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Heparan polyurethane blended modified polyethersulfone hollow fiber membrane and preparation method and application thereof

A technology of blending modification and polyurethane, which is applied in chemical instruments and methods, membrane technology, semipermeable membrane separation, etc., can solve the problem that the anticoagulant function has not been significantly improved, and does not involve membrane anticoagulant performance and compatibility There are still some problems to be improved to achieve the effect of excellent anti-protein pollution ability, easy operation and simple preparation method

Active Publication Date: 2013-04-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above reports are mainly aimed at the hydrophilicity and anti-protein fouling ability of the membrane, but there is no significant improvement in the anticoagulant function of the membrane when it is used in blood purification, or at least it does not involve the anticoagulant performance of the membrane
Moreover, the compatibility of synthesized polymers for modified membranes with PES needs to be improved

Method used

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  • Heparan polyurethane blended modified polyethersulfone hollow fiber membrane and preparation method and application thereof
  • Heparan polyurethane blended modified polyethersulfone hollow fiber membrane and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Add 10 parts of diphenylmethane diisocyanate, 5 parts of dimethylol propionic acid, and 85 parts of N-methylpyrrolidone into a dissolution tank equipped with a stirrer, temperature and reflux condenser, under stirring at a temperature of 85°C React for 6 hours, wash the product with methanol and distilled water, and dry to obtain carboxyl-containing polyurethane; add 100 parts of concentrated sulfuric acid to 10 parts of carboxyl-containing polyurethane for sulfonation, then wash with distilled water and dry to obtain carboxyl- and sulfonic acid-containing polyurethane; Put 10 parts of polyurethane containing carboxyl and sulfonic acid groups, 15 parts of polyethersulfone, and 75 parts of N-methylpyrrolidone into a dissolution kettle, and dissolve at 85°C for 24 hours under stirring to obtain a polyethersulfone solution; Degassing, placing and "curing" to obtain polyethersulfone spinning stock solution.

[0039]Filter the polyethersulfone spinning raw material by hydrau...

Embodiment 2

[0041] Add 10 parts of diphenylmethane diisocyanate, 5 parts of dimethylol propionic acid, and 85 parts of N-methylpyrrolidone into a dissolution tank equipped with a stirrer, temperature and reflux condenser, under stirring at a temperature of 85°C After reacting for 6 hours, the product was washed with methanol and distilled water and dried to obtain carboxyl-containing polyurethane; 10 parts of carboxyl-containing polyurethane were added to 100 parts of concentrated sulfuric acid for sulfonation, then washed with distilled water and dried to obtain carboxyl- and sulfonic-acid-containing polyurethane; Carboxyl and sulfonic acid polyurethane; then put 5 parts of polyurethane containing carboxyl and sulfonic acid group, 10 parts of polyethersulfone and 85 parts of N-methylpyrrolidone into the dissolution kettle, and dissolve it at 75°C for 20 hours under stirring to obtain Polyethersulfone solution; after filtration, defoaming, and "aging", the polyethersulfone spinning stock s...

Embodiment 3

[0044] Add 15 parts of diphenylmethane diisocyanate, 8 parts of dimethylolpropionic acid, and 77 parts of dimethylacetamide into a dissolution tank with a stirrer, temperature and reflux condenser, and keep stirring at a temperature of 70°C After reacting for 12 hours, the product was washed with methanol and distilled water, dried to obtain carboxyl-containing polyurethane; 10 parts of carboxyl-containing polyurethane was added to 100 parts of concentrated sulfuric acid for sulfonation, and then washed with distilled water and dried. Obtain carboxyl group and sulfonic acid group-containing polyurethane; then put 10 parts of carboxyl group and sulfonic acid group-containing polyurethane, 15 parts of polyethersulfone and 75 parts of dimethylacetamide into the dissolving tank, and dissolve at 90°C for 8 hours under stirring. A polyethersulfone solution is obtained; after filtering, defoaming, and placing for "aging", a polyethersulfone spinning stock solution is obtained.

[004...

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Abstract

The invention discloses a preparation method and application of a heparan polyurethane blended modified polyethersulfone hollow fiber membrane. The preparation method is characterized by comprising the following steps of: adding 10 to 25 weight parts of diphenylmethane diisocyanate, 5 to 13 weight parts of dimethylolpropionic acid and 62 to 85 weight parts of solvent into a dissolving kettle, performing reaction for 4 to 12 hours at a temperature of 70 to 90 DEG C, washing the product with methanol and distilled water and drying to obtain carboxyl-containing polyurethane; adding 10 weight parts of polyurethane into 100 weight parts of concentrated sulfuric acid to carry out sulfonation to obtain polyurethane containing carboxyl and a sulfonic acid group; adding 1 to 10 weight parts of heparan polyurethane, 10 to 25 weight parts of polyethersulfone and 70 to 89 weight parts of solvent into the dissolving kettle to dissolve for 2 to 24 hours at a temperature of 75 to 95 DEG C so as to obtain hollow fiber membrane spinning dope; and preparing the hollow fiber membrane with excellent blood compatibility, permanent hydrophilicity, capacity of resisting to protein pollution and an anticoagulation function by adopting a dry spraying and wet spinning technology.

Description

technical field [0001] The invention relates to a heparin-like polyurethane blending modified polyethersulfone hollow fiber membrane and a preparation method and application thereof, belonging to the field of functional polymer materials and preparation thereof. Background technique [0002] Polyethersulfone (PES for short) material is a special engineering plastic that was first successfully developed and commercialized by the British ICI company in 1972. Its brand name is "Victrex PES". Due to its high glass transition temperature and good physical and chemical stability, PES is a special polymer material for engineering with excellent performance. Polyethersulfone prepared into flat membrane or hollow fiber membrane has been widely reported in the fields of blood purification and water treatment, but the use of heparin-like polyurethane to modify polyethersulfone membrane to improve the blood compatibility of membrane materials There is no research report and product com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D69/08B01D67/00B01D61/24C08G18/83C08G18/76C08G18/34
Inventor 赵长生孙树东尹泽桦覃慧苏白海聂胜强向韬赵伟锋
Owner SICHUAN UNIV
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