283 results about "Acetanilide" patented technology

The invention provides a method for preparing pigment yellow 83. The method comprises the following steps: 3, 3'-dichlorobenzidine, 3, 3'-dimethylbenzidine, hydrochloric acid and water are stirred, dissolved and added to sodium nitrite for diazotization, so as to obtain a diazonium solution; a sodium hydroxide solution containing 4-chlorine-2, 5-dimethoxy acetyl acetanilide is dripped into an acetic acid solution at the temperature between 20 and 40 DEG C, so as to prepare a coupling solution; the acetic acid solution contains an emulsion formed by well mixing anionic surfactant, nonionic surfactant, solvent and water; the diazonium solution is dripped into the coupling solution within 1 to 5 hours; the emulsion formed by compounding the anionic surfactant and non-polar hyper-dispersant is added to the coupling solution, reacts for 1 hour, and is heated to 90 to 100 DEG C; polyethylene wax is added in the mixture; and then the mixture, is insulated for 1 to 3 hours, pumped, filtered, washed, dried and ground, so as to obtain a finished product. The preparation method has the advantage of obtaining the pigment yellow 83 which is bright in color light, high in tinting strength, high in covering power and good in dispersibility.

The present invention discloses an active red dye preparation method comprising the following steps: (1) a sulfonated para-ester is obtained by successive sulfonation, hydrolysis, dilution and salting-out of p-hydroxyethyl sulfone acetanilide as a starting material; (2) the acid number of the sulfonated para-ester is detected, according to the detected acid number, hydrochloric acid is added, and after the reaction is completed, a sulfonated para-ester diazonium salt is obtained; (3) a first-coupling fluid is obtained by first coupling of the sulfonated para-ester diazonium salt obtained by the step (2) and a J acid; and (4) an active red dye is obtained by secondary coupling of the first-coupling fluid obtained by the step (3) and a cresidine para-ester diazonium salt and processing. According to the method, on the basis of the acid number of the prepared sulfonated para-ester diazonium salt, the addition amount of the hydrochloric acid is determined, and the obtained active red dye has better strength.

The invention provides a 2-quinolinone compound and a preparation method and application thereof. The 2-quinolinone compound is 3-(2-benzimidazolyl)-6, 7-difluoro-2-quinolinone. The preparation method comprises the following steps: taking 3, 4-difluoro acetanilide as an initial raw material, reacting with POC13 (phosphorus oxychloride) and DMF (dimethyl formamide) to obtain 2-chlorine-6, 7-difluoro quinoline-3-formaldehyde, then hydrolyzing to generate 3-aldehyde group-6, 7-difluoro-2-quinolinone, then reacting with o-phenylenediamine to obtain the 2- quinolinone compound. The 2-quinolinone compound can be used as a fluorescent probe for quantitative detection of the content of Hg<2+>, and shows high sensitivity and selectivity, the detection process is simple and rapid, and the detection result is accurate.

The invention provides a method for synthesizing m-Aminoacetanilide. Compared with the prior method for synthesizing m-Aminoacetanilide, the method is characterized in that chlorine hydride gas replaces hydrochloric acid with a content of 31 percent, the step of concentrating a mother liquid in the subsequent steps is avoided, a large number of production resources and the cost are saved, the final reaction liquid is pumped and filtered to remove the product, the filter liquor can be reused for the next reaction immediately, and the step of concentrating the mother liquid is not needed; and the process is simple, the production cycle is short and the energy consumption is low.

The invention discloses a continuous sulfonating process for synthesizing p-aminophenyl-beta-hydroxyethyl sulfone sulphate. The process comprises the steps: performing reaction on chlorosulfonic acid and acetanilide which serve as raw materials; respectively atomizing chlorosulfonic acid and molten-state acetanilide and contacting with each other during feeding to perform reaction. According to the continuous sulfonating process for synthesizing p-aminophenyl-beta-hydroxyethyl sulfone sulphate, the molten-state acetanilide is used as a raw material, and the reaction on the acetanilide in an atomizing state and chlorosulfonic acid which is also in an atomizing state are carried out and the reaction temperature is easily controlled, so that the production of byproducts such as parachloroaniline is avoided, and the conversion rate of acetanilide serving as a raw material is high. The process is convenient to operate, short in production period, controllable in reaction process, less in labor demands, low in cost and easy for industrial production.

