14 results about "Iodobenzene" patented technology

The invention provides an aryl alkyl ketoxime derivative as well as a preparation method and application thereof, and relates to the field of aryl oxime derivatives. The preparation method of the aryl alkyl ketoxime derivative comprises the following steps: by taking potassium formate as an additive, carrying out free radical reaction on a compound I and a compound II under ultraviolet irradiation in the presence of tert-butyl nitrite to obtain the aryl alkyl ketoxime derivative, the compound I is substituted iodobenzene or iodopyridine; the compound II is substituted styrene or thienyl ethylene; wherein a hydrogen atom transfer / single electron transfer relay sequence is utilized to activate a compound I, and tert-butyl nitrite is adopted as a bifunctional reagent, and is used as a hydrogen atom transfer reagent and an oxime source. According to the preparation method of the aryl alkyl ketoxime derivative, pre-functionalization is not needed, a reaction substrate is wide in universality and good in compatibility, reaction conditions are mild, operation is easy and convenient, a target product can be efficiently and rapidly prepared on the premise of high yield, and a new way is provided for oxime synthesis.

The invention provides a preparation method of iodobenzene diacetate, and belongs to the technical field of preparation of drug intermediates. According to the method, 50wt% hydrogen peroxide reacts with acetic anhydride to obtain a peracetic acid system, separation and purification are not needed, the peracetic acid system directly reacts with iodobenzene, and iodobenzene diacetate is prepared. The method has the advantages of simple and easy process, mild conditions, low production cost and less wastewater discharge, and is suitable for industrial production.

The present application relates to the field of organic synthesis, specifically a method for synthesizing C3 fluorine alkyl substituted quinoxaline ketone derivatives from olefin derivatives and quinoxaline ketone derivatives under photocatalysis by using [bis(fluoroalkyl acetoxy)iodo] benzene as different fluorine alkyl sources. [Bis(fluoroalkyl acetoxy)iodo] benzene is used as a fluorine alkylating agent to generate fluorine alkyl radicals under photocatalysis, then the radicals add to olefin derivatives to obtain alkyl radicals, the alkyl radicals then add to quinoxaline ketone, and finally, after oxidation and deprotonation, C3 fluorine alkyl substituted quinoxaline ketone derivatives are obtained. The present application uses simple and stable [bis(fluoroalkyl acetoxy)iodo] benzene as a fluorine alkyl source to prepare C3 different fluorine alkyl substituted quinoxaline ketone derivatives from quinoxaline ketone and olefin derivatives in a three-component reaction without the action of photocatalysts. The synthesis method is simple and easy to operate, and different fluorine alkyl group substituted quinoxaline ketone derivatives can be quickly obtained.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of diaryl compounds containing silicon atoms. Toluene as shown in a formula 1a, iodobenzene as shown in a formula 2a and vinyl silane as shown in a formula 3 are mixed to react in the presence of a catalytic amount of PdCl2 (dppf), phosphorus ligand 4, 6-di (diphenylphosphine) phenazine and alkali metals LiN (SiMe3) 2 and CsF, and the diaryl compound containing silicon atoms as shown in a formula 4 is synthesized through the reaction. According to the invention, the combination reaction of toluene, iodobenzene and vinyl silane is realized by adopting a catalytic amount of PdCl2 (dppf), and the palladium catalyst shows obvious catalytic performance.

This invention provides a palladium-catalyzed method for the decarbonylation and cyclization of o-halobenzoic esters to synthesize 1-substituted phenanthrene compounds. The method involves the decarbonylation and cyclization of o-substituted iodobenzene, norbornadiene, and o-halobenzoic esters in an aprotic solvent under palladium catalysis to yield 1-substituted phenanthrene compounds. This method uses o-halobenzoic esters as cyclizing agents, which not only expands the applicability of cyclizing agents but also offers advantages such as milder reaction conditions, no need for inert gas protection (e.g., nitrogen), and no use of organophosphorus ligands. It is an economical and convenient method for preparing 1-substituted phenanthrene compounds.

