40 results about "Aminobenzoic acid derivative" patented technology

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives.are provided, where Q is CO2H, or a salt or ester thereof, or a C(O)N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.

The invention relates to an N-acyl anthranilic acid derivative or it's salt having collagen production inhibitory action.

The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds.A cyclic amino benzoic acid derivative represented by the general formula (1)[wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.

Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and / or depressing cortical and / or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.

The compound 3,3-dimethyl-butyric acid 4-((S)-2-amino-2-methoxycarbonyl-ethyl)-2-(3,3-dimethyl-butyryloxy)-phenyl ester of formula (I) has dopaminergic properties.

The present invention provides a method for producing a phenylalanine derivative(s) having a quinazolinedione ring of formula (5), including steps comprising ofreacting an acylphenylalanine derivative(s) of formula (1) with a carbonyl group-introducing reagent(s) and a derivative(s) of anthranilic acid to form an asymmetric urea intermediate(s);making the asymmetric urea intermediate(s) into a quinazolinedione compound(s) of formula (4) in the presence of a base(s); andN-alkylating quinazolinedione ring amide of the obtained quinazolinedione compounds with N-alkylation agents. This production method is an industrially applicable method for producing phenylalanine derivatives having a quinazolinedione skeleton, which are compounds highly useful as drugs having α 4 integrin inhibiting activity. In the formulae (1) and (5), R1 represents a phenyl group having a substituent(s) and the like, R2 represents an alkyl group and the like, R3 represents a dialkylamino group and the like, and R4 represents an alkyl group and the like.

The present disclosure provides pharmaceutical agents of the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.

The present disclosure provides pharmaceutical agents of the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.

The invention provides a rare-earth terbium complex, polyurethane foam doped with the rare-earth terbium complex and application thereof. The rare-earth terbium complex has a molecular formula of Tb(BAA)<3>.2H2O. The polyurethane foam is prepared by the following steps: synthesizing an aminobenzoic acid derivative BAA by taking o-aminobenzoic acid and isatoic anhydride as main raw materials, performing coordination with TbCl3.6H2O according to a molar ratio of 3:1, synthesizing a terbium complex Tb(BAA)<3>.2H2O, and doping the terbium complex in polyurethane foam, thereby obtaining the polyurethane foam with the advantages of excellent luminescence property and high thermal stability. The rare-earth terbium complex and the polyurethane foam doped with the rare-earth terbium complex are used for detecting H2PO4<->, CH3COO<-> and / or F<->. According to the rare-earth terbium complex and the polyurethane foam of the rare-earth terbium complex disclosed by the invention, the luminescence stability of terbium ions is improved, the luminescence lifetime is prolonged, the preparation cost is low, and the method is simple and easy to operate and has wide application prospects in the fields such as biological materials, medical treatment, agriculture, daily use chemicals and the like.

The present invention relates to a method for the one-pot preparation of trans-4-amino-1-cyclohexanecarboxylic acid derivatives with a trans ratio greater than 75%, by using a suitable catalyst and a suitable The solvent or solvent mixture reacts the 4-aminobenzoic acid derivative. The method uses low hydrogen pressure and is therefore suitable for industrial applications.

The object of the present invention is to provide 3-{[((2E)-2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-3-thienyl]ethylene) represented by the following formula }hydrazino) thiocarbonyl] amino} benzoic acid is a new type of organic amine salt or quaternary ammonium salt. The organic amine salt or quaternary ammonium salt has excellent in vivo dynamic properties and stability, and has useful properties as a drug.

The invention belongs to the technical field of lubricating oil. The invention relates to a vegetable-based lubricating oil and a preparation method thereof. The method comprises aminobenzoic acid derivatives (A), absolute ethanol (B), hydrazine (C), carbon disulfide (D), 1,3-dichloro- 2-Hydroxypropane (E) and vegetable oil (F) are used as raw materials, and a vegetable-based lubricating oil is obtained through multiple reactions such as esterification reaction, substitution reaction, addition etherification reaction, etc., which effectively solves the problem of existing vegetable-based lubricating oil. In addition to the defects of poor oxidation resistance and high temperature resistance, it also has excellent wear resistance, and the synthetic raw materials are widely used and environmentally friendly. It is foreseeable that the product has a broad market space.

The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylamino benzoic acid derivatives represented by specific Chemical formulas or their salts, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino]benzoic acid or its salt.

The present invention discloses one method of synthesizing quinazoline-4(3H) derivative. An One-Step process in no-solvent condition is adopted, and in the process, o-aminobenzoic acid derivative, triethyl orthoformate, trimethyl orthoformate or formic acid and aromatic amine derivative are used as material, and trifluoromethnesulfonate of RE element is used as catalyst. Compared with available technology, the present invention has high yield up to 98%, short reaction period in 60 min, recoverable catalyst, and other advantages and is suitable for industrial production and environment friendly.