71 results about "Iodobenzene" patented technology

The invention discloses a novel fluorescent probe based on triphenylamine and a preparation method and application thereof, the preparation method comprises the following steps: S1, dissolving 4-methoxyaniline and 1-bromo-4-iodobenzene in a solvent A, and then adding copper iodide, 1, 10-phenanthroline and potassium tert-butoxide for reaction to obtain a compound 1; s2, dissolving the compound 1 obtained in the step S1, (5-formylthiophene-2-yl) boric acid and anhydrous potassium carbonate in a solvent B, and then adding PdCl2 (dppf) for reaction to obtain a compound 2; and S3, dissolving the compound 2 obtained in S2 and malononitrile in a solvent C, and then adding triethylamine for reaction to obtain the TPA-CN probe. The TPA-CN probe is used for monitoring exogenous and endogenous SO2 and viscosity change in living cells. According to the invention, dual imaging of SO2 and viscosity in a biological system and a food sample can be realized.

The invention discloses 1, 2-dibromo-6-tert-butyl-9-(4-tert-butylphenyl)-9H-carbazole and a synthesis method of the 1, 2-dibromo-6-tert-butyl-9-(4-tert-butylphenyl) The method comprises the following steps: taking 3-nitrophthalic acid as an initial raw material, reacting trichloroisocyanuric acid with liquid bromine to obtain 1, 2-dibromo-3-nitrobenzene, reducing by stannous chloride to obtain 2, 3-dibromoaniline, carrying out diazotization reaction to obtain 2, 3-dibromophenylhydrazine, reacting with p-tert-butyl cyclohexanone, and reacting by using 2, 3-dichloro-5, 6-dibromophenylhydrazine to obtain 2, 3-dibromophenylhydrazine. The preparation method comprises the following steps: carrying out dehydrogenation on 2, 6-dicyanobenzoquinone to obtain 1, 2-dibromo-6-tert-butyl-9H-carbazole, and finally reacting the 1, 2-dibromo-6-tert-butyl-9H-carbazole with 4-tert-butyl iodobenzene to obtain the 1, 2-dibromo-6-tert-butyl-9-(4-tert-butylphenyl)-9H-carbazole. Due to the existence of a bromine atom functional group on the 1, 2-dibromo-6-tert-butyl-9-(4-tert-butylphenyl)-9H-carbazole, the further conversion of the compound has expandability, and the compound can be used as a material / drug molecule precursor in the fields of organic light-emitting semiconductors, pharmaceutical chemistry and the like.

The invention discloses an infrared shielding coating and a preparation method thereof, and relates to the technical field of coatings. The prepared infrared shielding coating comprises modified polyvinyl chloride, silicon crown ether, modified cobalt blue and chloroplatinic acid. The modified polyvinyl chloride is prepared by the following steps: pretreating polyvinyl chloride with 4-amino-2, 2, 6, 6-tetramethylpiperidine-1-oxygen free radicals, reacting the pretreated polyvinyl chloride with 4, 4 '-diaminodiphenyl ketone to obtain aminophenyl polyvinyl chloride, reacting the aminophenyl polyvinyl chloride with 4-iodobenzene styrene to obtain triphenylamino polyvinyl chloride, and reacting the triphenylamino polyvinyl chloride with silver antimonate hexafluoride. The modified cobalt blue is obtained by polymerizing aniline on the surface of cobalt blue pretreated by a silane coupling agent and then grafting 1-(chloro-methylphosphoryl) ethylene. The infrared shielding coating prepared by the invention has excellent infrared shielding, self-repairing and flame-retardant properties.

