104 results about "Ceramide" patented technology

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention belongs to the technical field of exosome freeze-dried powder, and discloses exosome freeze-dried powder and a preparation method thereof, the exosome freeze-dried powder contains mesenchymal stem cell exosome, trehalose, sodium hyaluronate, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide. According to the exosome freeze-dried powder, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide are added, the membrane structure integrity of the exosome is effectively protected, the retention rate of active substances in the exosome freeze-dried powder is high, and therefore the effects of resisting inflammation, regulating cell metabolism, promoting tissue repair and the like of the exosome can be fully exerted. In addition, glutathione can directly remove skin free radicals and inhibit oxidative stress injury, and has an anti-oxidation effect; ceramide can also supplement skin lipid barrier, enhance the water locking capacity and enhance the moisturizing effect of sodium hyaluronate; fructo-oligosaccharide can also regulate skin micro-ecological balance, and has anti-inflammatory and bacteriostatic effects.

The invention provides an external application medicine for incontinent dermatitis and a preparation method thereof. The composition is prepared from active ingredients such as a radix sophorae flavescentis extract, calamine, vitamin E, ceramide, a herba portulacae extract, glycyrrhizic acid, chitosan and colloidal oat powder according to a specific proportion. Moisturizing matrixes such as sodium hyaluronate and glycerol and functional components such as tea tree essential oil are supplemented. And through a preparation process of matching high-speed shearing with ultrasonic dispersion, uniform dispersion and stability of each component are ensured. Experimental results show that the composition shows a remarkable synergistic effect in the aspects of anti-inflammation, antibiosis, skin barrier repair and the like, the comprehensive relieving and repairing effect of the composition is superior to that of a conventional drug control, and all the components and a special preparation process are necessary for achieving the optimal effect. The product has no irritation to human skin, is good in safety, can be prepared into various dosage forms such as cream, hydrogel or spray, and is suitable for nursing and repairing sensitive skin.

The invention discloses retinol retinoate-ceramide lipidosome modified by hyaluronic acid and salts thereof and a preparation method of the retinol retinoate-ceramide lipidosome, and belongs to the technical field of cosmetic nano-carriers. The preparation method comprises the steps that retinol retinoate-ceramide lipidosome is prepared, hyaluronic acid is pretreated, and the hyaluronic acid and the salts thereof are combined to prepare the retinol retinoate-ceramide lipidosome. The liposome is modified by hyaluronic acid and salts thereof in a dual-mechanism manner, and purification and stabilization are realized; the preparation method of the retinol retinoate-ceramide liposome comprises the following steps: dissolving phospholipid, a functionalized lipid component with positive ions and amino functional groups, cholesterol, retinol retinoate and ceramide in absolute ethyl alcohol to serve as an organic phase, taking a phosphate buffer solution as a water phase, dropwise adding the organic phase into the water phase under a stirring condition, stirring, performing ultrasonic treatment, washing, and drying to obtain the retinol retinoate-ceramide liposome. Performing membrane extrusion to obtain a liposome suspension; the retinol retinoate-ceramide liposome modified by hyaluronic acid and salts thereof prepared by the invention has excellent stability, skin transmittance and anti-aging and moisturizing effects, also has low irritation, and is suitable for anti-aging cosmetics.

This disclosure provides: (i) a method of using an anticeramide antibody or an antigen-binding fragment thereof to improve hematopoietic stem cell transplantation for the treatment of various non-malignant and malignant diseases; and (ii) a composition for such treatment.

The features of the present invention for providing a novel neutrophil activator are as follows. 1. An IL-8 production accelerator containing at least one selected from GlcCer[d18:2(4E,8Z) / 18:0], GlcCer[d18:2(4E,8Z) / 20:0], GlcCer[d18:2(4E,8Z) / 22:0], GlcCer[d18:2(4E,8Z) / 24:0], and GlcCer[d18:2(4E,8Z) / 26:0] as an active ingredient. 2. An IL-8 production accelerator containing GlcCer[d18:2(4E,8E) / 24:0] as an active ingredient. 3. An IL-8 production accelerator containing at least one selected from GlcCer[t18:1(8Z) / 24:0] and GlcCer[t18:1(8Z) / 26:0] as an active ingredient. 4. An IL-8 production accelerator containing GlcCer[d18:1(4E) / 20:0] as an active ingredient. 5. An IL-8 production accelerator containing at least one selected from Cer(t18:0 / 22:0), Cer(t18:0 / 23:0), Cer(t18:0 / 24:0), Cer(t18:0 / 25:0), and Cer(t18:0 / 26:0) as an active ingredient. 6. An IL-8 production accelerator containing at least one selected from Cer[t18:1(8Z) / 24:0] and Cer[d18:2(4E,8Z) / 20:0] as an active ingredient. 7. An IL-8 production accelerator containing at least one selected from Oryza Ceramide A, Oryza Ceramide B, and Oryza Ceramide C as an active ingredient.

