10 results about "Co release" patented technology

The present invention discloses a carbon monoxide prodrug, its preparation method, and application. The carbon monoxide prodrug is obtained by coupling one or more oxalate structural fragments with a photosensitive CO prodrug. This type of organic small molecule can specifically release CO in response to hydrogen peroxide. Specifically, the oxalate fragment in the carbon monoxide prodrug reacts with hydrogen peroxide, causing proton transfer within the molecule. The resulting intermediate then undergoes a [2+3] cycloaddition reaction with hydrogen peroxide to form an epoxy bridge, which then releases carbon monoxide through electron transfer. Furthermore, the carbon monoxide prodrug provided by the present invention can achieve controlled release of CO in the absence of light and heavy metals, with a CO release efficiency of up to 100%. It has excellent application prospects in the preparation of drugs for CO delivery.

The application discloses a fluorescent response type manganese carbonyl carbon monoxide releasing agent, a preparation method and application, wherein the compound has the following structural formula: the manganese carbonyl compound provided by the application has good photosensitivity and fluorescent characteristics, CO release can be accurately controlled through green light, the release process can be tracked in real time by using the change of the fluorescent intensity, and the manganese carbonyl compound is expected to be a photo-triggered carbon monoxide releasing agent with application prospect.

The present invention belongs to the field of biochemistry and relates to a method for preparing a biochemical product having H2S and 1 O2 synergistically drives the BODIPY flavonoid nanoreagent of CO release ability and its preparation method and application. It is wrapped in the hydrophobic inner cavity of the micelle formed by mPEG DSPE2000, and the outer layer of the micelle is a silicon shell formed by N trimethoxysilylpropyl N, N, N tri-n-butylammonium bromide, which significantly improves the water solubility of the molecule. The core-shell structure of the formed nanomolecule is relatively stable, which can significantly improve the stability of the molecule in water. The iodinated BODIPY flavonoid compound of the present invention has very good photodynamic effect and CO release ability, has a very high singlet oxygen production efficiency under 660nm light irradiation, and has excellent stability. It has and its considerable application prospects in photodynamic and gas therapy in the fields of biochemistry and medicine. The phototherapy reagent synthesis method provided by the present invention is simple and relatively low in cost.

The invention provides a CO intelligent release platform based on a flexible implantable circuit and NFC induction. A forming method of the CO intelligent release platform comprises the following steps of constructing an NFC-LED module, forming a PDMS substrate, preparing a photosensitive composite layer, integrating devices and wirelessly activating a system. According to the CO intelligent release platform based on the flexible implantable circuit and NFC induction, a controllable CO release system based on a (carbon nitride / gold) composite nano-catalyst is constructed, and multiple mechanisms such as wireless NFC activation, blue light driving, nano-material directional reaction, release rate accurate regulation and control, targeted therapy and the like are combined; the defects of poor drug release accuracy, strong activation mode trauma, non-adjustable release rate, indefinite treatment window, high system energy consumption and the like in the prior art are overcome.

The invention specifically discloses a bionic nano platform as well as a preparation method and application thereof, and relates to the technical field of biological medicines. According to the bionic nano platform disclosed by the invention, efficient conversion from ultrasonic energy to chemical energy (CO release) is realized by constructing a Schottky heterojunction structure of Ni and LDH. In addition, by means of tumor cell membrane coating, homologous recognition characteristics are endowed to the nano-material, so that the nano-material can actively target brain glioma and penetrate through BBB, and precise delivery and deep tumor enrichment are achieved.

The present invention discloses a therapeutic system for the topic, transdermal and transcutaneous application of carbon monoxide (CO), comprising: (i) an adhesive layer, (ii) a gas-permeable and liquid- and solid-impermeable membrane, (iii) a reaction chamber comprising a CO releasing molecule A, and (iv) a gas-impermeable backing layer, wherein the transdermal therapeutic system is configured that the CO releasing molecule A can be brought into contact with a CO release triggering compound B in the reaction chamber (iii). The therapeutic system can be used for the treatment of wounds, inflammatory diseases of the skin, and inflammatory diseases of subcutaneous skin tissue, joints and tendons.

The present invention relates to a method for quantifying calcium oxalates contained in a sample of a surface formation or biomass, in which the sample is heated in an inert atmosphere from an initial temperature of 100 to 300°C to a final temperature of 575 to 800°C, and a curve (MES) is measured showing the temperature evolution of the amount of CO released by the sample during heating in an inert atmosphere. Then, the mass of carbon released by the calcium oxalates in the sample as CO during heating in an inert atmosphere is determined from the measured curve (MES) and an interpolation (INTER) of this curve between a first temperature (T1) of 390 to 450°C and a second temperature (T2) of 550 to 590°C. Then, using an exponential relationship, we deduce the mass of calcium oxalates in the sample. Figure 2 to be published.

The application discloses a kind of low CO release amount reconstituted tobacco preparation methods based on catalysis-pore-forming synergistic system, which includes tobacco waste pretreatment, preparation mixed slurry and tobacco concentrate;Catalyst, pore-forming agent and dispersing agent are included in catalysis-pore-forming composite adjuvant;Slurry is mixed with inorganic filler and formed into a substrate;Composite adjuvant and concentrated liquid are coated and impregnated;Sectional gradient drying;Balance moisture, cut silk screening to get finished product.The application reduces the reconstituted tobacco CO release amount by 25.37%-28.42% through the synergistic effect of "catalysis+pore-forming", and the sensory comprehensive score is improved by 6.6-7.0 points, and does not need to transform existing production line, suitable for papermaking method mainstream process industrial production, which can be widely used in high-grade cigarette raw material preparation.

The present application relates to a kind of prussian blue nanocomposite with photoresponsive release carbon monoxide and its preparation method and application, belong to medical preparation technical field.The present application has prussian blue nanocomposite with photoresponsive release carbon monoxide, including prussian blue nanoparticles and group a grafted on the surface of prussian blue nanoparticle: And group b:This prussian blue nanocomposite not only has good biocompatibility, also has excellent thermal conversion efficiency, simultaneously can also utilize light to control CO release amount, so that photothermal therapy and gas therapy synergistic effect, and then significantly improve the cure rate of tumor.

A froster system is provided that releases liquid CO from a high-pressure CO cylinder through a CO release nozzle located within a refrigerator. The froster system efficiently sterilizes, cools, freezes, or freezes a container placed in the nozzle. The froster system includes a high-pressure CO cylinder in fluid communication with the CO release nozzle, a cylinder-to-nozzle tubing connecting the CO cylinder and the CO release nozzle, and a controller that communicates user input to activate the froster system to release liquid CO.