210results about How to "Inhibits tyrosinase activity" patented technology

The invention relates to a tranexamic acid skin externally applied nano-preparation, as well as a preparation method and a use thereof. The nano-preparation is prepared from tranexamic acid, medicated oil, an emulsifier, pharmaceutical additives, a thickener and pure water. The tranexamic acid skin externally applied nano-preparation provided by the invention has good physiological skin compatibility and can effectively promote the percutaneous absorption of tranexamic acid, improve the effect of preventing or treating pigmentation of the tranexamic acid and avoid toxicity and side effects, which are caused by systemic administration of the tranexamic acid.

The invention discloses an additive-free natural whitening cosmetic which mainly contains an emulsifying agent, oil, an antioxidant, deionized water, a humectant, a penetration enhancer, a thickener, inositol, vitamin B3, a rice bran extract and rice bran leavening. The additive-free natural whitening cosmetic completely has no addition of chemical components, such as preservatives, artificial color, flavours and fragrances or mineral oil which have adverse influence on skin; 95 percent of the used raw materials are extracted from the natural world; and the used raw materials with a whitening function are extracted from rice and is safety and nonirritant, therefore the natural additive-free natural whitening cosmetic is obtained. Further, the preparation method can be used for preparing the cosmetic which has a skin whitening function or keeps the skin at a favorable state. The preparation method of the additive-free natural whitening cosmetic is simple and easy to operation.

The invention relates to a composition with the efficacies of whitening, moisturizing, repairing and caring the skin, as well as a preparation method and applications of the composition. The skin care composition is prepared from the following raw materials: water, sodium hyaluronate, sodium dihydrogen phosphate dihydrate, potassium chloride, sodium hydroxide, calcium chloride, glutamine, benzalkonium chloride, magnesium sulfate, aminobutyric acid, sodium ascorbate, alanine, arginine, lysine hydrochloride, valine, histidine, leucine, taurine, coenzyme A, alcohol, polysorbate 80, thiamine, disodium diphosphate, recombinant human epidermal cell growth factors and the like. The skin care composition disclosed by the invention can permeate the muscle bottom for replenishing water for the skin from the deep layer, so that the skin is full of elasticity, the color of the skin is brightened, the fine wrinkles are reduced, the skin is clean and watery, the balance of water and oil is regulated, the pores are shrunk, meanwhile, the brightness of the face can be increased, the injured epidermal layer is effectively repaired, the activity of tyrosinase is inhibited, the generation of skin melanin is reduced, so that the skin is healthy, natural and white.

The present invention relates to a novel benzoic acid amide derivative compound, isomers thereof, pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates thereof, or solvates thereof. The novel compound has excellent skin whitening effects.

The invention relates to an anoectochilus roxburghii flavone extraction process and application thereof in skin care products. The extraction process comprises the following steps of S1, conducting pulping, freeze drying and smashing on the anoectochilus roxburghii in sequence, and conducting extraction on the smashed anoectochilus roxburghii powder to obtain an anoectochilus roxburghii flavone crude extract liquid; S2, filtering the crude extract liquid obtained in the S1, reducing pressure and concentrating to obtain an anoectochilus roxburghii flavone crude extract; S3, conducting purification on the anoectochilus roxburghii flavone crude extract by adopting a Sephadex LH-20 gel column, so that an anoectochilus roxburghii flavone extract is obtained, wherein technological conditions in the S1 for freeze drying is a freezing temperature of 70-80 DEG C, freezing time of 40-60 hours and vacuum pressure of 15-25Pa. The provided extraction technology has high an extraction rate, and the anoectochilus roxburghii flavone extract obtained by extraction has high content of effective constituents, less impurities, and good antioxidant activity and tyrosinase activity inhibition.