The invention belongs to the technical field of catalytic synthesis, and particularly relates to a method for catalyzing a Suzuki reaction based on a Pd / UiO-66-NH2 (at) RGO composite material. According to the technical scheme, ZrCl4, 2-aminoterephthalic acid, graphene oxide, DMF and glacial acetic acid are sequentially added into a reaction kettle, stirred for 0.5 h and placed in a 473 K drying oven to react for 12 h, the mixture is cooled to the room temperature and then centrifuged, washed and dried in vacuum, Pd is loaded through an equivalent impregnation method, and the catalyst is obtained. Catalyzing Suzuki reaction of the obtained composite material Pd / UiO-66-NH2 (at) RGO, iodobenzene, phenylboronic acid and potassium carbonate in a reaction container, and reacting for 1 hour under the condition of 353 K; the preparation method of the Pd / UiO-66-NH2 (at) RGO provided by the invention is simple, and the Pd / UiO-66-NH2 (at) RGO shows ultrahigh catalytic ability in a Suzuki reaction.

The application relates to a metal organic tetrahedral cage compound, a preparation method and application thereof, and belongs to the technical field of fine chemical industry. The metal organic tetrahedral cage compound is obtained by reacting a rare earth metal cerium salt with H4BPDS as a ligand 3+ As a node, H4BPDS is used as a ligand. The metal organic tetrahedral cage compound prepared by the application has low raw material price, high yield, stable chemical properties, and can efficiently catalyze the reaction of aryl iodide and aryl sulfinate to prepare diaryl sulfone derivatives under mild light and warm conditions. For the catalysis of the reactions of 4-bromo-iodobenzene and 4-methylphenyl sulfinate sodium to prepare 4-bromophenyl-4-methylphenyl sulfone, 3-bromo-iodobenzene and 4-methylphenyl sulfinate sodium to prepare 3-bromophenyl-4-methylphenyl sulfone, and 4-bromo-3-fluoro-iodobenzene and 4-methylphenyl sulfinate sodium to prepare 4-bromo-3-fluorophenyl-4-methylphenyl sulfone, the yield can reach 95% at the highest.

The invention discloses a COF-based heterogeneous iodobenzene catalyst and its preparation method and application, belonging to the field of catalyst preparation technology. The COF-based heterogeneous iodobenzene catalyst is obtained by polymerizing a hydrazide monomer containing an iodophenyl group unit and 1,3,5-tris(4-formylphenyl)triazine; the structural formula of the hydrazide monomer containing an iodophenyl group unit is: The COF-based heterogeneous iodobenzene catalyst can be used as a catalyst for the chlorination reaction of anisole, catalyzing the chlorination reaction of anisole, achieving heterogeneous catalysis, and using a small amount, easy to recover, improving the utilization rate of the catalyst, and reducing the cost of anisole chlorination.

The invention belongs to the technical field of angiographic contrast agents, and particularly relates to an angiographic contrast agent for corpses and a preparation method of the angiographic contrast agent. The angiographic contrast agent for the corpse is prepared from the following components in parts by mass: 20 to 35 parts of iodine-containing polymer, 30 to 50 parts of iodo-benzene ring compound, 90 to 150 parts of glycerol triacetate, 30 to 40 parts of dimer acid and 600 to 800 parts of liquid paraffin, the iodine-containing polymer is obtained by copolymerizing (methyl) C4-6 alkyl acrylate, polyethylene glycol diacrylate and an iodine-containing monomer, and the iodine-containing monomer is selected from at least one of 3-iodine-ethyl acrylate, 3-iodine-methyl acrylate and (methyl) iodobenzyl acrylate. The blood vessel contrast agent disclosed by the invention can realize an excellent blood vessel contrast effect on a corpse, can also obtain a relatively ideal contrast effect for a corpse with relatively long death time, and provides powerful support for the corpse work.

