24 results about "Benzopyrone" patented technology

The invention belongs to the technical field of natural medicines, and particularly discloses a lipase inhibitor with a specific structure as well as a preparation method and application thereof, the inhibitor is derived from grape leaves and contains C6-C3-C6, 1, 2-benzopyrone, diphenyl ethylene and a phenolic hydroxyl structure, and the lipase inhibitor is a lipase inhibitor with a specific structure. Comprising the following components in percentage by mass: 72.1 to 97.5 percent of flavonoids, 2.5 to 5.1 percent of coumarins, 2.0 to 3.2 percent of stilbenes and 5.1 to 8.3 percent of phenolic acids. According to the lipase inhibitor with the specific structure as well as the preparation method and the application of the lipase inhibitor, the inhibitor can inhibit secretion of lipase, prevent fat from being decomposed into absorbable free fatty acid and monoacylglycerol, and reduce fat absorption; the total cholesterol and the low-density lipoprotein cholesterol are reduced, the blood fat level is improved, and the composition can be applied to preparation of health-care products, functional foods, sports nutritious foods and formula foods for special medical purposes.

The invention belongs to the field of medical chemistry, and relates to a benzopyrone compound, a benzopyrone composition and application of the benzopyrone compound and the benzopyrone composition in preparation of a medicine for treating hyperuricemia. The chemical structure is as shown in formula I; in the formula, R1 is fluorine or hydrogen; r2 is fluorine or hydrogen; r3 is hydrogen, nitryl or tertiary butyl; r4 is hydrogen, fluorine or trifluoromethyl; and R1, R2, R3 and R4 are not hydrogen at the same time. The benzopyrone compound provided by the invention has good inhibitory activity on XOD, and can reduce the level of uric acid, thereby being beneficial to treatment of hyperuricemia.

The invention provides a benzopyrone compound as shown in a formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The compound has a good inhibition effect on POLRMT, and can be used for treating and / or preventing diseases such as cancers mediated by POLRMT. # imgabs0 #

The invention relates to the technical field of organic synthesis, in particular to a synthesis method and application of a dibenzo-alpha-pyrone compound. The synthesis method comprises the following steps: taking a dipropiophenone compound as a raw material, using an oxidizing agent, lewis acid and an oxidation catalyst, and reacting in an organic solvent at room temperature. According to the synthesis method disclosed by the invention, the dibenzo-alpha-pyrone compound is prepared by taking the easily available benzophenone compound as a raw material through Baeyer-Villiger oxidation and Scholl oxidative coupling by a one-pot method, the reaction is simple and convenient, the condition is mild, and a more efficient and green method is provided for preparing bioactive substances such as urolithin a-c.

The invention belongs to the field of ophthalmic medicines, and particularly relates to application of a 9-ether-7H-furo [3, 2-g] benzopyran-7-ketone component in preparation of a medicine for protecting optic nerve injury, and the 9-ether-7H-furo [3, 2-g] benzopyran-7-ketone component is a compound of 9-ether-7H-furo [3, 2-g] benzopyran-7-ketone. The component of the benzopyran-7-ketone is a compound with a structure # imgabs0 # as shown in a formula A and at least one of pharmaceutically acceptable crystals, solvates and co-crystals of the compound. Researches show that the compound with the structure of the formula A can accidentally have RGCs protection activity and can be used for preparing medicines for treating optic nerve injury caused by various causes.

The invention discloses a fluorescent probe molecule based on 1, 2-benzopyrone, a preparation method of the fluorescent probe molecule and application of the fluorescent probe molecule in diagnosis of lung adenocarcinoma. The design of the probe is not limited to the detection of lung adenocarcinoma, can be expanded to the research of other disease related proteins, and has the potential of being applied to multi-mode cancer treatment. Besides, the probe can be used for quantitatively analyzing protein expression, so that accurate real-time monitoring is provided for dynamic change of a tumor microenvironment, and the probe has wide application value in biomedical research and is worthy of popularization and application. By integrating machine learning, bioinformatics and probe development into a novel platform for protein detection, disease diagnosis and treatment intervention, a new chemical mechanism and innovative application potential are highlighted. In addition, it can provide quantitative insight of protein expression at high temporal and spatial resolution, highlighting its wide use in biomedical studies.

