75 results about "Polyethersulfone membrane" patented technology

The invention relates to the technical field of reverse osmosis (RO) membranes, in particular to a ro membrane filter element for a water purifier. A ro membrane filter element for a water purifier is a polyethersulfone membrane with a hydrophilic modifier-polydopamine coating deposited on the surface, and the hydrophilic modifier is one or more of polyethylene glycol, hexanehexol and 3-sulfopropyl tetradecyl dimethyl betaine. The ro membrane filter element for the water purifier disclosed by the invention has extremely high anti-pollution performance.

The invention discloses a heterojunction AgI / MIL-53 (Fe, Co) composite polyethersulfone membrane and a preparation method and application thereof. The heterojunction AgI / MIL-53 (Fe, Co) composite polyethersulfone membrane is composed of a polyethersulfone membrane, AgI modified MIL-53 (Fe, Co) nano particles loaded on the polyethersulfone membrane and a polyamide nano layer. Preparing by adopting a particle adding mode of vacuum filtration and interfacial polymerization modification; the mold material is good in permeability, high in mechanical strength and excellent in pollution resistance.

The invention discloses a dual-modified polyethersulfone membrane and a preparation method thereof, and relates to the technical field of polyethersulfone membranes. According to the technical scheme, the preparation method comprises the following steps: carboxylating polyether sulfone to obtain carboxylated polyether sulfone; the preparation method comprises the following steps: carrying out cationization treatment on chitosan to prepare cationic chitosan; the prepared carboxylated polyether sulfone, cationic chitosan and an additive are prepared into the dual-modified polyether sulfone membrane through a phase inversion method. The problems of general membrane forming property, insufficient infiltration capacity, poor hydrophilicity, membrane body pollution and the like of the polyether sulfone membrane in the actual use process are solved, meanwhile, the biocompatibility of the polyether sulfone membrane is improved, and the service life of the membrane is also greatly prolonged.

The invention relates to the technical field of ultrafiltration membranes, in particular to an SPDA modified MIL-101 modified polyether sulfone ultrafiltration membrane as well as a preparation method and application thereof. According to the invention, on the basis of a Michael addition reaction, MIL-101 nanoparticles are subjected to sulfonated dopamine modification, and the hydrophilic polyether sulfone (PES) membrane is prepared through a blending modification method. Firstly, an SPDA modified MIL-101 nanometer material is synthesized, a PES ultrafiltration membrane is modified through blending, and the filtering performance and the anti-pollution performance of algae cell extracellular organic matter (EOM) are improved. The influence of the SPDA modified MIL-101 nano material on the performance structure of the ultrafiltration membrane under different addition amounts is further analyzed. And pure water flux and pollution flux are used for evaluating the permeation and separation performance of the membrane. The anti-pollution performance of the membrane is evaluated by alternately filtering the EOM solution and the pure water in three cycles, the ratio of reversible pollution to irreversible pollution and the flux recovery rate.

The invention discloses a hemodialysis membrane with a self-anticoagulation function and a preparation method of the hemodialysis membrane. The hemodialysis membrane with the self-anticoagulation function is obtained by modifying natural polymer fibrin, polydopamine and a sulfonic acid type polymer solution. The hemodialysis membrane is any one or more of a polysulfone membrane, a polyether sulfone membrane, a polyvinylidene fluoride membrane, a polymethyl methacrylate membrane, a polyacrylonitrile membrane, a polyamide membrane, a polyvinyl alcohol membrane, a cellulose acetate membrane and a polypropylene membrane. The invention is used for treating acute and chronic kidney diseases, has good biocompatibility, and shows good blood compatibility in the aspects of inhibiting protein adsorption, platelet adsorption and red blood cell adsorption, reducing hemolysis rate, prolonging blood coagulation time and the like. And the risk of thrombosis caused by improper use of an anticoagulant in a continuous anticoagulation treatment process can be effectively avoided, and the living quality and the survival time of a hemodialysis patient are effectively improved and prolonged.

