11 results about "Benzopyrone" patented technology

The invention belongs to the field of medical chemistry, and relates to a benzopyrone compound, a benzopyrone composition and application of the benzopyrone compound and the benzopyrone composition in preparation of a medicine for treating hyperuricemia. The chemical structure is as shown in formula I; in the formula, R1 is fluorine or hydrogen; r2 is fluorine or hydrogen; r3 is hydrogen, nitryl or tertiary butyl; r4 is hydrogen, fluorine or trifluoromethyl; and R1, R2, R3 and R4 are not hydrogen at the same time. The benzopyrone compound provided by the invention has good inhibitory activity on XOD, and can reduce the level of uric acid, thereby being beneficial to treatment of hyperuricemia.

The invention discloses composite nanoparticles loaded with fusarium solani dsRNA (double-stranded ribonucleic acid) and 1, 2-benzopyrone, which are prepared by the following steps: mixing aminated mesoporous silica with a fusarium solani dsRNA solution, and incubating at room temperature to obtain aminated mesoporous silica-dsRNA nanoparticles; then mixing the aminated mesoporous silica with a 1, 2-benzopyrone solution, and incubating at room temperature to obtain aminated mesoporous silica 1, 2-benzopyrone nanoparticles; finally, mixing the aminated mesoporous silica-dsRNA nano-particle solution with the aminated mesoporous silica 1, 2-benzopyrone nano-particle solution at room temperature, so as to obtain a composite nano-particle solution; according to the composite nano-particles, the stability of dsRNA and 1, 2-benzopyrone in an adverse environment is improved, meanwhile, the inhibition effect on root rot is enhanced, and the composite nano-particles have important application value in prevention and treatment of panax notoginseng root rot and promotion of panax notoginseng growth.

The present application relates to a kind of induction agent and the method for inducing paeonia obovata accumulate benzopyranone derivative.The preparation method includes the following steps: 1) obtain Fusarium oxysporum Strain, after scale-up culture, safety treatment is carried out, and the safety treatment includes: 1-1) the strain obtained by scale-up culture is collected, and inactivated bacteria powder is prepared by high temperature inactivation or ultraviolet irradiation treatment;And / or 1-2) after filtering the culture solution produced by scale-up culture, the obtained extracellular polypeptide and low molecular organic acid are separated by organic solvent separation, silica gel column chromatography or chromatography separation treatment, which are the purified inducer;2) the inactivated bacteria powder or the purified inducer is mixed with carrier adjuvant, and a water-dispersible preparation is prepared.The preparation method is safety treated, so that the prepared plant inducer does not cause plant diseases or environmental pollution.

The invention discloses a coumarin modified fluorescent organic silicon pressure-sensitive adhesive based on click reaction and a preparation method thereof, and relates to a coumarin modified fluorescent organic silicon pressure-sensitive adhesive and a preparation method thereof. The invention aims to solve the problem of poor adhesion performance of the existing organic silicon pressure-sensitive adhesive. The organic silicon pressure-sensitive adhesive can be simply, conveniently and effectively synthesized through cross-linking and thermocuring of a click reaction between vinyl in the vinyl silicone resin and sulfydryl on the coumarin modified mercaptopropyl silicone rubber, and the coumarin forms a rigid fused ring conjugated pi electron system due to benzo alpha-pyrone mother nucleus of the coumarin, so that the organic silicon pressure-sensitive adhesive can be used for preparing the organic silicon pressure-sensitive adhesive. After coumarin molecules absorb ultraviolet light, pi electrons in a conjugated system are transited to a high-energy excitation singlet state and then rapidly relaxed to the lowest excitation singlet state through internal conversion and vibration relaxation, and part of energy is dissipated as heat energy in the process; finally, the molecules in the lowest excitation singlet state release energy in a radiative transition mode to return to the ground state, and fluorescence is generated. The invention belongs to the technical field of pressure-sensitive adhesive preparation.

Methods and compositions for treating, inhibiting, and / or preventing diseases or disorders associated with aberrant bromodomain-containing protein 4 (BRD4) and phosphoinositide 3-kinase (PBK) activity are disclosed, the methods comprise contacting a solution, cell, tissue, or subject expressing BRD4 and PBK with a compound having Benzopyran-4-One core.

The invention discloses a benzopyrone analogue as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The benzopyrone analogue has a structural formula as shown in a formula B in the specification. The invention also discloses a preparation method and application of the benzopyrone analogue. The invention provides a benzopyrone analogue with a new structure, and the benzopyrone analogue is named as ZDZ-553. The benzopyrone analogue can obviously reduce the content of triglyceride and cholesterol in the liver, also can obviously inhibit the inflammatory reaction of the liver of an NASH mouse, and can obviously reduce the mRNA level of inflammatory factors IL-6, IL-1beta and TNF-alpha in the liver. Therefore, the benzopyrone analogue disclosed by the invention can be used for preparing the medicine for resisting the non-alcoholic steatohepatitis.

Provided in the present invention are benzopyrone compounds represented by formula (I) or pharmaceutically acceptable salts thereof, a preparation method therefor and the use thereof. The compounds have good inhibitory effect on POLRMT, and thus can be used for treating and / or preventing POLRMT-mediated diseases such as cancers.

The invention discloses a benzopyrone compound as well as a synthesis method and application thereof, and belongs to the field of chemical medicines. The benzopyrone compound as shown in the formula (I), or pharmaceutically acceptable salt, prodrug, hydrate or solvent compound, crystal form, stereoisomer or isotope variant thereof, provided by the invention, can be used for inhibiting the growth of cancer cells, treating and / or preventing melanoma, inhibiting cancer cells, and preventing cancer cells. Related diseases such as liver cancer, pancreatic cancer, lymphoma, acute myeloid leukemia, breast cancer, glioblastoma, cervical cancer, kidney cancer, colorectal cancer or ovarian cancer can be treated.

The invention discloses a uranyl ion fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of preparation of probes. The molecular formula of the probe is C36H27N2O6S +, according to the preparation method, 2-aminothiophenol, 2, 4-dihydroxy benzaldehyde, sodium pyrosulfite, phthalic anhydride and 3-acetyl-7-(diethylamino)-2H-benzopyran-2-ketone are taken as raw materials, the probe is prepared through three-step reaction, the molar ratio of key raw materials in each step is definite, and the synthesis process is simple. The probe is used for detecting uranyl ions in a water environment, the fluorescence spectrum of the probe is enhanced at 490 nm and weakened at 700 nm under excitation of 400 nm, the response time is about 20 minutes, the lower detection limit reaches 1.36 * 10 <-7 > mol / L, and the probe can resist interference of various metal ions, anions and small biological molecules and has the advantages of rapidness, sensitivity and good selectivity.

The present invention relates to a method for preparing 2-(2,5-difluorophenyl)-3-carboxy-7-chloro-(4H)-4-benzopyranone represented by formula 1 below, a novel intermediate used therein, and a method for preparing the same. Specifically, an object of the present invention is to provide a novel preparation method, in which the compound of formula 1 below can be efficiently and economically synthesized and can be mass-produced in a high yield.