289 results about "Ceramide" patented technology

The invention provides a technical method for improving the anti-aging effect of eurotium cristatum tea compound fermentation liquor, and belongs to the technical field of microorganisms, the Latin name of eurotium cristatum is Eurotium cristatum, the eurotium cristatum is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC M 2024643. According to the method, the yeast seed solution is inoculated into the tea-sea buckthorn leaf culture solution fermented by the eurotium cristatum, so that the content of anti-aging active components such as procyanidine B2, quercitrin, cyanidin-3-glucoside, nicotinic acid, naringenin and rutin in the fermentation culture solution can be remarkably increased through co-fermentation, and the elastase inhibition rate can be remarkably increased; the anti-aging effect of a component system of the fermentation culture solution is enhanced. The prepared tea-hippophae rhamnoides leaf compound fermentation liquor is suitable for development of anti-aging cosmetics and has a wide market prospect.

The invention relates to a preparation method and application of an artificially synthesized exosome with an anti-aging effect, and belongs to the technical field of cosmetics and biology. The artificially synthesized exosome is prepared from hydrogenated lecithin, phytosphingosine, cholesterol, ceramide, squalane, sodium stearoyl glutamate, a surface modification structure, polyol, an active component and water. The preparation method comprises the steps of preparation of an alcohol phase, preparation of a water phase, preparation of a mixed solution and high-pressure homogenization treatment. The artificially synthesized exosome prepared by the preparation method provided by the invention is good in stability and high in anti-aging activity.

The invention relates to the field of cosmetics, and discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application of the anti-wrinkle composition. The anti-wrinkle composition is prepared by compounding I-type collagen peptide nano-micelles, recombinant humanized III-type collagen, recombinant humanized XVII-type collagen, glycosylglycerol and ceramide. The skin care composition has the advantages that multiple synergistic effects are achieved, collagen generation is promoted, the skin moisturizing capacity is enhanced, and the skin barrier is repaired, so that the elasticity, compactness and smoothness of the skin are remarkably improved. The product disclosed by the invention has the effects of skin barrier repair, anti-aging care, collagen protection, collagen generation promotion, water locking and moisturizing and the like, and is suitable for research, development and application of skin care products for resisting wrinkles, tightening and delaying senescence.

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention relates to the technical field of cosmetics, in particular to moisturizing and anti-aging nanoemulsion, a preparation method thereof and moisturizing essence. The moisturizing and anti-aging nanoemulsion comprises the following raw materials in percentage by mass: 90-99% of an anti-aging component and 1-10% of a moisturizing component, and the anti-aging component comprises the following raw materials in percentage by mass: 1-20% of a glycosylglycerol solution, 0.5-3% of nicotinamide adenine dinucleotide, 0.1-5% of sodium coramate and the balance of a solvent; the moisturizing component comprises ceramide lipidosome. The raw materials in the moisturizing and anti-aging nanoemulsion synergistically exert effects, the moisturizing and anti-aging effects of the moisturizing and anti-aging nanoemulsion are improved, meanwhile, the stability and applicability of the moisturizing and anti-aging nanoemulsion are enhanced, and the moisturizing and anti-aging nanoemulsion is mild and non-irritant to skin and safe to use. The preparation method of the moisturizing anti-aging nanoemulsion is simple in process, high in production efficiency and beneficial to industrial production. The moisturizing essence has more remarkable moisturizing and anti-aging effects by adding the moisturizing and anti-aging nanoemulsion, and is safe to use.

The invention provides a skin care composition with an anti-aging effect and a preparation method and application thereof, and belongs to the technical field of beauty and skincare, the composition is characterized in that retinol, a polypeptide compound, ceramide, astaxanthin and resveratrol have a synergistic effect on component combination, so that all-around anti-aging is realized, and the skin care effect is good. According to the present invention, the raw materials are respectively adopted to provide effects of collagen generation promotion, muscle contraction wrinkle solving, barrier function enhancing, free radical scavenging, melanin formation inhibition and the like, the preparation method comprises the following steps: precise temperature control, suitable stirring mode, high-precision stirrer and other advanced technologies ensure uniform mixing of the components, inert gas protection and PID temperature controller retention of the activity and the effects of the components, in the aspect of application, the composition is reasonably added into face cream, emulsion, essence and facial mask, diversified requirements are met, deep nourishing, refreshing care, efficient permeation and instant effects are respectively provided, in a word, an efficient, safe and comprehensive anti-aging scheme is provided for consumers, aging signs are improved, and the composition is wide in prospect and high in value.