The invention relates to the technical field of photoresist, in particular to photoresist for a capacitive touch sensor and a preparation process of the photoresist. The invention discloses a preparation process of photoresist for a capacitive touch sensor. The preparation process comprises the following steps: preparing a modified photoreaction agent; preparing modified polyimide resin powder; preparing silicon dioxide hollow carbon spheres and nano titanium dioxide hybrid particles; and preparing the photoresist. The preparation method comprises the following steps: firstly carrying out nitration reaction on 4-tert-butylphenol, then reducing nitryl into amino to obtain amino substituted 4-tert-butylphenol, protecting the amino by di-tert-butyl dicarbonate ester, then oxidizing iodobenzene into a high-valence iodine active intermediate by taking m-chloroperoxybenzoic acid as an oxidizing agent, and reacting with Boc-amino substituted 4-tert-butylphenol to obtain the high-valence iodine-substituted 4-tert-butylphenol. And finally, carrying out a replacement reaction with silver trifluoromethanesulfonate, carrying out deprotection to obtain a modified photoreaction agent, and carrying out a condensation polymerization reaction on the modified photoreaction agent, 4, 4 '-hexafluoroisopropyl phthalic anhydride and the like to generate a polyamic acid prepolymer, so that the photoetching resolution can be greatly improved.

The invention belongs to the technical field of organic electrochemical synthesis, and relates to an electro-catalysis olefin diazotization reaction method, and belongs to the technical field of organic synthesis. Comprising the following steps: (1) adding an olefin compound, an azide source, a supporting electrolyte, an additive, an iodobenzene electrocatalyst and a solvent into a reactor; (2) inserting an anode and a cathode, and controlling current to carry out electro-catalytic reaction; and (3) after the reaction is finished, extracting and purifying to obtain a target product. The method for realizing the iodobenzene-mediated olefin diazotization reaction by using the two-phase electrochemical reaction system disclosed by the invention obtains olefin compound diazotization products with various substituent groups, and has the advantages of mild conditions, simplicity in operation, only addition of a catalytic amount of electrocatalyst, safety, greenness, low cost and wide variety universality of olefin substrates.

This invention discloses a covalent organic polymer (COP) supported palladium nanoparticle catalyst with adjustable bipyridine content, its preparation method, and its application in C-C bond coupling reactions. This invention prepares a COP support with a gradient of bipyridine content by controlling the mixing ratio of monomers 5,5'-diamino-2,2'-bipyridine and benzidine with 1,3,5-tris(p-formylphenyl)benzene. Utilizing the strong coordination of the nitrogen atom in the bipyridine unit with palladium, efficient palladium loading and high dispersion are achieved, yielding a series of Pd@COP heterogeneous catalysts. This catalyst has a simple preparation process, low palladium loading, and controllable cost. It exhibits excellent catalytic activity and stability in the Sonogashira coupling reaction, with mild reaction conditions and high product yield, making it suitable for the efficient synthesis of diarylaceyne compounds. The bipyridine content of the catalyst support in this invention can be precisely controlled, and the palladium loading increases with the increase of bipyridine content. The palladium is uniformly dispersed on the surface of the support without obvious agglomeration. In the Sonogashira coupling reaction of iodobenzene and phenylacetylene, the separation yield can reach 93% under optimal conditions. The catalytic activity is not significantly affected by the palladium loading density, and it has good prospects for industrial application.

