157 results about "Oxazoline" patented technology

A method for inactivating pathogens is described, comprising the steps of: partially deacylating a poly(2-alkyl-2-oxazoline) to yield a copolymer, an alkyl in the poly(2-alkyl-2-oxazoline) comprising a hydrocarbon chain, the copolymer comprising: first monomers, the first monomers comprising a -NH2 +CH2CH2- group; and second monomers, the second monomers comprising an acyl group, -C(=O)-R', attached to a nitrogen in a polymer backbone group comprising -NCH2CH2-, wherein R' comprises the hydrocarbon chain, the first monomers and the second monomers arranged in any order in the copolymer; preparing a formulation, the formulation comprising the copolymer and a total cationic charge in a range of 0.2 to 10 C / cm3, the total cationic charge at least 95% offset by counteranions in the formulation; contacting the pathogens with the formulation; and inactivating at least ninety percent of the pathogens within ninety minutes of the step of contacting.

The invention belongs to the technical field of medical polymer materials, relates to an amphiphilic block copolymer, a hydrogel material containing the amphiphilic block copolymer and a preparation method and application of the amphiphilic block copolymer, and particularly discloses a poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer and a preparation method and application of a hydrogel material of the poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer. The hydrogel material provided by the invention has excellent injectability, and the modulus and gelation temperature of a gel preparation can be adjusted by changing the molecular weight and concentration of the amphiphilic block copolymer, so that the hydrogel material adapts to different physiological environments, is applied to different indications, and can be applied to various diseases. Compared with other hydrogel in which the chemical structure of the polymer needs to be changed, the hydrogel is more convenient.

The invention relates to an epoxy hardener and a preparation method thereof and a preparation method of a visbreaking uncovering protective film, and the preparation method of the epoxy hardener comprises the following steps: adding 2, 2 '-(1, 3-phenylene)-dioxazoline and a phenolic hydroxyl group or carboxyl group-containing bifunctional monomer into a first solvent, stirring at normal temperature to obtain a first solution, heating to a first temperature, and stirring at normal temperature to obtain a second solution; the first temperature is 155 DEG C to 165 DEG C, and refluxing for 3.5 hours to 4.5 hours; adding a terminated monomer containing carboxyl or phenolic hydroxyl into a reaction system of the first solution, and continuing to carry out reflux reaction for 2.5-3.5 hours at the first temperature; and after the reaction is finished, purifying and drying to obtain the epoxy curing agent. The epoxy curing agent disclosed by the invention has compatibility with low-polarity glue and has a relatively high curing degree in a high-temperature environment; the viscosity-reducing uncovering protective film has the advantages that the viscosity is reduced at high temperature, and the uncovering design efficiency of different types of PCBs is improved.

The invention belongs to the field of photovoltaic technology, and provides a photovoltaic packaging adhesive film, a preparation method and application thereof, and a recovery method of a photovoltaic module. The photovoltaic packaging adhesive film comprises the following raw materials in specific amounts: matrix resin, a low-temperature cross-linking agent, a low-temperature catalyst, a silane coupling agent, an ultraviolet light stabilizer, an organic peroxide initiator, an assistant cross-linking agent and an alcohol compound serving as a reversible dynamic transesterification reaction group, the matrix resin is EVA (ethylene vinyl acetate), POE (polyolefin elastomer) and / or ethylene-butylene copolymer; the low-temperature cross-linking agent is a carboxylic ester type cross-linking agent, a bisoxazoline type cross-linking agent and / or a metal-organic ligand cross-linking agent with the reaction temperature of 150 DEG C or below; the low-temperature catalyst is a polynuclear metal catalyst, a solid acid resin catalyst, a solid base catalyst and / or a bimetallic MOF derivative catalyst with the reaction temperature of 150 DEG C or below. The adhesive film can realize recycling of the adhesive film and a photovoltaic module in a more efficient and energy-saving manner, is wide in adaptability, and has high crosslinking degree, peel strength and PID resistance.

The invention relates to the technical field of collagen, and provides cross-linked collagen and a preparation method and application thereof in the field of medical cosmetology, the preparation method of the cross-linked collagen comprises the following steps: collagen and an oxazoline compound are subjected to a cross-linking reaction under the condition that the pH value is 5-8, glycine is added to terminate the reaction after the reaction is finished, and the cross-linked collagen is obtained. And then cleaning, centrifuging and drying to obtain the cross-linked collagen. The oxazoline compound is subjected to ring-opening reaction with carboxyl (such as aspartic acid and glutamic acid) and amino (such as lysine and arginine) on a side chain of collagen to form a stable amido bond or similar covalent bond structure, so that efficient crosslinking is realized; and the oxazoline compounds do not contain free aldehyde groups, so that toxic by-products are not generated in the reaction process, and the unification of'high efficiency 'and'safety' is realized.

