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40 results about "Aminobenzoic acid derivative" patented technology

N-acyl anthranilic acid derivative or salt thereof

InactiveUS20110275797A1Improve securityPrevention, treatment, andOrganic chemistryDigestive systemDiseaseBenzoic acid
An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R1 represents a carboxyl group or the like; R2 represents a hydrogen atom or the like; R3 represents an optionally substituted aryl group or the like; X1 represents a carbonyl group; X2 represents a bonding hand; X3 represents a bonding hand; X4 represents a bonding hand or the like; and A represents an optionally substituted phenyl group or the like.)
Owner:TOYAMA CHEM CO LTD

N[S(4-aryl-triazol-3-yl)alpha-mercaptoacetyl]-p-amino benzoic acids as HIV reverse transcriptase inhibitors

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O)N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
Owner:ARDEA BIOSCI

N-acyl anthranilic acid derivative or salt thereof

The invention relates to an N-acyl anthranilic acid derivative or it's salt having collagen production inhibitory action.
Owner:TOYAMA CHEM CO LTD

Phenyl s-triazine ligand for metallic organic frame complex and synthesizing process therefor

InactiveCN101270094AImprove thermal stabilityHigh reactivity with coordinationOrganic chemistryMetal-organic frameworkSolvent
The present invention discloses a phenyl triazine ligand that is used for the complexes of a metal organic framework and has a structural formula as shown in the formula (1). In the formula, R1 is carboxyl, hydrogen or methyl; R2 is hydrogen, methyl or carboxyl. At first, the derivative of aminobenzoic acid is used for synthesizing the aromatic nitrile intermediate; then the aromatic nitrile intermediate has trimerization reaction to prepare the carboxyl-containing triazine ligand. The synthetic method has the advantages of simple process, low cost, high yield, easily available raw materials and mild reaction conditions. The phenyl triazine ligand can coordinate with metal ions through the thermal reaction of the solvent so as to form the complexes of the metal organic framework. And the phenyl triazine ligand can practically applied in the small-molecule detection, catalysis, hydrogen storage and other fields.
Owner:ZHEJIANG UNIV

Cyclic amino benzoic acid derivative

The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds.A cyclic amino benzoic acid derivative represented by the general formula (1)[wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
Owner:KYORIN PHARMA CO LTD

N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS

InactiveUS20080319201A1Organic chemistryBenzoic acidAryl
A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives.are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
Owner:ARDEA BIOSCIENCES INC

Novel tryptanthrin derivative, synthetic method and medicinal application thereof

The invention relates to a novel tryptanthrin (indole[2,1-b] quinazoline-6,12-diketone) derivative, a synthetic method and a medicinal application thereof. A general structural formula is as follows (see the description). The novel tryptanthrin derivative is synthesized through biomimetic synthesis, the general chemical structural formula of the novel derivative is shown in Figure 1, wherein in the formula, R,R1,R2,R3 are halogen, nitro, amido, hydroxy, alkyl, alkoxy and aryl, R1is morpholine, piperidine, N-methylpiperidine, N-ethylpiperidine, isonipecotic acid, piperazine, 1-(2-pyridyl) piperazine, dimethylamine, diethylamine, 1-(2-ethoxy) piperazine and 1-(2-furoyl) piperazine, and an o-aminobenzoic acid derivative reacts with an indole quinone derivative in solvents of methylbenzene, methyl alcohol, ethyl alcohol, dichloromethane, isopropanol and the like, so as to prepare the novel tryptanthrin derivative. The novel tryptanthrin derivative which has a good inhibiting effect and a good antibacterial effect on cancer cells is preliminarily screened through an MTT experiment and an antibacterial experiment, and the medicine has pharmacological effects in the aspects of tumor resistance, antibiosis and inflammation diminishing.
Owner:NORTHWEST UNIV

Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators

ActiveUS7632866B2BiocideSenses disorderN-phenylanthranilic acidDisease
Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and / or depressing cortical and / or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.
Owner:RAMOT AT TEL AVIV UNIV LTD

