The present invention discloses a polyfluoric terphenyl liquid crystal compound. The structural formula of the compound is as follows: R1 is C1-C8 alkyl, R2 is C1-C8 alkyl, fluoro, trifluoromethyl, trifluoromethoxy; U,V, W, X, Y and Z are fluorine substituent or hydrogen, at least one thereof is fluorine substituent. The synthetic process comprises the steps of preparing an intermediate 4-alkyl iodobenzene containing fluorine, preparing an intermediate phenyloboric acid containing fluorine, preparation an intermediate 4-alkyl biphenyloboric acid containing fluorine, and synthesizing target products of the polyfluoric terphenyl liquid crystal compound. The compound has the features of great dielectric anisotropy (delta e), excellent optical, heat, electrical and chemical stability, can be used for improving properties of the liquid crystal mixture, can be widely applied in TN, HTN, STN, TFT mixed liquid crystal materials, and further can be applied in a liquid crystal display.