Preparation process of dipyridamole-loaded polyurethane anticoagulant material

A technology for the preparation of pyridamole polyurethane, which is applied in the field of dipyridamole-loaded polyurethane anticoagulant materials and its preparation technology, can solve the problems of limited electrospinning process and complex technical parameters of coaxial electrospinning, and achieve Improve the success rate of transplantation, avoid acute thrombosis and intimal hyperplasia, and have good uniformity

Inactive Publication Date: 2016-08-24
胡作军 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in fact, the technical parameters of coaxial electrospinning are far more complicated than ordinary electrospinning. It is necessary to repeatedly adjust the internal and external fluid solution formula and adjust the electrospinning parameters to obtain a stable electrospinning process and flawless products.
[0006] At present, artificial blood vessels have been prepared by electrospinning technology, but these artificial blood vessels are often only composed of polyurethane, limited by the characteristics of the electrospinning process, in the prior art, there is no good process that can Preparation of artificial blood vessels with core-shell structure and loaded with antiplatelet agents

Method used

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  • Preparation process of dipyridamole-loaded polyurethane anticoagulant material
  • Preparation process of dipyridamole-loaded polyurethane anticoagulant material
  • Preparation process of dipyridamole-loaded polyurethane anticoagulant material

Examples

Experimental program
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Effect test

Embodiment 1

[0039] 1) Prepare the external fluid: dissolve 1.5g of polyurethane in 10ml of a mixed solution of tetrahydrofuran and N,N-dimethylformamide with a volume ratio of 5:5, and stir overnight;

[0040] 2) Prepare internal fluid: dissolve 30mg dipyridamole and 1.1g polycaprolactone (molecular weight 8000-10000) in 4.4g chloroform, and shake for 10 minutes;

[0041] 3) Coaxial electrospinning: inner fluid flow rate: 0.1ml / h, outer fluid flow rate: 0.7ml / h; coaxial spinning nozzle outer tube diameter 1.54mm, inner tube diameter 0.51mm; voltage: 15 ~ 20KV, ground The thread is added to the blood vessel mold, the distance between the coaxial spinning nozzle and the blood vessel mold is kept at 20 cm, and the speed of the blood vessel mold is 100 rpm; the temperature in the electrospinning box is kept at 40 ° C, and the humidity is 30% to 40%. Electrospinning time is 2 to 3 hours;

[0042] 4) After the electrospinning, the artificial blood vessel was removed from the mold, and dried in...

Embodiment 2

[0044] 1) Prepare the external fluid: dissolve 1g of polyurethane in 10ml of a mixed solution of tetrahydrofuran and N,N-dimethylformamide with a volume ratio of 7:3, and stir overnight;

[0045] 2) Prepare internal fluid: dissolve 60mg of dipyridamole and 1.1g of polyethylene glycol 6000 in 4.4g of chloroform, and shake for 10 minutes;

[0046] 3) Coaxial electrospinning: inner fluid flow rate: 0.1ml / h, outer fluid flow rate: 0.7ml / h; coaxial spinning nozzle outer tube diameter 1.54mm, inner tube diameter 0.51mm; voltage: 15 ~ 20KV, ground The thread is added to the blood vessel mold, the distance between the coaxial spinning nozzle and the blood vessel mold is kept at 20 cm, and the speed of the blood vessel mold is 100 rpm; the temperature in the electrospinning box is kept at 40 ° C, and the humidity is 30% to 40%. Electrospinning time is 2 to 3 hours;

[0047] 4) After the electrospinning, the artificial blood vessel was removed from the mold, and dried in vacuum at 80° C....

Embodiment 3

[0049] 1) Prepare the external fluid: dissolve 1.2g of polyurethane in 10ml of a mixed solution of tetrahydrofuran and N,N-dimethylformamide with a volume ratio of 3:7, and stir overnight;

[0050] 2) Prepare internal fluid: dissolve 80mg of dipyridamole and 2.0g of polyethylene glycol 6000 in 4.4g of chloroform, and shake for 10 minutes;

[0051] 3) Coaxial electrospinning: inner fluid flow rate: 0.2ml / h, outer fluid flow rate: 1.0ml / h; coaxial spinning nozzle outer tube diameter 1.54mm, inner tube diameter 0.51mm; voltage: 15 ~ 20KV, ground The thread is added to the blood vessel mold, the distance between the coaxial spinning nozzle and the blood vessel mold is kept at 20 cm, and the speed of the blood vessel mold is 100 rpm; the temperature in the electrospinning box is kept at 40 ° C, and the humidity is 30% to 40%. Electrospinning time is 2 to 3 hours;

[0052] 4) After the electrospinning, the artificial blood vessel was removed from the mold, and dried in vacuum at 80...

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Abstract

The invention discloses a dipyridamole-loaded polyurethane anticoagulative material and a preparation process thereof. The material adopts a core-shell structure, the inner layer is a dipyridamole loaded layer, and the outer layer is a polyurethane main body layer. When the material is used as an artificial blood vessel to be transplanted, the dipyridamole can be slowly released in a long term, adhesion, aggregation and activation of platelets on the surface of the artificial blood vessel are inhibited, the blood compatibility of the artificial blood vessel is improved, the acute thrombosis and intima proliferation can be effectively avoided, and the transplanting success rate of the artificial blood vessel can be effectively improved.

Description

technical field [0001] The invention relates to an interventional treatment material and a preparation process thereof, in particular to a dipyridamole-loaded polyurethane anticoagulant material and a preparation process thereof. Background technique [0002] At present, the large-caliber artificial blood vessel technology used in clinical practice is mature and has a good patency rate. However, for blood vessels with a diameter of less than 6 mm or areas with slow blood flow, such as coronary arteries or inferior knee arteries, the failure rate of artificial blood vessel grafts is high. The reason is mainly due to acute thrombosis and intimal hyperplasia. The activation of platelet adhesion on the surface of artificial blood vessels is the initial factor causing this, so it is very necessary to add antiplatelet drugs to artificial blood vessels. Polyurethane has good compliance and is often used in artificial blood vessel materials. There are few reports about antiplatele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/54A61F2/06
Inventor 胡作军赵勇秦原森刘瑞明
Owner 胡作军
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