The present invention provides a benzopyrone compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and use thereof. This type of compound has a good inhibitory effect on POLRMT and can be used to treat and / or prevent diseases mediated by POLRMT, such as cancer. JPEG2025538893000280.jpg28166

The present invention relates to a composition for preventing or treating a tumor necrosis factor-related disease, comprising a 4-benzopyrone derivative, and more specifically, to a composition for preventing or treating a tumor necrosis factor-related disease, the present invention relates to a 4-benzopyrone derivative, a pharmaceutically acceptable salt, solvate, racemate or stereoisomer thereof, a composition for preventing, ameliorating and treating tumor necrosis factor-related diseases comprising the same as an active ingredient, a method for treating tumor necrosis factor-related diseases using the same, and a method for inhibiting tumor necrosis factor (TNF) According to the reagent composition and the tumor necrosis factor inhibition method, the composition can be orally administered, so that injection side effects are avoided, immunogenic resistance is avoided, the composition can be easily administered in combination with an existing oral preparation, the dosage of the composition can be easily adjusted, and the activity of a tumor necrosis factor can be effectively inhibited by directly binding the composition to the tumor necrosis factor.

The invention discloses composite nanoparticles loaded with fusarium solani dsRNA (double-stranded ribonucleic acid) and 1, 2-benzopyrone, which are prepared by the following steps: mixing aminated mesoporous silica with a fusarium solani dsRNA solution, and incubating at room temperature to obtain aminated mesoporous silica-dsRNA nanoparticles; then mixing the aminated mesoporous silica with a 1, 2-benzopyrone solution, and incubating at room temperature to obtain aminated mesoporous silica 1, 2-benzopyrone nanoparticles; finally, mixing the aminated mesoporous silica-dsRNA nano-particle solution with the aminated mesoporous silica 1, 2-benzopyrone nano-particle solution at room temperature, so as to obtain a composite nano-particle solution; according to the composite nano-particles, the stability of dsRNA and 1, 2-benzopyrone in an adverse environment is improved, meanwhile, the inhibition effect on root rot is enhanced, and the composite nano-particles have important application value in prevention and treatment of panax notoginseng root rot and promotion of panax notoginseng growth.

The present invention relates to the field of compound synthesis, and discloses a method for synthesizing benzopyranone-fused indoline compounds and their applications. The method includes: mixing a catalyst, a compound represented by formula II, a compound represented by formula III, and a solvent uniformly, stirring at 0-150 °C until the reaction is completed, and separating to obtain a benzopyranone-containing fused ring indolinone compound represented by formula I; R 1 is selected from any one of alkyl and phenyl, and R 2 is selected from any one of hydrogen, halogen, and alkyl. The indoline compounds provided by the present invention have good pharmaceutical activities and are a class of novel pharmaceutical intermediates. The preparation method of the present invention has cheap and easily available raw materials and catalysts; the reaction conditions are mild, and good yields can be obtained at room temperature, and the operation is simple and convenient; the substrate has wide generality, and high yields can be obtained for a series of benzopyranone-containing fused ring indolinone compounds.

The present application relates to a kind of induction agent and the method for inducing paeonia obovata accumulate benzopyranone derivative.The preparation method includes the following steps: 1) obtain Fusarium oxysporum Strain, after scale-up culture, safety treatment is carried out, and the safety treatment includes: 1-1) the strain obtained by scale-up culture is collected, and inactivated bacteria powder is prepared by high temperature inactivation or ultraviolet irradiation treatment;And / or 1-2) after filtering the culture solution produced by scale-up culture, the obtained extracellular polypeptide and low molecular organic acid are separated by organic solvent separation, silica gel column chromatography or chromatography separation treatment, which are the purified inducer;2) the inactivated bacteria powder or the purified inducer is mixed with carrier adjuvant, and a water-dispersible preparation is prepared.The preparation method is safety treated, so that the prepared plant inducer does not cause plant diseases or environmental pollution.