The invention discloses Kluffa yeast and application of the Kluffa yeast in preparation of red camellia fermentation liquor with anti-aging and repairing functions, the Kluffa yeast is used for repairing PR-LQX002, the Latin name of the Kluffa yeast is Lachancea kluyveri, and the preservation number of the Kluffa yeast is CCTCC NO: M 20241723. The invention also provides a red camellia fermentation broth, a composition containing the fermentation broth and application of the red camellia fermentation broth in preparation of products with anti-oxidation, anti-saccharification, anti-wrinkle or repair effects. The fermentation broth is prepared from the following raw materials: red camellia flowers, red camellia leaves and Kluffa yeast PR-LQX002. The Kluffa yeast can greatly promote fermentation of flowers and leaves of the red camellia, and the obtained red camellia fermentation liquor not only contains active substances such as flavone, polyphenol and free amino acid, but also contains lipid substances such as ceramide, and has multiple effects such as saccharification resistance, repair, wrinkle resistance and oxidation resistance.

A biosynthesis method for preparing royal jelly acid and the use thereof in skin care, which belong to the technical field of genetic engineering and biosynthesis. The royal jelly acid is produced by means of fermentation on the basis of yeast engineering bacteria using a culture medium containing trans-2-decenoic acid. An assessment at both skin cell level and skin model level shows that royal jelly acid can promote the synthesis of stratum corneum lipids and ceramide on aging skin and repair the skin barrier; and also can promote the synthesis of mitochondria ATP and NADPH in skin fibroblasts, reduce the active oxygen content of mitochondria, improve mitochondrial dysfunctions, and inhibit apoptosis. Further experiments show that royal jelly acid can repair DNA damage of fibroblasts caused by ultraviolet irradiation, reduce telomere shortening caused by cell division and replication, and strengthen the protection of chromosomal terminal regions. The prepared royal jelly acid has wide application prospects in the development of functional skin care products for skin repairing, aging resisting, etc.

The invention belongs to the technical field of microorganisms, and particularly relates to an extracellular vesicle of phytobacterium plantarum and application of the extracellular vesicle. Specifically, the plant lactobacillus extracellular vesicles can promote HaCaT cells to generate ceramide, up-regulate expression of key genes in a skin ceramide synthesis route and recover a skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. A mouse skin injury model verifies that the EVs has good skin infiltration capacity and can remarkably reduce the skin injury score, relieve skin itch, improve the skin water content and reduce expression of proinflammatory factors in skin tissue and expression of pruritus-related cell factors.

The invention discloses an acne-removing essence and a preparation method thereof, and particularly relates to the technical field of skin care products, the acne-removing essence comprises the following components by mass: 0.5-5% of salicylic acid; 1%-5% of tartaric acid; 2%-6% of nicotinamide; 0.5%-2% of colloidal sulfur; 1.5%-3% of tea tree essential oil; 1%-2% of hyaluronic acid; 0.5%-1% of ceramide; 1%-3% of glycerol; 1%-2% of trehalose; the salicylic acid is used for penetrating into skin, helping to relieve dead skin cells, reducing inflammation and accelerating skin renewal; the tartaric acid is used for realizing a stripping effect, can remove aged cuticles on the surface of the skin and promote the generation of new cells, so that the problem of acnes is helped to be improved. The acne-removing essence prepared by the invention has a relatively good moisturizing effect, so that skin barrier can be well maintained, keratin metabolism is promoted, grease secretion is inhibited, acne is effectively prevented, inflammatory response of the acne is relieved, and the actual use effect of the acne-removing essence is relatively good.

Provided herein are lipid nanoparticles composition comprising a lipid component which comprises: (i) a first ionizable cationic lipid, (ii) a PEG-lipid, wherein the PEG-lipid comprises a PEG-Ceramide. Further provided are lipid nanoparticle compositions comprising a lipid component which comprises: (i) a first ionizable cationic lipid, (ii) a PEG-lipid, wherein the PEG-lipid comprises a PEG-Ceramide selected from: N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)5000]} (C8 PEG5000-Ceramide), N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]}(C8 PEG2000-Ceramide), N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]} (C8 PEG750-Ceramide), N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)5000]} (C16 PEG5000-Ceramide), N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]} (C16 PEG200-Ceramide), and N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]} (C16 PEG750-Ceramide) (iii) a phospholipid, and (iv) a permanently cationic lipid, an anionic lipid, or a second ionizable cationic lipid separate from the first ionizable cationic lipid.