The invention provides an aryl alkyl ketoxime derivative as well as a preparation method and application thereof, and relates to the field of aryl oxime derivatives. The preparation method of the aryl alkyl ketoxime derivative comprises the following steps: by taking potassium formate as an additive, carrying out free radical reaction on a compound I and a compound II under ultraviolet irradiation in the presence of tert-butyl nitrite to obtain the aryl alkyl ketoxime derivative, the compound I is substituted iodobenzene or iodopyridine; the compound II is substituted styrene or thienyl ethylene; wherein a hydrogen atom transfer / single electron transfer relay sequence is utilized to activate a compound I, and tert-butyl nitrite is adopted as a bifunctional reagent, and is used as a hydrogen atom transfer reagent and an oxime source. According to the preparation method of the aryl alkyl ketoxime derivative, pre-functionalization is not needed, a reaction substrate is wide in universality and good in compatibility, reaction conditions are mild, operation is easy and convenient, a target product can be efficiently and rapidly prepared on the premise of high yield, and a new way is provided for oxime synthesis.

The invention belongs to the technical field of preparation of diaryl iodonium salts, and particularly relates to a preparation method of a cationic photoinitiator 4-isobutylphenyl-4 '-methyl phenyl iodonium hexafluorophosphate, which comprises the following steps: step 1, in the presence of p-toluenesulfonic acid and persulfate, reacting p-iodobenzene with isobutylbenzene; and 2, adding hexafluorophosphate into the reaction solution in the step 1, and carrying out an ion exchange reaction to obtain the 4-isobutylphenyl-4 '-methyl phenyl iodonium hexafluorophosphate. The preparation method has the advantages of mild conditions and simple operation, greatly shortens the process route, avoids the use of acetone and other control reagents, and is suitable for industrial large-scale production. # imgabs0 #

The invention provides a preparation method of iodobenzene diacetate, and belongs to the technical field of preparation of drug intermediates. According to the method, 50wt% hydrogen peroxide reacts with acetic anhydride to obtain a peracetic acid system, separation and purification are not needed, the peracetic acid system directly reacts with iodobenzene, and iodobenzene diacetate is prepared. The method has the advantages of simple and easy process, mild conditions, low production cost and less wastewater discharge, and is suitable for industrial production.

The invention belongs to the technical field of organic synthesis, and provides a synthesis method of diiodosilane. The synthesis method is carried out in a first reactor and a second reactor which are connected in series, and comprises the following steps: adding a first metal chloride, a solvent, dichlorosilane (DCS) and iodobenzene into the first reactor, and carrying out a pre-reaction; after the pre-reaction, continuously introducing a solvent, dichlorosilane and iodobenzene into the first reactor; meanwhile, enabling the pre-reaction feed liquid in the first reactor to continuously flow into a second reactor filled with a second metal chloride; the first reactor and the second reactor simultaneously react; and when the volume of the reaction material liquid in the second reactor reaches a target liquid level, continuously extracting and collecting the reaction material liquid in the second reactor to realize continuous preparation of diiodosilane. The synthesis method provided by the invention is high in dichlorosilane conversion rate.

The invention relates to the field of drug synthesis, in particular to an amine compound for fungi drugs and a preparation method of the amine compound. Comprising the following steps: 1) adding N-bromosuccinimide (NBS) into 4-iodobenzene serving as an initial raw material in an acetonitrile solvent in the presence of benzoyl peroxide serving as a catalyst, and reacting to obtain a 1-bromomethyl-4-iodobenzene compound II; 2) adding N-methylacetamide into the compound II in a tetrahydrofuran solvent by using potassium carbonate as alkali, and reacting to obtain an N-(4-iodobenzyl)-N-methylacetamide compound III; and 3) heating the compound III in a sodium hydroxide solution for deacetylation to obtain the compound IN-methyl-1-(4-iodophenyl) methylamine. The invention aims to provide a preparation process of the N-methyl-1-(4-iodophenyl) methylamine compound I, which is simple, convenient, green, environment-friendly and suitable for industrial production.