Methods for producing phenylalanine derivatives having a quinazolinedione skeleton and intermediates for production thereof

The present invention provides a method for producing a phenylalanine derivative(s) having a quinazolinedione ring of formula (5), including steps comprising ofreacting an acylphenylalanine derivative(s) of formula (1) with a carbonyl group-introducing reagent(s) and a derivative(s) of anthranilic acid to form an asymmetric urea intermediate(s);making the asymmetric urea intermediate(s) into a quinazolinedione compound(s) of formula (4) in the presence of a base(s); andN-alkylating quinazolinedione ring amide of the obtained quinazolinedione compounds with N-alkylation agents. This production method is an industrially applicable method for producing phenylalanine derivatives having a quinazolinedione skeleton, which are compounds highly useful as drugs having α 4 integrin inhibiting activity. In the formulae (1) and (5), R1 represents a phenyl group having a substituent(s) and the like, R2 represents an alkyl group and the like, R3 represents a dialkylamino group and the like, and R4 represents an alkyl group and the like.
Owner:EA PHARMA CO LTD

Preparation method of polyimide composite electrode material containing ketone carbonyl bond chain structure

ActiveCN111710840AAvoiding Specific Capacity Reduction ProblemsReduce solubilityCell electrodesSecondary cells servicing/maintenanceAcyl groupKetone
The invention relates to a preparation method of a polyimide composite electrode material containing a ketone carbonyl bond chain structure. The method comprises the following steps: (1) by using an aminobenzoic acid derivative as an acylation reagent, carrying out amino functional modification on a carbon nano material by using a Friedel-Crafts acylation reaction to obtain an aminated carbon substrate material; (2) ultrasonically dispersing an aminated carbon substrate material into a solvent, then sequentially adding a diamine monomer and a dianhydride monomer under the protection of nitrogen, carrying out high-temperature reaction, and then cooling, filtering, washing and carrying out vacuum drying to obtain powder; and carrying out heat treatment in an inert atmosphere, to obtain the material. When the composite electrode material is used as a lithium ion battery negative electrode material, the composite electrode material has the electrochemical characteristics of high specific capacity, high multiplying power and high cycling stability.
Owner:DONGHUA UNIV

Process for the preparation of trans-4-amino-1-cyclohexanecarboxilic acid and its derivatives

The present invention relates to a one-pot process for the preparation of trans-4-amino-l-cyclohexanecarboxylic acid derivatives where the trans ratio is more than 75% by reaction of a 4-aminobenzoicacid derivative using an appropriate catayst and an appropriate solvent or solvent mixture under basic conditions. The process uses low hydrogen pressure and is therefore suitable for industrial application.
Owner:SIEGFRIED AG

Plant-based lubricating oil and preparation method thereof

The invention belongs to the technical field of lubricating oil, and relates to plant-based lubricating oil and a preparation method thereof. According to the method, aminobenzoic acid derivatives (A), absolute ethyl alcohol (B), hydrazine (C), carbon disulfide (D), 1,3-dichloro-2-hydroxypropane (E) and plant oil (F) are used as raw materials and subjected to esterification reaction, substitutionreaction, addition etherification reaction and other reactions, so that the plant-based lubricating oil is obtained. The plant-based lubricating oil has excellent wear resistance while the defects ofpoor oxidation resistance and high temperature resistance of existing plant-based lubricating oil are effectively overcome, and the synthetic raw materials are wide and environment-friendly. It can beforeseen that the product has a wide market space.
Owner:佛山市泓宝润滑油有限公司

Thiazolyl aminobenzoic acid derivative and application thereof

ActiveCN109232467AAvoid or reduce toxic side effectsGood inhibitory effectOrganic active ingredientsOrganic chemistryBcr-Abl tyrosine-kinase inhibitorT315i mutation
The invention discloses a thiazolyl aminobenzoic acid derivative with antineoplastic activity, which can be used for preparing an anticancer drug, in particular as a Bcr-Abl tyrosine kinase inhibitor,especially as a Bcr-Abl tyrosine kinase inhibitor of a T315I mutation.
Owner:NANHUA UNIV

