243 results about "Anthranilic acid" patented technology

Anthranilic acid drivatives, methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions containing such compounds.

An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R1 represents a carboxyl group or the like; R2 represents a hydrogen atom or the like; R3 represents an optionally substituted aryl group or the like; X1 represents a carbonyl group; X2 represents a bonding hand; X3 represents a bonding hand; X4 represents a bonding hand or the like; and A represents an optionally substituted phenyl group or the like.)

A polishing composition comprises: at least one compound selected from tetrazole compounds and derivatives thereof and anthranilic acid compounds and derivatives thereof; abrasive particles comprising associative abrasive particles; and an oxidizing agent.

The invention relates to an N-acyl anthranilic acid derivative or it's salt having collagen production inhibitory action.

The invention provides a rubber composition for golf balls which includes (A) a base rubber containing a polybutadiene having a cis-1,4 bond content of at least 60 wt %, (B) an unsaturated carboxylic acid and / or a metal salt thereof, and (C) an anthranilic acid derivative of the general formulawherein R1 and R2 are each independently a hydrogen atom or a hydrocarbon group of 1 to 20 carbons, m is an integer from 1 to 4, and n is an integer from 1 to 3, with the proviso that if m and / or n is 2 or more, each occurrence of R1 and R2 may be the same or different. The golf ball rubber composition of the invention enables a high-quality molded and crosslinked product having a suitable hardness and a high resilience to be obtained.

The invention provides a preparation method and application of an anti-soil polymer. The prepared polymer is used as a dispersant for a hydraulic cementing agent and / or an aqueous dispersion for potential hydraulic cementing agent and has good anti-soil performance. The preparation method the anti-soil polymer comprises a step of subjecting polyether macromonomer A with a special structure, monomer B containing a phosphoric acid or phosphorous acid group, optional monomer D and aldehyde C to condensation polymerization so as to prepare the anti-soil polymer, wherein the monomer D is selected from the group consisting of phenol, aniline, p- / o-aminobezene solfonic acid, p- / o-hydroxybenzoic acid, p- / o-aminobenzoic acid, p- / o-hydroxyezene solfonic acid, p- / o-toluidine and p- / o-methylphenol, a mol ratio of the polyether macromonomer A to the monomer B to the monomer D is 1: (0.5-12): (0-8.0), and a mol ratio of the polyether macromonomer A to the monomer B and the monomer D is 1: (0.5-12.0).

The anthranilic acid derivative or the salt thereof represented by the general formulawherein R1 and R2 are hydrogen atom, or the like; R3 is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R4 is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X1 is an alkylene or alkenylene group which may be substituted or a bond; X2 is the general formula -X3-X4- or -X4-X3-, wherein X3 is a sulfur atom, an imino group or a bond, or the like; X4 means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.

The present invention relates to a method for causing sodium sulfide or a mixture of sodium sulfide and sulfur to react with diazonium salt formed by diazotizing anthranilic acid, wherein the Na / S atomic ratio as calculated on the basis of the employed sodium sulfide and sulfur is adjusted to within the range of 1.33 to 2.0 during the reaction. Thus is made practicable the manufacture of thiosalicylic acid in a high yield without going through the individual route of isolating and reducing dithiosalicylic acid.

The invention provides a preparation method of acridine compounds, and relates to the technical field of photoinitiator. The preparation method comprises the following steps of: taking substituted N-methyl anthranilic acid as initial raw material, generating substituted acridone under the condition of acid, carrying out reaction on substituted bromobenzene and magnesium to generate grignard reagent, carrying out reaction on substituted acridone and the grignard reagent to generate substituted 9-oxhydryl-9-phenylacridine, and reducing to obtain the substituted 9-phenylacridine compounds. Different from the conventional synthesis route, the preparation method of the acridine compounds provided by the invention has more operation steps compared with the conventional one-step method, thus being slightly lower in yield compared with the conventional synthesis route, however, the preparation condition is mild relatively, and the high-temperature and high-pressure reaction and the use of expensive heavy metal catalyst can be avoided, so that the preparation method is good in environment protection.

The invention provides a novel synthetic method of a bis-benzoxazine ketone ultraviolet absorbent, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: A, stirring, anhydrides, used as raw materials, of o-aminobenzoic acid and (o-, m-, p-) phthaloyl dichloride or (o-, m-, p-)phthalic acid for a certain time in a non-polar solvent; B, adding chemical dehydrating agent or physical dehydrating agent in a reaction system without separating, slowly heating and refluxing for a certain time to obtain (o-, m-, p-)substituted bis-benzoxazine ketone ultraviolet absorbent; wherein the stirring time in the step A is not less than 1 hour, the refluxing time is 5-10 hours in the step B, the chemical dehydrating agent used in the step B is various dehydrating agents reacted with the water, including but not limited to alkaline calcium oxide, soda lime, acidic concentrated sulfuric acid, concentrated phosphoric acid, polyphosphoric acid, phosphorus pentoxide, thionyl chloride, acetic anhydride and the like, neutral molecular sieve, water-absorbent, anhydrous cupric sulfate and the like; the physical dehydrating agent comprises but not limited to non-protonic solvent such as benzene, methylbenzene, xylene and the like. The method provided by the invention has the advantages of being simple in operation flow, low in cost, simple in equipment, and suitable for the scale industrial production.