The present invention discloses a polyethersulfone membrane with low protein adsorption function and its preparation method. The polyethersulfone membrane comprises the following raw materials according to mass percentage: 10-30% of polyethersulfone, 3-15% of amphiphilic copolymer, 2-10% of pore former, 0.5-15% of non-solvent, and 55-75% of solvent. Through a carefully designed formulation and preparation process, the present invention successfully prepares a polyethersulfone membrane with low protein adsorption function. The addition of the amphiphilic copolymer P(PVP-r-PDMS) not only enhances the hydrophilicity and protein adsorption resistance of the membrane, but also realizes the optimization of the membrane structure through the fine regulation of the RTIPS method. Finally, a polyethersulfone hollow fiber membrane with excellent anti-fouling performance and high permeability is obtained, which has broad application prospects in the fields of hemodialysis, drug filtration, food industry, etc.

The invention relates to the technical field of natural product extraction, in particular to a process for separating and extracting nervonic acid from xanthoceras sorbifolia bunge. The preparation method comprises the following steps: extracting xanthoceras sorbifolia bunge kernels to prepare xanthoceras sorbifolia bunge oil; the xanthoceras sorbifolia bunge oil is filtered and refined through a composite polyethersulfone membrane, and mixed fatty acid is prepared; mixing fatty acids to prepare nervonic acid. Molybdenum disulfide and lithium fluoride treated by hydrochloric acid are jointly dispersed in a solution, and after a composite nano material prepared through treatment of molybdenum disulfide and lithium fluoride is used for treating a polyether sulfone membrane, the obtained composite polyether sulfone membrane does not generate pollution and has an adsorption effect on impurities in xanthoceras sorbifolia bunge oil; when the xanthoceras sorbifolia bunge oil is filtered by the polyether sulfone membrane, other impurities are adsorbed, the xanthoceras sorbifolia bunge oil is refined, the content of an extraction solvent and other impurities in the xanthoceras sorbifolia bunge oil is reduced, and the extraction rate and purity of nervonic acid extracted from the xanthoceras sorbifolia bunge oil are improved.

The invention discloses a biological-pollution-resistant polyethersulfone self-supporting ultrafiltration membrane as well as a preparation method and application thereof. The ultrafiltration membrane is prepared by fixing cellulose nanocrystals and antibacterial ions on the surface and in membrane holes of a polyethersulfone membrane through a polyphenol monomer. The biological pollution resistant polyether sulfone self-supporting ultrafiltration membrane provided by the invention can stably load a hydrophilic material and a bacteriostatic material, so that the ultrafiltration membrane has excellent hydrophilic performance and biological pollution resistance, and can be efficiently and stably applied to the field of water treatment or biological material treatment.

The invention provides a preparation method of a hydrophobic modified polyethersulfone porous membrane, which comprises the following steps: firstly, preparing a hydrophobic modified solution, then carrying out crosslinking pretreatment to form a hydrophobic crosslinking coating on a polyethersulfone base membrane, then carrying out crosslinking under ultraviolet irradiation, and finally preparing the hydrophobic polyethersulfone porous membrane. The pre-crosslinked membrane formed by crosslinking pretreatment is formed by forming a hydrophobic crosslinked coating on a polyethersulfone base membrane, and a hydrophobic monomer is grafted on the hydrophobic crosslinked coating under the irradiation of ultraviolet light; the hydrophobic cross-linked coating not only coats the outer surface of the polyethersulfone base membrane, but also can be impregnated on a porous structure in the polyethersulfone membrane, and finally the hydrophobic modified polyethersulfone porous membrane is prepared. Wherein the cross-linking agent is a monomer containing a plurality of unsaturated bonds, an addition polymerization reaction can occur among the unsaturated bonds to form a spatial net-shaped structure, the hydrophobic cross-linking coating can be firmly covered on the porous structure of the polyether sulfone and cannot fall off, and the hydrophobic monomer is also provided with unsaturated bonds, so that the addition polymerization reaction occurs between the hydrophobic monomer and the cross-linking agent, and a certain number of hydrophobic groups are grafted.

