The invention discloses hand joint disease treatment ointment and a preparation method thereof and belongs to traditional Chinese medicines and preparation technologies. The ointment is composed of main components and auxiliary components, the main components comprise asarum, Tougucao, Chuanwu, Cheqianzi, notopterygium, Atractylodes, coix seed, Shenjincao, Baishao, tuyuan, Mahuang, chuanxiong, safflower, Nerium indicum, guava leaf, Torreya grandis, strange willow, gallnut, Tianjihuang, acanthopanax senticosus, yindijiao, Capparis, Betula platyphylla, Hongfen, Myrtle, Podocarpus arvensis, pingdingmu.. the auxiliary material component is alum indanthrene; main material mixed powder obtained after main material processing and auxiliary material processing and auxiliary material powder are mixed and processed in a reaction kettle to obtain a pasty medicine finished product. The ointment is a medicine for external use, is used for relieving and treating swelling and pain of hand joints andmorning stiffness, has the characteristics of good treatment effect, small toxic and side effects, simplicity and convenience in use and simple preparation method, and particularly can meet and adaptto patients with gastrointestinal discomfort, weak physique and unsuitability for oral medicines.