The invention discloses a coumarin modified fluorescent organic silicon pressure-sensitive adhesive based on click reaction and a preparation method thereof, and relates to a coumarin modified fluorescent organic silicon pressure-sensitive adhesive and a preparation method thereof. The invention aims to solve the problem of poor adhesion performance of the existing organic silicon pressure-sensitive adhesive. The organic silicon pressure-sensitive adhesive can be simply, conveniently and effectively synthesized through cross-linking and thermocuring of a click reaction between vinyl in the vinyl silicone resin and sulfydryl on the coumarin modified mercaptopropyl silicone rubber, and the coumarin forms a rigid fused ring conjugated pi electron system due to benzo alpha-pyrone mother nucleus of the coumarin, so that the organic silicon pressure-sensitive adhesive can be used for preparing the organic silicon pressure-sensitive adhesive. After coumarin molecules absorb ultraviolet light, pi electrons in a conjugated system are transited to a high-energy excitation singlet state and then rapidly relaxed to the lowest excitation singlet state through internal conversion and vibration relaxation, and part of energy is dissipated as heat energy in the process; finally, the molecules in the lowest excitation singlet state release energy in a radiative transition mode to return to the ground state, and fluorescence is generated. The invention belongs to the technical field of pressure-sensitive adhesive preparation.

The present invention proposes a method for synthesizing 6H-benzo[c]chromen-6-one, which belongs to the field of organic synthesis technology. Benzoic acid and iodobenzene are reacted to prepare 6H-benzo[c]chromen-6-one. The present invention starts from benzoic acid, first undergoes an arylation reaction with iodobenzene, and after obtaining the important reaction intermediate 2-arylbenzoic acid, continues to undergo an intramolecular cyclization reaction. A catalyst, an oxidant, an additive, and a solvent are added to a reactor, and the reaction is started. After the reaction is completed, the target product is purified by column chromatography or recrystallization to obtain the target product. Compared with the prior art, the present invention has the advantages of simple reaction operation, short steps, and low cost.

The application relates to the technical field of organic synthesis, in particular to a synthesis method of a dibenzo-alpha-pyrone compound and application thereof. The synthesis method comprises the following steps: taking a diphenylpropanone compound as a raw material, using an oxidant, a Lewis acid and an oxidation catalyst, and reacting under the condition of an organic solvent and room temperature. The synthesis method takes an easily obtained benzophenone compound as a raw material, prepares the dibenzo-alpha-pyrone compound through one-pot method via Baeyer-Villiger oxidation and Scholl oxidation coupling, the reaction is simple, the condition is mild, and the synthesis method provides a more efficient and green method for preparing bioactive substances such as urolithin a-c.

Methods and compositions for treating, inhibiting, and / or preventing diseases or disorders associated with aberrant bromodomain-containing protein 4 (BRD4) and phosphoinositide 3-kinase (PBK) activity are disclosed, the methods comprise contacting a solution, cell, tissue, or subject expressing BRD4 and PBK with a compound having Benzopyran-4-One core.

The invention discloses a benzopyrone analogue as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The benzopyrone analogue has a structural formula as shown in a formula B in the specification. The invention also discloses a preparation method and application of the benzopyrone analogue. The invention provides a benzopyrone analogue with a new structure, and the benzopyrone analogue is named as ZDZ-553. The benzopyrone analogue can obviously reduce the content of triglyceride and cholesterol in the liver, also can obviously inhibit the inflammatory reaction of the liver of an NASH mouse, and can obviously reduce the mRNA level of inflammatory factors IL-6, IL-1beta and TNF-alpha in the liver. Therefore, the benzopyrone analogue disclosed by the invention can be used for preparing the medicine for resisting the non-alcoholic steatohepatitis.

A synthesis method of the crystal complexes I-IV comprises the following steps: respectively weighing 1 mmol of Co (NO3) 2.6 H2O, Ni (CH3COO) 2.4 H2O, ZnCl2 and CuCl2. 2H2O, dissolving the Co (NO3) 2.6 H2O, Ni (CH3COO) 2.4 H2O, ZnCl2 and CuCl2. 2H2O and 2 mmol of ligand 4-benzopyranone-2-carboxylic acid in 30 mL of absolute ethyl alcohol, mixing and carrying out ultrasonic treatment for half an hour, respectively adding 1 mL of pyridine, carrying out reflux heating and stirring for 24 hours, carrying out hot filtration, naturally volatilizing at room temperature, and drying to obtain the crystal complexes I-IV. Separating out blue crystals I after three days; separating out a green crystal II; precipitating a colorless crystal III and a blue crystal IV; the crystal complex I is used for preparing an anti-lung cancer reagent.