The invention discloses a skin whitening composition. The skin whitening composition consists of the following components in percent by mass: 1%-20% of nicotinamide, 1%-5% of arbutin, 1%-10% of carnitine, 0.1%-1% of angelica root extract, 0.1%-1% of mulberry bark extract, 0.1%-1% of peony root extract, 0.1%-1% of bletilla striata root extract, 0.01%-0.5% of poria cocos root extract, 0.01%-0.5% of white atractylodes rhizome root extract, 0.01%-0.5% of pearl extract, 10%-50% of glycerol and the balance of water. The invention further provides an application of the skin whitening composition in cosmetics. The skin whitening composition disclosed by the invention respectively acts from a plurality of directions from formation of melanin to transfer of melanin, to decomposition and removal of melanin, and the like, so that a synergetic skin-whitening effect is achieved, and therefore, the skin whitening composition has excellent skin-whitening and skin-tendering effects, can moisturize and nourish the skin, and has an anti-wrinkle effect after long-term use.

The invention discloses application of an aquilaria sinensis peel extract in preparation of whitening cosmetics. The aquilaria sinensis peel extract is prepared by a method comprising the following steps of: by taking aquilaria sinensis peel as the raw material, extracting the aquilaria sinensis peel through ethyl acetate; and drying an extracting solution to obtain the aquilaria sinensis peel extract. The aquilaria sinensis peel extract has an inhibition effect on tyrosinase and can be used for preparing a tyrosinase inhibitor in order to be applied to the whitening cosmetics.

The invention discloses a medicinal composition with an effect of removing chloasma. An oral preparation is prepared from the following active ingredients in percentage by weight: 10 to 50 percent of red-rooted salvia root extract, 10 to 40 percent of dangshen extract, 5 to 30 percent of rose extract, 5 to 30 percent of angelica dahurica extract, 3 to 25 percent of grape seed extract, 5 to 25 percent of vitamin C and 3 to 20 percent of vitamin E. The medicinal composition can effectively scavenge free radicals and restrain tyrosinase activity, thereby restraining the generation of melanin, achieving the effects of improving facial microcirculation, reinforcing facial nutrition and removing color sports and fulfilling the aim of removing chloasma; and the medicinal composition is good in curative effect, quick in response, low in price and free from toxic or side effect.

The invention discloses a freckle expelling facial mask which is prepared by soaking facial mask paper into liquid prepared from the following raw materials in parts by weight: 0.1-3 parts of micromolecular hyaluronic acid, 0.1-2.5 parts of macromolecular hyaluronic acid, 0.7-30 parts of synthesized egg white powder, 1-7 parts of an aloe extract, 0.7-9 parts of propylene glycol, 5-50 parts of 1,2-butanediol, 5-30 parts of glycerol, 20-80 parts of a ginseng extract, 20-50 parts of a bletilla striata extract, 10-50 parts of a leonurus extract, 30-50 parts of a white mulberry extract, 50-100 parts of a coix seed extract, and the balance of water which is added till being 1000 parts, wherein the aloe extract is powder or granules, and the water can be deionized water, distilled water or purified water. The freckle expelling facial mask disclosed by the invention has the effects of removing superoxide free radicals, activating glutathione reductase, suppressing activity of tyrosinase in skin melanocyte, remedying damaged skin and the like, has the functions of expelling freckles and preventing black spot regeneration, is free of irritation on skin, and is applicable to all skin types.

The invention provides a sunscreen lotion, which comprises: 3.5wt% of tetraethyl orthosilicate TEOS; 3wt% of ethanol absolute; 1wt% of glacial acetic acid; 6wt% of butyl titanate; 20-25wt% of nano-TiO2; 25-35wt% of micron-SiO2; and the balance deionized water. The sunscreen lotion is a titanium dioxide wrapped silicon dioxide composite particle. The invention also provides a SiO2 / TiO2 composite particle and a preparation method of modified SiO2 / TiO2 particle. The invention also provides a sunscreen cream containing the sunscreen lotion. The sunscreen lotion and the sunscreen cream provided by the invention have high ultraviolet absorption ability, good application effect, and anti-aging and whitening effect, and are easy to prepare.

