25 results about "Phosphatidylserines" patented technology

The present disclosure describes anti-inflammatory properties of red blood cell extracellular vesicles, e.g., as mediated by heme, hemoglobin and / or phosphatidylserine content. The present disclosure describes technologies useful for the treatment of inflammatory diseases, disorders, or conditions (e.g., atherosclerosis).

The present invention discloses a β-carotene-grape seed extract eye-care preparation for retinal protection, relating to functional health foods. The preparation comprises active components and food-acceptable excipients. In parts by weight, the active components include 1–4 parts lutein, 0.5 –2 parts meso-zeaxanthin, 2 – 6 parts β-carotene, 8 – 25 parts blueberry extract, 5 – 18 parts grape seed extract, 0.2–1 part L-ergothioneine, 0.5–3 parts saffron extract, and 1–5 parts phosphatidylserine. The excipients comprise a filler, disintegrant, binder, and lubricant, with a weight ratio of active components to excipients of 1:1 to 1:4. By combining these eight components at specific ratios, the invention achieves synergistic effects, protects retinal health, and reduces blue-light damage. Dual-phase microencapsulation based on solubility, together with standardized preparation steps, improves stability and utilization efficiency.

Disclosed in the present invention is a phosphatidylserine and docosahexaenoic acid (DHA) composite, and its application thereof in a functional preparation, belonging to the field of health-care food. By combining two substances in a specific ratio and further applying them to edible functional preparations, brain entry efficiency of unsaturated fatty acids including DHA is improved. The ratio verifies a synergistic interaction mechanism of two active ingredients. Phosphatidylserine promotes enrichment of fatty acids such as the DHA in a brain by enhancing permeability of a blood-brain barrier, promotes neurogenesis, and enhances learning and memory abilities. Moreover, combination of the phosphatidylserine (PS) and the DHA can significantly improve an expression level of neurotrophic factors and protect and repaire a nervous system. (Figl)

The present application relates to a kind of brain health nutrition capsule and its preparation method, belong to the technical field of functional health food.The preparation method includes the following steps: taking walnut kernel powder, DHA algal oil microcapsule powder, phosphatidylserine, ginkgo biloba extract and oligosaccharides are mixed, soft material is prepared by adding purified water, granulation is extruded by screen, and granule core is obtained by drying;Granule core is coated, and brain nutrition core granule is obtained by drying;Prepare base nutrition layer granule;Brain nutrition core granule and base nutrition layer granule are mixed, and composite granule is obtained, and composite granule is filled into capsule.The present application not only solves the three major obstacles of oxidation, precipitation and vitamin degradation of high polyphenol walnut base formula in gastric acid environment, but also unexpectedly builds from stomach protection to intestinal microecological optimization, finally realizes the cascade effect of brain nutrition efficient absorption, meets the core needs of teenagers brain health and intelligence, and truly realizes the effect of brain health and intelligence.

This invention belongs to the field of heavy metal pollution remediation technology, and relates to the preparation and application of a cadmium passivating agent for weakly alkaline soil. The weakly alkaline soil cadmium passivating agent mainly comprises the following components by weight: 30-50 parts of a mineral complex, 40-60 parts of a bioactive component, and 5-15 parts of an auxiliary stabilizer. The mineral complex includes natural sepiolite, calcium-based bentonite, and a polyether-polyester diblock copolymer; the bioactive component includes microbial agents, phosphorus-modified biochar, lecithin, and phosphatidylserine; and the auxiliary stabilizer includes nano-hydroxyapatite and a chitosan-grafted polyaspartic acid complex. This weakly alkaline soil cadmium passivating agent exhibits excellent remediation effects on cadmium in contaminated soil, effectively preventing or reducing the entry of cadmium and other heavy metals into the food chain, and has significant market potential.

The embodiments disclosed herein relate to a liposomal composition for sustained release of an active ingredient. In various implementations, the liposomal composition may have a first liposomal core of Phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) and the active ingredient dispersed within the first liposomal core. A second core may surround the first liposomal core, with the second core optionally containing one or more polypeptide and a polysaccharide.

This invention discloses an oral liquid for middle-aged and elderly men to cleanse blood, protect the brain, and promote hair growth, as well as its preparation method, belonging to the field of functional health food technology. Each bottle contains 50ml net content, one bottle daily, and is free of eight major allergens. The ingredients include resistant dextrin, erythritol, DHA algal oil microcapsule powder, phosphatidylserine, natto freeze-dried powder, various medicinal and edible extracts, ginseng, vitamins, folic acid, and purified water. This invention upgrades a solid beverage into an easily absorbed oral liquid dosage form, which is rapidly absorbed, does not harm the stomach and intestines, and can cleanse blood vessels, purify blood, assist in regulating blood pressure, blood sugar, and cholesterol, prevent and intervene in Alzheimer's disease, improve memory, and promote hair growth and darkening. The production process is mature and stable, suitable for industrial production, and is specially designed for middle-aged and elderly men, making it safe for long-term consumption.

