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274 results about "Tyrosinase inhibitor" patented technology
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A tyrosinase inhibitor is a substance that inhibits (works. against) tyrosinase. Tyrosinase is a type of enzyme. An. enzyme is a type of protein that helps produce chemical. reactions in the body.
Skin whitening agents
InactiveUS6365137B1Enhance and improve appearanceImprove stabilityCosmetic preparationsHair cosmeticsWhitening AgentsCarboxylic acid
Disclosed are stable compositions which are effective as skin whitening agents, comprising alpha, beta or gamma substituted mono-, di or polyhydroxy or polycarboxy carboxylic acids; mono-, di, tri or polyhydroxy alkyl compound; and effective amounts of an inhibitor of tyrosinase and a pigmentation reversing reagent. Also disclosed are methods of forming stable compositions of the type described above.
Owner:ENGELHARD CORP
Oligopeptide Tyrosinase Inhibitors and Uses Thereof
ActiveUS20090099091A1Promote skin absorptionIncrease peptide bindingCosmetic preparationsPeptide/protein ingredientsMedicinePeptide sequence
Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Peptide sequences disclosed include KFEKKFEK and YRSRKYSSWY.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Series of skin whitening (lightening) compounds
ActiveUS20100016347A1Strong inhibitory activityLow cytotoxicityAntibacterial agentsBiocideMelaninEnzyme inhibitor
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
Owner:UNIGEN
Tyrosinase inhibitor extract
The present invention discloses a tyrosinase inhibitor extract from lemon peels. The tyrosinase inhibitor extract contains a tyrosinase inhibitor content and provides advantageous skin whitening effects.
Owner:KAODER IND
Tyrosinase inhibiting agent
Owner:ANDRE
Polypeptide composition for skin whitening and spot relieving
ActiveCN105362088AInhibitory activityGood effectCosmetic preparationsToilet preparationsMedicineMedical product
The invention provides a polypeptide composition for skin whitening and spot relieving. The polypeptide composition comprises an MC1-R antagonist (namely an alpha-MSH competitive antagonist) and / or a composition of polypeptides inhibiting alpha-MSH expression and / or a tyrosinase inhibitor. The polypeptide composition can reduce the generation of melanin, and contributes to skin brightening, so as to achieve the purposes of relieving color spots (chloasma, butterfly rash, freckle and the like), improving sallow tone and whitening skin. The concentration of each polypeptide is 0.0001-5%. The polypeptide composition provided by the invention can be prepared into various beauty and skin-care products as well as medical products.
Owner:宇肽生物(东莞)有限公司
Macadamia nut green peel extract, cosmetics employing same as active ingredient and preparation method of macadamia nut green peel extract
The invention provides a macadamia nut green peel extract, namely macadamia nut green peel polyphenol or macadamia nut green peel aqueous extract which is prepared with the following method: taking macadamia nut green peel powder, adding warm water for water extraction three times, then adding 5% sulfuric acid, keeping quenching for 24h, and filtrating; washing a filter cake with deionized water to remove residual sulfuric acid until the washing liquid is neutral, and obtaining the macadamia nut green peel polyphenol; or washing macadamia nut green peel original crude drug coarse powder with water, putting into boiling water, boiling for 30min, stopping heating, keeping the water temperature at 60 DEGC-70 DEG C, performing ultrasonic extraction for 1h, centrifuging an aqueous extraction liquid at 2000r / min for 4min to obtain a supernatant liquid, then concentrating the supernatant liquid to thick paste, and obtaining the macadamia nut green peel aqueous extract. The macadamia nut green peel extract is used for preparing toning lotion and toning cream. The invention also provides application of the macadamia nut green peel polyphenol or macadamia nut green peel aqueous extract to preparation of cosmetics, as well as application to preparation of a tyrosinase inhibitor and preparation of an antioxidant.