The invention belongs to the technical field of organosilicon compounds, and particularly relates to a method for preparing 4-trimethoxysilyl styrene and application of the 4-trimethoxysilyl styrene. The preparation method comprises the following steps: taking 4-iodobenzene ethane and trimethoxysilane as raw materials, and carrying out a coupling reaction to synthesize 4-trimethoxysilyl phenyl ethane; the preparation method comprises the following steps: reacting 4-trimethoxysilyl phenyl ethane with NBS (N-bromosuccinimide), and synthesizing 4-trimethoxysilyl phenyl bromoethane through a free radical bromination reaction; and carrying out hydrogen bromide removal on the 4-trimethoxysilyl phenyl bromoethane, so as to prepare the 4-trimethoxysilyl styrene. According to the application, (1) the 4-trimethoxysilyl styrene is used as a modifier, and (2) the 4-trimethoxysilyl styrene is applied to preparation of a resin compound; and (3) the 4-trimethoxysilyl styrene can improve the adhesive force between the heat-resistant resin and the substrate. According to the invention, the 4-trimethoxysilyl styrene is successfully prepared through different inventive concepts and new routes, so that more possibilities for synthesizing the compound are given, and the yield is also improved.

The invention provides a preparation method of an N-tert-butyl-3-amino indole derivative, which comprises the following specific steps: 1) mixing a compound IV, N-propyl-4-methyl benzenesulfonamide, copper sulfate pentahydrate, 1, 10-felotourmaline, potassium carbonate and a first solvent, and after the reaction is finished, performing post-treatment to obtain a compound II; 2) mixing tert-butylamine, triethylene diamine, di-tert-butyl dicarbonate ester and dichloromethane at room temperature, and reacting for 12 hours to obtain N, N-di-tert-butyl urea; further reacting N, N-di-tert-butyl urea to obtain a compound III; and 3) mixing the compound II, the compound III, iodobenzene, a palladium catalyst, a diphosphine ligand, alkali and a second solvent, and reacting to obtain the N-tert-butyl-3-amino indole derivative with the structural formula of # imgabs0 #. The method provided by the invention can directly carry out amination ring formation reaction with iodobenzene through one-pot reaction.

The utility model discloses an impurity removal reaction separation device for deuterated iodobenzene. The impurity removal reaction separation device comprises a reactor body and a separation assembly, the reactor body is provided with a concentrated hydrochloric acid inlet and a deuterated iodobenzene raw material inlet which are respectively used for introducing concentrated hydrochloric acid and deuterated iodobenzene into the reactor body; a plurality of iron balls are arranged in the reactor body, and the reactor body is heated through an oil bath; the deuterated iodobenzene raw materials comprise deuterated iodobenzene and deuterated nitrobenzene; the deuterated nitrobenzene can react with iron balls and concentrated hydrochloric acid in the reactor body in an oil bath heating environment to generate deuterated aniline, and the deuterated aniline generates water-soluble aniline hydrochloride under an acidic condition; the separation assembly is communicated with the reactor body and is used for separating water-soluble aniline hydrochloride and water-insoluble deuterated iodobenzene, so that impurity removal of deuterated iodobenzene is realized. According to the utility model, deuterated nitrobenzene in impurities can be removed, and high-purity deuterated iodobenzene can be obtained.

The present application relates to the field of organic synthesis, specifically a method for synthesizing C3 fluorine alkyl substituted quinoxaline ketone derivatives from olefin derivatives and quinoxaline ketone derivatives under photocatalysis by using [bis(fluoroalkyl acetoxy)iodo] benzene as different fluorine alkyl sources. [Bis(fluoroalkyl acetoxy)iodo] benzene is used as a fluorine alkylating agent to generate fluorine alkyl radicals under photocatalysis, then the radicals add to olefin derivatives to obtain alkyl radicals, the alkyl radicals then add to quinoxaline ketone, and finally, after oxidation and deprotonation, C3 fluorine alkyl substituted quinoxaline ketone derivatives are obtained. The present application uses simple and stable [bis(fluoroalkyl acetoxy)iodo] benzene as a fluorine alkyl source to prepare C3 different fluorine alkyl substituted quinoxaline ketone derivatives from quinoxaline ketone and olefin derivatives in a three-component reaction without the action of photocatalysts. The synthesis method is simple and easy to operate, and different fluorine alkyl group substituted quinoxaline ketone derivatives can be quickly obtained.

