Novel preparation method of fatty acid plant sterol esters

A technology of phytosterol esters and phytosterols, which is applied in the solvent-free field of synthesizing fatty acid phytosterol esters using micellar catalysts, can solve the problems of poor solubility and bioavailability, unsuitable for use in the food industry, and low enzyme catalytic efficiency. The effect of low requirements on reaction conditions, easy purification of products, and simple process

Inactive Publication Date: 2012-01-18
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because most phytosterols exist in the form of crystals, there are the following problems in application: the crystalline form makes their solubility and bioavailability in the human body relatively poor; they are insoluble in water and have little solubility in oil , which greatly limits its application in food
The problem is that the catalytic efficiency of the enzyme is low and the dosage is large. To achieve an esterification rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 17.4g of hexanoic acid and add it into a reaction flask equipped with stirring and oil bath for temperature control, blow in nitrogen, heat, and then add 50g of phytosterol and 1.0mol% copper dodecyl sulfate. The reaction temperature was controlled at 80° C., and the reaction process was monitored in real time by thin-layer chromatography. Samples were taken every 0.5 h, and the reaction was performed for 3 h. Separation and purification to obtain phytosterol hexanoate.

Embodiment 2

[0030] Weigh 19.5g of octanoic acid and add it into a reaction flask equipped with stirring and temperature control in an oil bath, feed nitrogen, heat, and then add 50g of phytosterol and 1.2mol% zinc lauryl sulfate. The reaction temperature was controlled at 90° C., and the reaction process was monitored in real time by thin-layer chromatography. Samples were taken every 0.5 h, and the reaction was performed for 3 h. Separation and purification to obtain octanoic acid phytosterol ester.

Embodiment 3

[0032] Weigh 30g of lauric acid and add it into a reaction flask equipped with stirring and oil bath temperature control, feed nitrogen, heat, then add 50g phytosterol and 1.5mol% copper dodecyl sulfate. The reaction temperature was controlled at 100° C., and the reaction process was monitored in real time by thin-layer chromatography. Samples were taken every 0.5 h, and the reaction was carried out for 4 h. Separation and purification to obtain phytosterol laurate.

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Abstract

The invention relates to a novel preparation method for efficiently synthesizing fatty acid plant sterol esters by using micelle catalysts. The used technical scheme of the invention comprises the following steps of: firstly adding a certain amount of fatty acid into a reaction bottle fitted with stirring, oil bath and temperature control functions, and inletting nitrogen gas and heating; then adding a certain amount of plant sterol esters and the micelle catalysts with 0.5-3.0 mol percent, regulating a reaction temperature to be 80-160 DEG C and reacting for 2-6 hours; and preparing the fatty acid plant sterol esters by separating and purifying. The method provided by the invention has the advantages of simple process, high efficiency and convenience for mass production.

Description

technical field [0001] The invention relates to a method for preparing fatty acid phytosterol esters, in particular to a solvent-free method for synthesizing fatty acid phytosterol esters with a micelle catalyst. Background technique [0002] Phytosterol is an active ingredient in plants, which widely exists in various vegetable oils, nuts and plant seeds, as well as plant foods and vegetables and fruits. Phytosterols have physiological effects such as reducing blood cholesterol levels, preventing prostate diseases, anti-inflammatory, anti-cancer and anti-oxidation. Phytosterols have been widely added to various foods as functional food additives. In September 2000, the U.S. Food and Drug Administration (FDA) approved that foods with added phytosterols and phytosterol esters can use the label "good for health". At present, countries such as the European Union, the United States and Japan have widely used it in foods such as butter, dairy products, chocolate, bread and marg...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 贾承胜何文森冯骉张晓鸣
Owner JIANGNAN UNIV
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