Owner:JIANGCHENG ZHONGAO AGRI TECH DEV
Whitening liquid crystal composition as well as preparation method and application thereof
ActiveCN108451837AImprove stabilityGood whitening effectCosmetic preparationsToilet preparationsHigh concentrationCrystallography
The invention relates to the field of cosmetics and provides a whitening liquid crystal composition. The whitening liquid crystal composition is prepared from whitening active ingredients and liquid crystal carriers, wherein the whitening active ingredients are prepared from at least two of an active ingredient for promoting exfoliation, a tyrosinase inhibitor, an active ingredient for inhibitingmelanosome migration, an antioxidant active ingredient, an anti-inflammation active ingredient and an anti-glycation active ingredient; the liquid crystal carriers are prepared from the following rawmaterials: a liquid crystal emulsifying agent, a co-emulsifier and an emulsification thickening agent; the whitening liquid crystal composition is also prepared from liquid-state lipide for dissolvingthe whitening active ingredients and the liquid carrier raw materials as well as water. According to the whitening liquid crystal composition, through compounding of different whitening mechanisms and load of the liquid crystal carriers, an obvious synergetic effect is achieved, the stability and the whitening effect of the whitening liquid crystal composition can be obviously improved, and meanwhile, the problem of skin irritation easily caused by the load of the whitening active ingredients with high concentration is solved.
Owner:WUHAN BEST CARRIER NANO TECH
System and methods of melanoma prevention
InactiveUS20110021623A1Melanoma can be preventedAvoid actionCosmetic preparationsBiocideMelanocyteMedicine
Inhibiting the enzymic action of tyrosinase in the melanocyte prior to, during, or after ultraviolet (UV) radiation exposure, including over-exposure causing erythema, or sunburn, prevents the production of melanin and thereby melanoma. Melanoma can be prevented by using a tyrosinase inhibitor agent that inhibits the enzymic action of tyrosinase to prevent damage and / or death of melanocytes. The inhibitor agent can be applied to the skin or ingested.
Owner:RGT UNIVESITY OF NEW MEXICO
Active polypeptide and tyrosinase inhibitor composition for whitening and freckle removal
ActiveCN109157429ASuppress generationBeautiful whitening effectCosmetic preparationsToilet preparationsIn vivoMelanin synthesis
The invention discloses an active polypeptide and tyrosinase inhibitor composition for whitening and freckle removal. The composition comprises polypeptides with a melanogenesis inhibition function and / or polypeptides with a glycosylation resistance function, and other components with a tyrosinase activity inhibition function. The composition is capable of inhibiting melanogenesis, resisting glycosylation, eliminating saccharified dark yellow proteins and eliminating in-vivo free radicals, so as to achieve the aims of improving the skin types, whitening and removing freckles.
Owner:SHENZHEN WINKEY TECH CO LTD
A composition for lightening skin and hair
Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and / or (b2) at least one sun protection factor; and / or (b3) at least one anti-oxidants; and / or (b4) at least one anti-inflammatory agent; and / or (b5) at least one desquamating agent. on condition that compound a is present in an amount of from 0.00001 to 0.001 % b.w. - calculated on the total composition.
Owner:SYMRISE GMBH & CO KG
Application of aquilaria sinensis peel extract in preparation of whitening cosmetics
ActiveCN103405371AInhibits tyrosinase activityCosmetic preparationsToilet preparationsEthyl acetateInhibitory effect
The invention discloses application of an aquilaria sinensis peel extract in preparation of whitening cosmetics. The aquilaria sinensis peel extract is prepared by a method comprising the following steps of: by taking aquilaria sinensis peel as the raw material, extracting the aquilaria sinensis peel through ethyl acetate; and drying an extracting solution to obtain the aquilaria sinensis peel extract. The aquilaria sinensis peel extract has an inhibition effect on tyrosinase and can be used for preparing a tyrosinase inhibitor in order to be applied to the whitening cosmetics.
