The invention relates to a traditional Chinese medicine composition for treating infertility caused by premature ovarian failure. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 25-35 parts of human placenta, 25-35 parts of amethyst, 10-20 parts of prepared rehmannia root, 10-20 parts of radix paeoniae alba, 7-12 parts of bighead atractylodes rhizome, 14-16 parts of semen cuscutae, 14-16 parts of morinda officinalis, 14-16 parts of cistanche, 14-16 parts of herba epimedii, 8-10 parts of rhizoma curculiginis and 5-7 parts of honey-fried licorice root. The invention further provides application of the traditional Chinese medicine composition. According to the traditional Chinese medicine composition, the reproductive function of infertility patients caused by premature ovarian failure is improved, the total pregnancy rate of a traditional Chinese medicine group is increased compared with that of a DHEA group, and the transplantation success rate is obviously increased. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is mild in medicine flavor, warm and tonify, both essence and blood are taken into consideration, kidney yang is warmly tonified without losing dryness, the kidney is nourished, the spleen is not cold, cool and greasy, the primary and secondary effects are clear, the compatibility is rigorous, simple and essential effects are achieved, and the effects of warmly tonify kidney yang, tonify spleen, supplement qi, regulate brewing and recuperating eggs are jointly achieved.