The application relates to a chiral NSiN ligand based on a phenyloxazoline skeleton, a preparation method and application thereof, wherein the chiral NSiN ligand is prepared from a chiral phenyloxazoline bromide with R or S configuration through lithiation and silylation. The chiral NSiN ligand can be used in transition metal catalyzed asymmetric synthesis, and is used in catalyzing an allylic sulfonylation reaction with a cobalt catalyst, and shows high reaction activity and high stereoselectivity.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of an isoxazoline compound. The preparation method comprises the following steps: dissolving a compound 1 and ethyl acrylate in dichloroethane, then adding tert-butyl nitrite, alkali and K2S2O8, in an air environment, irradiating with a 35 W blue LED light source and stirring at room temperature for 12 hours, after the reaction is completed, reducing pressure to remove a solvent, and then performing silica gel column chromatography on a crude product to obtain a product, namely the isoxazoline compound. The synthesis method provided by the invention avoids the problem of residue of a traditional metal catalyst, and provides a new normal form for green synthesis of the isoxazoline compound. As a key intermediate, isoxazoline can derive beta-lactam, beta-amino alcohol and other structures, and a new path is provided for complex molecule synthesis.

Disclosed is a silicone-modified polyimide resin composition comprising a silicone-modified polyimide, a thermal curing agent, wherein the silicone-modified polyimide contains a repeating unit represented by the following general formula (I): in the general formula (I), Ar 1 is a tetravalent organic group having a benzene ring or alicyclic hydrocarbon structure, Ar 2 is a divalent organic group, R is independently selected from a methyl group or a phenyl group, and the thermal curing agent is an epoxy resin, an isocyanate, or a bisoxazoline compound. The silicone-modified polyimide resin composition obtained by the present application has excellent heat resistance, mechanical strength, and light transmittance.

The invention discloses a preparation method of end-group-functionalized polyoxazoline, which comprises the following steps: mixing a weak Bronsted acid initiator, an ion exchange catalyst and an oxazoline monomer, and carrying out cationic ring-opening polymerization reaction to obtain the end-group-functionalized polyoxazoline. The preparation method of the end group functionalized polyoxazoline has the advantages of simple and convenient operation process, low equipment requirement, high atom economy, wide compatibility range of functional groups, high functionalization efficiency, low cost and the like, and the adopted initiator weak Bronsted acid is high in commercialization degree, diversified in structure and wide in source; and finally, the polyoxazoline with the functionalized end group, which is controllable in molecular weight, narrow in molecular weight distribution, adjustable in topological structure and adjustable in performance, can be prepared.

The present invention relates to the technical field of biomedical materials, and specifically provides a bone and joint biological super-lubricating copolymer and a preparation method thereof. Dopamine is modified with methacrylic anhydride to prepare dopamine methacrylamide, and then a positively charged poly (2-ethyl-2-oxazoline) with good hydrophilicity and hydration lubrication performance and dopamine methacrylamide with adhesion performance are subjected to free radical polymerization to form a super-lubricating copolymer. The positively charged super-lubricating copolymer has good cell affinity, can promote the attachment, growth and differentiation of chondrocytes, and is beneficial to tissue repair and regeneration. The positively charged super-lubricating copolymer has high hydrophilicity, excellent hydration ability and lubricating properties, can adhere to the joint surface, absorb surrounding water molecules to form a hydration layer, effectively reduce surface friction and wear, and the unique adhesion properties of the copolymer and the phenol structure can effectively scavenge free radicals to achieve an anti-inflammatory effect.

The invention relates to synthesis of a tridentate bis (oxazoline phenyl) amino palladium metal methyl compound and preparation of a catalytic system, and belongs to the technical field of catalysts. The catalyst is used for catalyzing the polymerization reaction of isonitrile polymerization. A high-molecular-weight polymer can be obtained in the reaction process. The tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is obtained through one-step reaction, the raw materials are easy to obtain and modify, the economic efficiency is high, the catalyst does not need complex synthesis steps, the environmental protection property is good, and the tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is suitable for industrial production. The work provides a new thought for a new catalyst system.

The invention provides a temperature and humidity alternating resistant water-based paint and a preparation method thereof. The temperature and humidity alternating resistant water-based paint is composed of a component A and a component B, the component A comprises an elastic emulsion, an anti-freezing agent, a coalescing agent, a wetting dispersant, a defoaming agent, a thickening agent, a multifunctional additive, water and at least one of glass fibers, high silica fibers and sepiolite fibers; the component B comprises a cross-linking agent; the cross-linking agent is an isocyanate curing agent, an oxazoline cross-linking agent or an aziridine cross-linking agent. According to the temperature and humidity alternating resistant water-based paint provided by the invention, components with specific contents are adopted, so that relatively good overall interaction is realized, and a coating can have good stability in a complex temperature and humidity change environment; and the component A can also comprise a fireproof filler and a flame retardant, can expand and foam when meeting flames to form a foam expansion layer, has high strength and compactness, can prevent flame heat transmission and prolong the fire endurance of the base material, and has good fire resistance.

