100 results about "Nervonic acid" patented technology

The utility model discloses a purification device for nervonic acid processing, which comprises an accommodating box, a feed pipe is arranged on the back of the accommodating box, a discharge pipe is communicated with the bottom of the right side of the accommodating box, a sealing door is fixedly mounted on the front of the accommodating box, a filter box is arranged in an inner cavity of the accommodating box, a fixing block is arranged in the inner cavity of the filter box, and a filter screen is arranged in the fixing block. A containing groove is formed in the fixing block, and two moving rods are arranged in the containing groove. The filter box is convenient to maintain by arranging the sealing door, materials are convenient to guide by arranging the feeding pipe, an extracting solution is filtered by arranging the filter box, the moving rod is accommodated by arranging the accommodating groove, and the inner cavity of the filter box is cleaned by arranging the cleaning brush; the gear body is driven by arranging the second motor, the sliding block is limited by arranging the sliding groove, the sliding block is prevented from shaking in the moving process, and the fixed block is driven by arranging the first motor.

The invention relates to a nutritional composition, a food containing the nutritional composition and application of the nutritional composition. The nutritional composition comprises medium-chain and long-chain fatty acid triglyceride and nervonic acid, and the medium-chain and long-chain fatty acid triglyceride and the nervonic acid have a synergistic effect in the aspects of improving skeletal development and / or preventing or treating bone diseases.

The invention discloses a pharmaceutical composition for treating or improving Parkinson's disease and application of the pharmaceutical composition. The triterpenoid saponin compounds and the nervonic acid in different proportions are combined, and experiments prove that multiple indexes of Parkinson mice can be remarkably improved when the triterpenoid saponin compounds and the nervonic acid are combined in a specific proportion, and the effect of synergistically improving the Parkinson disease or the progress of the Parkinson disease is achieved. Therefore, the pharmaceutical composition disclosed by the invention can be used for more effectively treating or improving the Parkinson's disease, and has a wide application prospect in the field of treatment of the Parkinson's disease.

The invention relates to a method for extracting high-purity nervonic acid from malania oleifera oil, which comprises the following steps: 1, saponification-metal salt precipitation: taking malania oleifera oil, adding alkali, adding a non-aqueous solvent, heating, refluxing, saponifying, cooling, precipitating, filtering, and removing a solution to obtain filter residues; step 2, acidification: adding acid water into the filter residues obtained in the step 1 for acidification, standing for layering, and discarding a water layer to obtain an oil layer; 3, washing: washing the oil layer obtained in the step 2 to obtain a washed oil layer; 4, fractional precipitation: adding a first organic solvent into the washed oil layer obtained in the step 3, carrying out first-stage precipitation, and filtering to remove filter residues; and carrying out second-stage precipitation and filtration. And 5, recrystallization: adding a second organic solvent into the filter residue obtained in the step 4, recrystallizing, filtering, and taking the filter residue to obtain nervonic acid. The nervonic acid with the content not lower than 95%, the purity not lower than 98% and the yield not lower than 70% can be obtained.

The present invention relates to the use of a nutritional composition comprising medium- and long-chain fatty acid triglycerides and nervonic acid.

The invention belongs to the technical field of food, and particularly relates to a high-stability acer truncatum seed oil nano-emulsion and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 15-25 parts of acer truncatum seed oil, 0.56-2.3 parts of an emulsifier, 2-4 parts of a processing aid and 70-85 parts of water, the emulsifier comprises polyglycerol fatty acid ester, Tween 80 and sucrose fatty acid ester. The prepared nano-emulsion is high in grease content and small in particle size, the average particle size is 200 nm, and the nano-emulsion can have good stability after being placed at normal temperature for 30 d, still has high nervonic acid content and does not deteriorate.

The present invention relates to the use of a nutritional composition comprising medium and long chain fatty acid triglycerides and nervonic acids for non-therapeutic purposes of improving vision.