The invention discloses an interface in-situ assembled gel and nanoparticle composite polyether sulfone membrane as well as preparation and application thereof, and belongs to the technical field of nano material and membrane separation. According to the invention, a gel and nanoparticle composite structure is constructed in situ on the surface of the membrane and in pores through a phase separation strategy for the first time, a gel layer of a main body is formed by crosslinking polyphenol and zirconium oxychloride, and nanoparticles are formed by complexing unoccupied sites of polyethyleneimine and polyphenol; a nucleation site is provided for in-situ construction of the gel layer on the surface. Compared with a surface modification post-treatment method, the method disclosed by the invention has the advantages of process integration, coating stability and the like; compared with a mixed matrix membrane constructed by zeolite and carbon nanotubes, agglomeration and polymer embedding are avoided, and a coating constructed by mixing hydrophilic gel and nanospheres can be formed on the surface of the polymer.

The application provides a virus-removing polyether sulfone porous membrane and a preparation method thereof. The virus-removing polyether sulfone porous membrane comprises, in sequence along a thickness direction, an outer layer region and an inner layer region, wherein the average pore size of the outer layer region is 10-20 nm, the thickness of the outer layer region is 20-50 microns, the average pore size of the inner layer region is 5-10 microns, and the thickness of the inner layer region is 60-150 microns; and the virus-removing polyether sulfone porous membrane is prepared by a method comprising at least the following process: taking polyether sulfone as a raw material, and obtaining the virus-removing polyether sulfone porous membrane under the action of a water-soluble diluent and a hydrophilic additive; wherein the water-soluble diluent comprises ethylene carbonate and polyethylene glycol. The virus-removing polyether sulfone porous membrane has a high virus removal rate and a high protein permeation rate.

This invention discloses a multi-stage treatment method for photovoltaic fluoride-containing wastewater based on semi-permeable membrane separation and the semi-permeable membrane thereof. The multi-stage treatment method includes the following steps: S1, primary treatment; S2, secondary treatment; S3, tertiary treatment. This method first performs primary treatment on the initially high-impurity fluoride-containing wastewater, which can rapidly degrade organic matter and heavy metals in the wastewater. Then, secondary treatment removes most of the heavy metal ions from the wastewater. Crystallization can effectively remove dissolved salts from the wastewater, while electrodialysis can concentrate and recover metal ions from low-concentration wastewater and desalinate the wastewater. Finally, tertiary treatment efficiently separates fluoride ions from the wastewater, and reverse osmosis filtration further removes the remaining fluoride ions and other dissolved salts, ensuring effluent quality. The semi-permeable membrane is a modified polyethersulfone membrane, and water quality is further purified by adding microorganisms.

The invention discloses a purification method of cord blood mesenchymal stem cell source exosome, and relates to the technical field of bioengineering. The method comprises the following steps: firstly, carrying out pH regulation pretreatment on cell culture supernate through a technical path of combining gradient centrifugation and membrane filtration, and sequentially removing cell debris and large-particle impurities by adopting multi-stage differential centrifugation; then carrying out selective protein precipitation by utilizing polyethylene glycol with specific molecular weight, and realizing fine separation of the exosome by combining sucrose-meglumine diatrizoate density gradient centrifugation; and finally, terminal purification is completed under low-temperature and low-pressure conditions through a polyethersulfone membrane filtration system with an optimized pore size. According to the method, centrifugal parameters, reagent concentration and filtering conditions are precisely regulated and controlled, so that the particle size of the obtained exosome is intensively distributed in the range of 30-150nm, the protein purity reaches 95% or above, the recovery rate exceeds 85%, and the separation efficiency and quality of the exosome are remarkably improved.

