37 results about "Anthranilic acid" patented technology

The invention discloses a composition and a cosmetic with anti-allergy, itching-relieving and redness-removing effects. The composition is prepared from the following raw material components: a herba centellae extract with madecassoside content of not less than 85wt%, a dendrobium officinale stem extract and dihydrooat acyl o-aminobenzoic acid. The composition comprising the three components is added into the cosmetic, so that the cosmetic has good system stability, also has enhanced anti-allergy, itching-relieving and red-removing effects, and can improve skin problems from multiple dimensions.

The application belongs to the technical field of medicine, and relates to N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compounds and a preparation method and application thereof. The preparation method of the compound is as follows: taking o-aminobenzoic acid as a starting material, performing substitution reaction, condensation reaction, alkylation reaction and hydrolysis reaction to generate a key intermediate acridone acetic acid, and finally performing condensation reaction on the acridone acetic acid and substituted pyrimidine in the presence of TCFH and NMI condensing agents to obtain the target compound. The preparation method of the N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compound provided in the application is simple and feasible, and good results are shown in in-vitro anti-tumor activity tests, and the compound has excellent anti-proliferation ability on human breast cancer cells BT-549 and MDA-MB-231 in particular.

The application relates to a reagent combination for detecting depression, a manufacturing method, a detection system and application thereof, and belongs to the technical field of instrument detection. The reagent combination for detecting depression comprises a calibrator, a quality control sample and an extraction solution of a to-be-detected compound serving as a biomarker; wherein the to-be-detected compound is at least three kinds selected from 5-hydroxyanthranilic acid, methionine, gamma-aminobutyric acid, 3,4-dihydroxyphenylacetic acid, 2-picolinic acid, quinolinic acid, kynurenine, 5-hydroxytryptamine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, dopamine and norepinephrine. The reagent combination for detecting depression and the detection system can significantly improve the accuracy of diagnosis, are convenient to detect, have good repeatability of detection data, are high in specificity, and are accurate in clinical diagnosis results.

Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.

The invention provides a manganese content determination method which comprises the following steps: dissolving a to-be-determined sample with hydrochloric acid to form a to-be-determined solution; adding phosphoric acid into the solution to be determined; adding perchloric acid into the solution to be measured, and heating; by taking N-benzene o-carbamic acid as an indicator, titrating the to-be-measured solution added with phosphoric acid and perchloric acid by using an ammonium ferrous sulfate standard solution; and determining the content of manganese in the to-be-determined sample according to the dosage of the ammonium ferrous sulfate standard solution. The test method can be used for stably and accurately measuring the manganese content in the sample to be measured.

This invention discloses an optimization device for the ammoniation reaction product in the production of anthranilic acid, comprising a reaction chamber. A second conveying roller is movably connected to the lower left end of the inner surface of the reaction chamber, and a first conveying roller is movably connected to the upper right end of the inner surface of the reaction chamber. The first and second conveying rollers are connected by a conveyor belt. In this invention, raw materials and catalyst are fed into the reaction chamber through the inlet. Turning on the heating plate heats the raw materials and catalyst. Turning on the motor drives the first conveying roller to rotate, which, in conjunction with the conveyor belt, drives the second conveying roller to rotate. This allows the baffles to convey the raw materials and catalyst. Furthermore, the rotation of the second conveying roller drives a second rotating rod to rotate via a single-sided toothed synchronous belt, thereby allowing the stirring blades to stir the raw materials and catalyst, effectively improving the overall reaction efficiency.

The present application relates to the technical field of organic synthesis, and particularly relates to a method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone. A conventional method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone generally uses anthranilic acid as a starting material, and needs to be subjected to six-step continuous reactions to obtain the product, and the reaction time is long, the yield is low, and the operation is complicated. In view of the above problems, the present application provides a method for synthesizing 3-methyl-2-phenyl-2,3-dihydrobenzothiazine-4-ketone, which uses 2-mercapto-N-methyl benzamide as a starting material, and is completed through one-step reaction, and the starting material and catalyst are easy to obtain, the operation is simple, the reaction is fast, the equipment requirement is low, the post-treatment is simple, and the yield is high.