Provided in the present invention are benzopyrone compounds represented by formula (I) or pharmaceutically acceptable salts thereof, a preparation method therefor and the use thereof. The compounds have good inhibitory effect on POLRMT, and thus can be used for treating and / or preventing POLRMT-mediated diseases such as cancers.

The invention discloses a benzopyrone compound as well as a synthesis method and application thereof, and belongs to the field of chemical medicines. The benzopyrone compound as shown in the formula (I), or pharmaceutically acceptable salt, prodrug, hydrate or solvent compound, crystal form, stereoisomer or isotope variant thereof, provided by the invention, can be used for inhibiting the growth of cancer cells, treating and / or preventing melanoma, inhibiting cancer cells, and preventing cancer cells. Related diseases such as liver cancer, pancreatic cancer, lymphoma, acute myeloid leukemia, breast cancer, glioblastoma, cervical cancer, kidney cancer, colorectal cancer or ovarian cancer can be treated.

The invention discloses a uranyl ion fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of preparation of probes. The molecular formula of the probe is C36H27N2O6S +, according to the preparation method, 2-aminothiophenol, 2, 4-dihydroxy benzaldehyde, sodium pyrosulfite, phthalic anhydride and 3-acetyl-7-(diethylamino)-2H-benzopyran-2-ketone are taken as raw materials, the probe is prepared through three-step reaction, the molar ratio of key raw materials in each step is definite, and the synthesis process is simple. The probe is used for detecting uranyl ions in a water environment, the fluorescence spectrum of the probe is enhanced at 490 nm and weakened at 700 nm under excitation of 400 nm, the response time is about 20 minutes, the lower detection limit reaches 1.36 * 10 <-7 > mol / L, and the probe can resist interference of various metal ions, anions and small biological molecules and has the advantages of rapidness, sensitivity and good selectivity.

This solution discloses osthole 7 - derivatives with the general formula Ⅰ in the field of organic chemistry technology. Among them, R is phenyl or substituted phenyl; or R is naphthyl or substituted naphthyl; or R is quinolinyl or substituted quinolinyl; or R is thiophenyl or substituted thiophenyl; or R is isoxazolyl or substituted isoxazolyl; or R is 1,2 - benzopyrone group; or R is 2,3 - dihydro - 1 - benzofuranyl; or R is benzothiadiazolyl; or R is N - acetylindolinyl. The compound shown by the general formula Ⅰ has strong antibacterial activity and can be used as a drug against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), methicillin - resistant Staphylococcus aureus (MRSA) and fluoroquinolone - resistant Escherichia coli (FREC); at the same time, it can also be used in combination with other antibacterial active substances.

The invention provides a synthesis method of 6H-benzo [c] benzopyran-6-ketone, and belongs to the technical field of organic synthesis. Benzoic acid and iodobenzene are subjected to a reaction, and 6H-benzo [c] benzopyran-6-one is prepared. Benzoic acid and iodobenzene are subjected to an arylation reaction, after an important reaction intermediate 2-aryl benzoic acid is obtained, an intramolecular cyclization reaction continues, a catalyst, an oxidizing agent, an additive and a solvent are added into a reactor, the reaction is started, and after the reaction is finished, a target product is obtained through column chromatography or recrystallization purification. Compared with the prior art, the method has the advantages of simple reaction operation, short steps and low cost.

The present invention relates to a method for preparing 2-(2,5-difluorophenyl)-3-carboxy-7-chloro-(4H)-4-benzopyranone represented by formula 1 below, a novel intermediate used therein, and a method for preparing the same. Specifically, an object of the present invention is to provide a novel preparation method, in which the compound of formula 1 below can be efficiently and economically synthesized and can be mass-produced in a high yield.