36 results about "Acetanilide" patented technology

The present invention belongs to the technical field of organic synthesis, and provides an electrochemical synthesis method for N-aroyl amide compounds, which comprises the following steps: (1) in an electrochemical reaction device containing an aromatic hydrocarbon compound, an electrolyte and a nitrile solvent, a pre-oxidant is added, and then the anode and the cathode are assembled for electrolysis reaction; (2) after the reaction is completed, a saturated NaHCO3 solution is slowly added dropwise directly into the electrochemical reaction device for hydrolysis reaction to obtain the required N-aroyl amide compounds, wherein the pre-oxidant is selected from any one or more of acids, sulfates or persulfates. The electrochemical synthesis method of the present invention does not require the introduction of a directing group or pre-functionalization of the substrate, avoids the use of metal catalysts and the application of stoichiometric oxidants, has the advantages of greenness, high efficiency, high atom economy, etc., can be used for the synthesis of drug acetanilide, and has certain practical application value.

The invention belongs to the technical field of chemical synthesis and specifically discloses a preparation method of a diphenylamine-type adamantane substituent compound. The method comprises the following steps: adding adamantane alcohol and acetanilide to a solvent for reaction to obtain adamantane acetanilide; adding adamantane acetanilide and NBS to the solvent for reaction to obtain bromoadamantanacetanilide; adding bromoadamantanacetanilide, phenylboric acid, a catalyst and an alkali salt to the solvent for reaction to obtain phenyladamantanacetanilide; and adding phenyladamantanacetanilide and hydrochloric acid to the solvent for reaction to obtain adamantane diphenylamine. The method has readily available raw materials and simple operation, has achieved kilogram-level production, and has high product purity, with a liquid phase purity of over 99.9%.

The invention discloses a preparation method of N-methyl o-fluoroaniline, which is characterized in that o-fluoroaniline is used as a starting raw material, and a target product is efficiently synthesized through three steps of reaction: step 1, in the presence of a solvent and alkali, o-fluoroaniline and acetyl chloride are acetylated at low temperature to generate 2-fluoro-acetanilide, and the product is directly used for the next step after being roughly purified; 2, under the action of a solvent and alkali, carrying out controllable methylation on the 2-fluorine-acetanilide and dimethyl carbonate to obtain 2-fluorine-N-methylacetanilide; and 3, removing acetyl protection through acidic hydrolysis, and adding sodium thiosulfate to prevent oxidation to finally obtain a high-purity product. According to the method, excessive methylation is avoided through an acetyl protection strategy, the process does not need high-risk operations such as ultralow temperature and high pressure, the operation is simple and convenient, the energy consumption is low, and the product purity is gt; the total yield reaches 79.86%, and the method is green, safe and suitable for industrial production.

The invention discloses an HRP chemiluminescent substrate system, a kit and a preparation method, the HRP chemiluminescent substrate system is composed of a liquid A and a liquid B which are physically isolated and stored; the solution A is an alkaline buffer system with the pH value of 9.0-9.6, and comprises isoluminol or a salt substrate thereof, a cationic surface active agent CTAC and a metal chelating agent diethylene triamine pentaacetic acid; and the solution B is an acidic solution with the pH value of 4.5-5.5, and comprises an oxidizing agent and a reinforcing agent N-(3-chloro-4-hydroxyphenyl) acetanilide. According to the invention, the reinforcing agent N-(3-chloro-4-hydroxyphenyl) acetanilide is placed in the acidic liquid B, when the acidic liquid B is mixed with the alkaline liquid A, the mixed system is maintained at a specific pH value of 8.3-8.6, and the reinforcing agent is rapidly dissociated into phenoxy anions; and carrying out in-situ capture and enrichment on a micelle interface by CTAC cationic micelles with positive charges, which exist in the solution A in advance, through electrostatic attraction. And in cooperation with a low-ion-strength environment brought by no buffer salt in the liquid B, the system ensures the high activity of the HRP enzyme, realizes directional interface catalysis of the enhancer, and significantly improves the luminous efficiency and stability.

The present invention belongs to the technical field of organic synthesis processes, and particularly relates to a method for synthesizing 2-methoxy-4-nitroacetanilide in a continuous flow reactor. In the present invention, o-methoxyacetanilide is used as a substrate, and a mixed acid prepared by mixing concentrated sulfuric acid and concentrated nitric acid is used as a nitrating reagent. They are respectively pumped into the reaction zone of a continuous flow microchannel reactor through metering pumps for mixing and residence reaction to synthesize 2-methoxy-4-nitroacetanilide. It has a high nitration conversion rate and high reaction selectivity, can realize the continuous, safe, efficient and stable production of this product, significantly reduce the consumption of nitric acid and the discharge of three wastes, and has a low production cost.