The invention belongs to the technical field of cardio-cerebral oil preparation, and provides cardio-cerebral oil and a preparation method thereof. The invention aims to solve the technical problems that kapur is easy to volatilize and short in efficacy, and skin irritation is easily caused by high-concentration addition. The preparation method comprises the following steps: firstly, wrapping menthol in a molecular cavity of beta-cyclodextrin through a molecular inclusion technology to prepare a molecular capsule capable of effectively delaying volatilization and reducing irritation; secondly, preparing a bionic repair emulsion from various bionic lipids such as ceramide, cholesterol and fatty acid through an emulsification process, and taking the bionic repair emulsion as a core delivery carrier; meanwhile, components such as vanillyl derivatives are compounded to prepare a temperature-sensitive compound; the preparation method comprises the following steps: uniformly dispersing independent kapur, the molecular capsule and the temperature-sensitive compound into the bionic repair emulsion, and curing to obtain a finished product. Through molecular inclusion and the bionic repair emulsion, long-acting release of the effect of the kapur is realized, and the skin irritation of the product is reduced.

Described herein are covalently modified polypeptide antigens with improved immunogenicity and / or stability, as well as compositions, cells, and methods related to the polypeptide antigens. The polypeptide antigens are covalently conjugated to one or more steroid acid moieties to improve their stability and / or to elicit improved cellular immunity or improved cellular and humoral immunity against the antigens after administration to a subject. The steroid acids include bile acids and bile acid analogs that enhance endosomal trapping of cargo by enhancing the enzymatic cleavage of endosomal membrane- ensheathed sphingomyelin to ceramide and / or endosomal escape. The steroid acid moieties can be preconjugated to a peptide, and the steroid acid-peptide moiety is subsequently conjugated to the polypeptide antigen. The peptide can comprise one or more domains that confer additional functionality to the modified polypeptide antigen.

The invention introduces novel chemical modifications to sphingomyelin and ceramide molecules, making them readily available for targeted staining and detection techniques, such as click chemistry.

The present application relates to a kind of anti-aging repair essence containing chlorella active ingredient and preparation method thereof.The component of the anti-aging repair essence containing chlorella active ingredient includes chlorella active ingredient, barrier repair agent, humectant, antioxidant, thickening agent and deionized water;The barrier repair agent includes ceramide, cholesterol and plant sphingosine alcohol.The essence provided by the present application takes chlorella active ingredient as main active ingredient, is supplemented with barrier repair agent, humectant, antioxidant and other components, is synergized by promoting cell regeneration, antioxidant protection, promoting collagen synthesis, repairing skin barrier and other multi-target points, realizes the multiple effects of skin repair, anti-aging, whitening and freckle removal, and safety is good, is suitable for long-term use of various skin qualities.

The invention discloses a compound with high water dispersibility and a preparation method and application thereof.The preparation method of the compound with the high water dispersibility comprises the steps that an oil phase containing a water-insoluble compound, an amphiphilic substance and at least two surfactants is mixed with a water phase to obtain a mixed emulsion, then the mixed emulsion is diluted, and the compound with the high water dispersibility is obtained. The compound with high water dispersibility is obtained. The prepared compound with high water dispersibility can be subjected to freeze-drying treatment to obtain compound powder with high water dispersibility, the content of ceramide substances and / or sphingosine substances is high, the compound powder is easily dispersed in water, and the compound powder can stably exist and be dispersed in water under a long-time storage condition, so that the compound powder has good water dispersibility. The phenomena of layering, floccules, precipitation and the like are not easy to occur, and the preparation of daily chemical products is facilitated.

