oil, and the method comprises the following steps: S1, constructing a simulation structure of the phytosterol ester according to a composition mechanism of a molecular structure of the phytosterol ester; s2, acquiring a phytosterol ester mass spectrum splitting signal of the training set through mass spectrum detection scanning, and decoding a phytosterol ester mass spectrum splitting rule; s3, constructing a phytosterol ester mass spectrum simulation neutral loss trigger prediction database; and S4, when the neutral loss mass of the acyl chain in the detection sample is identified, triggering neutral loss scanning, and identifying the non-targeted phytosterol ester in the vegetable oil. According to the method, the phytosterol ester component in the oil and edible oil can be rapidly analyzed, analysis workers do not need to have professional mass spectrum unfolding ability, and rapid non-targeted recognition analysis can be carried out on the sample through mass spectrum library comparison; the method has the characteristics of no dependence on standard compounds, short analysis period, high result accuracy and good result reproducibility.

The present application relates to a kind of low-density extracellular vesicles and its preparation method and application, the low-density extracellular vesicles is derived from CD4 + Chimeric antigen receptor T (CD4 + CAR-T) cell culture fluid, after obtaining supernatant by ultracentrifugation, again by ultrafiltration cut-off purification is obtained.The present application is first isolated and identified from CD4 + CAR-T cell a new type of low-density extracellular vesicles (LD-EVs), the subtype is missed in traditional EV separation process, and the cognition to EV diversity is widened.The characteristics of LD-EVs are rich in sterol ester (especially cholesterin ester) by lipidomics etc., which is related to its low-density characteristics and potential membrane stability, signal transmission function, provides target for functional research and engineering modification.

The invention provides a composition beneficial to maintaining the healthy level of blood fat and application of the composition. Specifically, the composition provided by the invention comprises phytosterol ester, fish oil and beta-glucan, and the weight ratio of the phytosterol ester to the fish oil to the beta-glucan is 1: (1-5): (10-100). The composition disclosed by the invention can be beneficial to maintaining the healthy level of blood fat, reducing / preventing low-density cholesterol accumulation and reducing the cholesterol level.

The invention belongs to the technical field of natural food additives, and provides a method for extracting high-purity sterol from residual oil containing sterol ester. By optimizing transesterification reaction conditions and combining a specific strong acid catalyst and a gradient crystallization process, the sterol conversion efficiency and the crystal quality are remarkably improved; catalyst regeneration, solvent closed-loop recovery and seed crystal self-supply technologies are creatively adopted, and product purity breakthrough, resource consumption reduction and environment friendliness improvement are synchronously realized. The problems of impurity eutectic, waste liquid pollution and high cost in the traditional process are solved, and an overall solution is provided for efficient and green extraction of sterol.

Asphalt and asphalt binders and methods for preparing such compositions with sterol esters are disclosed herein. The sterol esters improve various rheological properties of asphalt and asphalt binders. Methods of determining changes or improvements in various rheological properties are also disclosed.

The invention discloses a pharmaceutical composition and application thereof. The composition comprises a basic component and a synergistic component, wherein the basic component comprises 0.1-9.4 wt.% of 1, 4-polyisoprene; the synergistic component comprises a first synergistic component and a second synergistic component, and the content of the first synergistic component and the second synergistic component is 90.0-99.9 wt.%. The first synergistic component comprises fatty acid and / or non-sterol fatty acid ester, and the second synergistic component comprises sterol and / or sterol ester. On the basis of the total mass of the synergistic components, the first synergistic component is prepared from 64.0 to 99.9 weight percent of unsaturated fatty acid and / or non-sterol unsaturated fatty acid ester and 0 to 24.0 weight percent of saturated fatty acid and / or non-sterol saturated fatty acid ester; and the second synergistic component comprises 0.1 to 2.0 weight percent of sterol and / or sterol ester. According to the composition disclosed by the invention, the pharmaceutical activity of the 1, 4-polyisoprene is improved, and a better drug effect can be obtained under the condition of the same dosage.