The invention relates to an artificially synthesized no-load exosome capable of promoting permeation and having a repairing effect as well as a preparation method and application of the artificially synthesized no-load exosome, and belongs to the technical field of cosmetics and biology. The artificially synthesized no-load exosome comprises a membrane core structure, the membrane structure of the artificially synthesized exosome comprises hydrogenated lecithin, phytosphingosine, cholesterol, ceramide, squalane, sodium stearoyl glutamate and a surface modification structure, and the core of the artificially synthesized exosome comprises water. The artificially synthesized no-load exosome provided by the invention has good particle size uniformity, particle size stability, permeation enhancing performance, permeation enhancing effect stability and skin repairing effect.

The invention relates to the technical field of skin care products, and particularly discloses a bionic liposome for simulating intercellular lipid components and a preparation method of the bionic liposome. The bionic liposome for simulating the intercellular lipid component comprises the following components in parts by mass: 30-38 parts of a solvent; 35 to 43 parts of a humectant; 1.34 to 1.66 parts of grease; 2.4 to 2.6 parts of a lipid substance; 2.58 to 3.22 parts of an emulsifier; 18 to 26 parts of a skin conditioner; 4.9 to 5.1 parts of composite ceramide; 1 to 3 parts of phytosphingosine; 0.09 to 0.11 part of a sphingomonas fermentation product extract; and the emulsifier is a compound of olive alcohol, polyglycerol-10 stearate, sodium stearoyl glutamate and sodium lauroyl lactylate. The method has the advantage that ceramide is not easy to crystallize and separate out.

The invention belongs to the technical field of exosome freeze-dried powder, and discloses exosome freeze-dried powder and a preparation method thereof, the exosome freeze-dried powder contains mesenchymal stem cell exosome, trehalose, sodium hyaluronate, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide. According to the exosome freeze-dried powder, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide are added, the membrane structure integrity of the exosome is effectively protected, the retention rate of active substances in the exosome freeze-dried powder is high, and therefore the effects of resisting inflammation, regulating cell metabolism, promoting tissue repair and the like of the exosome can be fully exerted. In addition, glutathione can directly remove skin free radicals and inhibit oxidative stress injury, and has an anti-oxidation effect; ceramide can also supplement skin lipid barrier, enhance the water locking capacity and enhance the moisturizing effect of sodium hyaluronate; fructo-oligosaccharide can also regulate skin micro-ecological balance, and has anti-inflammatory and bacteriostatic effects.

Provided herein are lipid nanoparticle (LNP) compositions (e.g., pharmaceutical compositions) comprising a therapeutic nucleic acid (TNA), wherein the LNP comprises an ionizable lipid; a "helper" lipid, e.g., a ceramide or distearoylphosphatidylcholine (DSPC); a structural lipid, e.g., a sterol; and one or more types of lipid-anchored polymers, as well as uses thereof.

The invention provides an external application medicine for incontinent dermatitis and a preparation method thereof. The composition is prepared from active ingredients such as a radix sophorae flavescentis extract, calamine, vitamin E, ceramide, a herba portulacae extract, glycyrrhizic acid, chitosan and colloidal oat powder according to a specific proportion. Moisturizing matrixes such as sodium hyaluronate and glycerol and functional components such as tea tree essential oil are supplemented. And through a preparation process of matching high-speed shearing with ultrasonic dispersion, uniform dispersion and stability of each component are ensured. Experimental results show that the composition shows a remarkable synergistic effect in the aspects of anti-inflammation, antibiosis, skin barrier repair and the like, the comprehensive relieving and repairing effect of the composition is superior to that of a conventional drug control, and all the components and a special preparation process are necessary for achieving the optimal effect. The product has no irritation to human skin, is good in safety, can be prepared into various dosage forms such as cream, hydrogel or spray, and is suitable for nursing and repairing sensitive skin.