This invention discloses a firming and wrinkle-reducing eye cream, comprising a moisturizer, a whitening agent, a skin repair additive composition, a thickener, a preservative, a film-forming agent, a skin moisturizer, and a surfactant. The weight ratio of the moisturizer, whitening agent, anti-aging additive composition, thickener, preservative, film-forming agent, skin moisturizer, and surfactant is 20:1:2:3:0.3:0.5:1:0.2. The moisturizer includes butylene glycol, glycerin, polydimethylsiloxane, and hydrogenated polyisobutylene. The skin-repairing additive composition includes hydroxypropyl tetrahydropyranotriol, adenosine, cell growth factors, ceramides, and salicylic acid, comprising olefins, betaine, trehalose, 1,2-hexanediol, hydrogenated lecithin, allantoin, and Euglena galactosides. The film-forming agents include polyacrylamide, cyclohexylsiloxane, and polydimethylsiloxane alcohol. The emollients include C13-14 isoparaffins, polydimethylsiloxane / vinyl dimethylsiloxane crosspolymers, and cyclopentamethoxysiloxane. This invention can repair cells and provide long-lasting anti-wrinkle and whitening protection for the corners of the eyes.

The invention discloses a private care wet tissue containing a bacteriostatic composition, the private care wet tissue comprises a composite non-woven fabric base material and an impregnation liquid, the impregnation liquid comprises the bacteriostatic composition, a soothing anti-inflammatory agent, a moisturizing repairing agent, an odor removal regulator, a cosolvent and a stabilizer; the preparation method comprises the following steps: adding purified water, a citric acid-sodium citrate buffer agent and EDTA (Ethylene Diamine Tetraacetic Acid) disodium into a vacuum stirring tank, then adding glycerol, micromolecular sodium hyaluronate and ceramide 3, and then adding L-lactic acid and a lactobacillus acidophilus fermentation product; sequentially adding nisin, cranberry extract, polyhexamethylene biguanide hydrochloride and beta-cyclodextrin inclusion tea tree essential oil, and finally adding dipotassium glycyrrhizinate, allantoin and citrus extract. Different from the prior art that private care wet tissues only have a single antibacterial function and neglect flora balance, peculiar smell is covered by depending on essence, the base material and the steeping liquor are designed at the same time, and the functions of bacteriostasis and antibiosis, gentle private care, odor removal and itching relieving, inflammation prevention and swelling prevention, flora balance maintenance and the like are achieved.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

The present application provides a kind of oil composition, containing monounsaturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acid is omega-9 fatty acid;Polyunsaturated acid is the mixture of omega-6 fatty acid and omega-3 fatty acid.The present application can repair and resist aging, all-purpose skin care, increase epidermal thickness, enhance barrier, anti-inflammatory soothing, anti-wrinkle firming, soothing repair red, nourish skin, and can be applied to sensitive skin, can inhibit LPS-induced HaCaT cell IL-6 secretion, increase the thickness of 3D skin model epidermis layer, and can promote the expression of silk aggregate protein (FLG), ceramide synthase 3 (CerS3), desmoglein core glycoprotein (DSG1) which has important role for skin barrier function, indicating that it can alleviate the inflammatory response produced by LPS stimulation HaCaT cell and has enhanced skin barrier function.

The invention provides an essential oil delivery system based on bionic lipidosome and a preparation method thereof, and belongs to the technical field of cosmetics and pharmaceutical preparations, a membrane material of the bionic lipidosome delivery system contains a component similar to skin cuticle lipid, and an inclusion compound formed by cyclodextrin and volatile active ingredients is encapsulated in the membrane material; the volatile active component is selected from plant essential oil or active components thereof with anti-aging, analgesic, anti-inflammatory or anti-allergy effects; the membrane material is prepared from hydrogenated soybean lecithin, cholesterol, ceramide, phytosphingosine, phytosterol and an antioxidant; according to the bionic liposome delivery system provided by the invention, the volatility of active ingredients can be remarkably reduced, the stability of the active ingredients can be improved, and slow release and synergistic infiltration promotion effects can be realized, so that the effects of the bionic liposome delivery system in anti-aging, pain relieving and other applications can be greatly enhanced.

The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and / or other glucosylceramide-based glycosphingolipids (GSLs).

The application discloses a low-irritation borage oil nano-liposome, a diaper-care preparation and application of the diaper-care preparation in diaper rash of infants and young children, and belongs to the field of infant skin-care preparations. The nano-liposome is composed of the following components in percentage by weight: 0.5-2.0% of biodecolorized borage oil, 1.0-3.0% of chitosan oligosaccharide-ceramide binary membrane material, 0.3-1.0% of prebiotic skin flora regulator, 0.8-1.5% of pH 5.5 weak acid buffer system, 0.05-0.2% of edible-grade microencapsulated menthol, and the balance of sterile water for injection. The application also provides a diaper-care preparation containing the low-irritation borage oil nano-liposome, which is suitable for daily prevention and acute-phase intervention of infants and young children aged 0-36 months, has the characteristics of high bioavailability, low irritation, rapid repair and easy carrying, and has important clinical application value.