Owner:GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
Radix gentianae extract and preparation method and application thereof
InactiveCN106137812AEasy to preparePrevent agingCosmetic preparationsToilet preparationsAlcoholActive agent
The invention discloses a radix gentianae extract and a preparation method and application thereof. The preparation method of the radix gentianae extract comprises the following steps that 1, radix gentianae and a solvent are mixed, extracted and filtered, pressure is reduced, the solvent is removed, and the radix gentianae extract is obtained; 2, the radix gentianae extract is dissolved in water, sampled to a resin filling column andeluted through water and an ethanol solution in sequence, eluent is collected, pressure is reduced, ethyl alcohol and water are removed, and the radix gentianae extract is obtained. The preparation method of the radix gentianae extract is simple, and the obtained radix gentianae extract can be applied as tyrosinase inhibitor, elastinase inhibitor, antioxidant active agent and anti-aging active agent, preferentially applied in preparation of skin care products or cosmetics.
Owner:JALA GROUP CORPORATION
Alpha-arbutin co-conveying nanometer composition and preparation method and application thereof
The invention relates to the field of cosmetics and provides an alpha-arbutin co-conveying nanometer composition. The alpha-arbutin co-conveying nanometer composition comprises alpha-arbutin, other skin-whitening active components and a nanometer medicine carrier; the alpha-arbutin accounts for 0.05 to 20.0 percent of the total mass of the co-conveying nanometer composition; other skin-whitening active components comprise at least one of a tyrosinase inhibitor outside the alpha-arbutin, a melanosomal migration inhibitor, an antioxidant, an anti-glycation active substance and an anti-inflammatory agent; the raw materials of the nanometer medicine carrier comprise an emulsifier and a co-emulsifier; and the alpha-arbutin co-conveying nanometer compositionl also comprises grease and water. Remarkable synergistic effect is achieved through compounding of different skin-whitening mechanisms and loading of the nanometer medicine carrier; the melanin content of skin is obviously reduced through multi-target-point effect; and the co-conveying nanometer composition can realize sustained release and controlled release of medicines, has large medicine carrying quantity, high stability, high water solubility, high skin permeability and excellent skin-whitening effect, and can be widely applied to cosmetics.
Owner:WUHAN BEST CARRIER NANO TECH
Natural skin whitener: 4-hydroxy-oxindole-3-acetic acid
InactiveUS20100158842A1Potent anti-irritantPotent anti-oxidantBiocideCosmetic preparationsWhitening AgentsHyperpigmentation disorder
A cosmetic and dermatological composition comprises 2, 3-dihydro-4-hydroxy-2-oxo-1-H-indole-3-acetic acid (4-hydroxy-1-oxindole-3-acetic acid) as an active ingredient for use as a melanin inhibitor and as an anti-tyrosinase enzyme inhibitor. This composition is excellent as a skin whitening agent. Since it also has potent antioxidant and anti-irritant activities it is useful in a cosmetic composition for improving hyperpigmentation disorders of the skin.
Owner:SPECTRUM DYNAMICS LLC
Process for antimicrobial treatment of fresh produce, particularly mushrooms
InactiveUS7048956B2Reduce bacteria countPrevent bacterial growthClimate change adaptationFatty substance preservation using additivesElectrolysisAdditive ingredient
Preservative compositions using toxicologically acceptable ingredients, and employing a pH of 9.0 or above for at least part of the process, for reducing the initial population and controlling the growth of spoilage bacteria and human pathogens and for preventing unwanted color changes in fresh and processed produce, particularly mushrooms. Aqueous solutions of preservatives are prepared and applied in multiple stages to the mushrooms, by spraying or immersion. More specifically, disclosed is a method for preserving fresh and processed mushrooms, comprising the steps of: contacting the mushrooms with an antimicrobial solution having a pH of about 9.0 or above; and rinsing the mushrooms one or more times immediately after the contacting step with pH-neutralizing solutions having a pH sufficient to return the produce to its physiological pH. In a preferred embodiment, electrolyzed basic water is used in the first stage high-pH rinse step and electrolyzed acid water is used in the second stage neutralizing solution step. Tyrosinase inhibitors such as ascorbates, erythorbates, EDTA or calcium chloride are added to the neutralizing solutions to inhibit enzymatic browning.