The utility model relates to the production technology field of anthranilic acid, specifically disclose a kind of storage equipment for anthranilic acid production, including storage tank, the bottom of the storage tank inner chamber is equipped with hot plate, the top of the storage tank is equipped with anti-precipitation subassembly, the anti-precipitation subassembly includes frame, the bottom of the frame is fixedly connected with storage tank, the top of the frame is equipped with electric push rod, the output end of the electric push rod is through and extends to the inner chamber of frame and is equipped with push plate. The utility model is transmitted to the storage in storage tank by feed inlet and stores anthranilic acid, when needing to carry out anti-precipitation to anthranilic acid in storage tank, first, anthranilic acid is heated by hot plate, then electric push rod operates, push plate is moved downward by electric push rod, push plate is moved downward by the cooperation of the sliding slot and the sliding block in frame, movable shaft is moved downward by push plate.

The invention belongs to the field of pesticides, and discloses a compound with a structure as shown in a formula I. A preparation method of the compound comprises the following steps: reacting anthranilic acid with formamide, and then reacting with 1, 4-dibromobutane under the action of sodium hydride to obtain 3-(4-bromobutyl) quinazoline-4 (3H)-ketone; then, phenylacetic acid sequentially reacts with methyl alcohol, hydrazine hydrate, potassium hydroxide, carbon disulfide and 3-(4-bromobutyl) quinazoline-4 (3H)-ketone, and the quinazolinone derivative containing the oxadiazole unit is obtained. The quinazolinone derivative containing the oxadiazole unit is a novel compound, has an inhibiting effect on fusarium graminearum, rhizoctonia solani and botrytis cinerea, and can be used for preventing and treating plant diseases caused by fungi.

The present invention relates to the preparation of ortho-aminobenzoic acid by means of microbial fermentation, wherein mixtures of glucose and xylose are used as fermentable substrates.

The application belongs to the technical field of biological gene engineering, and particularly relates to a protein for generating methyl o-aminobenzoate, a gene thereof and application. S A protein for generating methyl o-aminobenzoate from adenosylmethionine and o-aminobenzoate, wherein the amino acid sequence of the protein is shown as SEQ ID NO. 2. The experiment of the application proves that methyl o-aminobenzoate methyltransferase CsAAMT is found in a new tea variety 'Zhongchaxiangning', the gene corresponding to the protein is expressed in Escherichia coli, and the purified recombinant protein has the activity of catalyzing S o-aminobenzoate from adenosylmethionine and o-aminobenzoate, and further, the tea leaves without the aroma component can release methyl o-aminobenzoate by transiently overexpressing the gene in tea leaves.

The present invention relates to methods for diagnosis and monitoring of food addiction, obesity and related disorders, as well as for the evaluation of treatments directed to said disorders, based on the determination and comparison of Microviridae bacteriophages, preferably Gokushovirus, levels. It also relates to kits and uses for said purposes. Furthermore, the invention relates to anthranilic acid for use in the treatment or prevention of food addiction, obesity and related disorders, and non-therapeutic use in body fat reduction.

This invention provides a method for preparing 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one, relating to the field of compounds. The preparation method of this invention includes the following steps: (1) reacting anthranilic acid with terephthaloyl chloride in an organic solvent to generate intermediate A; (2) centrifuging the reaction product of step (1) to separate the wet crystalline intermediate A and the centrifugal mother liquor; (3) performing a cyclization reaction between the wet crystalline intermediate A from step (2) and acetic anhydride; (4) centrifuging, washing, and drying the reaction product of step (3) to obtain the target 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one product. This invention prepares 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one with not only low yellowness values ​​and high purity, but also high yield. The preparation method of the present invention has significant industrial value, and is particularly applicable to the field of polymer material additives where strict requirements are placed on product purity and yellowness.