The present invention belongs to the technical field of oral preparations, and specifically relates to a collagen composition for brightening the skin and a preparation method thereof. The composition of the collagen composition includes the following raw materials by weight: 40 to 60 parts of fish collagen peptides, 2 to 5 parts of arbutin extract, 0.1 to 0.5 parts of black pepper extract, 3 to 6 parts of glutathione, 1 to 3 parts of ellagic acid, 1 to 2 parts of shea butter, 3 to 5 parts of antioxidants, 1 to 2 parts of squalane, 1 to 2 parts of ceramide, 0.5 to 1 part of sodium bicarbonate, 5 to 10 parts of β-cyclodextrin, 1 to 3 parts of lecithin, and 0.5 to 1 part of silicon dioxide. The present invention uses polyethylene glycol grafted amino nanocellulose magnetic carriers to fix enzymes, improve enzyme thermal stability and resistance to denaturation, optimize cross-linking to retain enzyme activity, simplify recovery processes, reduce costs, improve collagen peptide production and quality, and protect active ingredients through nano- and embedding technologies to enhance absorption efficiency and product stability.

The invention discloses a preparation method of an external skin care product, belongs to the technical field of cosmetics, and aims to solve the problems of weak effect of a single target spot, poor transdermal permeability of active ingredients and easy inactivation in the prior art. The method comprises the following steps: preparing a composition containing an A-phase licorice extract and a B-phase bearberry extract, wherein the mass ratio of the A phase to the B phase is 1: (1.5-3); the preparation method comprises the following steps: preparing a liposome suspension of which the entrapment rate is greater than or equal to 88% and the particle size is 50-200nm by using a hydrogenated soybean lecithin-phytosterol-ceramide composite membrane material through a membrane dispersion-high-pressure homogenization method; mixing with auxiliary materials to prepare essence or emulsion; and smearing according to 0.5-1mg / cm < 2 > to realize double-target synergistic blackening inhibition. According to the scheme, the melanin inhibition rate reaches 54%-62% through the double-target design in cooperation with composite membrane material liposome delivery, the active ingredient retention rate is larger than or equal to 89% after storage at 45 DEG C for 6 months, the transdermal rate is increased to 40%-48%, and the method is mild, low in irritation and remarkable in application value.

The invention provides a thermal spring water microelement liposome and an application thereof in improving a skin barrier function, the thermal spring water microelement liposome comprises the following components: 24-27 mg of hydrolyzed collagen, 50-60 mg of hydrogenated phosphatidylcholine, 34-39 mg of dilauroyl phosphatidylcholine, 30-35 mg of ceramide, 55-60 mg of cholesterol, 2-4 mg of hyaluronic acid, 1-5 mg of a preservative, and the balance of thermal spring water added to 1000 mg. The thermal spring water microelement lipidosome disclosed by the invention has the functions of improving a skin barrier function, replenishing water and preserving moisture, locking water and preserving moisture at the same time, reducing percutaneous moisture loss and moistening skin, and has the effects of softening, moistening and resisting oxidation.

The invention provides a synergistic anti-aging composition based on a white truffle fungus extract, hydrolyzed keratin and soluble collagen and a preparation method of the synergistic anti-aging composition. The essence comprises the following components in percentage by mass: 0.5-5% of a white truffle fungus extract, 1-8% of hydrolyzed keratin and 2-10% of soluble collagen, and is supplemented with cross-linked modified hyaluronic acid, glycerol, ceramide, tocopheryl acetate, phenoxyethanol and a solvent. The preparation method comprises the following steps: preparing the cross-linked modified hyaluronic acid, performing low-temperature enzymolysis extraction on the white truffle bacteria, mixing and dissolving, and preparing the composition. The anti-aging effect of the composition is effectively improved and the stability of the composition is improved through the ternary synergistic effect (the white truffle bacteria can resist oxidation, the hydrolyzed keratin can repair a barrier and the collagen can promote regeneration) and process optimization.

The invention provides a metabolic marker combination for ovarian cancer diagnosis and application thereof, and belongs to the technical field of in-vitro diagnosis. The invention provides a metabolic marker combination for ovarian cancer diagnosis. The metabolic marker combination comprises phosphatidylcholine 34: 4, threonic acid, phosphatidylcholine 32: 2, pyroglutamic acid, phosphatidylcholine 36: 6 and ceramide d38: 2. According to the metabolic marker combination, plasma samples of a healthy subject and an ovarian cancer patient are analyzed, a group of biomarkers with significant difference are screened from the plasma samples, and the metabolic marker combination is a non-invasive, non-invasive and high-accuracy metabolic marker combination for distinguishing the healthy subject and the ovarian cancer patient. The method can be used for constructing a diagnostic model for distinguishing healthy subjects from ovarian cancer patients. The metabolic marker combination disclosed by the invention can be used for improving the diagnosis and evaluation capability of ovarian cancer patients, so that early discovery, early diagnosis and early intervention can be realized clinically, and the survival rate of the ovarian cancer patients is improved.