The production process of p-acetamido benzene sulfonyl chloride as intermediate for sulfanilamide medicine includes the following steps: chlorosulfonating acetylaminobenzene as main material with chlorosulfonic acid to produce sulfonated oil and absorbing hydrogen chloride gas to prepare hydrochloric acid; separating sulfonated oil, adding water and decomposing chlorosulfonic acid to obtain separated oil while absorbing produced hydrogen chloride gas; separating the separated oil and adding water to deposit out p-acetamido benzene sulfonyl chloride; further separating, eliminating p-acetamido benzene sulfonyl chloride mother liquid, water washing the crystal while side producing sulfuric acid; using the side produced sulfuric acid in recovering p-amido benzene sulfonic acid; and reusing crystal eliminating water in the separation. The present invention realizes the comprehensive utilization, protects environment and lowers the cost.

The invention relates to a preparation method for N-acetyl acetanilide. The method comprises the following steps of adding N-acetyl acetanilide crystal seeds and an emulsifying agent to deionized water at a temperature of 0-10 DEG C to carry out a reaction; then dropwise adding diketene and aniline simultaneously under the control of a certain temperature; keeping the reaction at the temperature; cooling to a temperature of 0 DEG C; filtering and drying to obtain the N-acetyl acetanilide. The method has the advantages of effectively preventing product caking, improving product appearance and performance, increasing product yield and greatly reducing wastewater quantity.

An alpha-(pyrazole-formyl) acetylphenylamine compound with high bactericiding activity and its formula are disclosed.

The invention relates to a para-acetylsulfanilamide synthesis method combined with waste water treatment. The method comprises the following steps of: hydrolyzing reaction liquid (commonly called sulfonated oil) generated by chlorosulfonation of acetanilide and chlorosulfonic acid at low temperature; directly adding the reaction liquid hydrolyzed at low temperature into ammonia water to perform amination; and neutralizing and filtering to obtain solid para-acetylsulfanilamide (p-ASN), wherein the filtrate contains p-aminobenzene sulfonic acid and ammonium sulfate; the p-aminobenzene sulfonic acid in the filtrate is recovered by an adsorption method; and the ammonium sulfate is obtained by concentrating, crystallizing, filtering and drying the residual adsorption solution. The method has the advantages that: all the sulfuric acid generated after the sulfonated oil is hydrolyzed is converted into the ammonium sulfate, so the treatment problem of a large amount of high-concentration acidic waste water is solved from the source; the quantity of the liquid to be treated in the new process is 25 percent of that of the liquid to be treated in the conventional process, so a great amount of water resource and capital are saved; the byproducts such as the ammonium sulfate and the p-aminobenzene sulfonic acid can be recovered, so resources can be utilized circularly and comprehensively; and the steamed water in the concentration process of the ammonium sulfate and the p-aminobenzene sulfonic acid is neutral and can serve as industrial water to be recycled.

The present invention relates to novel analide derivatives of formula I, enantiomers and stereoisomers thereof, and their pharmaceutically acceptable salts. The invention also relates to pharmaceutical compositions containing the compounds and methods of treating hypercholesterolemia and atherosclerosis therewith.

The invention discloses a preparation technique for azo disperse dyes, which comprises preparing esterification solution and coupling reacting. Wherein, the esterification solution comprises mainly one of: 1) 3-N, N-acetoxylated amido-4-methoxyl-1-acetanilide; 2) N- cyanoethyl-N-acetoxylated amido aniline; 3) 3-N, N-acetoxylated amido-1-acetanilide. This invention increases concentration of esterification solution from 65% to about 90% to decrease COD in waste water more than 60%, and has high efficiency.