Owner:PENN STATE RES FOUND
Application of dimethylaminobenzaldehyde thiosemicarbazide in the whitening cosmetics
ActiveCN101040824AInhibition of tyrosinase activityInhibition of activityCosmetic preparationsToilet preparationsAlcoholWhitening Agents
The invention relates to a paradimethy-laminobenzaldehyde thiosemicarbazone as tyrosinase restrainer, in particular to the paradimethy-laminobenzaldehyde thiosemicarbazone applied in beauty cosmetics. The invention uses paradimethy-laminobenzaldehyde thiosemicarbazone with high-effect restrain function on the activity of tyrosinase as whitening agent to prepare beauty cosmetics, and provides a relative beauty cosmetics and a preparation. The invention uses paradimethy-laminobenzaldehyde thiosemicarbazone as whitening agent of de-crease beauty cosmetics solution which contains sea fish collagen peptide, paradimethy-laminobenzaldehyde thiosemicarbazone, alcohol, glycerin, methyl glycol, plant essence, conservative and water, that dissolves sea fish collagen peptide into water to obtain solution A, dissolves conservative and paradimethy-laminobenzaldehyde thiosemicarbazone into alcohol to obtain solution B, adds glycerin and methyl glycol into solution B to obtain solution C, mixes the solutions A and C, and adds water to form solution D, and adds plant essence into the solution D.
Owner:GUANGZHOU TUOLONG BIOTECH DEV
Tyrosinase polypeptide inhibitor
InactiveCN102492018AReduce melanin contentBiocideCosmetic preparationsWhitening AgentsPhosphorylation
The invention relates to a tyrosinase polypeptide inhibitor, which consists of a polypeptide. In the polypeptide, one or more amino acids are further subjected to acetylation, amidation, formylation, hydroxylation, lipolyzation, methylation or phosphorylation modification. The tyrosinase inhibitor provided by the invention can be taken as a medical composition, comprises the polypeptide, and further comprises a pharmaceutically-acceptable supporting agent. The medicinal composition provided by the invention can be used for inhibiting the generation of black pigments under the action of activity inhibition of tyrosinase, and can be widely applied to cosmetics such as a whitening agent.
Owner:萧乃文
Compound having tyrosinase inhibitory activity and synthesis method of compound
InactiveCN104447269AHigh activityImprove quality controlCosmetic preparationsFruit and vegetables preservationDiseaseVitamin C
The invention discloses a compound having a tyrosinase inhibitory activity and a synthesis method of the compound, belonging to the fields of foods, cosmetics and medicines. The synthesis method comprises the following steps: carrying out a reaction between 2,4-dihydroxy benzaldehyde and 2,4-dihydroxy acetophenone under the catalysis of boric acid and vitamin C by taking polyethylene glycol 400 (PEG400) as a solvent for 6h so as to achieve the green synthesis of an efficient tyrosinase inhibiting agent; and carrying out gel column chromatography and high performance liquid chromatography separation so as to prepare a pure product of the efficient tyrosinase inhibiting agent. On the basis of mass spectrum and nuclear magnetism analysis, the substance is determined as 1,3,5-tris-(2,4-dihydroxy-phenyl)-pentane-1,5-dione. The compound disclosed by the invention can be used for effectively inhibiting enzymatic browning of fruits and vegetables, the preparation of whitening cosmetics as well as the preparation of a pharmaceutical preparation for preventing and treating human hyperpigmentation diseases and melanoma caused by excess melanin as well as other requirements to inhibit the activity of the tyrosinase.