The invention discloses application of acid polysaccharide from tribonema to preparation of functional food or feed containing prebiotics, and the acid polysaccharide is prepared by the following method: (1) adding dried tribonema powder into water, stirring and extracting, and collecting supernate; (2) adding the residues into water, stirring and extracting, collecting supernate, merging the supernate, concentrating, deproteinizing, precipitating and collecting precipitate; dissolving the precipitate in water, dialyzing, and freeze-drying; (3) dissolving the tribonema crude polysaccharide in water, and adding absolute ethyl alcohol for first-stage precipitation; adding absolute ethyl alcohol into supernate obtained after the first-stage precipitation to carry out second-stage precipitation; adding absolute ethyl alcohol into supernate obtained after the second-stage precipitation to carry out third-stage precipitation; (4) testing the total sugar content of each stage of precipitate; and (5) dissolving the precipitate with the highest total sugar content in water, and carrying out ultrafiltration treatment by adopting a polyether sulfone membrane to obtain the tribonema-derived acidic polysaccharide. The polysaccharide disclosed by the invention has prebiotic activity.

This invention discloses a stable nalmefene hydrochloride injection and its preparation method, relating to the field of biomedical technology. The injection consists of nalmefene hydrochloride, sodium chloride, hydrochloric acid, and water for injection, and contains no metal ion chelating agents, with a pH value controlled between 3.5 and 3.6. The method includes: preparing the solution and adjusting the pH under high-purity nitrogen protection in a solution preparation system with low metal ion introduction risk; filtering the solution through a polyethersulfone membrane with low metal leaching, and then filling it into ampoules with a vulcanized inner surface. This invention, through the systematic integration of multiple measures such as source control of the solution preparation system, inert atmosphere protection, precise pH control, surface passivation of packaging materials, and the use of high-purity materials, synergistically inhibits the metal ion catalytic oxidation of the active ingredient, ensuring that the content of the key degradation impurity II (2,2'-bisnalmefene) remains stably below the quality standard during long-term storage, solving the problem of chemical stability control of products in chelator-free formulations, and combining safety and process robustness.

The present invention discloses a self-supporting polyethersulfone ultrafiltration membrane that resists biofouling, as well as its preparation method and application. The ultrafiltration membrane is produced by immobilizing cellulose nanocrystals and antibacterial ions on the surface and within the pores of the polyethersulfone membrane using polyphenol monomers. The self-supporting polyethersulfone ultrafiltration membrane can stably support hydrophilic and antibacterial materials, thereby imparting excellent hydrophilic properties and biofouling resistance, and can be efficiently and stably applied in water treatment or biological material processing.

The invention discloses a preparation method of a polyamide composite membrane with high pollution resistance, a polyethersulfone membrane is used as a supporting layer, and on the basis of interfacial polymerization, chitosan quaternary ammonium salt is used for coating modification on the surface of the polyamide composite membrane. A hydrophilic functional group of the chitosan quaternary ammonium salt enhances the interaction between water molecules and the surface of the membrane and relieves the adsorption and deposition of pollutants on the surface of the membrane, so that the organic pollution resistance of the membrane is enhanced. In addition, positive charges carried by the chitosan quaternary ammonium salt can destroy bacterial cell membranes to cause bacterial death, so that the biological pollution resistance of the membrane is enhanced. The polyamide composite membrane prepared by the invention has excellent organic pollution and biological pollution resistance under the condition that the water production efficiency and the separation performance are hardly influenced, and has a relatively good application prospect.

The invention discloses a bionic modification method of a hemodialysis membrane and application of the bionic modification method, and belongs to the technical field of medical materials.The method comprises the steps that vinylbenzylamine and vinyltriethoxysilane are dissolved in triethyl phosphate to be stirred, an initiator azodiisobutyronitrile is added, and heating polymerization is conducted to obtain a polymer [P (EP-VTES)]; carrying out amidation reaction to form a gallic acid functional polymer (Ga-EPTES); ga-EPTES is cross-linked to the surface of a polyethersulfone membrane in a monomolecular layer form, and the hemodialysis membrane with the functions of resisting oxidation and removing free DNA is prepared. According to the bionic modification method of the hemodialysis membrane, the functional limitation and modification defects of a traditional blood purification material are broken through, an efficient, safe and large-scale solution is provided for sepsis treatment, and the bionic modification method has scientific value and clinical transformation potential.