The invention discloses a ceramide composition capable of promoting cell repair and a preparation method and application thereof, and belongs to the technical field of foods.The ceramide composition is prepared from, by weight, 0.5-2 parts of rice bran oil powder, 0.5-2 parts of salvia officinalis extract and 5-32 parts of bioactive peptide. The bioactive peptides comprise fish collagen peptide, cubilose peptide and sea cucumber peptide, and the weight ratio of the fish collagen peptide to the cubilose peptide to the sea cucumber peptide is (30-55): 1: (1-10). Through the synergistic effect of the rice bran oil powder, the salvia officinalis extract and the bioactive peptide, cell repair is promoted jointly, and efficient repair of a skin barrier is achieved.

The present invention relates to a composition comprising, preferably consisting of, (i) a single empty liposome, wherein said single empty liposome is selected from (a) an empty liposome comprising cholesterol, wherein the amount of cholesterol is at least 30% (weight per weight), wherein preferably said empty liposome comprising, further preferably consisting of, cholesterol and sphingomyelin; or (b) an empty liposome consisting of sphingomyelin; or (ii) a mixture of empty liposomes; wherein said mixture of empty liposomes comprises, preferably consists of, at least one empty liposome selected from (a) an empty liposome comprising cholesterol, wherein the amount of cholesterol is at least 30% (weight per weight), wherein preferably said empty liposome comprising, further preferably consisting of, cholesterol and sphingomyelin; (b) an empty liposome consisting of sphingomyelin; and (c) an empty liposome comprising, preferably consisting of, phosphatidylcholine and sphingomyelin; and at least one empty liposome independently of each other selected from an empty liposome comprising, preferably consisting of, lipids or phospholipids selected from cholesterol, sphingomyelins, ceramides, phosphatidylcholines, phosphatidylethanolamines, phosphatidylserines, diacylglycerols, and phosphatidic acids containing one or two or more saturated or unsaturated fatty acids longer than 4 carbon atoms and up to 28 carbon atoms; for use in a method for preventing or reducing biofilm formation or for eradicating or reducing existing biofilm.

The invention provides an antibacterial composite hydrogel dressing loaded with a herba houttuyniae nano preparation as well as a preparation method and application of the antibacterial composite hydrogel dressing, and belongs to the technical field of medicines. According to the composite hydrogel dressing, methacrylamide hydrogel serves as a matrix, houttuynia cordata carbon dots are prepared through a hydrothermal synthesis method, the houttuynia cordata carbon dots and houttuynia cordata exosomes are jointly loaded in the methacrylamide hydrogel, and the composite hydrogel dressing is obtained. Wherein the herba houttuyniae carbon dots endow the hydrogel dressing with remarkable antibacterial activity and biocompatibility; ceramide, monogalactose diglyceride, phosphatidyl ethanolamine and the like in lipid components of the herba houttuyniae exosome have potential anti-inflammatory and tissue regeneration functions. The composite hydrogel loaded with the cordate houttuynia nano preparation prepared by the invention can realize controlled release of cordate houttuynia carbon dots and exosomes at wound parts, not only can promote cell proliferation and migration, but also can promote healing of diabetic wounds, and provides a new thought for healing of diabetic wounds.

The invention discloses retinol retinoate-ceramide lipidosome modified by hyaluronic acid and salts thereof and a preparation method of the retinol retinoate-ceramide lipidosome, and belongs to the technical field of cosmetic nano-carriers. The preparation method comprises the steps that retinol retinoate-ceramide lipidosome is prepared, hyaluronic acid is pretreated, and the hyaluronic acid and the salts thereof are combined to prepare the retinol retinoate-ceramide lipidosome. The liposome is modified by hyaluronic acid and salts thereof in a dual-mechanism manner, and purification and stabilization are realized; the preparation method of the retinol retinoate-ceramide liposome comprises the following steps: dissolving phospholipid, a functionalized lipid component with positive ions and amino functional groups, cholesterol, retinol retinoate and ceramide in absolute ethyl alcohol to serve as an organic phase, taking a phosphate buffer solution as a water phase, dropwise adding the organic phase into the water phase under a stirring condition, stirring, performing ultrasonic treatment, washing, and drying to obtain the retinol retinoate-ceramide liposome. Performing membrane extrusion to obtain a liposome suspension; the retinol retinoate-ceramide liposome modified by hyaluronic acid and salts thereof prepared by the invention has excellent stability, skin transmittance and anti-aging and moisturizing effects, also has low irritation, and is suitable for anti-aging cosmetics.

