52results about How to "Improve the success rate of transplantation" patented technology

The invention discloses a double-layer artificial skin and a preparation method thereof, wherein, cell-free membranous biological derivative material is used as a surface layer, and a fibroblast, extracellular matrix synthesized and secreted by the fibroblast and a cell growth factor are compounded in the interior of biological support material to form a dermis, and then the surface layer and thedermis are combined to form the double-layer artificial skin; a compact surface layer structure can effectively reduce the loss of water, electrolytes and protein from surface of wound, avoid the invading and the reproduction of bacteria to the impaired surface of wound as well as the infection of the surface of wound, and be beneficial to epitheliosis and epithelial growth; the dermis can directly repair the surface of wound, promote the ingrowth of cells around the surface of wound and the angiogenesis, induce the differentiation from stem cells to skin cells and quicken wound healing; the artificial skin has the advantages of being capable of promoting the regeneration of skin, improving the elasticity, the flexibility and the mechanical abrasion resistance of skin after the surface ofwound is healed, reducing excess scar tissues, controlling the contracture, having excellent biocompatibility, increasing the success rate of transplant and improving the quality of healing; the double-layer artificial skin has wide material resources and simple production method, and is applicable to the clinical treatment of skin defect caused by inflammation, ulcer, thermal burns, iatrogenicity and the like.

The invention discloses a seaweed plant transplanting device and a transplanting method, which relate to the technical field of ecological engineering and mainly include a seedling storage mechanism, an insertion mechanism, a walking frame and a driving mechanism. The invention not only realizes the mechanized transplantation of seaweed plants, but also the row spacing, plant spacing, and insertion depth of the plants can be adjusted and controlled, and the efficiency can reach 2000 transplanting units / person / day, and the transplanting efficiency has been greatly improved compared with manual transplantation. The efficiency of manual transplantation is increased by 233%, which is significantly higher than that of other current seagrass transplanting machines; in addition, the invention realizes the miniaturization of the seaweed transplantation device, light weight, simple operation, high success rate of transplantation, and a single person can complete the whole eelgrass Transplanting work; the transplanting method of the present invention has little damage to the natural grass bed, and only gathers vegetative branches with rhizomes to form a transplant unit through binding. Environment friendly.

The invention provides a self-help hematopoietic stem cell matching method and device. The self-help hematopoietic stem cell matching method includes that when an initiating terminal initiates a request to a self-help response module, the self-help response module automatically analyzes number of the terminal; the self-help response module feeds back to the initiating terminal to require the initiating terminal to provide request information needed for matching; the self-help response module feeds matching operation information back to the initiating terminal. By the self-help hematopoietic stem cell matching method and device, a patient is enabled to perform hematopoietic stem cell matching retrieval timely at all times and places, updated matching can be timely sent to a mobile terminal of the patient after data are updated, convenience is brought to clinic treatment, and survival probability of the patient is increased.

The invention discloses a dipyridamole-loaded polyurethane anticoagulative material and a preparation process thereof. The material adopts a core-shell structure, the inner layer is a dipyridamole loaded layer, and the outer layer is a polyurethane main body layer. When the material is used as an artificial blood vessel to be transplanted, the dipyridamole can be slowly released in a long term, adhesion, aggregation and activation of platelets on the surface of the artificial blood vessel are inhibited, the blood compatibility of the artificial blood vessel is improved, the acute thrombosis and intima proliferation can be effectively avoided, and the transplanting success rate of the artificial blood vessel can be effectively improved.

A sealed shell-protected anal sphincter prosthesis in the technical field of medical devices, comprising: a coil box, a prosthesis clamping mechanism provided with an upper fixing ring, an arc-shaped swing leg and a lower fixing ring in sequence from top to bottom in the axial direction; The left sealing shell and the right sealing shell covering both sides of the prosthesis clamping mechanism, wherein: the left sealing shell and the right sealing shell are fixedly connected, and the prosthesis clamping mechanism is axially encapsulated with a driving device outside the ring structure, and the arc The shaped swing leg is connected with the driving device, and the bottom of the driving device is provided with a wire passing barrel, and the wire passing barrel passes through the right sealing shell and is sealed and connected with the coil box through a silicone tube. The present invention greatly reduces the contact area with biological tissues by installing a sealed shell on the outside of the clamping mechanism, improves the smoothness of the outer surface of the mechanism, thereby avoiding mechanism failures caused by tissue rejection hyperplasia and adhesion after the mechanism is implanted.

The invention provides a bionic double-layer dressing, which comprises a decellularized animal small intestinal submucosa and a gel layer cross-linked on the film layer, and the film layer and the gel layer together form a bionic double-layer dressing with a double-layer structure; The preparation steps include preparation of decellularized small intestinal submucosa, preparation of decellularized small intestinal submucosa powder, preparation of decellularized small intestinal submucosa solution and preparation of bionic double-layer dressing. To the surface of the submucosa of the decellularized small intestine, the bionic double-layer dressing was obtained after freezing and cross-linking. The bionic double-layer dressing prepared by the invention not only has excellent tensile properties, but also has a semi-permeable barrier, which can prevent water evaporation and bacterial penetration. At the same time, the bionic double-layer dressing prepared by the invention is beneficial to the healing of the wound, can significantly increase the healing speed of the wound, and the wound healing rate is obviously accelerated on the 3rd day and the 7th day after the operation.

The invention discloses 2,7-substituted 3H-imidazole[4,5-b]pyridine compounds shown as the structural formula I, or pharmaceutically acceptable salt, ester and precursors, and / or hydrate and medicinal compositions thereof, and a preparation method for the compounds. The compounds, or pharmaceutically acceptable salt, ester and precursors, and / or hydrate and medicinal compositions thereof can serve as antagonists of CR4 and are used for treating or preventing CXCR4 receptor activation related diseases.

The invention belongs to the field of histocytology and tissue engineering and discloses a tissue-engineered epidermis with hypodermal cells and a preparation method thereof. The method for preparing the tissue-engineered epidermis with hypodermal cells comprises the following steps: obtaining epidermis cells; inoculating the obtained epidermis cells, culturing the cells until the density is 80-100 percent by using an epidermis culture medium, replacing the medium into a mixed culture medium, culturing for 16-24 hours, and collecting the epidermis cell layer, thereby obtaining the tissue-engineered epidermis piece; transferring the obtained tissue-engineered epidermis onto a semi-permeable polymer or a silicone mold substrate or a petrolatum gauze, thereby obtaining a film with the epidermis cell layer; and culturing the hypodermal cells, paving the obtained hypodermal cells on the epidermis cell layer with the film of the epidermis cell layer, and culturing for 1-2 hours, thereby obtaining the product. The preparation method provided by the invention is easy to operate and short in period, the tissue-engineered epidermis can be mutually stimulated and induced with receptor skin tissues, and formation of a complete epidermal structure of the receptor is promoted.