The present invention relates to the field of microbiology, and discloses an L-tryptophan fermentation strain and a method for fermentation production of L-tryptophan by using the L-tryptophan fermentation strain. According to the present invention, the L-tryptophan fermentation strain with the preservation number of CGMCC No.7941 has anthranilic acid tolerance; and compared with the original strain, the strain of the present invention has the better anthranilic acid tolerance, and can make the more anthranilic acid be converted into the tryptophan, such that the high concentration tryptophan can be accumulated so as to increase the yield and the production efficiency of the L-tryptophan and meet the large-scale industrial production of the L-tryptophan.

The invention discloses a synthesis method for 2,3,6,7-triptycene tetracarboxylic dianhydride. The method comprises the following steps of: 1) preparing 2,3,6,7-tetramethylanthracene from o-xylene and benzyl alcohol or methylene chloride under the catalysis of anhydrous aluminum trichloride; 2) diazotizing the 2,3,6,7-tetramethylanthracene, anthranilic acid and amyl nitrite to generate a crude product 2,3,6,7-tetramethyl triptycene; 3) performing chromatographic separation on the crude product 2,3,6,7-tetramethyl triptycene, and flushing the separated 2,3,6,7-tetramethyl triptycene by using a mixed eluting agent to obtain 2,3,6,7-tetramethyl triptycene; 4) oxidizing the 2,3,6,7-tetramethyl triptycene in a mixed solvent consisting of potassium permanganate, pyridine and water under a reflux condition to generate 2,3,6,7-triptycene tetracarboxylic acid; and 5) refluxing and dehydrating the 2,3,6,7-triptycene tetracarboxylic acid in acetic anhydride to generate the 2,3,6,7-triptycene tetracarboxylic dianhydride. The method has the characteristics of readily available and low-cost raw materials, high yield and high product purity.

The invention relates to a novel tryptanthrin (indole[2,1-b] quinazoline-6,12-diketone) derivative, a synthetic method and a medicinal application thereof. A general structural formula is as follows (see the description). The novel tryptanthrin derivative is synthesized through biomimetic synthesis, the general chemical structural formula of the novel derivative is shown in Figure 1, wherein in the formula, R,R1,R2,R3 are halogen, nitro, amido, hydroxy, alkyl, alkoxy and aryl, R1is morpholine, piperidine, N-methylpiperidine, N-ethylpiperidine, isonipecotic acid, piperazine, 1-(2-pyridyl) piperazine, dimethylamine, diethylamine, 1-(2-ethoxy) piperazine and 1-(2-furoyl) piperazine, and an o-aminobenzoic acid derivative reacts with an indole quinone derivative in solvents of methylbenzene, methyl alcohol, ethyl alcohol, dichloromethane, isopropanol and the like, so as to prepare the novel tryptanthrin derivative. The novel tryptanthrin derivative which has a good inhibiting effect and a good antibacterial effect on cancer cells is preliminarily screened through an MTT experiment and an antibacterial experiment, and the medicine has pharmacological effects in the aspects of tumor resistance, antibiosis and inflammation diminishing.

A method for measuring vanadium in vanadium-nitrogen alloy belongs to the technical field of analytical chemistry. The advantages of this method lie in that the reagents used in the determination process are few in type, the time is short, the operation is simple, and the method has high precision and accuracy, and is especially suitable for the analysis of a large number of samples. The present invention adopts mixed acid to dissolve the sample, under the acidity of 12% to 25%, adding ammonium persulfate to oxidize vanadium (IV) to pentavalent, using N-phenyl-substituted anthranilic acid as an indicator, using ferrous ammonium sulfate as an indicator Standard solution titration. Chromium, manganese and cerium do not interfere with the determination.

An anthranilic acid derivative represented by the general formula (X) [wherein R1 represents hydrogen or a carboxy-protecting group; R2 represents optionally substituted phenyl, a heterocyclic group, etc.; R3 represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X1 represents carbonyl, etc.; X2 represents optionally substituted alkylene group, a bond, etc.; X3 represents oxygen, a bond, etc.; and X4 represents a group represented by the general formula -X5-X6- or -X6-X5- (wherein X5 means oxygen, a bond, etc.; and X6 means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.