The invention discloses a method for predicting the performance of a GO separation membrane based on molecular simulation and a preparation method of the GO separation membrane. Based on a molecular dynamics simulation technology, revealing a relationship among a GO interlayer water distribution state, an interlayer spacing and a chemical environment, and obtaining an interlayer water distribution state beneficial to ion transmission and corresponding geometric and chemical parameters of the membrane; the GO ion separation membrane is prepared under the guidance, a suspension of single-layer GO is prepared, a polyethersulfone membrane is adopted as a substrate, and thermal reduction treatment is performed after vacuum filtration and membrane formation. By reasonably regulating and controlling the interlayer spacing and the chemical environment of the GO membrane, fine regulation and control are carried out on the distribution state of water molecules containing interface bound water and non-interface free water in a confinement channel, and selective transmission of Li < + > relative to Na < + > and Mg < 2 + > by the GO membrane can be realized.

The invention discloses a preparation method of a multilayer graphene oxide modified separation membrane. The preparation method comprises the following steps: preparing a dopamine solution by using a tris (hydroxymethyl) aminomethane hydrochloride solution; cutting a polyethersulfone film, putting the cut polyethersulfone film into a dopamine solution, and carrying out co-deposition operation; after codeposition is completed, taking out the polyethersulfone film, performing interfacial polymerization on the polyethersulfone film by using a 1, 3, 5-trimesoyl chloride solution, and preparing a graphene oxide / tannic acid mixed solution and a ferric chloride solution; putting the polyethersulfone membrane subjected to interfacial polymerization into a graphene oxide / tannic acid mixed solution for co-deposition, taking out the polyethersulfone membrane, and putting the polyethersulfone membrane into a ferric chloride solution for cross-linking; the codeposition-crosslinking operation is repeated twice, then the polyether sulfone membrane is taken out and dried, and the multi-layer graphene oxide modified separation membrane is obtained.The multi-layer graphene oxide modified separation membrane is reasonable in structure, the polyamide layer not prone to falling off is prepared through the adhesiveness of dopamine, then graphene oxide is codeposited multiple times, the membrane aperture is further reduced, and the hydrophilicity of the membrane is further improved.

The application relates to a method for purifying umbilical cord blood mesenchymal stem cell-derived exosomes, and relates to the technical field of bioengineering. The method combines gradient centrifugation and membrane filtration. First, the cell culture supernatant is pretreated by adjusting the pH, and cell debris and large-particle impurities are removed by multi-stage differential centrifugation. Then, selective protein precipitation is carried out by using polyethylene glycol with a specific molecular weight, and the exosomes are finely separated by sucrose-meglumine diatrizoate density gradient centrifugation. Finally, terminal purification is completed under low-temperature and low-pressure conditions by using a polyether sulfone membrane filtration system with optimized pore size. By precisely controlling the centrifugation parameters, reagent concentration and filtration conditions, the exosomes obtained by the method have a particle size concentrated in the range of 30-150 nm, a protein purity of more than 95%, and a recovery rate of more than 85%, and the separation efficiency and quality of the exosomes are significantly improved.

The application provides a composite pervaporation desalination membrane and a preparation method and application thereof. The composite pervaporation desalination membrane comprises a separation layer with a separation function and an organic porous base membrane layer serving as a support; the raw materials of the separation layer comprise a polyvinyl alcohol aqueous solution, a PFSA-g-GO nanocomposite and a crosslinking agent, the addition amount of the PFSA-g-GO nanocomposite is 0.2-4.5 mass%, the addition amount of the crosslinking agent is 1-10 mass%, and the mass% is the percentage of the mass of each component to the mass of the polyvinyl alcohol; and the organic porous base membrane layer is a polyacrylonitrile membrane or a polyethersulfone membrane. The preparation method is simple and easy to implement, and has low cost, and can simultaneously improve the water flux and desalination rate of the composite pervaporation desalination membrane.