The invention discloses an active composition, and a preparation method and an application thereof in cosmetics or skin care products; the preparation method of the active composition comprises the following steps: respectively mixing 50-60 parts by mass of sugar maple sap, 10-30 parts by mass of white birch sap and 10-20 parts by mass of coconut water to form a mixed solution, and then carrying out enzyme inactivation, clarification, refining, concentration and stabilization of the mixed solution successively to form the active composition. The active composition prepared by the preparation method can effectively inhibit tyrosinase activity, eliminates free radicals, and has good antioxidation effect; and the active composition is applied in preparing the cosmetics or skin care products, and the obtained cosmetics or skin care products have lasting antioxidation and whitening efficacies in addition to having a natural and fresh plant smell.

The invention discloses caffeoyl hydroquinone ester, a preparation method of caffeoyl hydroquinone ester and application of caffeoyl hydroquinone ester in preparation of a tyrosinase inhibitor. According to the preparation method, a strong tyrosinase inhibitor compound (p-hydroxyphenyl caffeate) is extracted and separated from sphagneticola trilobata; the plant raw material source is rich; the preparation method is high in economical benefit, and environmentally friendly; the pharmacology experiment shows that the compound p-hydroxyphenyl caffeate has the tyrosinase inhibiting activity superior to that of kojic acid and is expected to be further developed to be a novel synergist of whitening cosmetics, a medicine for treating chromatodermatosis, an insect control agent and even a food preservative, and has good prospect.

The present invention relates to a composition for the skin whitening and wrinkle improvement, comprising an extract of Vaccinium uliginosum as an active ingredient. The Vaccinium uliginosum extract has the effects of inhibiting and scavenging reactive oxygen species produced in skin tissue as a result of ultraviolet irradiation to the skin, effectively inhibiting tyrosinase activity to inhibit the production of melanin in melanin cells, inhibiting the secretion of cytokines in keratinocytes, promoting the production of procollagen, and inhibiting the decomposition of collagen. Thus, the extract will be useful for the prevention of skin photo aging caused by ultraviolet radiation, the enhancement of skin whitening and the improvement of wrinkles. In addition, the Vaccinium uliginosum extract is suitable to use as a component for improving skin wrinkles in cosmetics, foods and drugs, because the Vaccinium uliginosum extract can achieve the effect of improving skin conditions, even when it is applied to the skin or used internally.

The invention discloses a natural plant composition with a skin whitening effect and application thereof to cosmetics. The natural plant composition is prepared from, by mass, 0.01-20% of white mulberry root bark extract, 0.01-20% of rhizoma atractylodis extract, 0.01-20% of radix paeoniae alba extract, 0.01-20% of ginger root extract, 0.01-20% of Chinese yam extract and the balance water. According to the plant composition, efficient tyrosinase inhibiting activity of the white mulberry root bark extract, the rhizoma atractylodis extract and the radix paeoniae alba extract, excellent oxidation resistance and free radical scavenging activity of the ginger root extract and excellent moisture retention performance of the Chinese yam extract are combined organically, formation of melanin of the skin base layer is effectively reduced, the skin can be fairer, clearer and brighter, and the effect of whitening the base is achieved.

A ferment extract from a bacterial strain the Eupenicillium crustaceum species useful in the cosmetic treatment and / or care of the skin, mucous membranes, hair and / or nails and cosmetic uses of same.

The invention belongs to the technical field of cosmetics and discloses water-emerging moisturizing tone-up cream and a preparation method thereof. The water-emerging moisturizing tone-up cream is prepared by the following materials in percentage by weight: 3%-7% of emulsifying agent, 1%-5% of thickening elastomer, 0.5%-3.5% of silicone oil, 5%-10% of grease, 5%-8% of titanium dioxide powder, 1%-5% of oil-phased thickening agent, 15%-25% of moisturizing agent, 0.9%-1.5% of PH regulating agent, 0.1%-0.8% of preservative, 1%-3% of active ingredient and the balance of deionized water. The water-emerging moisturizing tone-up cream has the effects that the mouthfeel is good, the fresh and nourishing effects are achieved, the ductility is good, the natural spot-covering and whitening effects are achieved, and when the water-emerging moisturizing tone-up cream is applied, the silky and smooth effects and the water-emerging and nourishing effects are achieved. When in application, the water-emerging moisturizing tone-up cream has the natural whitening effect and water-emerging skin feel, and also can realize internal whitening and moisturizing effects.