Provided are compositions and methods for reducing pre-existing antibodies against viral vector or gene-editing related proteins. The compositions showed reduction in various antibody titers by administration of a liposome composition complexed with a protein or fragment thereof of a viral vector. The liposomes comprise phosphatidylcholine and phosphatidylserine, wherein some or all of the PS is present as lyso-PS. The compositions and methods can be used in conjunction with gene therapy and nucleic acid based vector based vaccinations and therapeutics.

The utility model belongs to the field of phosphatidylserine production technology especially for a kind of efficient catalytic reaction kettle of preparation phosphatidylserine, including kettle body, the kettle body is by outer tube, and the inner tube of fixed connection on the inner wall of outer tube is composed, kettle body is located in the center of inner tube and is provided with stand, and stand is inserted with equidistant distribution's stirring catalytic mechanism, the stand includes the column body rotationally connected in the center of kettle body, and the outer wall of column body is along the length direction of column body and is provided with the T-shaped groove of array distribution.This utility model is through setting outer tube and inner tube, when using, the circulation of solution can be realized by circulating pipeline, conduit, liquid inlet pipe, water pump, liquid injection mechanism, so that solution reciprocating contact with enzyme catalysis board frame, avoid existing dead angle, and the mode can make that solution is heated evenly, in turn guarantee the preparation effect of phosphatidylserine, solved the device efficiency low, the problem of poor processing effect of present stage.

The present invention discloses a SAMe, 5-HTP, and St. John's wort compound nutritional supplement for emotional support and joint care, comprising 15-25 parts of S-adenosylmethionine, 5-10 parts of 5-hydroxytryptophan, 3-8 parts of St. John's wort extract, 8-15 parts of sodium chondroitin sulfate, 2-5 parts of sodium hyaluronate, 0.5-1.2 parts of vitamin B6, 1-3 parts of vitamin E, 4-9 parts of phosphatidylserine, and pharmaceutical excipients. The weight ratio of S-adenosylmethionine to 5-hydroxytryptophan is 3:1-5:2, the weight ratio of St. John's wort extract to 5-hydroxytryptophan is 0.6:1-0.8:1, and the weight ratio of the joint-care agents to the total core active ingredients is 10:3-20:3. The hypericin content in the St. John's wort extract is not less than 3%. By optimizing the component ratios and utilizing synergistic functional excipients, the present invention achieves dual synergy in emotional support and joint care, with high product stability and excellent bioavailability.

This invention provides a mutant phospholipase D for the efficient synthesis of phosphatidylserine, its products, and applications. The mutant is based on phospholipase D with the amino acid sequence shown in SEQ ID NO.1, obtained by mutating one or more of five sites at positions 87, 136, 189, 379, and 458 of this amino acid sequence. The amino acid mutation types at these sites include: L87E, M136G, I189R, E379L, and A458Y. This invention provides both a mutant phospholipase D and its applications. This mutant phospholipase D exhibits improved thermostability and catalytic activity, enabling the catalytic preparation of phosphatidylserine series products. The phosphatidylserine series products prepared using this enzyme can effectively alleviate metabolic syndrome induced by antipsychotic drugs.

The present application relates to a kind of drug composition for preventing and adjuvant therapy of Alzheimer's disease and preparation method thereof, belong to medical health technical field.The prescription of the drug composition prepared in the present application includes the following active ingredients, phosphatidylserine, pyrrole quinoline quinone, coenzyme Q10, curcumin, EGCG, alpha-lipoic acid, acetyl L-carnitine, magnesium threonate, vitamin E, folic acid and vitamin B12.The preparation method of the drug composition also includes the following steps: the product is loaded with energy by weak magnetic resonance equipment to the composition.The drug composition reaches the effect of antioxidation, anti-inflammation, improves cerebral blood flow and protects neuron by the synergistic effect of multiple functional components, so as to help slow down the progress of Alzheimer's disease.

The utility model discloses a kind of catalytic reaction devices for phosphatidylserine, belong to phosphatidylserine production technical field, including concentrically arranged outer cylinder and inner cylinder, outer cylinder is sleeved in inner cylinder outside, annular temperature control cavity is equipped between outer cylinder and inner cylinder, temperature control assembly is equipped in annular temperature control cavity, outer cylinder bottom end is equipped with driving motor, driving motor output end penetrates outer cylinder bottom wall and extends into inner cylinder inner chamber, and is fixedly connected with stirring assembly, stirring assembly upper portion detachably connected with catalytic assembly, locking mechanism is equipped in stirring assembly inside, locking mechanism is used to lock catalytic assembly on stirring assembly upper portion.The utility model accurately adjusts temperature by temperature control assembly, locking mechanism locks catalytic assembly on stirring assembly, and continuously stirs and catalyzes extraction liquid, ensures that catalytic reaction process is stable during reaction process, after catalytic reaction, catalytic assembly can be extracted and replaced, without filtering and removing catalyst, more time-saving and labor-saving, convenient operation.