Owner:JIANGNAN UNIV
Use of black mulberry extract as tyrosinase inhibitor
InactiveCN101450047AHigh activityReduced activityCosmetic preparationsHydroxy compound active ingredientsFood additiveHypopigmentation
The invention relates to an application for extracting natural compound (I) from black mulberry, the compound (I) has strong inhibition effect for tyrosinase and is applied for preventing skin mottle, freckle, senile plaque or the like skin chromatosis and whitening, and the compound (I) is a food additive. The activity of the compound (I) is strong proved by the mensuration of the inhibition activity, the compound (I) has good stability and obvious growth inhibition action for the melanoma cell, can reduce the activity of the tyrosinase in the melanoma cell and biological synthesis level of the melanin in the cell.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
Series of skin whitening (lightening) compounds
ActiveUS8362305B2Strong inhibitory activityLow cytotoxicityAntibacterial agentsBiocideMelaninEnzyme inhibitor
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
Owner:UNIGEN
Tomato extract as well as preparation method and application thereof
InactiveCN104146899AAvoid formingGood whitening effectCosmetic preparationsToilet preparationsBiotechnologyUltrasonic assisted
The invention discloses a tomato extract as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, cleaning a tomato, crushing and homogenizing to obtain a tomato homogenate liquid; mixing the tomato homogenate liquid and water to obtain a mixed liquid; extracting the mixed liquid by ultrasonic assistance with power of 30-40w for 6-10 minutes; extracting in a water-bath kettle at 45 DEG C for 30-40 minutes after the ultrasonic-assisted extraction; centrifuging on a refrigerated centrifuge at 8000r / min and 4 DEG C for 15 minutes after the extraction is completed so as to obtain supernate; filtering the supernate, controlling the pressure of the filtrate to be 0.08-0.1MPa, and concentrating at reduced pressure and 50-65 DEG C; and controlling the temperature of the concentrated residue to be minus 20-minus 40 DEG C, and freezing and drying to obtain the tomato extract. The extract is capable of inhibiting tyrosinase, can be applied to whitening skin-care products as a tyrosinase inhibitor, is safe and reliable in performance, and does not have side effect. The preparation method is simple, and is convenient to operate.
Owner:SHANGHAI INST OF TECH
Peptide tyrosinase inhibitors and uses thereof
ActiveUS20110293709A1Less irritable to human skinIncrease peptide bindingCosmetic preparationsHair cosmeticsSkin treatmentsMedicine
Disclosed are peptides which inhibit the enzymatic activity of tyrosinase as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Methods of skin treatment are also provided, the methods further including use of a peptide characterized by the amino acid sequence SFLLRN (SEQ ID NO: 1).
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Purpose of substituent phenyl furaldehyde thiosemicarbazone compound as insect tyrosinase inhibitor
The invention provides a new purpose of a substituent phenyl furaldehyde thiosemicarbazone compound (I) as an insect tyrosinase inhibitor to prevent and control cotton bollworms as. A study on the substituent phenyl furaldehyde thiosemicarbazone compound in inhibiting the activity of cotton bollworm tyrosinase proves that the compound has good function of inhibiting insect tyrosinase and can be used for preventing and controlling pests as the insect tyrosinase inhibitor. In the invention, R refers to 2-Br, 4-Br, 3-F, 4-F, 2-C1, 3-C1, 4-C1, 2-NO2, 3-NO2, 4-NO2, 2, 5-C12, 2, 4-F2, 2, 4, 6-Br3, 2, 4-NO2.
Owner:CHINA AGRI UNIV
Formulations of low oil content comprising diphenylmethane derivatives
The present invention relates to specific (cosmetic) formulations for improving the bioavailability and activity of skin- or hair-lightening or senile keratosis-reducing diphenylmethane derivatives (tyrosinase inhibitors) of the following formula (1).
Owner:SYMRISE GMBH & CO KG
Hyroxy-pyridone derivative with multiple biological activities and usage thereof
ActiveCN104529885AHas tyrosinase inhibitory activityAntibacterialAntibacterial agentsCosmetic preparationsMedicinal chemistryDrug biological activity
The invention discloses a hyroxy-pyridone derivative with multiple biological activities. The hyroxy-pyridone derivative has any of the following general molecular formulas (please see the specifications), wherein in the general molecular formula 1, R refers to CH2C6H5 or CH3 or CH(CH3)2 or CH(CH3)CH2CH3 or CHCH2(CH3)2 or CH2CH2SCH3, and R' refers to an alkyl radical or a hydrocarbon oxygroup; in the general molecular formula 2, R and R' refer to CH2C6H5 or CH3 or CH(CH3)2 or CH(CH3)CH2CH3 or CHCH2(CH3)2 or CH2CH2SCH3. The invention further discloses a preparation method of the hyroxy-pyridone derivative. The hyroxy-pyridone derivative can be used as a tyrosinase inhibitor or used for retaining freshness of cosmetics or foods.