The invention discloses a Tibetan medicine composition with whitening and freckle removing functions and application and a preparation method of the Tibetan medicine composition. Aiming at the defects that in the prior art a whitening and freckle removing product which takes Tibetan medicine materials as raw materials is high in price, the invention provides the Tibetan medicine composition with the whitening and freckle removing functions. The Tibetan medicine composition comprises the following raw material components: 2-4 parts of chishuluodi, 1-3 parts of iris ensata thumb, 1-3 parts of western Sichuan synotis wallichii, 1-3 parts of Chinese parsley fruit and 1-3 parts of swertia multicaulis. The composition is a Tibetan medicine composition which is prepared from components in appreciate ratio. The chemical analysis experiment and the human body testing show that the Tibetan medicine composition has the whitening and freckle removing functions. The Tibetan medicine composition can be used for preparing whitening and freckle removing products, and can be used for preparing whitening and freckle removing medicines and / or healthcare products. The invention further provides a preparation method of the Tibetan medicine composition.

The invention relates to a plant moisturizing toner for people staying up all night and a preparation method thereof. The plant moisturizing toner comprises water, butanediol, diglycerin, sodium hyaluronate, sodium polyacrylate, xanthan gum, tremella polysaccharide, tremella extract, vitamin C magnesium phosphate, saussurea involucrata extract, edelweiss extract, reed extract, licorice root extract, angelica root extract, salvia miltiorrhiza extract, dogwood fruit extract, boxthorn root extract, p-hydroxyacetophenone and 1,2-hexanediol. The preparation method includes the steps of mixing and heating the sodium polyacrylate, the xanthan gum, the water, the butanediol, the diglycerin, the sodium hyaluronate and the p-hydroxyacetophenone; adding the tremella polysaccharides, the tremella extract, the vitamin C magnesium phosphate, the saussurea involucrata extract, the edelweiss extract, the reed extract, the licorice root extract, the angelica root extract, the salvia miltiorrhiza extract, the dogwood fruit extract, the boxthorn root extract and the 1,2-hexanediol after cooling down, and performing stirring; performing cooling and discharging. The plant moisturizing toner has a goodskin nourishing effect.

The invention discloses hair-strengthening nutrient solution containing an alpine plant extract. The nutrient solution comprises a component A, a component B and a component C. The component A is prepared from, by weight, 60-100 parts of deionized water and 0.01-0.05 part of a chelating agent. The component B is prepared from, by weight, 0.1-0.5 part of a pH regulating agent, 1-5 parts of a cacumen platycladi extract liquid, 0.5-1.5 parts of panthenol, 1-5 parts of a compound plant pilatory, 0.5-1 part of pyridoxine HCl, 0.1-1 part of nicotinamide, 0.01-0.2 part of the alpine plant extract, 0.01-2 parts of a ginger root extract, 0.4-1 part of a plant allergy-alleviating component, 0.01-0.5 part of a asiaticoside compound component, 0.01-2 parts of a moisturizing component and 0.0001-0.001part of a radix polygoni multiflori extract. The component C comprises, by weight, 2-3 parts of an antibacterial component. The hair-strengthening nutrient solution comprises traditional herbal medicine components for preventing hair loss and strengthening hair and is capable of replenishing hair root energy, timely repairing with the nutritional components and reducing scalp grease to make hair thick, black and high in strength.

