15 results about "Co release" patented technology

The present invention relates to the field of targeted therapy technology, and particularly, to a carrier, a targeted nanoparticle, a method for preparing same, and use thereof. The carrier disclosed in the present invention comprises tocilizumab grafted with a terminal carboxyl group-containing dye. The targeted nanoparticle comprises a carrier and a CO-release molecule. The carrier encapsulates the CO-release molecule to form a core-shell structure. In the targeted nanoparticle based on tocilizumab, the carrier is constructed by grafting the terminal carboxyl group-containing dye, and the carrier encapsulates the CO-release molecule. The carrier possesses a targeting effect, and the photothermal effect of the carrier can achieve the regulated CO release by NIR laser or targeted and controllable CO release under free radical stimulation, thereby achieving exogenous / endogenous dual-response release of CO. The present invention features good application prospects.

The present invention discloses an organic polymer composite material based on BODIPY light-controlled CO release, as well as its preparation method and application, belonging to the field of biomedicine technology. Tetraaldehyde BDP and 2,2'-bipyridine-5,5'-diamine are dissolved in an organic solvent, ultrasonically dispersed to form a suspension, and after cyclic deoxygenation, heated in a sealed environment for reaction to obtain a powdered black solid BB-COF. BB-COF and pentacarbonyl manganese bromide are suspended in anhydrous ether under a protective atmosphere, and stirred at room temperature for reaction to obtain an organic polymer composite material based on BODIPY light-controlled CO release. The composite material prepared by the present invention has an eggshell-like spherical structure and the ability to release CO under light-controlled CO. It can achieve antibacterial effects through a quadruple synergistic mechanism of photothermal therapy, photodynamic therapy, Fenton reaction, and carbon monoxide (CO) release, making it safer for use in organisms.

The present invention discloses a carbon monoxide prodrug, its preparation method, and application. The carbon monoxide prodrug is obtained by coupling one or more oxalate structural fragments with a photosensitive CO prodrug. This type of organic small molecule can specifically release CO in response to hydrogen peroxide. Specifically, the oxalate fragment in the carbon monoxide prodrug reacts with hydrogen peroxide, causing proton transfer within the molecule. The resulting intermediate then undergoes a [2+3] cycloaddition reaction with hydrogen peroxide to form an epoxy bridge, which then releases carbon monoxide through electron transfer. Furthermore, the carbon monoxide prodrug provided by the present invention can achieve controlled release of CO in the absence of light and heavy metals, with a CO release efficiency of up to 100%. It has excellent application prospects in the preparation of drugs for CO delivery.

The application discloses a fluorescent response type manganese carbonyl carbon monoxide releasing agent, a preparation method and application, wherein the compound has the following structural formula: the manganese carbonyl compound provided by the application has good photosensitivity and fluorescent characteristics, CO release can be accurately controlled through green light, the release process can be tracked in real time by using the change of the fluorescent intensity, and the manganese carbonyl compound is expected to be a photo-triggered carbon monoxide releasing agent with application prospect.

The present invention belongs to the field of biochemistry and relates to a method for preparing a biochemical product having H2S and 1 O2 synergistically drives the BODIPY flavonoid nanoreagent of CO release ability and its preparation method and application. It is wrapped in the hydrophobic inner cavity of the micelle formed by mPEG DSPE2000, and the outer layer of the micelle is a silicon shell formed by N trimethoxysilylpropyl N, N, N tri-n-butylammonium bromide, which significantly improves the water solubility of the molecule. The core-shell structure of the formed nanomolecule is relatively stable, which can significantly improve the stability of the molecule in water. The iodinated BODIPY flavonoid compound of the present invention has very good photodynamic effect and CO release ability, has a very high singlet oxygen production efficiency under 660nm light irradiation, and has excellent stability. It has and its considerable application prospects in photodynamic and gas therapy in the fields of biochemistry and medicine. The phototherapy reagent synthesis method provided by the present invention is simple and relatively low in cost.

The invention provides a CO intelligent release platform based on a flexible implantable circuit and NFC induction. A forming method of the CO intelligent release platform comprises the following steps of constructing an NFC-LED module, forming a PDMS substrate, preparing a photosensitive composite layer, integrating devices and wirelessly activating a system. According to the CO intelligent release platform based on the flexible implantable circuit and NFC induction, a controllable CO release system based on a (carbon nitride / gold) composite nano-catalyst is constructed, and multiple mechanisms such as wireless NFC activation, blue light driving, nano-material directional reaction, release rate accurate regulation and control, targeted therapy and the like are combined; the defects of poor drug release accuracy, strong activation mode trauma, non-adjustable release rate, indefinite treatment window, high system energy consumption and the like in the prior art are overcome.

The invention specifically discloses a bionic nano platform as well as a preparation method and application thereof, and relates to the technical field of biological medicines. According to the bionic nano platform disclosed by the invention, efficient conversion from ultrasonic energy to chemical energy (CO release) is realized by constructing a Schottky heterojunction structure of Ni and LDH. In addition, by means of tumor cell membrane coating, homologous recognition characteristics are endowed to the nano-material, so that the nano-material can actively target brain glioma and penetrate through BBB, and precise delivery and deep tumor enrichment are achieved.