The invention relates to a synthetic method of p-aminobenzenesulfonamide, which is characterized by successively includes the following steps: (a) adding chlorosulfonic acid into a reaction kettle, controlling the temperature to be 40-50 DEG C, adding acetanilide, increasing the temperature to 55-60 DEG C and performing a reaction for 1-2 h to obtain a first mixture; (b) adding dichloroethane, increasing the temperature to 65-75 DEG C, dropwisely adding a catalyst and SOCl2, and continuously performing the reaction for 1-3 h; (c) controlling the temperature in the reaction kettle to be 15-20 DEG C, dropwisely adding the mixed liquid obtained in the step (b) into ammonia water being 22-25% in mass concentration, stirring the liquid for 0.5-1 h, increasing the temperature to 40-42 DEG C and continuously performing the reaction with stirring for 1-2 h, and filtering the liquid to obtain a crude product of the p-aminobenzenesulfonamide; and (d) adding the crude product in a hydrolysis kettle, adding a NaOH solution being 20-30% in mass concentration, heating the mixture to 90-95 DEG C to perform reflux hydrolysis for 2-3 h, adding an acid solution to regulate the pH value to 6.5-6.7, performing centrifugation, and drying a filter residue to obtain the p-aminobenzenesulfonamide. In the method, the addition quantities of the reactants are accurately controlled so that the use amount of the chlorosulfonic acid is reduced. The method is reduced in cost and is increased in yield and purity of the product.

The invention relates to a process for producing p-acetamidobenzene sulfonyl chloride. The process comprises: adding chlorosulfonic acid and antifebrine into acetanilide serving as a raw material to perform chlorosulfonation to obtain sulfonated oil; adding water into the obtained sulfonated oil to perform a hydrolysis reaction; subjecting the product of the hydrolysis of sulfonated oil to vacuum filtration; circularly absorbing one hydrogen chloride gas product to prepare diluted hydrochloric acid; and dissolving the other p-acetamidobenzene sulfonyl chloride product in a dissolving kettle, crystallizing, centrifuging and drying to obtain finished p-acetamidobenzene sulfonyl chloride. The process is characterized in that: dichloroethane is added in the dissolution process as a solvent, the finished product obtained after centrifugation is dried by air flow and then packed under vacuum, and thus, the finished product is obtained. In the production process disclosed by the invention, the mass ratio of the added dichloroethane solvent and the acetanilide raw material is (4-8):1, air flow is used for drying, the quality guarantee period of the prepared finished product is as long as 180 days, and the finished product is more stable.

The invention belongs to preparation of compound products of fine chemical engineering and particularly relates to a preparation method of 2-br-4-fluoacetanilide, which comprise the steps of: acetylation: adding para-fluoro aniline and glacial acetic acid into a reaction flask, heating to 50 DEG V, dropping acetic anhydride, carrying out reaction for 1-3h under the condition of 55-100 DEG C to prepare an intermediate para-fluoro acetanilide; and (2) bromination: dropping bromine at 45-55 DEG C, carrying out reaction for 1-3h under the condition of 50-60 DEG C, then dropping hydrogen peroxide at 40-55 DEG C, carrying out reaction for 1-3h under the condition of 50-60 DEG C, decolorizing and crystallizing with sodium hydrogensulfite, recrystallizing with an ethanol water solution to obtain a finished product of the 2-br-4-fluoacetanilide. The 2-br-4-fluoacetanilide has a chemical reaction formula shown in the specification, the whole process is shorter in reaction time and simple in operation, the reaction conversion rate for the acetylation and the bromination is up to above 90%, a finally obtained product has high purity, and the preparation method is suitable for enlarged industrial production; and thus, the production cost is reduced.

The invention relates to a process for synthesizing 1-[(2,4-dichlorobenzene) methyl]-1H-indazole-3-carboxyl acid which consists of, using phenylhydrazine as starting raw material, producing beta-acetylphenylhydrazine through reaction with glacial acetic acid, reacting with hydrated chloral and hydroxylamine hydrochloride, obtaining N-acetamido-isonitro-acetanilide, preparing 1H-indazole-3-carboxylic acid under the condition of concentrated sulfuric acid, finally subjecting 1H-indazole-3-carboxylic acid with 2,4-dichlorin benzyl chloride.