Aminobenzoic Acid Derivatives

This invention relates to N-alkylated anthranilic acid derivative and their use in lubricants, such as engine oils, as TBN boosters. The invention particularly relates to compositions that deliver an ash-free base to a lubricant in the form of a basic amine additive, without adversely impacting seal compatibility and / or degradation, and methods thereof.
Owner:THE LUBRIZOL CORP

Rare earth terbium complex, polyurethane foam doped with rare earth terbium complex and its application

The invention provides a rare-earth terbium complex, polyurethane foam doped with the rare-earth terbium complex and application thereof. The rare-earth terbium complex has a molecular formula of Tb(BAA)<3>.2H2O. The polyurethane foam is prepared by the following steps: synthesizing an aminobenzoic acid derivative BAA by taking o-aminobenzoic acid and isatoic anhydride as main raw materials, performing coordination with TbCl3.6H2O according to a molar ratio of 3:1, synthesizing a terbium complex Tb(BAA)<3>.2H2O, and doping the terbium complex in polyurethane foam, thereby obtaining the polyurethane foam with the advantages of excellent luminescence property and high thermal stability. The rare-earth terbium complex and the polyurethane foam doped with the rare-earth terbium complex are used for detecting H2PO4<->, CH3COO<-> and / or F<->. According to the rare-earth terbium complex and the polyurethane foam of the rare-earth terbium complex disclosed by the invention, the luminescence stability of terbium ions is improved, the luminescence lifetime is prolonged, the preparation cost is low, and the method is simple and easy to operate and has wide application prospects in the fields such as biological materials, medical treatment, agriculture, daily use chemicals and the like.
Owner:CHONGQING UNIV OF TECH

Rare-earth terbium complex, polyurethane foam doped with rare-earth terbium complex and application thereof

The invention provides a rare-earth terbium complex, polyurethane foam doped with the rare-earth terbium complex and application thereof. The rare-earth terbium complex has a molecular formula of Tb(BAA)<3>.2H2O. The polyurethane foam is prepared by the following steps: synthesizing an aminobenzoic acid derivative BAA by taking o-aminobenzoic acid and isatoic anhydride as main raw materials, performing coordination with TbCl3.6H2O according to a molar ratio of 3:1, synthesizing a terbium complex Tb(BAA)<3>.2H2O, and doping the terbium complex in polyurethane foam, thereby obtaining the polyurethane foam with the advantages of excellent luminescence property and high thermal stability. The rare-earth terbium complex and the polyurethane foam doped with the rare-earth terbium complex are used for detecting H2PO4<->, CH3COO<-> and / or F<->. According to the rare-earth terbium complex and the polyurethane foam of the rare-earth terbium complex disclosed by the invention, the luminescence stability of terbium ions is improved, the luminescence lifetime is prolonged, the preparation cost is low, and the method is simple and easy to operate and has wide application prospects in the fields such as biological materials, medical treatment, agriculture, daily use chemicals and the like.
Owner:CHONGQING UNIV OF TECH

Synthetic method for dibenzepin derivative

The invention discloses a synthetic method for a dibenzepin derivative. The method comprises the steps that substituted bromobenzoic acid, cuprous oxide and N-methylmorpholine are reacted with substituted aniline, so that 2-(N-substituted phenyl) aminobenzoic acid derivative (IV) is produced; the compound (IV) is reacted with sodium hydride and methyl iodide, so that 2-(N-methyl-N-substituted phenyl) aminobenzoic acid methyl ester derivative (V) is produced; the compound (V) is subjected to basic hydrolysis, so that 2-(N-methyl-N-substituted phenyl) aminobenzoic acid derivative (VI) is obtained; the compound (VI) is condensed with methoxy lamine hydrochloride under the effect of carbonyldiimidazole, so that 2-(N-methyl-N-substituted phenyl) amino-N'-methoxybenzamide derivative (VII) is produced; the compound (VII) is reacted with iodobenzene diacetate in acetonitrile at room temperature, so that the dibenzepin derivative (I) is obtained. The method has the advantages that the operation is simple, the reaction raw materials and reaction reagents are easy to obtain, the yield is higher and the like.
Owner:TIANJIN UNIV