Provided herein are methods and materials for using organisms (e.g., engineered yeast strain-derived) to generate lipid compositions which can modulate cellular aging, extend lifespan, and / or modulate gut homeostasis in a subject. The lipid compositions contain at least twelve of the lipids selected from a phosphatidylethanolamine (PE); a lysophosphatidylethanolamine (LPE); a diacylglycerol (DG); a monoglyceride (MG); an acyl carnitine (AcCa); a phosphatidic acid (PA); a phosphatidylglycerol (PG); a lysophosphatidylcholine (LPC); a triacylglycerol (TG); a cholesterol ester (ChE); a wax ester (WE); a phosphatidylserine (PS); a phosphatidylcholine (PC); a phosphatidylinositol (PI); a ceramide (Cer); and a lysophosphatidylserine (LPS).

The invention discloses a stable supramolecular collagen hyaluronic acid body as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, constructing a supramolecular solvent system by taking betaine as a hydrogen bond receptor and taking polyol / sodium hyaluronate as a hydrogen bond donor, and preparing the stable supramolecular collagen hyaluronate from the supramolecular solvent and lipidosome colostrum prepared from lecithin, cholesterol, ceramide, collagen, polyol and water. According to the invention, collagen and sodium hyaluronate are not in direct contact in space in a form of lipidosome wrapping, the problems that flocculent precipitates are easily generated and the system is unstable when collagen and sodium hyaluronate are commonly used can be solved, and a dual delivery system formed by the supramolecular solvent and lipidosome has excellent human body permeability and efficacy.

The present invention provides A ceramide compound, comprising: a structure of general formula I or an enantiomer or diastereomer of general formula I:in which:R1 is selected from the condensation residues of ferulic acid, sinapic acid, abscisic acid, sotretinoin, tretinoin, fusidic acid, royal jelly acid, sorbic acid, caffeic acid or trans-cinnamic acid;R2 is selected from one of the following structures:—C15H29, —C15H31, —C15H27, —CHOHC14H27, —CHOHC14H29.The present disclosure also provides a ceramide compound containing conjugated carboxylic acid, preparation method therefor and application thereof. The invention reacts functional carboxylic acid with sphingosine base to obtain a class of ceramide compound with novel structure. The introduction of physiologically active molecular fragments of functional carboxylic acids into ceramides will enhance the original efficacy of this type of molecules and also improve the physical and chemical properties of ceramide compound. For example, improving the antioxidant properties of ceramide compound.

The invention belongs to the technical field of cosmetics, and particularly relates to a mask formula and a processing method thereof, the mask formula takes natural active ingredients as a core, and multiple skin care advantages are realized through scientific proportioning and an innovative process. A film forming system adopts a sodium alginate and hydroxypropyl methylcellulose compounding technology to form an air-permeable film, so that the air-permeable film can be tightly attached to the skin to promote absorption, and the skin stuffiness feeling of a traditional mask is avoided; cold-pressed camellia-seed oil is selected as a matrix, high-content oleic acid of the cold-pressed camellia-seed oil is highly matched with a sebum structure, and a bionic lipid barrier is formed by matching with ceramide, so that the water locking and repairing capability is remarkably improved. Microencapsulated nicotinamide and concentrated portulaca oleracea extract are creatively applied in an active system to achieve synergistic interaction, the microencapsulated nicotinamide continuously whitens skin and fades spots through a slow release technology, and the concentrated portulaca oleracea extract contains flavonoid compounds to accurately relieve inflammation and reduce sensitivity risks.

The invention belongs to the technical field of fermentation and metagen preparations, and particularly relates to application of bifidobacterium breve metagen in the aspects of scavenging free radicals and relieving oxidative aging. According to the present invention, the oxidative free radical scavenging experiment results show that the bifidobacterium breve NKU BB 1-2 metagen has good oxidative free radical scavenging ability, and has good scavenging ability on hydroxyl free radicals, superoxide anions and DPPH free radicals; meanwhile, through component analysis, it is found that the bifidobacterium breve NKU BB 1-2 metagen contains various antioxidant and anti-aging bioactive substances such as flavonoids, indoles, amino acids, bile acids and ceramides; a cell model experiment verifies that the bifidobacterium breve NKU BB 1-2 metagen can obviously relieve oxidative damage to the cells and improve the oxidation resistance of the cells, so that oxidative aging is relieved.