The present invention provides a covalent conjugate. The conjugate includes an antibody or antibody derivative, at least two LL37-derived polypeptides, and a payload. The antibody or antibody derivative targets a cell that has phosphatidylserine in its outer leaflet. The payload includes: a small molecule cytotoxic drug of less than 3 kDa, or a plurality thereof; or a peptide or protein of less than 100 kDa. Uses and methods of using these covalent conjugates are also provided, related to enhancing delivery of the antibody / derivative or the payload, e.g. to enhance therapeutic or diagnostic effectiveness.

This invention belongs to the field of biopharmaceutical technology, specifically relating to a composition for preventing and improving Alzheimer's disease and its preparation method. The composition is prepared by the following method: (S1) adding phosphatidylserine, an emulsifier, and walnut peptides to walnut paste to obtain an oil phase; (S2) dissolving xylitol, whole milk powder, and taurine in water, and slowly adding the oil phase during homogenization to obtain a mixed solution; (S3) dissolving a stabilizer in water to obtain a stabilizer solution, adding the stabilizer solution to the mixed solution, adding water to make up to volume, mixing thoroughly, and homogenizing to obtain the composition for preventing and improving Alzheimer's disease. This invention avoids the precipitation phenomenon caused by the Maillard reaction of walnut peptides. The antioxidant components in walnut paste can prevent the oxidative degradation of phosphatidylserine, solving quality problems such as oxidative rancidity and fat stratification in walnut paste, improving the stability of the composition, extending the shelf life of the product, and enhancing the product's competitiveness.

The application discloses a nano material for targeting and driving resuscitation of dying cells, and a preparation method and application thereof. The nano material is a nano platelet vesicle with phosphatidylserine exposed to the outer layer of the membrane after nanoization and centrifugal treatment. The material is obtained by separating and enriching platelets from peripheral blood, then nanoizing the platelets, and then inducing the phosphatidylserine on the platelet membrane to evert through high-speed centrifugation. The material is used for preparing a medicine for promoting tissue repair, and the medicine promotes resuscitation of dying cells by targeting the dying cells and enhancing the membrane repair capacity of the dying cells, so as to promote tissue repair, including repair of orthopedic, muscle, skin, spinal cord or visceral tissue, especially repair of diabetic foot, skin avulsion injury, ischemic skin flap or spinal cord injury. The resuscitation of dying cells is promoted successfully without intervention of lysis programmed cell death initiation, so that the problems of off-target effect and treatment paradox existing in current mainstream small molecule inhibitor strategy are effectively solved.

A composition to improve learning and cognitive functions, comprising a combination to promote cognitive brain performance: DHA from fish oil, phosphatidylserine and phosphatidylcholine; as well as a combination to provide energy and reduce brain fatigue: B vitamins and galangal extract.

This invention discloses a method for recovering L-serine based on the enzymatic synthesis reaction solution of phosphatidylserine, comprising the following steps: phosphatidylcholine and L-serine undergo an enzymatic reaction under the catalysis of phospholipase, resulting in a mixed aqueous solution containing L-serine and choline; porous media and alcohol are added to the obtained mixed aqueous solution of L-serine and choline, causing crystals to precipitate, resulting in a solid mixture of L-serine and porous media; the solid mixture of L-serine and porous media is obtained through solid-liquid separation; the obtained solid mixture of L-serine and porous media is dissolved in water, and after solid-liquid separation, an L-serine solution is obtained. This invention adds porous media before crystallization, causing capillary phase separation in the L-serine aqueous solution. This capillary phase separation results in a lower saturation concentration required for L-serine crystallization and a smaller amount of ethanol consumed, thus reducing the production cost of phosphatidylserine.

This invention discloses a single-domain antibody targeting phosphatidylserine, an engineered exosome based on this antibody, its preparation method, and its application in the preparation of skin repair products. The single-domain antibody has the amino acid sequence shown in SEQ ID NO:1. This invention further provides an engineered exosome whose surface is covalently linked to the single-domain antibody, and whose interior is enriched with mRNA encoding GPX4. This exosome is derived from human placental mesenchymal stem cells treated with a specific sequential induction protocol that can mimic the damaged microenvironment and upregulate the expression of specific functional molecules. The constructed engineered exosome can actively recognize and target the delivery of therapeutic molecules to damaged skin cells with everted phosphatidylserine, thereby effectively inhibiting ferroptosis, repairing UV-induced photoaging damage, and enhancing skin barrier function, providing a new technical solution to address the problem of insufficient targeting in existing exosome therapies.