The invention discloses a high-purity ptyltetracid dianhydride and a synthesis method thereof, and polyimides synthesized on the basis of the ptyltetracid dianhydride. The method comprises the following steps: carrying out Friedel-Crafts reaction on cheap accessible industrial dichloromethane and o-xylene by using anhydrous AlCl3 as a catalyst to obtain 2,3,6,7-tetramethyl anthracene, carrying out D-A addition on the 2,3,6,7-tetramethyl anthracene and anthranilic acid or equivalent thereof to obtain 2,3,6,7-tetramethyl triptycene and derivative thereof tetramethylptycene, and oxidizing to obtain high-value ptyltetraformic acid; and carrying out high-temperature high-pressure solvothermal synthesis on the ptyltetraformic acid to obtain the corresponding high-purity high-yield ptyltetracid dianhydride. The solvothermal method for synthesizing dianhydride is suitable for dianhydride which can not be easily purified under normal pressure, and has the advantages of low loss and high yield. The ptyltetracid dianhydride and biphenyl diamines with different substituent groups are polycondensed by a one-step process to obtain a series of novel polyimides.

A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.

The invention relates to a method for synthesizing Varenicline intermediate 2, 3, 4, 5-tetralin-1, 5-methylene-hydrogen-benzoazepine. The method includes the following steps: under the action of catalyst, mixing amyl nitrite with o-aminobenzoic acid solution to generate diazonium salt, then mixing the diazonium salt with cyclopentadiene, and heating to react to generate compound 1; feeding ozone into the solution of compound 1, after complete conversion, adding reducing agent to generate compound 2, then dripping the compound 2 to the mixed solution of triacetoxy sodium borohydride and benzylamine to generate compound 3 by loop closing; and hydrogenating the compound 3 under the action of palladium and carbon for debenzylation and reduction to obtain M intermediate 2, 3, 4, 5-tetralin-1, 5-methylene-hydrogen-benzoazepine. The method has the advantages of greatly simplifying the method for preparing Varenicline intermediate, being simple in production process and safe in operation, well ensuring no harm to the environment and control on production cost, increasing yield and being capable of becoming a process in great industrial production.

The invention discloses an amide derivative containing an alpha-aminoketone structure and a preparation method and application thereof. A structural formula of the amide derivative is shown in the attached figure. The preparation method comprises the following step of using substituted o-aminobenzoic acid and substituted carboxylic acid R3COOH as initial raw materials, and performing a series of reactions, so as to obtain the amide derivative. When the amide derivative is used for preparing an insecticide, the amide derivative containing the alpha-aminoketone structure is dissolved into a thinner, so as to obtain the insecticide; the weight percentage of the amide derivative containing the alpha-aminoketone structure in the insecticide is 0.001 to 99.99%. During specific application, the insecticide is a conventional preparation, such as a water emulsion, a suspension agent, wettable powder and a water dispersible granule.

The invention discloses a recycling method of o-aminobenzoic acid from mother liquid or waste water, which comprises the following steps: loading weak alkaline ion exchanging resin or phenylethene-diethyl benzene strong-polar large-hole adsorbing resin in the adsorbing column; adding acid or alkaline to adjust pH value for mother liquid or waste water; assembling adsorbing column under 5-40 deg.c with flow speed at 2-4BV / h; eluting through 2-6% sodium hydroxide solution under 25-45 deg.c with flow speed at 2-3BV / h; recycling sodium o-aminobenzoic solution.

A process for preparing quinazolin-4-one or its derivative by reacting anthranilic acid or its derivative with formic acid or its derivative in the presence of ammonia, or by reacting ammonium anthranilate or its derivative with formic acid or its derivative.

The invention discloses an anthranilic acid compound, of which the structure is shown in a general formula I, wherein the definitions of substitutional groups are shown in an instruction book. The anthranilic acid compound has broad-spectrum insecticidal activity, and in particular to spodoptera exigua hubner and diamond back moth, the compound has better activity, and can also achieve good control efficiency under the condition of low dose.

The present invention relates to novel anthranilic acid derivatives of the general formula (I)in which R1, R2, R3, R4, R5, Qx, A, Qy and n have the meanings given in the description, to their use as insecticides and acaricides for controlling animal pests, also in combination with other agents for activity boosting, and to a plurality of processes for their preparation.

The invention is concerned with novel anthranilic acid derivatives of formula (I) wherein R1 to R14 and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.

The invention discloses a method for treating and recycling waste water in an anthranilic acid production technology. Through the adoption of the method provided by the invention, waste water in the anthranilic acid production technology can be treated, and recycled organic substances can be directly subjected to cyclic utilization; the CODCr being about 24000 mg / L of waste water before treatment is reduced to 80 mg / L below after treatment to reach the national-level emission standard; coarse sodium chloride salt can be recycled; resin is subjected to desorption and regeneration by using 4-6% of dilute sodium hydroxide solution or dilute hydrochloric acid, and a desorption solution can be taken as raw materials to be input in the acidizing step or degrading step of the original production technology, so that the product quality is not affected, 99% of anthranilic acid and phthalimide in the waste water can be recycled, and distilled effluent can be utilized repeatedly; waste water can be treated while the waste recycling can be realized.

The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.