The invention relates to the field of new materials, and discloses a preparation method of halogenated carbazole, halogenated carbazole is 2-bromocarbazole, and the preparation method comprises the following steps: step 1, mixing raw materials of 1-bromo-3-fluoro-4-iodobenzene, 2-aminophenylboronic acid, inorganic base, dimethyl sulfoxide and tetrakis (triphenylphosphine) palladium, and carrying out Suzuki-Miyaura coupling reaction; and 2, continuously heating, and carrying out a ring closing reaction to obtain the 2-bromocarbazole. According to the invention, the 2-bromocarbazole is prepared by adopting a one-pot method of coupling first and cyclization second, so that the method has the advantages of few impurities, simple overall preparation method, less waste material generation and convenience in industrial mass production.

The invention relates to a nanoscale targeted health intervention nutritional ingredient embedding method, and belongs to the technical field of ingredient embedding. The specific embedding method comprises the following steps: preparing 1-[(tert-butoxy) methyl]-4-iodobenzene by utilizing iodobenzene methanol or tert-butyldimethylsilyl chloride solution; adding selenium powder, a first catalyst and alkali, and reacting to obtain 1-[(t-butoxy) methyl]-4-({4-[(t-butoxy) methyl] phenyl} disilyl) benzene; trifluoroacetic acid is added for a reaction, and bis (4, 1-hydroxy benzyl) diselenide is obtained; dissolving the mixed solution, EGCG and a second catalyst in an organic solvent to obtain a mixed solution containing EGCG; dropwise adding an oxalyl chloride solution into the mixed solution containing EGCG for reaction to obtain a SeOE polymer; the preparation method comprises the following steps: emulsifying and homogenizing a SeOE polymer solution and a polyvinyl alcohol solution, centrifuging and freeze-drying to obtain the SeOE polymer nanoparticles. According to the invention, by introducing an ROS sensitive chemical part, the ROS removal capability of the targeted delivery polymer and the oxidation stability of EGCG are improved.

The invention discloses a method for preparing sulfonium salt from functional ionic liquid. The method comprises the following steps: S1, mixing iodobenzene / iodobenzene, benzene / methylbenzene, ionic liquid and trifluoromethanesulfonate / perfluorobutyl sulfonate, and reacting with hydrogen peroxide for 12-24 hours to obtain a mixed solution; and S2, recovering the aromatic hydrocarbon in the mixed solution obtained in the step S1 until no fraction exists, adding phenyl sulfide, heating, reacting for 12-24 hours, and after the reaction is finished, purifying to obtain the triaryl sulfonium salt. The method is simple in process operation and low in equipment requirement, and the functional ionic liquid adopted in the reaction is a green solvent, is non-oxidative, non-combustible and non-volatile, has good stability and can be recycled and reused for multiple times; (methyl) benzene and iodo (methyl) benzene generated in the process reaction and post-treatment process can be recycled and reused, so that the production cost is greatly reduced; the total yield of the target product synthesized by the method can reach 80%, the purity of the product can also reach 99% or above, the three wastes generated in the production process are few, no acid wastewater is generated, the method is environment-friendly, the industrial feasibility is high, the method can be applied to industrial production on a large scale, and the ever-increasing market requirements are met.