The utility model discloses a hemodialysis filter with a blood perfusion adsorption function. The hemodialysis filter comprises a filter, two dialysate connectors, a plurality of hollow fiber filaments, two blood connectors and a plurality of adsorption particles. The two dialysate connectors are fixedly connected with the outer wall of the filter, the inner ends of the two dialysate connectors penetrate through the inner wall of the filter, and the dialysate connectors are used for conveying dialysate; the plurality of hollow fibers are mounted on the inner wall of the filter and are made of polyether sulfone membranes; the two blood interfaces are respectively connected in series with the two ends of the filter; the plurality of adsorption particles are mounted in the hollow fiber filaments which are far away from the blood connector and the dialysate connector and are 1 / 3-1 / 2 of the number of the hollow fiber filaments, and the adsorption particles are resin carbon soaked by heparin. According to the hemodialysis and perfusion combined device, the hemodialysis and perfusion functions can be simultaneously completed by a single device through the combination of the characteristics of the hemodialysis filter and the hemoperfusion device, so that the occurrence of infection of patients is reduced.

The invention discloses acid polysaccharide derived from tribonema and a preparation method and application thereof, the preparation method comprises the following steps: (1) adding dried tribonema powder into water, stirring and extracting, and collecting supernate; (2) adding the residues into water, stirring and extracting, collecting supernate, merging the supernate, concentrating, deproteinizing, precipitating and collecting precipitate; dissolving the precipitate in water, dialyzing, and freeze-drying to obtain tribonema crude polysaccharide; (3) dissolving the tribonema crude polysaccharide in water, and adding absolute ethyl alcohol for first-stage precipitation; adding absolute ethyl alcohol into supernate obtained after the first-stage precipitation to carry out second-stage precipitation; adding absolute ethyl alcohol into supernate obtained after the second-stage precipitation to carry out third-stage precipitation; (4) testing the total sugar content of each stage of precipitate; and (5) dissolving the precipitate with the highest total sugar content in water, and carrying out ultrafiltration treatment by adopting a polyether sulfone membrane to obtain the tribonema-derived acidic polysaccharide. The purification process is simple, convenient and efficient.

The invention provides a method for extracting nervonic acid from xanthoceras sorbifolia bunge. The method comprises the following steps: S1, performing low-temperature squeezing pretreatment on xanthoceras sorbifolia bunge kernels to obtain low-impurity crude oil; s2, performing ultrasonic-assisted PEG-4000 / ammonium sulfate aqueous two-phase extraction to enrich nervonic acid; s3, filtering through a composite polyether sulfone membrane loaded with amino modified montmorillonite-graphene, and intercepting impurities such as erucic acid in a targeted manner; s4, carrying out mild saponification and acidification; and S5, carrying out low-temperature gradient crystallization to obtain high-purity nervonic acid. Compared with the prior art, molecular distillation, a toxic solvent and a composite membrane are not needed, high-targeting interception-high-flux synergy is achieved, an aqueous two-phase system can be recycled, the final nervonic acid purity is larger than or equal to 99.5%, the extraction rate is larger than or equal to 0.8%, the waste liquid amount is reduced by 70%, the total consumed time is shortened to 10-12 h, and the problems that in the prior art, purity is low, pollution is large, and cost is high are solved.

This invention relates to the field of wastewater treatment technology, specifically to a process and system for removing heavy metals from ink wastewater. It includes the following steps: coagulating ink wastewater with a metal composite coagulant, adsorbing and removing sludge wastewater with an ink sludge-based adsorbent, and filtering wastewater using a catechol-modified polyethersulfone membrane, followed by detection. This invention utilizes high-iron copper slag with titanium tetrachloride and acetylacetone to prepare a metal composite coagulant, transforming the copper slag into a high-value-added water treatment agent. This significantly reduces the production cost of the coagulant. Through the synergistic leaching of dilute sulfuric acid and hydrogen peroxide, the iron element in the copper slag is efficiently extracted and oxidized into Fe, which has a strong coagulation effect. 3+ The trace amounts of copper and other metal ions dissolved also provide a basis for subsequent composite reactions, thus improving the overall treatment efficiency and effluent quality of oily sludge wastewater.