The invention relates to a washing and caring composition with dandruff removing, itching relieving and repairing effects and a preparation method of the washing and caring composition, and belongs to the technical field of daily chemicals. Aiming at dandruff formation and itching factors of scalp, the piroctone olamine salt, palmitoyl tetrapeptide-10, tetrapeptide-1 and speranskia herb extract are correspondingly compounded to play a role in removing dandruff and relieving itching, and the limitation of a single component is made up by compounding chemical components and plant extracts, so that more efficient and milder scalp care is realized. In addition, the dihydrooat acyl o-aminobenzoic acid, pyridoxine tripalmitate and quaternary ammonium salt-73 are combined for use, so that the shampoo also has an excellent synergistic repairing capability on scalp with symptoms such as acne, red and swollen, slight folliculitis and the like.

The utility model relates to methyl anthranilate production raw material storage equipment, which belongs to the technical field of storage equipment and comprises a storage tank, a stirring shaft, a stirring paddle, a stirring motor, a heat preservation jacket, a liquid inlet pipe, an exhaust pipe, a feeding port, a sealing cover, a discharging pipe, a gas distribution pipe and a nitrogen tank. The other end of the nitrogen conveying pipe extends into the storage tank, an outlet of the nitrogen conveying pipe faces the discharging pipe downwards, the nitrogen conveying pipe is connected with the gas distribution pipe through a pipeline, valves are arranged on the liquid inlet pipe, the exhaust pipe, the discharging pipe and the nitrogen conveying pipe, and a temperature measuring device is arranged in the storage tank. According to the utility model, temporary storage and mixing functions of anthranilic acid and methanol are integrated in one storage tank, so that the number of equipment and the occupied area are reduced, the production cost is reduced, two raw materials are respectively added through the sealed feeding hole and the liquid inlet pipe and are directly mixed in the storage tank, the volatilization and waste of the raw materials in the conveying process are avoided, and the production efficiency is improved. The raw material utilization rate is improved.

The present invention relates to the preparation of cyano-anthranilic acid derivatives from 2-amino-5-formyl-3-methylbenzoic acid derivatives, including 2-amino-5-cyano-3- methylbenzoic acid, in the presence of N-methylpyrrolidone (NMP), N,N- dimethylformamide (DMF), N,N-dimethylacetamide (DMA), dimethylsulfoxide (DMSO), and the mixtures thereof, used as a dehydration agent. The present invention discloses an efficient, high yield process to obtain cyano-anthranilic acid intermediate further leading to the manufacturing of diamides, in particular, cyantraniliprole.

The application discloses a synthesis method of quinolino pyrrolo dione compounds. Heterocyclic compounds containing quinolino pyrrolo skeleton exhibit broad-spectrum pharmacological activities, including antimicrobial, analgesic, antiviral, anticonvulsant, anti-Alzheimer's disease and antitumor activities. A method for synthesizing quinolino pyrrolo dione derivatives by one-pot method through a cascade cyclization reaction under the promotion of iron from anthranilic acid hydrazide and maleimide is provided. The method has the advantages of simple operation, mild reaction condition, simple and easily available raw materials and the like.

The present invention provides methods for increasing the response of a plant to a pest and / or pathogen by increasing the production of the plant by one or more plant defense compounds derived from anthranilic acid. Also provided are methods for identifying and selecting microbial strains useful for plant treatment to increase plant response to attack by pests and / or pathogens.

The invention belongs to the technical field of gene engineering and enzyme engineering, and particularly relates to hydroxyl o-aminobenzoic acid hydroxyl cinnamyl transferase 5 sourced from oat and application of the hydroxyl o-aminobenzoic acid hydroxyl cinnamyl transferase 5 in synthesis of oat alkaloid. The invention provides a key enzyme, namely hydroxyl anthranilic acid hydroxyl cinnamyl transferase 5 in an oat alkaloid synthesis route and a preparation method of the hydroxyl anthranilic acid hydroxyl cinnamyl transferase 5. The recombinant hydroxy o-aminobenzoic acid hydroxy cinnamyl transferase 5 prepared by the invention can catalyze the synthesis of oat alkaloid in vitro, and specifically, 5-hydroxy o-aminobenzoic acid and coumaroyl coenzyme A or caffeoyl coenzyme A are used as substrates; the oat alkaloid A and the oat alkaloid C can be synthesized under the catalysis of the hydroxyl o-aminobenzoic acid hydroxyl cinnamyl transferase 5, and a theoretical basis and a research direction are provided for developing and utilizing biosynthesis of the oat alkaloid.