The invention relates to the field of medicine, in particular to a composition and application thereof to the preparation of a product for improving chloasma. The composition provided by the invention comprises a Chinese angelica extract, a stem cell extract A and a stem cell extract B. Experiments show that the composition provided by the invention can reduce the relative activity of tyrosinase to be 89.8% and reduce the relative content of melanin in cells to be 82.8%, so that the composition provided by the invention can effectively inhibit the activity of the tyrosinase and reduce the melanin content of the cells. The effects are obviously more excellent than those of a control group which gives the Chinese angelica extract singly or gives the stem cell extract singly. In addition, the composition provided by the invention is used for improving the chloasma, the effective rate can reach 95% and the remission rate can reach 70%.

The invention provides applications of a biological active peptide with melanin synthesis inhibition activity in skin whitening, and belongs to the technical field of biological medicine and comestic.The amino acid sequence of the biological active peptide is represented by formula I: X1-(Gly-L-Gys)n-X2-X3 (I), wherein X1 is used for representing nothing or L-Phe, X2 is used for representing nothing or Gly, X3 is used for representing nothing or L-Phe, X1 and X3 are not used for representing nothing at the same time, and n is equal to or smaller than 8. The biological active peptide is capable of penetrating epidermis, entering corium layer, penetrating cell membrane, and entering cells, and is hydrolyzed into corresponding glycine and cysteine under the effect of hydrolase in cells, so that tyrosinase is inhibited, synthesis of melanin is inhibited, and effective skin whitening is achieved. The biological active peptide can be used for preparing a plurality of preparations used for preventing and treating human body chromatosis diseases and melanoma caused by excess melanin, and other preparations used for inhibiting the activity of tyrosinase.

The invention provides a low molecular weight fucoidan and application thereof in preparing cosmetics. Flavobacterium with preservation number of CGMCC NO. 14855 is utilized to produce fucoidan degrading enzyme after fermenting, and the fucoidan degrading enzyme is further utilized to degrade the fucoidin to obtain the low molecular weight fucoidan. The experimental results show that the low molecular weight fucoidan can significantly inhibit tyrosinase activity and has significant antioxidant activity. The low molecular weight fucoidan provided by the invention has the potential to be prepared into whitening and anti-aging cosmetics; and raw materials are derived from kelp, which is a pure natural extract, safe and non-irritating, and has good market application prospects.

The invention provides a preparation method of asiatic pennywort herb fermented raw stock, wherein the preparation method comprises the steps: mixing asiatic pennywort herb powder, water and a zymocyte solution to obtain an initial system, fermenting to obtain a fermentation solution, sterilizing the obtained fermentation solution, centrifuging to obtain supernatant, and thus obtaining the asiaticpennywort herb fermented raw stock. According to the adopted fermentation method, no organic reagent is added in the process of extracting effective components of asiatic pennywort herb, the fermentation temperature and the fermentation pH are mild, the structures of the plant active components are not damaged, and the natural activity of plants is maintained.

The invention discloses vibration massage eye cream containing a ganoderma lucidum fermentation filtrate. The vibration massage eye cream is prepared from the components in parts by weight: a component A: deionized water, a thickener, a humectant, a preservative and sodium hyaluronate, a component B: an emollient, jojoba seed oil, wheat germ oil, an emulsifier, tocopherol acetate, ascorbyl tetraisopalmitate and tocopherol, a component C: a alpine vegetation extract, a centella asiatica extract, the ganoderma lucidum fermentation filtrate, ubiquinone, a pHconditioning agent and the deionized water, and a component D: pullulan, a wild soy protein, essential oil and acetyl tetrapeptide-5. According to the vibration massage eye cream, traditional Chinese medicine herbs and high-end scientificand technological ingredients are combined, the vibration massage eye cream is rich in Chinese ganoderma lucidum fermentation filtrate and other plant active substances and other functional ingredients, dark circles under eyes are reduced, skin elasticity is improved, synthesis of collagen is promoted, vitality of eye cells is improved, and thus skin around the eyes looks more elastic and youthful.