This invention provides a high-performance polyethersulfone membrane and its preparation method, comprising the following steps: sulfonated polyethersulfone is blended with polyethersulfone and dissolved in a mixed solvent containing ionic liquid, and aminated nano-SiO2 particles are added, followed by ultrasonic dispersion to achieve covalent grafting, resulting in a premix; aminated Fe3O4 nanoparticles are added to the premix, and after ultrasonic dispersion, a crosslinking agent is added and stirred until homogeneous, resulting in a casting solution; the casting solution is degassed until no bubbles are visible, then cast onto a substrate, and coated using a doctor blade, with a magnetic field applied below the doctor blade during the coating process; the coated membrane is immersed in a coagulation bath, and through the synergistic effect of phase inversion and interfacial crosslinking reaction, a polyethersulfone membrane is obtained; the membrane exhibits high water permeability, antifouling properties, and high mechanical strength.

The present application belongs to the technical field of analytical chemistry, environmental monitoring and water quality online detection, and particularly relates to a hydroxyapatite-chitosan modified polyether sulfone membrane, a preparation method thereof and application of the membrane in detection of heavy metal ions in combination of membrane solid phase extraction and laser-induced breakdown spectroscopy. The present application mixes chitosan, hydroxyapatite and an aqueous glacial acetic acid solution to obtain a functional solution; the functional solution is coated on the surface of a polyether sulfone microporous filter membrane, and then solidified by alkali neutralization to obtain a hydroxyapatite-chitosan modified polyether sulfone membrane. The hydroxyapatite-chitosan modified polyether sulfone membrane provided by the present application can be well adapted to LIBS, can realize effective enrichment of trace heavy metals in a liquid sample to the membrane surface, can construct a high-stability solid target, and can realize rapid, high-sensitivity and high-anti-interference detection of heavy metal ions in the liquid sample.

The invention provides an anticoagulant hollow fiber membrane for blood purification and a preparation method thereof, and relates to the technical field of medical polymer membranes, and the preparation method comprises the following steps: respectively introducing a spinning solution and an internal solidification solution into a coaxial spinning nozzle for hollow fiber spinning, so that the spinning solution is firstly in contact with the internal solidification solution on a lumen side, an initial phase separation interface is formed on the lumen side, and the initial phase separation interface is formed on the lumen side; according to the preparation method, a hydrophilic polymer component and a surface anticoagulation modification component are introduced into a polyether sulfone membrane matrix, and the solvent exchange rate between an internal coagulation liquid and a spinning liquid is controlled in the spinning phase inversion process, so that a sulfobetaine polymer is directionally migrated to a lumen side interface and is enriched on a blood contact inner surface; on the premise of ensuring the structural strength of the membrane body and the stability of the pore structure, a high-density anticoagulation functional layer is constructed on a blood contact interface, so that the separation of structural support and interface functions is realized, the blood compatibility is improved, and the blood coagulation risk is reduced.

The invention discloses a modified polyethersulfone hollow fiber hemodialysis membrane and a preparation method thereof, a main body part of the hemodialysis membrane is a polyethersulfone membrane, a modifier of the polyethersulfone membrane comprises polyvinylpyrrolidone and citric acid, and modifier molecules are combined on the inner surface of a hollow fiber membrane to form the hemodialysis membrane. According to the hemodialysis membrane disclosed by the invention, the polyvinylpyrrolidone and the citric acid which are added into the core liquid are used as modifiers, the hydrophilicity of the polyvinylpyrrolidone and the anticoagulant property of the citric acid are utilized, and a proton donating group on a citric acid molecule is respectively connected with carbonyl on the polyvinylpyrrolidone in the core liquid, so that the hemodialysis membrane is prepared. Oxygen atoms on a main chain of polyethersulfone in the spinning solution act to form hydrogen bonds, polyvinylpyrrolidone and citric acid are combined on the inner surface of the hollow fiber membrane, and meanwhile, polyvinylpyrrolidone and polyethersulfone molecular chains are wound to further fix the hollow fiber membrane, so that the hollow fiber membrane is prepared. The modified polyether sulfone hollow fiber hemodialysis membrane has lasting and stable hydrophilicity and anticoagulation performance.