The invention belongs to the technical field of microorganisms, and discloses penicillium buchneri and application thereof. The name of the penicillium buchneri is Penicillium buchneri CP16-M4, the preservation number of the penicillium buchneri is GDMCC (China General Microbiological Culture Collection Center) NO: 67183, and the penicillium buchneri is preserved in Guangdong Province Microbial Culture Collection Center on November 17, 2025. When the penicillium buchneri is used for fermenting the dried orange peel, not only can the total flavone content of the dried orange peel be increased, but also the types of volatile substances are increased, and the relative content of N-methyl anthranilate is greatly increased. Therefore, the penicillium buchneri can be used for accelerating aging of the pericarpium citri reticulatae, and the pericarpium citri reticulatae with high active ingredient content can be rapidly obtained.

The invention relates to the technical field of environmental protection engineering, in particular to an ammonia gas absorption device and process for anthranilic acid production. Comprising a first buffer tank, an underground absorption tank, a second buffer tank and a spray tower which are sequentially communicated, the spray tower comprises a tank body, the tank body is fixedly connected with water inlet pipes which are distributed in a linear array mode, the water inlet pipes are fixedly connected and communicated with a distribution shell, the distribution shell is rotationally connected and communicated with swing shells which are distributed in an annular array mode, and the swing shells are fixedly connected with the tank body. The swing shell is rotationally connected with and communicates with liquid spraying pieces distributed in a linear array mode, a plurality of pairs of guide rings are arranged in the tank body, and each pair of guide rings are jointly and fixedly connected with a material containing shell. By adjusting the inclination angle of the swing shell, the range of spraying liquid sprayed by the liquid spraying pieces distributed in the same linear array is overlapped, the impact force on the surface of filler is enhanced, instant scouring force is provided for stripped impurities, relative displacement and mutual extrusion are generated between the fillers through deformation of the material containing shell, and the impurities are promoted to be separated from the fillers.

The present invention discloses a diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry of formula 3 and its synthesis method and application in an asymmetric catalytic reaction, wherein C2-symmetry is lost by introducing different groups into the diphenylamine backbone to realize precise control of “electronic effect” of the ligand backbone. An anthranilic acid derivative and an orthochlorobenzoic acid derivative are used as starting materials to prepare a compound of formula 1, and then the compound of formula 1 is reacted with a chiral amino alcohol compound to prepare a β-bishydroxy amide compound of formula 2, and the compound of formula 2 is further subjected to condensation to obtain the diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry of formula 3. The present invention also provides an application of a catalyst formed by coordination of the diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry with copper salt, zinc salt, nickel salt, iron salt or rhodium salt, in an asymmetric catalytic reaction.

The invention discloses an application of 3-hydroxy o-aminobenzoic acid in preparation of fat-reducing and weight-reducing products. According to the present invention, the first research results show that the 3-hydroxyanthranilic acid can significantly improve the secretion amount of leptin in the mouse body and influence the food intake of the mouse so as to achieve the purposes of reducing the mouse body weight increase, reducing the mouse body weight and improving the mouse obesity; therefore, the 3-hydroxy o-aminobenzoic acid can be used for preparing a fat-reducing and weight-reducing product which is high in biological safety and does not cause any adverse reaction.

The invention discloses a preparation method of high-purity dihydrooat alkaloid, which comprises two continuous reaction stages of nucleophilic substitution and electrophilic addition and a post-treatment stage of separation and purification, and comprises the following steps: under the condition of nitrogen protection, carrying out nucleophilic substitution reaction on p-hydroxyphenylpropionic acid and carbonyl diimidazole to generate an N-acyl imidazole active intermediate; dropwise adding into an organic solvent of o-aminobenzoic acid without separation to complete electrophilic addition reaction, so as to generate a dihydrooat alkaloid solution with high selectivity; after the reaction is finished, cooling to room temperature, extracting, separating and concentrating an organic phase to separate out a crude product or concentrating a reaction solution until the reaction solution is dry and separating out a crude product in an acidic aqueous solution, and recrystallizing to obtain the high-purity dihydrooat alkaloid. The one-pot process strategy of step-by-step activation and controllable addition is adopted, the reaction has the advantages of being high in chemical selectivity, mild in reaction condition, high in raw material conversion rate and simple and convenient in aftertreatment, phenolic hydroxyl protection is avoided, the problem of high-selectivity amidation is solved, and the preparation cost is effectively reduced.