The invention discloses a synthesis method of environmental-friendly p-(beta-sulfatoethylsulfonyl) aniline. The synthesis method comprises the following steps: (1) in the presence of a chlorination inhibitor, carrying out sulfonation reaction on acetanilide and chlorosulfonic acid, and then carrying out chlorination reaction on the obtained product and thionyl chloride, so that a chlorosulfonation substance is obtained; and (2) sequentially carrying out condensation reaction, sulfonating reaction and hydrolysis reaction on the chlorosulfonation substance obtained in the step (1), so that environmental-friendly p-(beta-sulfatoethylsulfonyl) aniline is obtained. According to the preparation method, by changing a production formula, introducing the chlorination inhibitor, and changing the reaction reactivity of reaction raw materials, p-chloroacetanilide byproducts are greatly reduced, so that an effect that a para-ester product parachloroaniline meets the standard is finally achieved.

The invention discloses a treatment method for p-beta hydroxyethyl sulfone acetanilide mother liquor waste water. The treatment method comprises the following steps of performing pretreatment on p-beta hydroxyethyl sulfone acetanilide mother liquor water to recover p-beta hydroxyethyl sulfone acetanilide in mother liquor waste water, and then sequentially performing diazo reaction, coupling, primary condensation and secondary condensation to prepare a yellow reactive dye. According to the treatment method disclosed by the invention, p-beta hydroxyethyl sulfone acetanilide in the p-beta hydroxyethyl sulfone acetanilide mother liquor waste water produced in the production process of para-ester is reasonably utilized, and p-beta hydroxyethyl sulfone acetanilide in the waste water is used for synthesizing an intermediate of the reactive dye after hydrolysis, so that the waste is turned into treasure, the high-concentration waste water produced in the production process of the para-ester can achieve up-to-standard emission after treatment at the relatively low cost, and the para-ester and the related industry of the para-ester can realize sustained development.

The invention discloses a preparation method for 3-substituted trifluoromethyl indole. Various substituted acetanilides are taken as a reaction substrate with a medium to excellent reaction yield, excellent reaction chemical selectivity, and high area selectivity; another isomer (2-substituted trifluoromethyl indole) is monitored to be not detected in detection; the conditions are gentle; the substrate is wide in scope of application (wherein R is H or various electron-donating groups such as CH3, OCH3, SCH3 and the like, as well as various electron withdrawing groups such as NO2, Cl and the like, and Ar is various substituted benzene rings); the preparation method is simple and convenient in operation, relatively low in cost, less in side reaction, high in product purity, convenient in separation and purification, and suitable for large-scale preparation; and a product prepared by the preparation method has a very good application prospect in the biomedicine field.

The invention relates to the technical field of organic synthesis, and discloses a method for synthesizing 4-methoxy-2-nitroaniline by using a continuous flow reactor. The method comprises the following steps: S1, respectively adding a 4-methoxyaniline solution and acetic anhydride into a continuous flow reactor I, and carrying out an acetylation reaction to obtain a reaction solution I containing4-methoxyacetanilide; S2, respectively adding a nitration reagent and the reaction solution I into a continuous flow reactor II, and carrying out a nitration reaction to obtain a reaction solution IIcontaining 4-methoxy-2-nitroacetanilide; S3, respectively adding hydrolysate and the reaction solution II into a continuous flow reactor III, and carrying out a hydrolysis reaction to obtain a reaction solution III containing 4-methoxy-2-nitroaniline; and S4, carrying out post-treatment on the reaction solution III to obtain 4-methoxy-2-nitroaniline. The method is high in reaction speed, small inamount of byproduct 4-methoxy-3-nitroaniline, high in heat and mass transfer efficiency, high in reaction safety, high in selectivity, high in yield and purity and convenient in after-treatment.