The invention relates to the field of pesticide synthesis, in particular to a synthesis method of ethonicotinic acid. 5-ethyl pyridine-2. 3-dicarboxylic acid diethyl ester and 2-amino-2. 3-dimethyl butyramide are used as raw materials and react in a sodium ethoxide ethanol solution at the temperature of 50-70 DEG C, hydrogen chloride gas is introduced into a system for acidification after the reaction is completed, and imazethapyr and a by-product sodium chloride are obtained. The hydrogen chloride gas is directly introduced in the acidification process, and the acidification process is free of hydration, so that on one hand, no direct wastewater is generated, the generation of wastewater with high salt content and high organic matter content is avoided, the treatment cost is reduced, on the other hand, the byproduct sodium chloride is firstly removed from the system by controlling the ethanol amount of the system, and then concentration and crystallization are performed; the high-purity imazethapyr of which the purity is greater than 99% is obtained by utilizing the solubility of the solvent ethanol to impurities, and the quality of both byproducts and main products is at a higher level in the industry.

To provide a solid preparation of a sustained-release pharmaceutical composition in which even a solid preparation has excellent structural stability while maintaining an effect of sustained-release of a pharmaceutical composition.SOLUTION: A solid preparation of a sustained-release pharmaceutical composition contains: (1) (R)-2-(2-aminothiazole-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl] acetic acid anilide or a pharmaceutically acceptable salt thereof; (2) one or more kinds of polymeric substances which form hydrogel having the average molecular weight of 100,000 or more or in which 5% aqueous solution has viscosity of 25°C 12 mPa s or more; and (3) one or more kinds of non-hydrophilic additives showing dissolubility that [amount of water for dissolving 1 g at 20±5°C exceeds 10 mL], where the solid preparation without considering coating does not contain a hydrophilic component showing dissolubility that [amount of water for dissolving 1 g at 20±5°C is 10 mL or less] other than a polymeric substance forming hydrogel of the component (2).SELECTED DRAWING: Figure 2

Herbicide concentrate compositions containing a combination of herbicides are provided; in particular, the present invention relates to aqueous herbicide concentrate compositions containing a particulate encapsulated acetanilide herbicide and a protoporphyrinogen oxidase inhibitor (PPO inhibitor).

The invention provides a phosphotungstic acid supported Zr-SBA-12 molecular sieve as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve catalysts. According to the preparation method, an SBA-12 molecular sieve is taken as a carrier, Zr is introduced into an SBA-12 molecular sieve framework through a hydrothermal synthesis method, then phosphotungstic acid is loaded on the Zr-SBA-12 molecular sieve through a direct hydrothermal method, and the composite catalyst with high acidity, site density and good structural stability is obtained. Through the synergistic effect of the metal Zr and the phosphotungstic acid, the number of acid sites and the catalytic activity of the catalyst are remarkably improved, the surface acidity of the molecular sieve is improved, and the problems of difficult recovery and high cost are solved. And the phosphotungstic acid supported Zr-SBA-12 molecular sieve as a catalyst has important research value and application prospect in the field of acetanilide nitration reaction.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 4-amino-2-methylbenzoic acid, and more particularly relates to a preparation method of 4-amino-2-methylbenzoic acid as a raw material of a tolvaptan intermediate, wherein 3-methylaniline is used as a raw material to prepare 3-methylacetanilide with an acylating agent, the 3-methylacetanilide is subjected to Friedel-Crafts acylation with oxalyl chloride under a Lewis acid catalytic system to prepare 4-acetylamino-2-methylbenzoic acid, and finally, the 4-acetylamino-2-methylbenzoic acid is deprotected under alkaline conditions, and then acidified to obtain the target compound 4-amino-2-methylbenzoic acid, wherein the raw material used in the preparation method is cheap and easy to obtain, the production equipment has low requirements, the process condition is simple, the safety factor is high, no ammonia nitrogen and other three wastes are generated, the cost is low, and the industrialized production is easy to implement.

