Preparation method of sterol ester

A technology of sterol esters and sterols, which is applied in the preparation of steroids, chemical instruments and methods, steroids, etc., can solve the problems of sterol purity decline, achieve the effect of simple and easy operation, and improve the purity

Active Publication Date: 2014-07-16
内蒙古昶辉生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Those skilled in the art know that fatty alcohols such as wax alcohol, policosanol, etc., also exist in TOP, and when crystallization method is used to obtain sterol final product, they will form co-crystallization with sterol, resulting in a decrease in the purity of sterol in the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Using 80g of 50% industrial sodium hydroxide and 600ml of 50% methanol aqueous solution, under the condition of 80℃~90℃, saponify 385g of tall oil pitch (the mass percentage of sterol is 14.27%) for 1.5h~2h. Add 390g of soft water to the mixture, then extract with dichloroethane at 60°C to 65°C, use 1000ml of dichloroethane each time, extract 3 times, combine the dichloroethane layers, and add to the original bottom flask , concentrated under vacuum to obtain 138.2 g of crude sterol.

[0022] The crude sterol obtained above was dissolved in 200 ml of dichloromethane, and dissolved completely at 80°C to 85°C. 100 ml of 50% methanol aqueous solution was added thereto. The resulting mixture was allowed to stand at 15 °C for 10 h. The sterol solid was then filtered off and washed with dichloromethane at 5°C. After drying, 46.54 g of sterols with a purity of 70% to 80% were obtained.

[0023] The fatty alcohol in the sterol product obtained in the previous step is remove...

Embodiment 2

[0026] The sterol crystals with a purity of more than 98% obtained in Example 1 were esterified with 1.5 mol of oleic acid at 200°C to obtain sterol oleate with a purity greater than 98%.

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Abstract

The application relates to a method for extracting phytosterol from oil slick asphaltum and a preparation method of sterol ester. The method comprises the following steps: carrying out saponification on tall oil pitch to obtain a crude sterol product; leaching the crude sterol product to obtain a sterol product with the purity of 70-90%; distilling to remove fatty alcohol in the sterol product; crystallizing the obtained product, wherein the purity of the crystal is larger than or equal to 98%. The method in the invention can be used for effectively removing the content of the fatty alcohol in a phytosterol product, improving the purity of the finial product of phytosterol; the steps are simple and easy to operate, and are suitable for industrial production.

Description

technical field [0001] The application relates to a method for extracting phytosterols from pulp tall oil pitch and a method for preparing sterol esters. Background technique [0002] Pulp tall oil, or tall oil, also known as "liquid rosin" or tall oil, is a viscous yellow-black liquid that is a by-product of conifer pulp manufacturing. Tall oil is the third largest by-product in the Kraft Process after lignin or hemicellulose, and the crude tall oil (CTO) in each ton of wood pulp can reach 30kg~50kg. Depending on the wood used, the composition of crude tall oil will vary greatly, and generally crude tall oil contains phytosterols, phytostanols, lipids, fatty alcohols, fatty acids, and terpenes. Tall oil pitch (TOP) is obtained after distillation of crude tall oil to remove volatile substances. Typical TOP is dark brown, which contains about 15% free and combined sterols, about 40% free and combined fatty acids and abietic acids, about 10% wax alcohols (C 16~30 Alcohols),...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00C07J75/00
Inventor 赵永强马亚琼白易贾洪涛廖小雪
Owner 内蒙古昶辉生物科技股份有限公司
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