2045 results about "Skin whitening" patented technology

The present invention discloses the utilization of zeolites for controlled-release of cosmetic and pharmaceutical compositions by nano-diffusion technology. The treatment and protection of skin surface requires that certain compositions be delivered to the skin surface and allowed to remain on the skin surface for as long as possible before such ingredients are absorbed into deeper layers of skin and carried into the bloodstream. Zeolites do not absorb into the skin, which is useful for topical delivery of cosmetic and pharmaceutical compositions, for example antiaging, anti-wrinkle, antioxidants, skin whitening, acne treatment, rosacea treatment, sun screens, UV blocks, anesthetics, skin soothers, anti-irritants, anti-inflammatory agents, vitamins, hormones, and such that are electronically attached to the outer surfaces of such zeolites and are released to the outer surface of skin by a diffusion-controlled thermodynamic process.

The present invention concerns a composition for retarding skin aging which contains an edible herb medicine or medicines round in Taiwan, in particular a plant extract or extracts having melanine formation-unhibiting, elastase-inhibiting, hyaluronidase-inhibiting, active oxygen-eliminating and / or radical-capturing type antioxidant activities, and a medicinally acceptable base and / or additives for external dermal application. The composition is useful in promoting skin whitening effects, maintaining the tension and elasticity of the skin, facilitating skin moistening and providing the skin with anti-inflammatory and / or anti-allergic properties.

The present invention concerns methods and compositions that can be used, for example, in skin whitening or hyperpigmentation applications. The composition, in non-limiting aspects, can include a vitamin C derivative, niacinamide, an extract formulation comprising cucumber and lemon extract or compounds that include the following formulas: where R1, R2, R3, R4, and R5 are independently an H, an alkyl group, a hydroxyalkyl group, or a carboxyalkyl group where R1, R2, R3, R4, and R5 are independently an H, an alkyl group, a hydroxyalkyl group, or a carboxyalkyl group and where x is an integer from 1 to 30.

The present invention relates to boosting of the skin whitening benefits of commonly used tyrosinase inhibitors, tyrosinase competitors, and melanin and other color bodies' reducing agents. The activity of such compositions can be synergistically enhanced by the inclusion of at least one antioxidant composition. This synergistic benefit is further increased if a UV-inhibitor or UV-absorber is also included in such compositions. This is both unexpected and surprising because most such tyrosinase inhibitors, tyrosinase competitors, or melanin reducing agents are also known to possess antioxidant and UV-absorbing properties. Thus, the skin whitening benefits are synergistically increased by combining at least one of the following; (i) a tyrosinase inhibiting agent, or (ii) a tyrosinase competing agent, or (iii) a melanin reducing agent, or (iv) combinations thereof; with at least one antioxidant composition. The additional inclusion of at least one UV inhibitor or absorber composition provides further enhancement of skin whitening effects from such tyrosinase inhibiting, tyrosinase competing or melanin reducing agents that are formulated in combination with an antioxidant composition. In a related application, the skin whitening property of a sunscreen composition can be boosted by the inclusion of an antioxidant composition and a tyrosinase inhibitor, tyrosinase competitor, or melanin and other color bodies reducing composition.

Disclosed are stable compositions which are effective as skin whitening agents, comprising alpha, beta or gamma substituted mono-, di or polyhydroxy or polycarboxy carboxylic acids; mono-, di, tri or polyhydroxy alkyl compound; and effective amounts of an inhibitor of tyrosinase and a pigmentation reversing reagent. Also disclosed are methods of forming stable compositions of the type described above.

The invention discloses a skin whitening composition which comprises a white mulberry root-bark extract, a chamomile extract, a rhodiola rosea extract, a grape seed extract, a licorice extract, a morus australis extract, arbutin, kojic acid dipalmitate, nicotinamide, tetrahydrodiferuloylmethane, a moisturizer and a preservative. The effective skin whitening ingredients of the skin whitening composition can inhibit the activity of tyrosinase, can block the transportation of melanin and can inhibit the formation of melanin; the skin whitening composition can be applied to skin whitening cosmetics and is safe and effective.

The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

Disclosed is a pharmaceutical preparation for external application to the skin, which comprises a phosphorylated sugar. The phosphorylated sugar may be an inorganic salt of a phosphorylated sugar. The phosphorylated sugar may be in the form of a calcium salt, a magnesium salt, a potassium salt, a zinc salt, an iron salt or a sodium salt. Also disclosed is a pharmaceutical preparation for externalapplication to the skin, which comprises a phosphorylated sugar and a second component. The second component is selected from the group consisting of a moisturizing component, a skin-whitening agent,an UV-absorber, an anti-inflammatory agent, a cell-activating agent and an anti-oxidant. The moisturizing agent may be ascorbic acid or an ascorbic acid derivative.