The invention discloses a synthesis method of an atorvastatin intermediate. The method comprises the following steps of: catalyzing alpha-chlorophenylacetyl chloride and fluorobenzene to perform Friedel-Crafts acylation reaction by taking immobilized Bronsted-Lewis acidic ionic liquid as a catalyst, and performing condensation reaction on a product and isobutyryl acetanilide under the action of alkali and the assistance of microwaves, the preparation method comprises the following steps: adding 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenyl pentanamide into an organic solvent to obtain the atorvastatin intermediate 2-[2-(4-fluorophenyl)-2-oxo-1- By utilizing the characteristics of large specific surface area and abundant active sites of graphite-like carbon nitride, the graphite-like carbon nitride is used as an ionic liquid immobilization carrier and a parent nucleus to participate in the ionic liquid preparation process, the catalytic activity of the ionic liquid is retained, the catalyst is simple to separate, the reaction rate and selectivity are improved, the steps are simple, and the method is suitable for industrial production. The method has the advantages of mild reaction conditions in each step, low cost, high yield and easily available reaction conditions, and improves the application prospect.

The invention discloses a method for preparing an acetylglucosamine derivative through biotransformation of marine microbacterium and application of the acetylglucosamine derivative, the marine microbacterium is microbacterium HN-3-14 and has been preserved in Guangdong Microbial Culture Collection Center on March 3, 2025, and the preservation number is GDMCC No.65964. The invention further discloses a preparation method of the acetylglucosamine derivative through biotransformation of the marine microbacterium HN-3-14. The method comprises the following specific steps: inoculating a microbacterium seed solution into a special culture medium, carrying out fermentation culture and HPLC separation to obtain four acetanilide derivatives formed by biotransformation of microbacterium HN-3-14, and exploring the cytotoxicity and anti-inflammatory activity of the obtained derivatives, so that the method is expected to be applied to preparation of anti-inflammatory drugs.

The invention relates to the technical field of organic synthesis, and discloses an adamantyl aniline derivative and a preparation method thereof.The preparation method comprises the steps that 1-(4-bromophenyl) adamantane and acetamide serve as raw materials and are subjected to high-temperature acylation and then react with NBS to obtain bromo-adamantyl acetanilide, then the bromo-adamantyl acetanilide reacts with strong base to obtain bromo-adamantyl acetanilide; according to the present invention, the raw materials are easily available, the operation is simple, the yield is high, and the purity of the obtained product is high, such that the method has characteristics of easily available raw materials, easily available raw materials, easily available raw materials, easily available raw materials, easily available raw materials, easily available raw materials, easily available raw materials, easily available raw materials, easily available raw materials and easily available raw materials.

1-methyl-2-carboxyl-3-acetanilide indole compounds and applications thereof. The compounds can block the interaction between NLRP3 and NEK7, effectively inhibit the activation and assembly of NLRP3 inflammasome, and have good prevention and treatment effect on NLRP3 inflammasome related inflammatory diseases such as Alzheimer's disease and Parkinson's disease. Thus, the compounds can be used for preparing drugs for treating and / or preventing NLRP3 inflammasome related inflammatory diseases, and provide a new choice for the development of NLRP3 inflammasome small molecule inhibitors.

The application discloses a synthesis method of an atorvastatin intermediate. The method comprises the following steps: firstly, using a solidized Brønsted-Lewis acidic ionic liquid as a catalyst, catalyzing a Friedel-Crafts acylation reaction of alpha-chlorobenzene acyl chloride and fluorobenzene, then, under the action of alkali and microwave assistance, performing a condensation reaction of the product and isobutyryl acetanilide, and finally, obtaining the atorvastatin intermediate 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide. The method uses the characteristics of a large specific surface area and rich active sites of graphite-like carbon nitride, simultaneously uses the graphite-like carbon nitride as an ionic liquid solid carrier and as a mother nucleus to participate in the preparation process of the ionic liquid, retains the catalytic activity of the ionic liquid, improves the reaction rate and selectivity through simple separation of the catalyst, and has the advantages of low cost, high yield, easy reaction conditions, and improved application prospect.