The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and / or other glucosylceramide-based glycosphingolipids (GSLs).

The invention discloses a skin care moisturizer preparation method, which comprises: S1, heating an oil phase component to a molten state under a vacuum condition to obtain a homogeneous oil phase; s2, mixing and swelling a water phase component containing a macromolecular thickening agent under a heating condition to obtain a homogeneous water phase; s3, mixing the water phase and the oil phase under a vacuum condition, shearing and homogenizing at 70-80 DEG C to form a primary emulsion, and then starting to cool; s4, when the temperature of the system is reduced to a first preset temperature interval, adding a first group of active substances and uniformly dispersing; and S5, when the temperature of the system is continuously reduced to a second preset temperature interval, adding a second group of active substances, uniformly dispersing, and then adjusting the pH value of the system to 5.5-6.0. According to the present invention, the ceramide, the recombinant collagen and the decarboxylated carnosine are adopted, and the ceramide and the squalane are adopted to simulate the skin lipid so as to actively repair the barrier;

This disclosure presents compositions of anti-ceramide antibodies and their antigen-binding fragments. [Solution] This disclosure further presents a method for preventing or inhibiting cell death in a subject requiring such prevention, comprising the step of administering an anti-ceramide antibody or antigen-binding fragment to the subject. Subjects requiring such prevention may be suffering from autoimmune diseases, GI syndrome, or GvHD.

The invention belongs to the technical field of cosmetics, and particularly relates to a composition with soothing and repairing effects and a preparation method and application thereof.The composition with the soothing and repairing effects is prepared from, by weight, 0.5%-4.0% of humulus lupulus extract, 0.5%-4.0% of humulus lupulus extract, 0.5%-4.0% of humulus lupulus extract, 0.5%-4.0% of humulus lupulus extract and the balance water. And 0.1%-2.0% of a Velcro root extract. According to the technical scheme, the humulus lupulus extract, the magic claw root extract and the ceramide are scientifically compounded, so that a multi-channel synergistic effect is realized, and the soothing and repairing effects are effectively improved.

This skin cosmetic provides a pleasant feel upon application, leaves the skin feeling plump after application, and maintains a smooth and plump skin condition even after wearing a mask. [Solution] A skin cosmetic is provided that is free of dihydric alcohols having 6 or more carbon atoms and phenoxyethanol, characterized by containing (A) 1 to 20% by mass of 1,3-propanediol, (B) 0.5 to 4% by mass of 1,2-pentanediol, (C) 0.01 to 0.5% by mass of glycerin mono-2-ethylhexyl ether, and (D) 0.00001 to 0.001% by mass of ceramide.

The present application relates to the field of cosmetic technology, and discloses an anti-inflammatory soothing cosmetic composition, which comprises the following components in percentage by weight: a barrier repair component: 0.5-4%, an immunomodulatory component: 0.5-3%, a nerve soothing component: 0.3-2.5%, an anti-inflammatory plant complex: 0.3-3%, a moisturizing soothing enhancer: 1-10%, and a balance of auxiliary materials. The above components significantly enhance anti-inflammatory soothing and barrier repair through a five-dimensional synergistic mechanism of 'barrier repair-immune tolerance-nerve desensitization-anti-inflammatory itching-moisturizing stability maintenance'; the introduction of ceramides, rare ginsenosides, plant sterol esters, and free fatty acids synergistically constructs 'bionic liposomes', which are closer to the lipid composition of human stratum corneum, enhance transdermal absorption and stability, and significantly improve repair efficiency; the synergistic effect of dipotassium glycyrrhizinate, tamarix flower extract, spilanthes extract, dinoxanthin, and baicalin suppresses rapid anti-inflammatory itching, strengthens barrier repair, and is suitable for highly sensitive skin.

The invention discloses a recombinant Yarrowia lipolytica engineering strain for producing nervonic acid and application of the recombinant Yarrowia lipolytica engineering strain, and belongs to the technical field of genetic engineering and biological engineering. Beta-keto acyl-CoA synthase AtKCS, CraKCS and LaKCS are expressed in the Yarrowia lipolytica, recombinant Yarrowia lipolytica capable of synthesizing nervonic acid is obtained, supply of C18: 1 delta9-CoA is further enhanced, accumulation of C24: 0-CoA is reduced, endoplasmic reticulum is expanded, key genes are driven by a strong promoter, supply of malonyl CoA and NADPH is increased, and the yield of nervonic acid is increased, the nervonic acid yield of the engineering strain NA10 reaches 451.80 mg / L, and a foundation is laid for subsequent biosynthesis of lipid derivatives such as C24: 1-ceramide and the like.