The invention discloses whitening emulsion containing magnolia-biondii extract. The whitening emulsion is prepared from A components, B components and C components. A preparing method of the emulsionincludes the steps that 1) the A components with the formula quantity are weighed, put into a water phase pot, stirred, heated to 80 DEG C to 85 DEG C and completely dissolved ready for use; 2) the Bcomponents with the formula quantity are weighed, put into an oil phase pot, stirred, heated to 65 DEG C to 75 DEG C and completely dissolved ready for use; 3) the water-phase materials obtained in the step 1) are sucked into an emulsifying kettle and stirred, the temperature is reduced to 70 DEG C, the oil-phase materials obtained in the step 2) are sucked into the emulsifying kettle and homogenized for 1 min to 5 min and continue to be stirred, and the temperature is reduced; 4) when the temperature is reduced to 45 DEG C, the C components are added, and the mixture is stirred to be even; 5)when the temperature is reduced to 40 DEG C or below, materials are filtered out. The whitening emulsion can meet the requirements of persons for natural, skin whitening and healthy skin care products, and meanwhile the invention provides the preparing method of the whitening emulsion.

The invention discloses traditional Chinese medicine composition extract having effects of whitening and its use in cosmetics. The traditional Chinese medicine composition extract comprises 10-50 parts of ginseng, 10-50 parts of licorice root, 10-40 parts of Chinese angelica, 5-30 parts of scutellaria baicalensis and 1-10 parts of safflower. A preparation method of the traditional Chinese medicine composition extract comprises the following steps of crushing the above traditional Chinese medicines, adding an extraction solvent into the crushed traditional Chinese medicines, carrying out heating extraction at a temperature of 50-80 DEG C 1-3 times, for 0.5-2h every time, carrying out filtration, merging the filtrate, carrying out reduced pressure concentration at a temperature of 60 DEG C, carrying out purification by a D101-type or AB-8-type macroporous resin column, collecting 40-70% of an alcohol elution part, carrying out reduced pressure concentration at a temperature of 60 DEG C until a ratio of the traditional Chinese medicine soup to the traditional Chinese medicines is in a range of 1: 2-1: 10, adding 10-60% of butanediol into the concentration product for dissolution, and carrying out filtration to obtain traditional Chinese medicine active component extract. The traditional Chinese medicine composition extract has effects of health care and whitening, can be used in skin care cosmetics and realizes skin care and whitening.

The invention relates to a Podocarpus revocation and it's making method. It uses the organic solution and the gel chromatography method to draw up the leaf of the Podocarpus to obtain the Podocarpus revocation, wherein the Podocarpus revocation is at least one bis-flavonoid. The Podocarpus revocation has the effect of anti-skin aging.

The invention mainly relates to a cosmetic additive and a preparation method thereof, in particular to a macula removing and whitening cosmetic additive and the preparation method thereof. The macula removing and whitening cosmetic additive is made from raw materials of the following percentage contents: 35 to 40 percent of extracting solution of rhododendron thymifolium maxim, 35 to 40 percent of extracting solution of rhododendron and 20 to 30 percent of extracting solution of safflower. The adding content of the additive in cosmetic is 5 to 10 percent. The preparation method of the azalea red macula removing and whitening cosmetic additive comprises the steps that: 35 to 40 percent of extracting solution of rhododendron thymifolium maxim, 35 to 40 percent of extracting solution of rhododendron and 20 to 30 percent of extracting solution of safflower are matched, 8 to 10 times of water are added to carry out boiling for 1.5 to 2 hours, the mixture is put stilly and filtered; residue is added with 8 to 10 times of water again and boiled for 1 hour; the extracting solution of two times are mixed to prepare stock solution, which is decolorized and concentrated until the original material contained is 1g / ml and put at the temperature of minus 10 DEG C to 0 DEG C for storage. The additive has the advantages of effectively inhibiting the formation of melanin, being capable of maintaining and cleaning skin, long guarantee period and being a safe, highly efficient and nontoxic macula removing and whitening agent.