The invention relates to the technical field of aniline preparation, in particular to a method for preparing acetoacetanilide through electrochemical selective debromination. The method comprises the following steps: (1) taking a sulfuric acid aqueous solution as an anolyte, taking an organic alkali aqueous solution as a catholyte, putting bromoacetoacetanilide as a reaction raw material into the catholyte, uniformly mixing, and carrying out electrolysis debromination to obtain a suspension; (2) adjusting the pH value of the suspension to be acidic, separating to obtain a solid and an acid solution, washing the solid with water, and drying to obtain a white filter cake, namely acetoacetanilide; and (3) carrying out electrodialysis dissociation on the acid liquor obtained in the step (2) to respectively obtain organic alkali and recovered acid liquor. The acetoacetanilide is prepared by taking the bromoacetoacetanilide as the raw material, so that the method is environment-friendly and convenient to use, and has value in both the angle of green chemistry and the economical efficiency.

The invention discloses a method for recovering acetanilide in the production process of chloro oxytetracycline. The method comprises the following steps: after the chlorination reaction is finished and most methanol is recovered, adding an organic solvent which is selected from alcohols or high-boiling-point polar aprotic solvents capable of forming azeotrope with water into the residual liquid; removing residual methanol and moisture by distillation; transferring the obtained organic solvent solution containing acetanilide to a downstream process, adding hot water to dissolve acetanilide, and simultaneously evaporating or extracting to recover the organic solvent; and finally cooling and crystallizing the acetanilide hot water solution to obtain the product. According to the method, the solvent is introduced in the distillation stage, so that the problems of equipment blockage and scaling caused by precipitation of acetanilide, oxytetracycline raw materials and byproducts are effectively prevented, and continuous and stable operation of rectification and subsequent operation is ensured; meanwhile, dangerous and high-energy-consumption links such as high-temperature melt discharging, cooling solidification and mechanical crushing in the prior art are thoroughly avoided, and the safety, economical efficiency and operation efficiency of the process are remarkably improved.

The application discloses a continuous separation system and method for liquid aniline derivative intermediates, and the liquid aniline derivative intermediates are liquid 3-(N,N-diallyl) amino-4-methoxy acetanilide or liquid 3-(N,N-diethyl) amino acetanilide. The application can quickly separate product heavy oil, mother liquor water and floating oil components by using a continuous oil-water separator, a floating oil intermediate tank and a product oil intermediate tank. The emulsified materials in the mother liquor water can be effectively recovered by using the mother liquor intermediate tank for salting-out demulsification. The separated mother liquor clear liquid enters an MVR evaporation system, and ammonium chloride salt and distilled water are obtained through evaporation, concentration and crystallization. The ammonium chloride concentrate can be recycled for salting-out demulsification. After the liquid aniline derivative intermediate crude product is subjected to the continuous separation system and method, the separation efficiency of the liquid material is high, the overall material yield is improved, the solid content of the product is obviously improved, the system stability is good, and the wastewater treatment cost is reduced.

The invention discloses a method for recycling o-methyl-bis-acetanilide mother liquor through multistage membrane separation, and belongs to the field of chemical engineering. The method comprises the following steps: firstly, fully stirring the obsolete mother liquor of o-methylacetoacetanilide, then filtering through a molecular sieve filter membrane to remove suspended solids with larger particle sizes, directly treating filter residues in an incinerator, and then pumping filtrate into pervaporation membrane equipment; under the reverse osmosis action of the pervaporation membrane, water molecules are separated through the pervaporation membrane to obtain high-purity water which can be directly reused as reclaimed water; and the residual liquid is directly pumped into the evaporation tower and is condensed and refluxed to obtain high-purity ethanol which can be used as ethanol for preparing mother liquor next time, and the residual liquid at the bottom of the evaporation tower can be directly sent to an incinerator for treatment.

The invention discloses a method for synthesizing 2, 6-dichloroaniline through light induction, and relates to the technical field of organic synthesis.The method comprises the steps that aniline and acetic anhydride are mixed and stirred, and acetanilide is obtained; acetanilide is dropped into concentrated sulfuric acid to obtain a mixed solution, the mixed solution and concentrated sulfuric acid are subjected to a continuous flow reaction through a microchannel according to a preset molar ratio, and p-nitroacetanilide is obtained; the method comprises the following steps: mixing p-nitroacetanilide and a photocatalytic solution, placing the mixture in a photocatalytic reactor, and in an inert gas atmosphere, carrying out a catalytic chlorination reaction through irradiation of visible light with a preset wavelength to obtain 2, 6-dichloro-4-nitroacetanilide; the preparation method comprises the following steps: mixing 2, 6-dichloro-4-nitroacetanilide with a hydrochloric acid solution, and heating and refluxing to obtain 2, 6-dichloro-4-nitroaniline; the method comprises the following steps: by taking palladium on carbon as a catalyst, carrying out a denitrification reaction on 2, 6-dichloro-4-nitroaniline under the action of hydrogen to obtain 2, 6-dichloroaniline; the method can solve the technical problems of poor reaction selectivity, low yield and loss of traditional synthesis of 2, 6-dichloroaniline.