The application belongs to the technical field of biological medicine, and particularly relates to a biomarker for early screening, diagnosis or monitoring of multiple cancers and application. The application realizes early high-precision screening and diagnosis of multiple cancers by screening and adopting a brand-new biomarker combination, namely, exosome surface phosphatidylserine (PS) and / or prolyl 4-hydroxylase beta subunit (P4HB), and the performance is significantly better than that of existing biomarkers. The technical scheme has the advantages of non-invasiveness, convenience, rapidness and the like, and simultaneously has high sensitivity and high specificity, and can realize accurate identification in the super-early or early stage of cancer, and is expected to develop into a new generation of non-invasive tumor diagnosis tool.

This invention provides a pharmaceutical composition for improving memory function, relating to the field of pharmaceutical technology. The composition comprises vitamin B6, vitamin B12, lutein, anthocyanins, phosphatidylserine, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), levodopa, benserazide, and selegiline. Vitamin B6, vitamin B12, lutein, anthocyanins, phosphatidylserine, DHA, and EPA nourish the brain; levodopa, benserazide, and selegiline are used for neuropharmacological treatment; anthocyanins, lutein, and EPA synergistically improve cerebral microcirculation, enhance blood oxygen supply, scavenge free radicals, reduce inflammation, and decrease brain cell aging and necrosis, thereby delaying the process of memory decline; levodopa, benserazide, and selegiline synergistically supplement and protect dopamine, with benserazide enhancing the bioavailability of levodopa and selegiline inhibiting dopamine degradation.

Composition comprising: a) Omega-3 fatty acids up to 1.5 g; b) Bacopa monnieri up to 600 mg; c) Ginkgo biloba up to 240 mg; d) Ginseng up to 2 g; e) Taurine up to 6 g; f) Phosphatidylserine up to 300 mg; g) Pantothenic acid up to 10 g; and h) Vitamin B1 up to 10 mg.

This invention discloses a *Acer truncatum* seed oil-PS composite composition that promotes nerve development, belonging to the field of food nutrition technology. The composite composition comprises the following components by weight: 8-12 parts *Acer truncatum* seed oil, 3-6 parts phosphatidylserine, 1-2 parts phospholipids, 2-4 parts flaxseed oil, 0.5-2 parts arachidonic acid phosphatidylinositol, 1-3 parts docosahexaenoic acid phospholipids, 0.3-1.5 parts sialic acid, 0.2-1 parts phytosterols, 0.1-0.8 parts d-α-tocopherol, 0.5-2 parts emulsifier, and 0.05-0.3 parts antioxidant synergist. This invention scientifically combines multiple nutritional components to form a synergistic system, meeting the nutritional needs of nerve development, providing comprehensive nutritional support, and significantly enhancing the promotion effect. Simultaneously, it constructs a brain-targeting lipid-phospholipid hybrid nanocarrier, combined with refined processing, to improve the targeting and bioavailability of the composition, retaining biological activity, and possessing good storage properties and safety for use, facilitating widespread application.

This invention discloses a nutritional supplement containing five-grain insect oil, its preparation method, and its application. The active ingredients of this nutritional supplement are composed of five-grain insect oil, DHA, and phosphatidylserine in a mass ratio of (2-4):(1-3):(1-2), preferably 3:2:1. The preparation method includes mixing and emulsifying five-grain insect oil, DHA, and phosphatidylserine, adding a wall material for microencapsulation, spray drying to obtain microencapsulated powder, and then mixing with excipients to form the target dosage form. The nutritional supplement prepared by this invention can effectively refresh the mind, relieve mental fatigue, improve concentration and memory, and delay cognitive decline, making it suitable for long-term consumption by mental workers, students, and the middle-aged and elderly.

The present application relates to the technical field of functional food preparation, and discloses a layered sustained-release phosphatidylserine and sleep-aiding factor nutritional formula and a preparation process, the formula comprising the following components by weight: phosphatidylserine: 0.5-1.7 parts; caprylic / capric triglyceride: 1.5-8.5 parts; sodium octenyl succinate starch: 0.8-3.5 parts; whey protein isolate: 0.4-2.0 parts; soy lecithin: 0.008-0.05 parts; mixed tocopherols: 0.0005-0.005 parts; ascorbic acid palmitate: 0.0002-0.003 parts; gamma-aminobutyric acid: 0.3-0.8 parts; L-theanine: 0.5-1.0 parts; glycine: 6.0-15.0 parts; magnesium glycinate: 2.0-5.5 parts. The present application realizes high stability and intestinal sustained release of PS microcapsule emulsion and stomach rapid release of sleep-aiding factors through microfluidic multilayer wet integration technology.