The invention relates to the technical field of health food, in particular to a nervonic acid nutrient composition for relieving sleep disorder and application of the nervonic acid nutrient composition for relieving sleep disorder. The active components comprise natural vegetable oil such as acer truncatum seed oil purified nervonic acid, linseed oil and the like and gamma-aminobutyric acid extracted by fermentation; the synergistic component is prepared from soybean enzymolysis phosphatidylserine, saccharomycetes fermentation coenzyme Q10 and plant source B vitamins; the slow-release carrier adopts pectin-Arabic gum composite gel and plant starch to form a natural cross-linked structure, and long-acting release for 8-12 hours is realized through physical cross-linking. Green technologies such as ultrasonic dispersion and low-temperature drying are adopted in the preparation process, and chemical synthesis steps are avoided; the composition can improve the difficulty in falling asleep and improve the sleep quality, the activity retention rate is greater than or equal to 85% after the composition is stored at 45 DEG C for 6 months, and the composition is suitable for preparing capsules, gel candies and other health-care foods and has no dependence after being taken for a long time.

The invention provides a cosmetic application of nervonic acid. The cosmetic application is selected from the group consisting of anti-saccharification, energy metabolism, DNA damage repair, soothing and / or repair efficacy. The invention also relates to application of nervonic acid in preparation of an external skin preparation with anti-saccharification, energy metabolism, DNA damage repair, soothing and / or repair effects.

The invention discloses a self-emulsifying nervonic acid eye drop, which is prepared from the following raw material components in percentage by mass: 1 to 10 weight percent of nervonic acid, 30 to 60 weight percent of oil phase, 20 to 40 weight percent of surfactant and 10 to 20 weight percent of co-emulsifier, the oil phase is at least one of sunflower seed oil, squalane, olive oil and castor oil. According to the invention, the oil phase rich in unsaturated fatty acid is adopted, so that the eye cream has good solubility to nervonic acid, is mild and low-sensitive, can soften the cuticle of eyes and reduce the permeation resistance of nervonic acid, and is suitable for sensitive periocular skin. The prepared self-emulsifying nervonic acid eye drops overcome the defect that nervonic acid is almost insoluble in water, and compared with water-based eye drops, the self-emulsifying nervonic acid eye drops have the advantage that the drug loading capacity and the stability are obviously improved.

This invention relates to the field of oil and fat synthesis technology, specifically to a method for preparing nervonic acid monoglyceride. In this invention, nervonic acid and glycerol are used as raw materials, and an esterification reaction is carried out under microwave assistance to obtain a first mixture containing nervonic acid monoglyceride, nervonic acid diglyceride, nervonic acid triglyceride, unreacted nervonic acid and glycerol, and a catalyst. Glycerol and the catalyst are removed by ethyl acetate extraction to obtain a second mixture. Subsequently, taking advantage of the temperature-sensitive nature of nervonic acid monoglyceride in edible oils, it is separated and purified to obtain nervonic acid monoglyceride. The esterification reaction under microwave assistance not only avoids the corrosion and contamination problems caused by traditional acid catalysts, but also significantly shortens the esterification reaction time, improves synthesis efficiency, and effectively inhibits the isomerization of cis-nervonic acid during the reaction, ensuring the stability of the product configuration.

The invention relates to nervonic acid-loaded near-infrared light response type injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological engineering. According to the invention, P (NIPAM-co-NHMAM) and a modified natural polymer material are combined to prepare a temperature-responsive hydrogel capable of realizing reversible volume shrinkage / expansion at a specific temperature, near-infrared light physiotherapy and irradiation are combined to damage local skin, and the hydrogel is stimulated to realize reversible volume deformation by controlling tissue temperature, so that the temperature-responsive hydrogel can be used for preparing the hydrogel with the reversible volume shrinkage / expansion at the specific temperature. Therefore, accurate and wireless space-time regulation and control of nervonic acid release behaviors are realized. Therefore, the nervonic acid loaded near-infrared light response type injectable hydrogel disclosed by the invention can realize efficient carrying and light response controllable release of nervonic acid, promotes functional recovery after spinal cord injury, and has a relatively good application prospect and research significance.

The invention provides a preparation method of acer truncatum seed oil, belonging to the technical field of vegetable oil processing, the acer truncatum seed oil prepared by the method contains higher content of nervonic acid, which has important significance for wider application of nervonic acid in the fields of biology, medicine and the like. Besides, the acer truncatum seed oil prepared by the method has more excellent antioxidant, anti-inflammatory and anti-aging effects, and can be added into cosmetics as a functional component so as to develop skin care products with multiple effects.