The objetive of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-alpha-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivative, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

The present invention discloses a tyrosinase inhibitor extract from lemon peels. The tyrosinase inhibitor extract contains a tyrosinase inhibitor content and provides advantageous skin whitening effects.

The invention relates to a soluble microneedle patch used for skin whitening and a preparation method thereof. The soluble microneedle patch comprises a needle point and a substrate, the needle point comprises the following raw materials in parts by weight: 1 part of arbutin, 15-30 parts of hyaluronic acid or its salt, and 5-25 parts of a forming material; wherein the hyaluronic acid or its salt is hyaluronic acid or sodium hyaluronate; and the forming material is selected from at least one of fructose, mannose, carboxymethylcellulose sodium and hydroxypropyl methylcellulose. The soluble microneedle patch has good mechanical strength, hardness and dissolvability, avoids the disadvantage that a traditional skin-caring mode cannot perform arbutin advantage, and has obvious effects for lightning color spots and whitening skin.

The invention discloses a traditional Chinese medicine facial mask for skin whitening, which is prepared form the following raw materials: rhizoma atractylodis macrocephalae, radix angelicae, rhizoma bletillae striatae, radix ampelopsis, radix paeoniae alba, white poria, silkworm larva and pearl powder. The facial mask provided by the invention is capable of adjusting sebum, improving skin microcirculation, and reaching the effects of skin whitening and removing freckles, and has the characteristics of being safe and reliable, free of any toxic and side effects, high in use ratio of effective components and taking effect quickly.

The invention relates to a skin-whitening chloasma-reducing skin-brightening composition comprising raw materials of, by weight: 0.5 to 20 parts of nicotinamide, 0.1 to 15 parts of L-ascorbic acid 2-glucoside, 0.1 to 10 parts of an yeast extract, 0.05 to 10 parts of sodium lactate / sodium gluconate, 0.01 to 3.5 parts of sodium hydroxide, and 10 to 60 parts of water. With the composition provided by the invention, appearing and transferring of skin melanin can be inhibited or prevented from various perspectives; skin collagen protein synthesizing can be promoted, skin nutrients can be supplemented, such that skin aging can be retarded; and whitening effects can be achieved rapidly. Whitening active components are likely to be decomposed, oxidized, and discolored. With the composition, the problems can be solved; influences of lights and heat on the effective components are reduced. The product produced by the invention is safer than other whitening agents. With the product produced by the invention, nutrients required by skins can be provided. With a sustained-releasing technology, the whitening effect is more durable.

The invention relates to a water-soluble active extract derived from fruit peels, the preparation method and the application thereof. The fruit peel is treated by the steps of drying, pulverization, extraction, flocculation, separation and concentration, to prepare a water-soluble active extract. Then, the extract is added in cosmetic matrixes to allow a cosmetic to have skin-whitening and anti-skin ageing functions. The fruit peel extract is obtained after the screening of tyrosinase-inhibiting, antioxidant and free radical-scavenging activities in the water-soluble extracts of fruit peels such as Citrus peels, and has skin-whitening and anti-skin ageing effects. The water-soluble active extract has the advantages of easily-accessible raw materials, renewable resources and simple preparation method. The obtained extract has good stability and durable effect and serves as cosmetic additives in any stage of cosmetic production, without the risks of solvent residue and microbial contamination.

The invention discloses a skin whitening microemulsion. More specifically, the skin whitening microemulsion contains sorbitan sesquioleate and PEG-20 sorbitan oleate; one or more oily components selected from hydrocarbon oil, synthetic grease, animal or vegetable oil, silicone oil and a mixture of silicone oil; polyhydric alcohol and water; one or more water-soluble skin whitening raw materials. The prepared skin whitening microemulsion is a water-in-oil system, is good in stability, can be stored for a long term, has a good solubilization effect on the water-soluble skin whitening raw materials, and can be made into a product containing high effective ingredients.

The invention discloses a whitening cosmetic composition which comprises, by weight percentage, 0.01-5.00% of glycyrrhiza glabra extract, 0.1-10.00% of whitening compound, 0.01-10.00% of citrus peel extract and 75.00-99.85% of cosmetic auxiliary material substrate, wherein the whitening compound comprises water, butanediol, arbutin, citric acid, sodium sulphite, acetyl tyrosine, saxifraga sarmentosa extract, peony root extract, amino-propanol ascorbic acid phosphate ester, radix scutellariae root extract, glutathione and hydrolyzed mirabalan. The whitening cosmetic composition contains the glycyrrhiza glabra extract, the whitening compound and the citrus peel extract, and the composition has safe and efficient skin whitening effects.