The invention relates to the technical field of helicene compound synthesis processes, in particular to red-light nitrogen-thia-bis (9-helicene) and a synthesis method and application thereof.The red-light nitrogen-thia-bis (9-helicene) is characterized in that benzothiophene-2-boric acid is used as a raw material, 2-bromo-4-(tert-butyl)-1-iodobenzene, a catalyst and anhydrous potassium carbonate are added, and a compound 2 is obtained through heating reaction; taking the compound 2 as a raw material, adding n-butyllithium for reaction, and then adding trimethyl borate to obtain a compound 3; taking the compound 3 as a raw material, adding 1-bromo-3, 6-diiodocarbazole, a catalyst and anhydrous potassium carbonate, and carrying out heating reaction to obtain a compound 4; taking the compound 4 as a raw material, and adding an anhydrous ferric trichloride solution dissolved by nitromethane to obtain a compound 5; the preparation method comprises the following steps: taking a compound 5 as a raw material, adding sodium tert-butoxide, a catalyst and a phosphine ligand, carrying out a heating reaction to obtain a compound 6, i.e., red-light aza-bis (9-helicene), and embedding an anti-aromaticity module into a bis-helicene system to finally obtain the aza-bis (9-helicene) compound with exocarpium citri grandis fluorescence emission.

This invention provides a method for the diarylation of C(sp3)-H bonds. The method comprises: reacting a pyridine derivative with pinacol iodophenylboronic acid in a catalytic system of Ag2CO3, an amino acid ligand, and a noble metal catalyst. This method can achieve highly efficient diarylation of distal methyl C(sp3)-H bonds with yields of 52-66%, under mild reaction conditions, and with simple operation.

The invention discloses a synthesis method of a benzomorpholone derivative, and belongs to the technical field of organic chemistry. According to the method, a 3-hydroxy-2-indolone derivative and a triazole derivative react in an organic solvent at the temperature of 20-30 DEG C by taking commercialized cheap iodobenzene as a catalyst and selecting a fluorine reagent as an oxidizing agent, so that the benzomorpholone derivative can be obtained. The method is simple to operate, the raw materials are easy to obtain, the reaction steps are short and efficient, and the reaction yield is as high as 96%.

The invention discloses a synthesis method of 2, 3, 5, 6-tetrachloropyridine, which is characterized in that pyridine is used as an initial raw material, dichloro iodobenzene is used as a chlorination reagent, MOF-Cu / Al is used as a synergistic catalyst, and 2, 3, 5, 6-tetrachloropyridine is prepared through reaction in an organic solvent. According to the present invention, the process conditions are mild, the operation is simple and convenient, the 2, 3, 5 and 6 sites of the pyridine ring can be efficiently and selectively chlorinated under the mild conditions, the yield is stabilized at 90% or more, the by-product iodobenzene can be recycled, and the generation of the HCl waste gas and the large amount of the solid waste in the traditional process is avoided.

The present application provides a preparation method of a carbazole-based organic electroluminescent host material. Using inexpensive substrates 2-bromo-5-fluoro-nitrobenzene and 1-naphthylboronic acid, the coupling intermediate S1 is obtained through a Suzuki coupling reaction, and the ring-closing intermediate S2 is obtained by reduction with triphenylphosphine; the brominated product S3 is obtained by reacting with a brominating reagent in a suitable solvent; the intermediate S4 is synthesized using iodobenzene or an iodobenzene derivative; the intermediate S5 is obtained by reacting an arylamine with intermediate 4; the ring closure is achieved through C-H activation under Pd catalysis to obtain the intermediate S6; the 7,9-dihydrobenzo[g]indolo[2,3-b]carbazole derivative S7 is synthesized using iodobenzene or a benzene derivative.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a method for synthesizing an N-N cross-coupling product. N-alkoxy amide and benzotriazole are used as reaction substrates, iodobenzene diacetate is used as an initiator, N-alkoxy amide, benzotriazole and iodobenzene diacetate are mixed in the form of solid reactants, molecules of the solid reactants collide under the stirring effect, dehydrogenation coupling reaction of N-N bonds is promoted, and the N-N cross-coupling product is obtained. The method does not need to use a solvent, is simple to operate, mild in reaction condition, wide in substrate universality and low in cost, and solves the problem of low yield of an N-N cross-coupling product formed by a preparation method in the prior art.