Owner:浙江欧托电气有限公司
3-substituted phenyl propionaldehyde thiosemicarbazone compounds, and preparation method and application thereof
InactiveCN102229552AEnhanced inhibitory effectBiocideOrganic chemistryHeliothis armigeraOrganic solvent
The invention discloses 3-substituted phenyl propionaldehyde thiosemicarbazone compounds, and a preparation method and application thereof. The structures of the compounds are shown as a formula I, wherein R is any one of 4-F, 4-Cl, 2-Cl, 2,4-Cl2, 4-OCH3, 2-OCH3, 3-OCH3, 4-OC2H5, 4-NO2, 2-NO2, 4-CH3, 4-isopropyl, 3-Br and 2,4-dimethoxy. The preparation method comprises the following step of performing condensation reaction on substituted phenyl propionaldehyde shown as a formula II with thiosemicarbazide in an organic solvent in the presence of an acidic compound to obtain the 3-substituted phenyl propionaldehyde thiosemicarbazone compounds. The research on inhibition activity of heliothis armigera tyrosinase by the compounds of the formula I proves that the compounds have better inhibition effect on the heliothis armigera tyrosinase and can serve as an insect tyrosinase inhibitor for preventing and controlling pests.
Owner:CHINA AGRI UNIV
Preparation method of Beauveria sp. extract with functions of tyrosinase inhibitor and antioxidant
InactiveCN102329837AHas inhibitory activityHas antioxidant activitySugar derivativesMicroorganism based processesFermentationBiology
Owner:ANHUI AGRICULTURAL UNIVERSITY
Novel tyrosinase inhibitor and use thereof
InactiveCN1827631AInhibits the action of tyrosinaseSuppress generationCosmetic preparationsSugar derivativesHydrogenMedicinal chemistry
The invention relates to a new tyrosinase inhibitor and its usage. The inventive content is that it provides biphenylglycosidicderivatives which can be used in the spheres of medicine and daily-use chemistry as melanin inhibiting agents or brightening agents, speaking in detail, it provides biphenylglycosidicderivatives represented by the above general formula (I), in which R1 stands for hydrogen, hydroxy,oxomethyl or gluconic group, R2 stands for hydrogen, hydroxyl or gluconic group, and R3 and R4 stand for hydrogen or gluconic group; and provides compositions with the said tyrosinase inhibitors. The new tyrosinase inhibitors and the compositions with the new compounds can be used as cosmetics to restrain melanin or brighten, medicines, externally used skin-care agent and so on.
Owner:JINAN UNIVERSITY
Uses of 2-hydroxy-N-(4-hydroxyphenyl)-benzamide compounds in preparation of tyrosinase inhibitors
InactiveCN105693546AImprove securityStrong inhibitory activityOrganic active ingredientsCosmetic preparationsDiseaseMelanin
Uses of 2-hydroxy-N-(4-hydroxyphenyl)-benzamide compounds in preparation of tyrosinase inhibitors are disclosed. The uses include aspects of (a) preparing the tyrosinase inhibitors or compositions inhibiting tyrosinase, (b) preparing compositions inhibiting melanogenesis and (c) preparing compositions for preventing or treating pigmentary dermatoses. Test results prove that the 2-hydroxy-N-(4-hydroxyphenyl)-benzamide can inhibit activity of intracellular tyrosinase of B16 cells at the cellular level, thus effectively reducing the amount of melanin synthesized by the B16 cells, and therefore the 2-hydroxy-N-(4-hydroxyphenyl)-benzamide compounds can be used for preventing food brownness degeneration, preparing medicines treating hyperpigmentation skin diseases and preparing whitening cosmetics.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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