This invention relates to the field of nervonic acid preparation technology, specifically to a high-efficiency separation device for nervonic acid from garlic fruit oil based on molecular distillation technology. The device includes a molecular distillation apparatus, internally comprising, from top to bottom, a driver, a film scraping system, and a condensation system. The film scraping system includes a rotating shroud driven by the driver, a centrifugal disc located at the bottom of the rotating shroud, a pressure rod located inside the rotating shroud, and a transmission rod rotating at the bottom of the pressure rod and slidably inserted into the centrifugal disc. The centrifugal disc of this invention uses centrifugal force generated by high-speed rotation to evenly distribute the material onto the evaporation wall, forming an initial ultrathin film. Simultaneously, the scraper rotates accordingly, performing secondary scraping and homogenization of the initial liquid film. Utilizing the synergistic structure of centrifugal material distribution and mechanical scraping, the problem of uneven material distribution in traditional methods is solved at its source, and dynamic renewal of the evaporation interface is achieved, thereby improving heat and mass transfer efficiency.

The application relates to the technical field of nervonic acid purification, and discloses a nervonic acid purification device and a purification method thereof, which comprise a fixed-shell type flow guide mechanism and a rotary type filtering mechanism, the inside of the rotary type filtering mechanism is provided with an outer filter cylinder capable of rotating and filtering liquid, an inner filter cylinder capable of rotating and located at the center of the outer filter cylinder, and a horn collecting shell capable of making raw materials flow between the circumferential inner wall of the outer filter cylinder and the circumferential outer wall of the inner filter cylinder. The nervonic acid purification device and the purification method thereof filter nervonic acid liquid by using the bidirectional rotation of the inner filter cylinder and the outer filter cylinder. The rotation of the inner filter cylinder can prevent solid raw materials from adhering to the surface of the filtering holes of the inner filter cylinder, so that the filtering efficiency of the equipment is ensured. The rotation of the outer filter cylinder can make the solid raw materials adhered to the circumferential inner wall of the outer filter cylinder produce a centrifugal phenomenon, so that the nervonic acid liquid adhered to the inside of the solid raw materials can be thrown out, and the filtering effect of the equipment is ensured.

The invention relates to a myxomycete oral liquid containing nervonic acid and a preparation method of the myxomycete oral liquid, and belongs to the technical field of health-care products. The oral liquid is prepared from the following raw materials: pure honey, a nutrient solution, a ganoderma lucidum stock solution, ganoderma lucidum stock seeds, an acer truncatum leaf extract, acer truncatum seed kernels and the like, wherein the nutrient solution is obtained by boiling acer truncatum leaves, red dates and Chinese wolfberry fruits according to a specific proportion and filtering. The preparation method comprises the steps of mixing and homogenizing, staged fermentation and post-treatment, and the generation of active ingredients is promoted by controlling parameters such as fermentation temperature and dissolved oxygen conditions. The nervonic acid content in the product is greater than or equal to 0.8 mg / ml, the polysaccharide content is greater than or equal to 8 mg / ml, and the product has the effects of neuroprotection, immunoregulation and the like. By optimizing the formula and the process, the problems of unstable active components, low bioavailability and the like in the prior art are solved, the shelf life of the product can reach 24 months, and the preparation method is suitable for industrial production.

1. Name of the designed product: packaging box (DHA nervonic acid drink). 2. Use of the designed product: for product packaging. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view 1.

The invention relates to the technical field of functional food, health care products and medicines, in particular to a composition for neuroprotection and cognitive function improvement and a preparation method and application thereof. The invention provides a composition for neuroprotection and cognitive function improvement. The composition is prepared from calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, by compounding the calcium beta-hydroxy-beta-methylbutyrate, nervonic acid and menthol, the compound has a synergistic effect and can be applied to preparation of food, health care products or medicines for protecting nerves, delaying nerve aging, improving learning and memory ability, repairing nerve injury and preventing or assisting in treating neurodegenerative diseases.

The invention relates to the technical field of nervonic acid extraction, in particular to a device and method for separating nervonic acid from malania oleifera oil for biological medicine manufacturing, the device comprises a distiller, the distiller comprises a sealing tank and a dismounting cylinder, and a film scraping mechanism and a plurality of negative pressure tanks are arranged in the sealing tank and the dismounting cylinder respectively. According to the device and method for separating nervonic acid from malania oleifera oil for biological medicine manufacturing, a spiral scraping plate of a lifting part is linked with a reciprocating lead screw through a clamping ring, synchronous rotation and up-down reciprocating motion are achieved, the whole surface of a condensation pipe is covered, a condensate liquid film is actively scraped away, heat resistance of a retained liquid film is eliminated, the condensation efficiency is improved, and the efficiency of separation of nervonic acid from malania oleifera oil is improved. The nervonic acid fraction is prevented from staying on a condensation wall for a long time, and the condition of thermal degradation or backmixing is prevented.

