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External preparation for skin containing a phosphorlated saccharide

An external preparation for skin, the technology of phosphorylated sugar, which is used in preparations for skin care, skin diseases, cosmetics, etc., and can solve the problems of instability, unsatisfactory effect, weak heat and oxidation.

Active Publication Date: 2008-10-08
EZAKI GLICO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Ascorbic acid, hydroquinone, and kojic acid are very weak and unstable to heat and oxidation, especially in water, whereby there is a problem of, for example, coloring in skin external preparations due to their degradation over time
In addition, their two derivatives, magnesium ascorbyl phosphate and arbutin with β-bonded glucose on the phenolic group of hydroquinone, have improved thermal and oxidative stability, but their effects are still not satisfactory

Method used

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  • External preparation for skin containing a phosphorlated saccharide
  • External preparation for skin containing a phosphorlated saccharide
  • External preparation for skin containing a phosphorlated saccharide

Examples

Experimental program
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Effect test

preparation example Construction

[0254] (5. Preparation method of skin external preparation)

[0255] The skin external preparation according to the present invention can be prepared by a known method.

[0256] (6. How to use external skin preparations)

[0257] The external preparation for skin according to the present invention can be used by a method similar to conventional ones. The external preparation for skin according to the present invention can be applied to the skin at any frequency such as once a day, twice a day, three times a day, etc. The application area of ​​the external preparation for skin according to the present invention is also arbitrary. The application area can be appropriately selected according to the type of the skin external preparation. The skin external preparation according to the present invention can be applied to an arbitrary area of ​​the skin of the body. Examples of areas of application include the face, head, arms, hands, legs and feet.

Embodiment 1

[0263] (Example 1: Moisturizing effect obtained by lotion containing phosphorylated sugar potassium salt)

[0264] A body lotion was prepared containing 0.5% phosphorylated sugar potassium salt, 2.5% glycerin, 1.0% polyethylene oxide sorbitan monolaurate, preservatives, fragrance and purified water. Separately, the same body lotion as a control was also prepared except that it did not contain phosphorylated sugar potassium salt. These lotions were administered to 16 women aged 22-34 for 2 months. After that, observe its effectiveness. None of the women who used the lotion experienced skin problems, such as reddened skin. Additionally, 87.5% of users reported feeling more moisturized with the lotion containing phosphorylated sugar potassium salt.

Embodiment 2

[0265] (Example 2: Moisturizing effect obtained by cream containing phosphorylated sugar potassium salt)

[0266] Prepared by 0.1% phosphorylated sugar potassium salt, 0.2% phosphorylated sugar calcium salt, 2% beeswax, 5.0% stearyl alcohol, 10.0% squalane, 2.5% glyceryl monostearate, 1.0% polyethylene oxide A beauty cream composed of cetyl ether, 5.0% glycerin, 0.2% potassium hydroxide, antioxidants and pure water. The cream was applied to 10 women aged 22-34 for 2 weeks. Afterwards, listen to how they feel. As a result, there were no subjects whose skin problems such as rough skin became worse. In addition, 80% of the subjects felt moisturized.

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PUM

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Abstract

Disclosed is a pharmaceutical preparation for external application to the skin, which comprises a phosphorylated sugar. The phosphorylated sugar may be an inorganic salt of a phosphorylated sugar. The phosphorylated sugar may be in the form of a calcium salt, a magnesium salt, a potassium salt, a zinc salt, an iron salt or a sodium salt. Also disclosed is a pharmaceutical preparation for externalapplication to the skin, which comprises a phosphorylated sugar and a second component. The second component is selected from the group consisting of a moisturizing component, a skin-whitening agent,an UV-absorber, an anti-inflammatory agent, a cell-activating agent and an anti-oxidant. The moisturizing agent may be ascorbic acid or an ascorbic acid derivative.

Description

technical field [0001] The present invention relates to a functional skin external preparation containing phosphorylated sugar. The present invention also relates to an external preparation for skin excellent in skin moisturizing effect, skin firmness and luster improvement effect, cell activation effect or whitening effect. The present invention also relates to an external preparation for skin which is excellent overall from the viewpoints of stability as a preparation, safety, and the like. Background technique [0002] The skin loses its original water retention, shrinkage and flexibility due to the effects of aging, ultraviolet radiation, active oxygen, etc. The decrease in water retention of the skin leads to the formation of wrinkles on the skin, which makes the appearance worse, and also causes dryness and roughness of the skin. Furthermore, improving skin water retention is also very important during the treatment of diseases such as allergies and atopic dermatitis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61Q19/00A61Q5/00
CPCA61Q19/007A61Q17/04A61K8/73A61K8/498A61Q19/10A61Q19/02A61Q19/08A61K8/60A61P17/00A61Q5/00A61Q19/00
Inventor 田中智子釜阪宽杉本和久西村隆久栗木隆
Owner EZAKI GLICO CO LTD
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