The invention discloses an application of 3-hydroxy o-aminobenzoic acid in preparation of a pancreatic tissue targeting agent. The research finds that after 3-hydroxyanthranilic acid is injected into the abdominal cavity of a mouse, the 3-hydroxyanthranilic acid is specifically enriched in pancreatic tissues of the mouse at high concentration, which indicates that the 3-hydroxyanthranilic acid has the capability of serving as a target head to specifically target the pancreatic tissues; therefore, the 3-hydroxyanthranilic acid can be used for preparing a pancreatic disease targeted therapeutic drug, so that the pancreatic disease therapeutic drug is enriched in pancreatic tissues along with the 3-hydroxyanthranilic acid, and a more effective therapeutic effect is exerted.

The present invention relates to the use of anthranilic acid in a process for preparing a compound selected from copper phthalocyanine, quinacridone, 2-[(2-methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide (PY74), and 2-({2-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazole-5-yl)carbamoyl]propyl}diazenyl)benzoic acid (PY151). In particular, the anthranilic acid is produced or obtained from a microorganism.

The present inventions relates to oral care compositions comprising or consisting of: component (a) comprising safraleine; component (b) comprising citral; and optionally component (c), which is selected from the group consisting of L-menthone, eugenol, cis-3-hexenol, thymol, toscanol, ebanol, hexyl acetate, methyl salicylate, gamma decalactone, gamma undecalactone, cassyrane, vanillin, dimethyl anthranilate, α-ionone, carvone, eucalyptol or mixtures and / or isomers thereof, wherein the oral care composition is adapted to reduce or eliminate malodor. The invention further relates to the use of the oral care compositions to reducing and / or eliminating malodor.

A kind of algorithm model for depression detection, detection system, program and storage medium.The training method of the artificial intelligence model includes: constructing artificial intelligence model, its input includes the concentration of 3-4 kinds of to-be-detected compounds selected from 5-hydroxyanthranilic acid, methionine, gamma-aminobutyric acid, 3,4-dihydroxyphenylacetic acid, 2-picolinic acid, quinolinic acid, kynurenine, 5-hydroxytryptamine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, dopamine, norepinephrine, homocysteine, and the output is the risk index of suffering from severe depression;Large sample data is used to train the artificial intelligence model.The AUC of the detection model of the application is greater than or equal to 0.95, even 0.99;Accuracy rate reaches more than 90%;High sensitivity;Algorithm is simple, iterative convergence is fast, is convenient for transplantation, can be embedded into detection system, also can be used as a single data processing unit, works using encryption key or external U disk mode.

The invention discloses recombinant escherichia coli for producing 4-aminophenylalanine as well as construction and application of the recombinant escherichia coli, and belongs to the technical field of genetic engineering. The recombinant Escherichia coli is prepared by the following steps: by taking Escherichia coli as an original strain, integrating an amino deoxy chorismate synthetase gene, an amino deoxy chorismate mutase gene, an amino deoxy prebenzoate dehydrogenase gene, a tyrosine transaminase gene and an aspartate aminotransferase gene on an Escherichia coli genome; the shikimic acid dehydrogenase gene, the amino deoxygenated chorismate lyase gene and the transcriptional regulation factor gene tyrR are knocked out, and the expression of the chorismate mutase gene and the anthranilic acid synthetase gene is weakened to obtain the shikimic acid dehydrogenase gene. By utilizing the genetically engineered bacterium, the yield of 4-aminophenylalanine reaches 3.6 g / L, and a strain basis can be provided for large-scale production of 4-aminophenylalanine.