The invention discloses a method for extracting and separating nervonic acid from vegetable oil, and belongs to the technical field of nervonic acid extraction and separation. The extraction and separation method of nervonic acid comprises the following steps: (1) mixing vegetable oil with an alkaline ethanol solution, and carrying out saponification reaction to obtain fatty acid salt; (2) adding an acid solution into the fatty acid salt, stirring to fully acidify the fatty acid salt, standing for layering, separating an oil phase, and washing to be neutral to obtain mixed fatty acid; (3) performing macroporous resin column chromatography separation and purification on the mixed fatty acid, and collecting eluent to obtain a chromatography sample; and (4) mixing the chromatography sample with a solvent, recrystallizing, and drying to obtain nervonic acid with the content of 95% or above. The method provided by the invention has the advantages of simple process steps, no need of special production equipment, good extraction stability and repeatability, high nervonic acid extraction purity and high yield.

The invention discloses a pharmaceutical composition for preventing and / or treating Parkinson's disease and application of the pharmaceutical composition, and relates to the technical field of biological medicine. The composition comprises nervonic acid, salvianolic acid A and pharmaceutically acceptable auxiliary materials. Experiments prove that the composition can improve intestinal flora, obviously promote alleviation of symptoms of a Parkinson's disease model animal, promote regeneration of dopaminergic neuronal cells and neural stem cells, relieve neuroinflammation, promote repair of damaged nerves, improve dyskinesia of mice caused by Parkinson's disease and improve the Parkinson's disease resistance of the mice. Therefore, the polypeptide has potential application value in treatment of the human Parkinson's disease. According to the invention, the effect of the composition is confirmed from the perspective of improving the change of intestinal flora by utilizing the relationship of the brain-intestinal axis, and a basis is provided for intervening the treatment of Parkinson's disease through the intestinal flora.

The invention discloses a recombinant Yarrowia lipolytica engineering strain for producing nervonic acid and application of the recombinant Yarrowia lipolytica engineering strain, and belongs to the technical field of genetic engineering and biological engineering. Beta-keto acyl-CoA synthase AtKCS, CraKCS and LaKCS are expressed in the Yarrowia lipolytica, recombinant Yarrowia lipolytica capable of synthesizing nervonic acid is obtained, supply of C18: 1 delta9-CoA is further enhanced, accumulation of C24: 0-CoA is reduced, endoplasmic reticulum is expanded, key genes are driven by a strong promoter, supply of malonyl CoA and NADPH is increased, and the yield of nervonic acid is increased, the nervonic acid yield of the engineering strain NA10 reaches 451.80 mg / L, and a foundation is laid for subsequent biosynthesis of lipid derivatives such as C24: 1-ceramide and the like.

The invention belongs to the technical field of biological medicine, and discloses a brain targeting peptide-nervonic acid conjugate crossing a blood brain barrier and a preparation method and application thereof.The brain targeting peptide and nervonic acid are covalently coupled, so that the targeting property of nervonic acid is improved, the blood brain barrier crossing capacity of nervonic acid is enhanced, and by increasing the accumulation amount of nervonic acid in brain parenchyma, the brain targeting peptide-nervonic acid conjugate crossing the blood brain barrier is obtained. Precise delivery of nervonic acid is achieved, and the brain-targeted peptide-nervonic acid conjugate can be applied to treatment of brain-related diseases.

The present invention provides a method for improving the purity of nervonic acid, which belongs to the technical field of separation and purification, and comprises the following steps: (1) preparing pretreated rapeseed powder; (2) extracting rapeseed oil by supercritical carbon dioxide extraction; (3) mixing rapeseed oil, water and emulsifier evenly, ultrasonicating in an ice-water bath for 10-15 minutes, and obtaining an emulsion; (4) adding the emulsion to a culture medium to obtain a fermentation substrate, adding mixed bacteria to the fermentation substrate, shaking, and culturing in a constant temperature shaker for 40-45 hours; obtaining a culture solution; (5) preparing a mixture containing nervonic acid; (6) preparing a crude nervonic acid; (7) mixing the crude nervonic acid and ethanol in a mass ratio of 1: (4-6) to obtain a mixture, subjecting the mixture to gradient crystallization, and after the crystallization is completed, separating by suction filtration, and drying the filter cake to obtain nervonic acid. The nervonic acid prepared by the method of the present invention has high purity and high yield.