This invention discloses a method for preparing a diarylcarbazole material, relating to the field of organic light-emitting device technology. The method includes: obtaining intermediate A through a nitration reaction of 4-bromo-2-chloro-1-fluorobenzene; obtaining coupling intermediate B through a Suzuki coupling reaction of intermediate A and 1-naphthoboric acid; preparing intermediate C through a nitro cyclization reaction of intermediate B; coupling intermediate C with iodobenzene or iodobenzene derivative D to form intermediate E; preparing pinacol borate intermediate F using intermediate E; obtaining intermediate H through a Suzuki coupling reaction of intermediate F and o-bromoaniline or o-bromoaniline derivative G; cyclizing intermediate H under alkaline conditions to obtain intermediate I; and coupling intermediate I with a haloaryl derivative J to obtain the diarylcarbazole material. The preparation route provided by this invention has high reaction selectivity, produces a single product, has no obvious reaction defects, and avoids the problems of isomers in cyclization reactions and polybromination in bromination reactions.

The invention belongs to the technical field of preparation of deuterated organic compounds, and particularly relates to a method for synthesizing deuterated iodobenzene by taking elemental iodine as a raw material, which comprises the following steps: reacting sodium chlorite as an oxidant and elemental iodine as an iodinating agent with deuterated benzene to prepare the deuterated iodobenzene. According to the method for synthesizing deuterated iodobenzene, the conversion rate of deuterated benzene with high price is increased, no by-product is generated, the requirement on equipment is low, heavy water or semi-deuterated water generated by reaction can be recycled, and the utilization rate of a deuterium source is increased.

This invention belongs to the field of molecular synthesis and materials technology, and discloses a method for preparing small molecule materials based on benzothiophene-benzodithiophene (DBDTT) and benzoselenophene-benzodiselenophene, as well as their applications. The method includes: using 1-chloro-2-iodobenzene or 1-chloro-2-bromobenzene and trimethylethynylsilane as raw materials, after a stalk coupling reaction, removing the TMS (trimethylsilyl group) with potassium hydrofluoric acid to obtain a key intermediate; using S8 or Se as a sulfur source or selenium source, and potassium carbonate as a base, a series of fused-ring thiophene / selenophene small molecule materials are synthesized through a cascade cyclization reaction. The substrates of this invention are simple to synthesize, the raw materials are inexpensive and readily available; no metals are involved; the reaction can be carried out under air conditions; the reaction efficiency is high, with three rings fused simultaneously in a single step; the yield is moderate, and even at a large scale (10 mmol), the yield can still reach 58%. Therefore, this method is suitable for industrial production.

The invention discloses a novel AIE photosensitizer as well as a preparation method and application thereof. The molecule takes triphenylamine as an electron-donating group and iodobenzoselenazole as an electron-withdrawing group, and is constructed through thiophene, benzothiadiazole or carbazole units. Researches show that DZTSe can efficiently generate type I and type II active oxygen, has low dark toxicity and good mitochondrial targeting ability, and is distributed in organelles such as endoplasmic reticulum, Golgi apparatus and the like. Under illumination, DZTSe induces pyroptosis by activating a caspase-1 / GSDMD pathway, releases DNA by damaging mitochondria, activates a cGAS-STING pathway, and promotes expression of type I interferon and inflammatory factors. Animal experiments show that DZTSe can significantly prolong the lifetime of mice with prostatic cancer, convert an immunosuppression microenvironment into an immune support state, and effectively inhibit primary and distal tumors.

This invention discloses an axially chiral bipyridine ligand, its preparation method, and its uses. The axially chiral bipyridine ligand has the structure of general formula (Ⅰ): the axially chiral bipyridine ligand contains a binaphthalene structure, wherein part A is selected from A-1, A-2, or A-3; part B is a hydrogen atom or is the same as part A. The complex catalyst formed in situ in the reaction system of the axially chiral bipyridine ligand and copper salt in this invention exhibits high catalytic activity, good to excellent enantioselectivity, and good substrate universality in the asymmetric ring-opening iodination, thioesterification, and hydrolysis of cyclic diaryliodonium salts to synthesize highly optically pure, diverse substituted 1,1'-bi-2-iodobenzene compounds, 1,1'-bi-2'-iodo-2-thioester compounds, and 1,1'-bi-2'-iodo-2-phenol compounds, respectively, showing great promise for industrial applications. This invention belongs to the field of asymmetric synthetic chemistry.