The invention belongs to the technical field of compound synthesis, and particularly discloses a synthesis method of 1-(2-bromophenyl)-4-(2-((2, 4-dimethylphenyl) sulfenyl) phenyl) piperazine. The synthesis method comprises the following steps: in an inert atmosphere, performing a coupling reaction on votioxetine and o-bromo iodobenzene in a system containing a cuprous catalyst, ethylene glycol, inorganic alkali and an alcohol solvent to obtain 1-(2-bromophenyl)-4-(2-((2, 4-dimethylphenyl) sulfenyl) phenyl) piperazine. According to the synthesis method provided by the invention, a cuprous substance is taken as a catalyst, ethylene glycol is taken as a specific ligand, inorganic base is taken as an acid-binding agent, and an alcohol solvent is taken as an organic solvent, so that the coupling reaction can be fully carried out on the vothioxetine and the o-bromoiodobenzene in a reaction system, and the yield of the 1-(2-bromophenyl)-4-(2-((2, 2-dibromophenyl)-4-(2-((2, 2-dibromophenyl)-2-bromophenyl)-2-(2, 2-dibromophenyl)-2 the purity and the yield of the (2, 4-dimethylphenyl) sulfenyl) phenyl) piperazine are improved.

The invention discloses a method for efficiently preparing Fmoc-Dap-OH, which comprises the following steps: A, taking L-asparagine as a starting material, and reacting with 9-fluorenyl methyl-N-succinimido carbonate to obtain solid powder Fmoc-Asn-OH; and B, uniformly mixing the solid powder Fmoc-Asn-OH and the solid powder iodobenzene diacetic acid according to a ratio, then adding the mixture into a second mixed solvent formed by mixing an ether solvent and water in a manner of stirring while adding, and after the reaction is finished, obtaining the solid powder Fmoc-Asn-OH / iodobenzene diacetic acid, wherein the ether solvent is selected from one or more of tetrahydrofuran, ethylene glycol dimethyl ether and methyl tetrahydrofuran. According to the present invention, the test research results show that the reaction efficiency is substantially improved by combining the special feeding mode with the adaptive solvent system under the condition of ensuring the yield, the reaction can be completed in a short time, the target product can be obtained, the method is suitable for industrial production, and the technical defects of the existing method are overcome.

The invention provides a method for reversible disulfide bond exchange mediated by free radicals. According to the method, hydroxyl (p-toluenesulfonyloxy) iodobenzene (HTIB) is used as a free radical initiator, and controllable exchange of disulfide bonds is realized under the condition of biological compatibility. The technology has wide application potential, and is especially suitable for the field of biological medicines, such as chemical modification of amino acids, peptides, carbohydrates, proteins and drug molecules. Different from a traditional transition metal catalyzed disulfide bond exchange method, the method has the advantages that the reversible disulfide bond exchange reaction is efficiently realized under mild and biocompatible conditions, the method is applicable to the fields of protein engineering, drug development, dynamic covalent chemistry and the like, and a new way is provided for synthesis and modification of biomolecules. # imgabs0 #

The present invention proposes a method for synthesizing 6H-benzo[c]chromen-6-one, which belongs to the field of organic synthesis technology. Benzoic acid and iodobenzene are reacted to prepare 6H-benzo[c]chromen-6-one. The present invention starts from benzoic acid, first undergoes an arylation reaction with iodobenzene, and after obtaining the important reaction intermediate 2-arylbenzoic acid, continues to undergo an intramolecular cyclization reaction. A catalyst, an oxidant, an additive, and a solvent are added to a reactor, and the reaction is started. After the reaction is completed, the target product is purified by column chromatography or recrystallization to obtain the target product. Compared with the prior art, the present invention has the advantages of simple reaction operation, short steps, and low cost.