The present invention relates to a composition for fat grafting containing adipose tissue treated with nervonic acid. According to the present invention, during fat tissue graft surgery, the survival rate and engraftment rate of fat included in grafted adipose tissue may be increased, thereby improving efficiency of fat tissue grafting.

The application discloses a pharmaceutical composition for treating or improving Parkinson's disease and application thereof. The application combines triterpene saponins and nervonic acid in different proportions, and proves through experiments that the combination in the specific proportion can significantly improve multiple indexes of Parkinson's mice, and has the effect of synergistically improving Parkinson's disease or the progress of Parkinson's disease. Therefore, the pharmaceutical composition of the application can be used for more effectively treating or improving Parkinson's disease, and has a wide application prospect in the treatment field of Parkinson's disease.

This invention discloses a nervonic acid-rich *Xanthoceras sorbifolium* diester oil and its preparation method, belonging to the field of oleochemical technology. The invention first removes some long-chain monounsaturated free fatty acids from *Xanthoceras sorbifolium* oil through saponification and low-temperature settling. Then, porous organic polymer materials are used to further enrich nervonic acids with higher molecular weight and larger particle size. Glycerol is added to the free fatty acids, and esterification with lipase catalyzes the synthesis of diglycerides, thus obtaining a nervonic acid-rich *Xanthoceras sorbifolium* diester oil. The addition of a compound antioxidant effectively prevents oxidative rancidity of the diester oil. The *Xanthoceras sorbifolium* diester oil prepared by this invention has a rich nervonic acid content, a high diglyceride content, and excellent thermal stability, thus showing good application prospects and value in the field of oleochemicals.

The invention discloses an extraction method of Brassica rapa seed oil, and belongs to the technical field of compound extraction. According to the method, green solvent dimethyl ether (DME) is combined with a response surface method to optimize process parameters (pressure, temperature and time) for extracting the turnip seed oil, fatty acid composition of the obtained turnip seed oil is analyzed through gas chromatography, and saponified matter of the turnip seed oil is prepared and used for follow-up activity and functional evaluation. After optimization, under the conditions that the extraction pressure is 6 MPa, the extraction temperature is 47 DEG C and the extraction time is 83 min, the DME extraction rate (31.72%) of the method is higher than that (30.94%) of Soxhlet extraction of a traditional extraction method. More importantly, rare unsaturated fatty acids such as nervonic acid and the like are effectively retained by lower extraction temperature, and 21 fatty acids are identified by component analysis. The unique fatty acid composition guaranteed by an optimized process is directly associated with the remarkable biological activity of the fatty acid composition. Core advantages of the method in turnip seed oil extraction are proved, and scientific basis and technical support are provided for industrialization of turnip seed oil in the field of cosmetics.

The invention provides a method for extracting nervonic acid from xanthoceras sorbifolia bunge. The method comprises the following steps: S1, performing low-temperature squeezing pretreatment on xanthoceras sorbifolia bunge kernels to obtain low-impurity crude oil; s2, performing ultrasonic-assisted PEG-4000 / ammonium sulfate aqueous two-phase extraction to enrich nervonic acid; s3, filtering through a composite polyether sulfone membrane loaded with amino modified montmorillonite-graphene, and intercepting impurities such as erucic acid in a targeted manner; s4, carrying out mild saponification and acidification; and S5, carrying out low-temperature gradient crystallization to obtain high-purity nervonic acid. Compared with the prior art, molecular distillation, a toxic solvent and a composite membrane are not needed, high-targeting interception-high-flux synergy is achieved, an aqueous two-phase system can be recycled, the final nervonic acid purity is larger than or equal to 99.5%, the extraction rate is larger than or equal to 0.8%, the waste liquid amount is reduced by 70%, the total consumed time is shortened to 10-12 h, and the problems that in the prior art, purity is low, pollution is large, and cost is high are solved.