The invention provides a preparation method of a Cistanche tubulosa extract and a skin-whitening anti-aging cosmetic. The preparation method comprises pulverizing, performing crude extraction, centrifugally collecting the obtained crude extract, standing, eluting, and drying to obtain the Cistanche tubulosa extract. The preparation method is simple, and has no pollution. The extract has the content of echinacoside not lower than 25%, the content of verbascoside not lower than 55%, and the content of total glycosides not lower than 80%. Proven by the antioxidant activity test, the Cistanche tubulosa extract has antioxidant, skin whitening and anti-aging effects. The skin-whitening anti-aging cosmetic is prepared by adding the Cistanche tubulosa extract into a cosmetic, is safe and free of stimulation proven by cytotoxicity and safety test, and also has good skin whitening effect.

A composition which is effective as a skin whitening and skin exfoliation agent. The composition includes one or more hydroxy acids in combination with one or more extracts of one or more jojoba plant parts. The composition further includes Simmondsin. A method of promoting skin whitening and skin exfoliation, comprising the step of topically administering to an individual a composition in an amount effective to whiten and exfoliate skin, where that composition comprises one or more hydroxy acids in combination with one or more jojoba extracts.

The invention relates to the technical field of skin care products, in particular to multifunctional liquid crystal mask liquid and a preparation method thereof. The multifunctional liquid crystal mask liquid comprises liquid crystal emulsifiers, thickening agents, humectants, sodium hyaluronate, preservatives, various functional components and water. The functional components comprise water-soluble or oil-soluble substances with skin whitening, anti-wrinkling, anti-allergy and anti-acne functions. The mask liquid is liquid crystal emulsion, the various functional components can be solubilizedby the aid of lamellar liquid crystals of an oil-water interface, the functions of a mask are remarkably increased, water-soluble substances in a liquid crystal layer and oil-soluble functional components in an oil phase can be effectively protected, failure of the mask liquid is avoided, and performance of the functional components in the mask liquid is promoted. According to the multifunctionalliquid crystal mask liquid produced by the method, a liquid crystal structure is similar to a human skin structure, has high skin safety, simulates human skins and is called a 'second human skin layer', the permeability of the mask liquid is improved, and skin absorption is facilitated.

The invention relates to skin whitening external preparations which contain tocopherol phosphate and / or a salt thereof as an active ingredient capable of prevention and / or removal of skin pigmentation, cosmetics including the skin whitening external preparation and cosmetic cares using the cosmetic. The skin whitening external preparations have excellent skin whitening effects and are readily producible so that they can find wide use for the purpose of skin whitening.

The invention relates to a small RNA / DNA whitening product series, which mainly consists of a small RNA skin whitening lotion and a small RNA skin beauty cream. The small RNA skin whitening lotion mainly comprises efficient active ingredients for removing skin pigmentation and whitening skin, such as nano single-strand or double-strand oligonucleotides for specially and efficiency restraining genes (Asip, Mclr, Mitf, Dct, Silv, Oca2, Myo5a, Loc51151, Rab27a, Pomc, OA1,F2rl1, Kinesin, Slc24a5, Tyr and Tyrp1) relevant to melanin generation and a transdermal agent for stimulating oligonucleotides to enter skin melanocytes; the small RNA skin beauty cream comprises a plurality of highly active materials for maintaining pure and white skin and small RNA segments to prevent the sunshine from damaging the protective components of the skin and remove free radicals, and anti-aging and anti-inflammatory effective molecules. In addition, the invention further provides a formulation, a method and a procedure for preparing the series of whitening products.

A composition which is effective as a skin whitening agent is disclosed. The composition includes Simmondsin. In certain embodiments, the composition comprises an extract of jojoba. A method of promoting skin whitening, comprising the step of topically administering to an individual a composition in an amount effective to whiten skin, where that composition comprises a jojoba extract.

The invention provides a polypeptide composition for skin whitening and spot relieving. The polypeptide composition comprises an MC1-R antagonist (namely an alpha-MSH competitive antagonist) and / or a composition of polypeptides inhibiting alpha-MSH expression and / or a tyrosinase inhibitor. The polypeptide composition can reduce the generation of melanin, and contributes to skin brightening, so as to achieve the purposes of relieving color spots (chloasma, butterfly rash, freckle and the like), improving sallow tone and whitening skin. The concentration of each polypeptide is 0.0001-5%. The polypeptide composition provided by the invention can be prepared into various beauty and skin-care products as well as medical products.