The invention discloses a continuous reaction research process of low-biphenylamine impurity 2, 4-dimethyl-bis-acetanilide, and belongs to the field of chemical synthesis. The invention aims to provide the continuous reaction research process for the low-bis-phenylamine impurity 2, 4-dimethyl-bis-acetanilide (2, 4-dimethyl-N-acetoacetanilide), the retention time of the 2, 4-dimethyl-N-acetoacetanilide raw material is shortened, the bis (2, 4-dimethyl phenyl) amine impurity is reduced, the yield of the 2, 4-dimethyl-N-acetoacetanilide is increased, and the production cost is reduced. Meanwhile, the auto-polymerization of the diketene is reduced, the consumption of the 2, 4-dimethylaniline is reduced, and the problems of high impurity content of the bis (2, 4-dimethylphenyl) amine in the existing 2, 4-dimethyl-N-acetoacetanilide and poor batch stability are solved.

The application provides a kind of catalyst recyclable carboxin synthesis method, belong to organic synthesis technical field, comprising: the condensation reaction of alpha-chloroacetyl acetanilide and 2-mercaptoethanol under alkaline conditions, intermediate is obtained by separation;With toluene as solvent, the obtained intermediate is mixed with ionic liquid catalyst to form a reaction system, heating reaction, after the reaction is completed, the temperature of the reaction system is reduced to 5-25 DEG C, the reaction system is layered, then separation treatment is carried out, carboxin product and separated ionic liquid catalyst are obtained, then the separated ionic liquid catalyst is regenerated by dehydration and recycled;Wherein, the ionic liquid catalyst is 1-(polyethylene glycol monomethyl ether group)-3-(3-sulfopropyl) imidazole hydrogen sulfate salt.The reaction system has homogeneous high-efficiency conversion at high temperature and automatic separation at low temperature, which realizes the green upgrading of carboxin synthesis process.

The invention discloses a preparation method of a fluorescent dye crude product, which is characterized by comprising the following steps: adding 1, 1, 2-trimethyl-3-(4-sulfonic acid butyl)-1H-benzo [e] indole inner salt and 2-[6-(acetanilino)-1, 3, 5-hexantrienyl]-1, 1-dimethyl-3-sulfonic acid butyl-1H-benzo [e] indole inner salt into absolute ethyl alcohol, dropwise adding triethylamine, reacting for 4-5 hours, filtering, washing, and drying to obtain the fluorescent dye crude product, namely the 2-[6-(acetanilino)-1, 3, 5-hexantrienyl]-1, 1-dimethyl-3-sulfonic acid butyl-1H-benzo [e] indole. Dropwise adding an absolute ethyl alcohol solution of sodium iodide, after dropwise adding, adding purified water, heating and stirring to completely dissolve the solid, and then cooling and crystallizing to obtain a fluorescent dye crude product; meanwhile, the invention discloses a refining method of the fluorescent dye crude product. And the yield of the fluorescent dye is ensured, and impurities and solvent residues meet the limit.

This invention relates to a method for the selective nitration of 4-acetamidoanisole using a continuous flow microchannel reactor, belonging to the field of compound synthesis. The method includes: mixing 4-acetamidoanisole with a solvent to obtain feed solution A; using nitric acid as feed solution B; washing the microchannel reaction system with a solvent; pumping feed solution A and feed solution B separately into the microchannel reactor using metering pumps; after the reaction is complete, the product flows out from the outlet of the microchannel reactor, and the reaction solution is collected; diluting the reaction solution with ice water, precipitating the product, filtering, washing, and drying to obtain 4-acetamido-2-nitroanisole, or separating the reaction solution by washing with water, distilling under reduced pressure, and drying to obtain 4-methoxy-2-nitroacetanilide. This method only requires changing the solvent system of one feed solution to obtain two isomers with excellent selectivity. It features high reaction safety, short reaction time, simple post-processing, avoids the dangers of batch nitration reactions, and significantly reduces economic costs.