Method for manufacturing dispersion of quinoline derivative

A method for manufacturing a dispersion of a quinoline derivative that is dispersed at a high concentration and has a small particle size. The method includes the steps of preparing a solution by dissolving an N-arylanthranilic acid derivative in an organosulfonic acid, heating the solution and obtaining a reaction liquid in which a quinoline derivative has been produced by a condensation ring-closing reaction, and obtaining a dispersion of the quinoline derivative by mixing the reaction liquid with an aqueous solution. The step of mixing the reaction liquid with an aqueous solution may be performed in a mixing field having a micro-channel.
Owner:CANON KK

Perovskite battery assembly with ultraviolet protection layer and preparation method thereof

The invention relates to a perovskite battery assembly with an ultraviolet protection layer. The internal structure of the perovskite battery assembly comprises a transparent substrate layer, an ultraviolet protection layer, a transparent conductive layer, an upper transmission layer, a perovskite light absorption layer, a lower transmission layer and an electrode layer. The ultraviolet protectivelayer is arranged on the front surface or the back surface of the transparent substrate layer, wherein the ultraviolet protection layer comprises a UVP (ultraviolet protection) additive substance, and the UVP additive comprises at least one of a p-aminobenzoic acid derivative, a salicylate derivative, a benzophenone derivative, a benzylidene camphor derivative, a triazine derivative, a phenyl benzimidazole derivative, a phenyl benzotriazole derivative, an imidazoline derivative, a benzylidene malonate derivative and a 4, 4-diarylbutadiene derivative. The invention also discloses a preparationmethod of the perovskite battery assembly with the ultraviolet protection layer. According to the invention, the ion migration caused by the ultraviolet light is reduced or eliminated, and the stability, especially the illumination stability, of the perovskite solar cell is improved.
Owner:HANGZHOU MICROQUANTA SEMICON CO LTD

Ortho-aminobenzoic acid derivative and application thereof

The invention relates to the technical field of cosmetics and medicines, in particular to an ortho-aminobenzoic acid derivative compound and application thereof. By preparing a series of compounds with an anti-inflammatory function, the obtained anti-inflammatory compound can be used for preparing cosmetic reagents or pharmaceutical reagents, and the cosmetic reagents and the pharmaceutical reagents are not specifically limited. For example, the cosmetic can be a smoothing toner, a nutritional toner, a massage cream, an emollient, a gel, a nutritional cream, a mask, a gel or a shower gel shampoo and other washing type cosmetics, and can also be a cream, ointment, cream, plaster or spray and other similar pharmaceutical preparation products. The compound can be used for a sensitive skin andcan also be added to infant and child cosmetics to reduce irritation.
Owner:福建莲珂科技有限公司

Organic amine salt of aminobenzoic acid derivative and production method thereof

The object of the present invention is to provide 3-{[((2E)-2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-3-thienyl]ethylene) represented by the following formula }hydrazino) thiocarbonyl] amino} benzoic acid is a new type of organic amine salt or quaternary ammonium salt. The organic amine salt or quaternary ammonium salt has excellent in vivo dynamic properties and stability, and has useful properties as a drug.
Owner:NISSAN CHEM IND LTD

Organic amine salt of aminobenzoic acid derivative, and method for producing same

The purpose of the invention is to provide a novel organic amine salt or quaternary ammonium salt of the 3-[[((2E)-2-[1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene]hydrazino)carbonothioyl]amino] benzoic acid represented by the formula shown below. The organic amine salt or quaternary ammonium salt has excellent pharmacokinetic characteristics and stability, and possessed properties useful for a drug.
Owner:NISSAN CHEM IND LTD
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