The invention discloses an anti-allergic skin-whitening mask solution and a preparation method thereof. The anti-allergic skin-whitening mask solution is prepared from the following components in percentage by weight: 0.1-2 percent of O / W-type emulsifier, 0.1-2 percent of co-emulsifier, 0.1-1 percent of antioxidant, 3-8 percent of emollient, 0.01-0.2 percent of ethylene diamine tetraacetic acid disodium (EDTA-2Na), 0.01-5 percent of desensitizer, 1-8 percent of first moisturizer, 0.01-0.5 percent of thickener, 0.01-0.5 percent of second moisturizer, 0.01-0.5 percent of pH modifier, 0.01-0.5 percent of preservative, 1-6 percent of glucan, 0.01-0.5 percent of rose essential oil, 0.01-0.3 percent of agave leaf extract, 0.5-2 percent of rice bran yeast and the balance of deionized water. The mask solution has the advantages that the preparation method is simple; by virtue of an oil-in-water emulsification system, functional matters in the mask solution are more easily absorbed and permeate into the skin, high activity is kept, the cell activity is comprehensively improved, the skin reviving process is accelerated, the skin is kept wetted and translucent, the health and the elasticity of the skin are restored, and the soothing effect and the repairing effect are achieved.

The invention relates to application of paeonol in preparation of cosmetic for eliminating macula and whitening skin or in preparation of medicament for whitening skin or curing pigment deposition ailment. The cosmetic and medicament are both external use. The mass concentration of said paeonol is 0.01-5 %, optimization scheme is 5-10%. The paeonol and ground substance carrier are mixed to form tincture, spirit, cataplasm, ointment, cream, emulsion, oil agent, face mask, gel, film coating agent, aerosol and solution agent to which other component such as light screening agent and / or antioxidant and / or component for eliminating macula and whitening skin except paeonol can be added. The mechanism of paeonol directly restraining tyrosine enzyme activity, melanin generation and transport is various. The application of paeonol in cosmetic or medicament has unambiguous effect on skin whitening and curing pigment deposition ailment.

The invention belongs to the technical field of cosmetics and particularly a biological skin brightening facial mask liquid and a preparation method thereof. The biological skin brightening facial mask liquid is prepared from the following components in percentage by mass: 0.1-2 percent of glabridin, 0.5-3 percent of microalgae skin brightening agent, 0.5-2.5 percent of citrus peel extract, 0.05-2percent of alpha-arbutin, 0.1-3 percent of radix paeoniae extract, 0.5-5 percent of yeast extract and the balance of matrix. The prepared facial mask liquid is capable of reducing melanin from multiple aspects and in multiple ways aiming to various parts in the process from generation to discharge of the melanin, has the remarkable effects of skin whitening and brightening, is capable of replenishing water, preserving moisture, resisting ageing and keeping skin healthy at the same time and does not have irritation.

The invention provides an apple facial mask based on a traditional Chinese medicine formula.The apple mask comprises a silk matrix and a water-soluble substance.The water-soluble substance comprises apple extract, traditional Chinese medicine extract, seaweed extract, sodium hyaluronate, beta-glucan and assistant.The traditional Chinese medicine extract comprises tremella extract, centella asiatica extract, polygonum cuspidatum root extract, scutellaria root extract, tea extract, glycyrrhiza glabra root extract, chamomilla recutita flower extract, rosmarinus officinalis leaf extract and purslane herb extract.The seaweed extract contains chondrus crispus and bio-saccharide gum-1.The assistant comprises butanediol, propylene glycol, diglycerol, polyethylene glycol-400, Carbomer, hydroxyethyl cellulose, urea, allantoin, glycine betaine, nicotinamide, sodium glutamate, triethanolamine, 1,2-hexanediol, decoyl hydroximic acid, 1,3-propylene glycol, hexanediol and deionized water.The apple mask has the effects that stability is good, dispersibility is high, nutrients are proper in quantity and balanced, antibiosis and anticorrosion effects are achieved, and moisturizing, skin whitening and stain lightening are achieved.

The invention discloses a skin-whitening composition as well as a preparation method and applications of the skin-whitening composition. In the skin-whitening composition, various whitening agents and sun-screening agents with excellent properties are matched for use, so that the melanin formation can be inhibited, moreover, ultraviolet rays can be absorbed, and free radicals can be eliminated. The skin-whitening composition is prepared from radix puerariae extract, glutathione, kojic dipalmitate, ascorbyl glucoside, nicotinamide, beta-hydroxy acid, undecylenoyl phenylalanine, chamomile extract, green tea extract, licorice root extract, pomegranate bark extract, 1,3-butanediol, phenoxyethanol and water. The components are mixed to achieve the synergistic skin whitening effect, the skin whitening effect is obvious, safe and steady, and no toxic and side effects are caused.