The invention relates to a preparation method of light-resistant and waterproof paint, which comprises the following steps: adding water, emulsifier and acrylate, heating to 45 DEG C, and stirring for 45 minutes; adding a monomer A, emulsifying for 40-60 minutes, and heating to 75 DEG C; introducing return water, heating to 80 DEG C, keeping the temperature, dropwisely adding initiator, and reacting for 2 hours to obtain a core layer emulsion; dropwisely adding a monomer B and the initiator into the obtained core layer emulsion simultaneously for 1-3 hours, then keeping the temperature at 75-85 DEG C, and reacting for 2 hours; adding 10-20 parts by weight of light-resistant material, keeping the temperature at 75-85 DEG C, and reacting at 1-3 hours; adding 0.5-1.0 part by weight of metal salt, regulating the pH value to 4.0, keeping the temperature at 75-85 DEG C, and reacting for 1-2 hours; cooling to 50 DEG C, adding 0.2 part by weight of crosslinking agent, and reacting for 30 minutes; adding 0.3 part by weight of organic silicon and 0.1 part by weight of acetanilide, and reacting for 60 minutes; and adding ammonia water to regulate the pH value to 5, thus obtaining the light-resistant and waterproof paint. The obtained acrylate resin has favorable light resistance and water resistance, and the production process is environment-friendly.

The present invention relates to a preparation method of m-fluoroaniline. Water and m-amino acetanilide hydrochloride are mixed, cooled to be at the temperature of minus 5 DEG C and 0 DEG C, and added into NaOH aqueous solution to be neutralized; borofluoric acid aqueous solution is added; and the temperature of the mixed solution is maintained between minus 5 DEG C and 0 DEG C. Then NaNO2 aqueous solution is dropped for diazo reaction, and the borofluoric diazonium salt is prepared. The diazonium salt is added into a reaction bottle to be heated and decomposed until nearly no gas is emitted; and the decomposition and fluorination are stopped. NaOH aqueous solution are added into the reaction bottle, acetyl is eliminated through mixing and hydrolysis, steam distillation and static demixing are completed, and the product m-fluoroaniline is in the oil layer. The main raw materials for synthesis, m-amino acetanilide hydrochloride, NaNO2, borofluoric acid and NaOH are all cheaper and easily accessible, the technologies of diazo reaction, decomposition and fluorination are simpler, the cost is low, and the present invention is easy for industrialization.

The invention relates to a method for synthesizing n-acetylsulfanilyl chloride by using sulfur trioxide as a sulfonating agent. The method comprises the following steps: (a) sequentially adding acetanilide and glacial acetic acid into a reaction kettle, stirring and warming to 40 to 70 DEG C; (b) inflating sulfur trioxide gas into the reaction kettle, reacting for 3 to 15 hours at the temperature of 40 to 70 DEG C to enable acetanilide to be completely converted and stopping inflating the sulfur trioxide gas; (c) warming temperature in the reaction kettle to 65 to 80 DEG C and decompressing to recycle the glacial acetic acid; (d) controlling temperature in the reaction kettle as 60 to 90 DEG C, dropwise adding thionyl chloride to react for 2 to 4 hours, decompressing to recycle unreacted thionyl chloride and cooling. Therefore, quality of n-acetylsulfanilyl chloride is guaranteed, waste water and waste acid are prevented from being generated, processing cost is saved, and environmental friendliness is facilitated.

The invention belongs to the technical field of organic synthesis and particularly relates to a preparation method of 2-amino-5-phenylthio-(2-methoxy)acetanilide. According to the method, 2-nitro-5-(phenylthio)aniline is prepared from 2-nitro-5-mercaptoaniline and benzene halide and then subjected to a reaction with methyl methoxyacetate, 2-nitro-5-phenylthio-(2-methoxy)acetanilide is generated and subjected to catalytic hydrogenation reduction finally, and the target product is obtained. The preparation method has good reaction selectivity, and the obtained target product is high in purity and yield; use of high-toxicity materials is avoided, requirements for equipment and operation conditions are reduced, and safety and stability of the preparation method are improved; doses of the reaction materials are optimized, and excess benzene halide and methyl methoxyacetate can be recycled after being recovered simply; little solid waste is produced, waste treatment cost is reduced greatly,and the requirement for environmental protection is met.