The present invention discloses a therapeutic system for the topic, transdermal and transcutaneous application of carbon monoxide (CO), comprising: (i) an adhesive layer, (ii) a gas-permeable and liquid- and solid-impermeable membrane, (iii) a reaction chamber comprising a CO releasing molecule A, and (iv) a gas-impermeable backing layer, wherein the transdermal therapeutic system is configured that the CO releasing molecule A can be brought into contact with a CO release triggering compound B in the reaction chamber (iii). The therapeutic system can be used for the treatment of wounds, inflammatory diseases of the skin, and inflammatory diseases of subcutaneous skin tissue, joints and tendons.

The present invention relates to a method for quantifying calcium oxalates contained in a sample of a surface formation or biomass, in which the sample is heated in an inert atmosphere from an initial temperature of 100 to 300°C to a final temperature of 575 to 800°C, and a curve (MES) is measured showing the temperature evolution of the amount of CO released by the sample during heating in an inert atmosphere. Then, the mass of carbon released by the calcium oxalates in the sample as CO during heating in an inert atmosphere is determined from the measured curve (MES) and an interpolation (INTER) of this curve between a first temperature (T1) of 390 to 450°C and a second temperature (T2) of 550 to 590°C. Then, using an exponential relationship, we deduce the mass of calcium oxalates in the sample. Figure 2 to be published.

The invention provides a model for representing smoke CO release amount based on a cigarette microstructure and application of the model. According to the model, a 3D-mu CT scanning technology is adopted to construct a high-resolution fault sequence image in a cigarette sample, a cigarette three-dimensional structure model is established according to the fault sequence image, cigarette structure characteristic parameters are obtained, a cigarette three-dimensional pore throat ball-stick model is established according to the cigarette structure characteristic parameters, and the cigarette three-dimensional pore throat ball-stick model is established according to the cigarette structure characteristic parameters. And finally, regression processing is carried out on the model and the characteristic parameters, then a BP neural network model is established, neural network model training and optimization are carried out according to a CO release amount data set of the cigarette, and the method is obtained. The model has the advantages of being high in precision, high in speed, small in needed calculation force and the like, tests show that after the model is trained for 1000 times, the average absolute error of a test set is 0.0016, the average deviation of a training set is-0.0002, the average deviation of the test set is-0.0003, and the application requirement for adjusting the cigarette microstructure and quantitatively controlling the smoke CO release amount can be met.

The application discloses a kind of low CO release amount reconstituted tobacco preparation methods based on catalysis-pore-forming synergistic system, which includes tobacco waste pretreatment, preparation mixed slurry and tobacco concentrate;Catalyst, pore-forming agent and dispersing agent are included in catalysis-pore-forming composite adjuvant;Slurry is mixed with inorganic filler and formed into a substrate;Composite adjuvant and concentrated liquid are coated and impregnated;Sectional gradient drying;Balance moisture, cut silk screening to get finished product.The application reduces the reconstituted tobacco CO release amount by 25.37%-28.42% through the synergistic effect of "catalysis+pore-forming", and the sensory comprehensive score is improved by 6.6-7.0 points, and does not need to transform existing production line, suitable for papermaking method mainstream process industrial production, which can be widely used in high-grade cigarette raw material preparation.

The present application relates to a kind of prussian blue nanocomposite with photoresponsive release carbon monoxide and its preparation method and application, belong to medical preparation technical field.The present application has prussian blue nanocomposite with photoresponsive release carbon monoxide, including prussian blue nanoparticles and group a grafted on the surface of prussian blue nanoparticle: And group b:This prussian blue nanocomposite not only has good biocompatibility, also has excellent thermal conversion efficiency, simultaneously can also utilize light to control CO release amount, so that photothermal therapy and gas therapy synergistic effect, and then significantly improve the cure rate of tumor.

A froster system is provided that releases liquid CO from a high-pressure CO cylinder through a CO release nozzle located within a refrigerator. The froster system efficiently sterilizes, cools, freezes, or freezes a container placed in the nozzle. The froster system includes a high-pressure CO cylinder in fluid communication with the CO release nozzle, a cylinder-to-nozzle tubing connecting the CO cylinder and the CO release nozzle, and a controller that communicates user input to activate the froster system to release liquid CO.

The invention discloses an organic polymer composite material based on BODIPY light-controlled CO release as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: dissolving tetraaldehyde BDP and 2, 2 '-bipyridine-5, 5'-diamine in an organic solvent, carrying out ultrasonic dispersion to form a suspension, carrying out circulating deoxidation, and carrying out a heating reaction in a sealed environment to obtain a powdery black solid BB-COF; the preparation method comprises the following steps: suspending BB-COF and pentacarbonyl manganese bromide in absolute ether in a protective atmosphere, and stirring at room temperature for reaction to obtain the organic polymer composite material based on BODIPY light-controlled CO release. The composite material prepared by the invention has an egg-shell-shaped spherical structure and light-controlled CO release capability, and can resist bacteria through a quadruple synergistic mechanism of photothermal therapy, photodynamic therapy, Fenton reaction and CO release, so that the composite material has better safety when being applied to organisms.