The invention discloses a combined collecting agent for galena and application of the combined collecting agent. The combined collecting agent comprises a benzene derivative containing amino / amido and phenolic hydroxyl and ethyl xanthate. The combined collecting agent comprises four combined types of 2-acetamido phenol and ethyl xanthate, 2-amino-4-methylphenol and ethyl xanthate, 2 '-hydroxy-5'-methylacetanilide and ethyl xanthate, and salicylamide and ethyl xanthate, has a good selective collecting effect on lead in preferential flotation, can effectively reduce mutual inclusion of lead and zinc, and has the advantages of being high in selectivity, high in recovery rate and high in recovery rate. And the dosage is low. By means of the combined collecting agent, flotation separation of galena and sphalerite is effectively achieved, the benzene derivative containing amino / amido and phenolic hydroxyl has a selective collecting effect on galena, meanwhile, the activation effect of inevitable ions on sphalerite is eliminated through chelation, the use amount of ethyl xanthate is reduced, and the flotation efficiency of galena and sphalerite is improved. The separation effect of the lead-zinc sulfide ore is improved, the utilization rate of lead-zinc metal resources is increased, and meanwhile the ore dressing cost can be reduced.

The invention discloses acetoacetanilide refining equipment and a process thereof. The acetoacetanilide refining equipment comprises a mounting platform, a control module, a reaction mechanism, an injection module, an accurate dropwise adding module and a material adding module, the control module is mounted at the top of the mounting platform; the reaction mechanism is embedded in the middle of the inner side of the mounting platform; the injection module is arranged at the top end of the mounting platform and located on the right side of the reaction mechanism, and the injection module is electrically connected with the control module; the accurate dripping module is arranged at the top end of the mounting platform and is positioned on the rear side of the reaction mechanism; according to the acetoacetanilide refining equipment and the acetoacetanilide refining process, the reaction container is movably connected with the heating part, so that the reaction container and a heat source can be quickly separated from each other when the acetoacetanilide is heated and then cooled in the acetoacetanilide refining process; the temperature in the reaction container is quickly reduced, and the acetoacetanilide refining efficiency is improved.

The invention relates to the technical field of pharmaceutical analysis, in particular to a method for detecting bromoacetoacetanilide and aniline in a rebamipide tablet, impurities are detected by using a liquid chromatography-mass spectrometry technology, adopting an Agilent C18 chromatographic column and taking a 0.1% formic acid solution-acetonitrile mixed solution as a mobile phase, and the content of the impurities is calculated by adopting an external standard method. According to the method for detecting bromoacetoacetanilide and aniline in the rebamipide tablet, a liquid chromatography-mass spectrometry technology is adopted, quantitative detection of bromoacetoacetanilide and aniline is achieved, and the method is high in specificity, high in sensitivity, good in stability, high in sensitivity, high in sensitivity and high in reliability. According to the method, the content of bromoacetoacetanilide and aniline in the rebamipide tablet can be effectively measured, the quality control of the rebamipide tablet is perfected, the product quality is controllable, and the safety and effectiveness of the product are ensured.

A herbicidal concentrate composition containing a herbicide combination is provided. Specifically, the present invention relates to a herbicidal aqueous concentrate composition containing a microencapsulated acetanilide herbicide and a protoporphyrinogen oxidase inhibitor (PPO inhibitor).

The present application relates to the technical field of aniline preparation, in particular to a method for electrochemically selectively debrominating to prepare acetoacethylaniline. The method comprises the following steps: (1) using sulfuric acid aqueous solution as an anode liquid, using organic alkali aqueous solution as a cathode liquid, putting bromoacetoacethylaniline as a reaction raw material into the cathode liquid, mixing uniformly, electrolyzing to debrominate, and obtaining a suspension; (2) adjusting the pH value of the suspension to be acidic, separating to obtain a solid and an acid liquid, and the white filter cake obtained after the solid is washed with water and dried is acetoacethylaniline; (3) performing electrodialysis dissociation on the acid liquid obtained in step (2) to obtain organic alkali and recovered acid liquid respectively. The present application uses bromoacetoacethylaniline as a raw material to prepare acetoacethylaniline, is environmentally friendly and convenient to use, and has value from the perspective of green chemistry and economy.

Herbicidal concentrate compositions containing a combination of herbicides are provided. In particular, the present invention relates to aqueous herbicidal concentrate compositions containing a particulate encapsulated acetanilide herbicide and a protoporphyrinogen oxidase inhibitor (PPO inhibitor).