The invention relates to the technical field of soothing and repairing cosmetics, in particular to a soothing and repairing mirabilis jalapa liposome composition, a mask liquid and a preparation method and application of the soothing and repairing mirabilis jalapa liposome composition and the mask liquid. The composition comprises a saussurea involucrata liposome, a triple ceramide liposome and a dihydroavena alkaloid liposome, wherein the weight ratio of the saussurea involucrata liposome to the triple ceramide liposome to the dihydroavena alkaloid liposome is (1-8): (1-5): (1-7); the particle size of the mirabilis jalapa liposome is 50 to 150 nm; the particle size of the triple ceramide liposome is 100 to 200 nm; the particle size of the dihydrooat alkaloid liposome is 100 to 200 nm. According to the invention, specific active components are selected and compounded in a liposome form, so that a synergistic regulation effect can be realized, the expression of a TRPV1 receptor and inflammatory factors is remarkably inhibited, and a good soothing and repairing effect is further realized.

The present invention relates to a dermatological composition for external application, containing, as an active ingredient, a complex ingredient comprising betulin, a ceramide, a soybean extract, and a green tea seed extract. The dermatological composition for external application has the effects of improving the skin barrier by activating keratinocyte proliferation, enhancing the moisture retention of the skin by reducing transepidermal water loss, and improving acne by inhibiting the lipase activity of Cutibacterium acnes.

The invention relates to a quaternary lipid barrier repairing composition which is prepared from the following raw materials: tea-seed oil, camellia-seed oil, a phytosterol derivative and meadowfoam seed oil. Through compounding of the tea-seed oil, the camellia-seed oil, the phytosterol derivative and the meadowfoam seed oil, multi-dimensional barrier repair synergy of passive supplement, active repair and antioxidant protection is realized. The quaternary lipid system is highly similar to a human body sebum membrane structure, and can rapidly fill up cuticle lipid gaps, significantly reduce transdermal moisture loss and efficiently repair a skin physical barrier; the phytosterol derivative can be cooperated with the tea-seed oil and the camellia-seed oil, lipid components can be directly supplemented, a skin lipid synthesis mechanism can be activated, skin endogenous generation proportion-coordinated cholesterol-ceramide-free fatty acid is guided, and self-reconstruction of a barrier is achieved; the meadowfoam seed oil has excellent oxidation resistance, so that secondary damage of oxidative stress to lipid can be effectively resisted, and the stability and durability of repair are ensured.

Provided herein are methods, compositions, and kits for treating tumors by combining patient-derived immune effector cells with cytokine and therapeutic agents. In one aspect, apheresis material is processed to isolate at least two products selected from T cell, NK cell, and dendritic cell populations, which are formulated and administered to the patient. In another aspect, invariant natural killer T (iNKT) cells are expanded ex vivo using an IL-15:IL-15Rα complex and α-galactosylceramide delivered on a bacterial minicell nanoparticle, enabling scalable production of functional cells. Additional embodiments include tumor microenvironment preconditioning regimens and use of IL-15 superagonists to convert "cold" tumors into "hot" tumors.

The present invention relates to a cosmetic composition for promoting skin regeneration, and more particularly, to a cosmetic composition for promoting skin regeneration by further comprising a polydeoxyribonucleotide (PDRN) in a composition comprising a sponge microneedle, a lactic acid bacteria exosome, and a ceramide in a specific weight ratio, and more particularly, to a cosmetic composition for promoting skin regeneration by adding a polydeoxyribonucleotide (PDRN) to a composition comprising a sponge microneedle, a lactic acid bacteria exosome, and a ceramide in a specific weight ratio. The sponge microneedle forms a microchannel in a skin cuticle to promote transmission of effective components, the lactic acid bacteria exosome induces cell viability through a cell signal transduction function, and the ceramide strengthens a skin barrier. By adding PDRN in the range of 0.001 to 3% by weight relative to the total weight of the composition, proliferation of skin fibroblasts, collagen synthesis and wound healing can be promoted. The composition can be prepared into various dosage forms such as face cream, emulsion, essence, ampoules or facial masks, and the improved skin regeneration effect is provided by simultaneously achieving the effects of strengthening the skin barrier, activating cells and promoting tissue regeneration.