Method for manufacturing a decorative panel (1) comprising a substrate (2) of thermoplastic material and a top layer (3) provided thereon, said method comprising a step (S1) of preparing a feedstock material with a polymer fraction comprising polyethylene terephthalate (PET) and / or modified PET, and at least one additive, said method comprising a subsequent step (S2) of extruding said feedstock material characterized in that said additive is a chain extender showing one or more of the following properties: - said chain extender comprises an epoxide; - said chain extender comprises a cyclic carboxylic anhydride; - said chain extender comprises an isocyanate; - said chain extender comprises an oxazoline; - said chain extender comprises an epoxy acrylate with terminal and / or internal epoxy groups; - said chain extender comprises a methacrylate; - said chain extender comprises a caprolactam; - said chain extender comprises a pyromellitic dianhydride; - said chain extender comprises a polyol.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a rivaroxaban intermediate. 4-(3-oxomorpholinyl) phenyl isocyanate, namely a compound 1, and (2s)-3-chloro-2-hydroxy propyl carbamic acid tert-butyl ester, namely a compound 2 are subjected to a reaction, and an intermediate (S)-tert-butyl-(2-oxo-3-(4-(3-carbonyl morpholine) phenyl) oxazoline-5-methylene) carbamate, namely a compound 3, is obtained. The reaction conditions are mild and stable, the intermediate can be prepared with high yield and high purity, the problems of long reaction time, high-temperature reaction and the like are avoided, and the method is suitable for industrial production.

The application discloses a bisoxazoline pyridine functionalized porous organic polymer and preparation and application thereof; firstly, a styryl functionalized PyBox monomer (VPyBox) is designed and synthesized, and VPyBox, styrene and divinylbenzene are subjected to free radical polymerization under initiation of azobisisobutyronitrile in a certain proportion to obtain a series of porous organic polymers (POP-PyBox); the POP-PyBox can be used as a solid N , N , N tridentate ligand for Co-catalyzed hydrosilylation of arylalkynes with diphenylsilane; the heterogeneous catalyst system developed by the application has a catalytic activity comparable to that of a homogeneous catalyst reported in the literature, and the catalyst is easy to separate and recover; the recovered catalyst can be recycled for more than 6 times, which can not only greatly reduce the preparation cost of vinylsilane, but also simplify the post-treatment process and reduce the three wastes, and has a good practical application prospect.

The invention discloses a chiral oxazoline ligand containing an indole skeleton as well as a synthesis method and application of the chiral oxazoline ligand. The chiral ligand has a structure as shown in a formula 1, and R1 is selected from one of alkyl, substituted alkyl, aryl and substituted aryl. The chiral oxazoline ligand of the indole skeleton can realize high-enantioselectivity Friedel-Crafts reaction of an indole skeleton compound, the reaction is one of important carbon-carbon bond forming methods in organic synthesis, and a chiral indole derivative can be efficiently generated; the chiral indole derivative has important application in synthesis of natural products and bioactive compounds. In addition, raw materials used for preparing the compound are cheap and easy to obtain, the synthesis route is short, the related reaction is a basic organic chemical reaction, the process is simple and convenient, the product is easy to separate and purify, and the method is suitable for large-scale synthesis.

The present application discloses a kind of composite antistatic film and preparation method thereof, relate to the field of automobile parts film materials.Compound antistatic film includes core layer and outer layer, and core layer is made using toughening modified PET resin, and outer layer is made using antistatic PET resin;Toughening modified PET resin includes 100 weight portions of the first PET resin, 24.3 30.8 weight portions of hydroxyl-terminated polyurethane resin, 1.0 1.5 weight portions of the first hydroxy graphitized carbon nanotube, 8.8 10.4 weight portions of the first bis-oxazoline chain extender;Antistatic PET resin includes 100 weight portions of the second PET resin, 0.85 1.0 weight portions of the second hydroxy graphitized carbon nanotube, 3.5 4.8 weight portions of the second bis-oxazoline chain extender.The composite antistatic film of the present application has both toughness and antistatic property, can improve the forming efficiency of composite antistatic film, can also promote the rapid derivation of static electricity, improve the dustproofness of composite antistatic film.

This invention belongs to the field of organic ligand technology, and specifically discloses a phosphoxazolin ligand having the structure shown in general formula I or general formula II, or its tautomers, enantiomers and diastereomers: , R 1 Selected from hydrogen, alkyl, perfluoroalkyl, alkoxy, aryl; R 2 Selected from hydrogen, alkyl, perfluoroalkyl, alkoxy, aryl; R 3 Selected from alkyl, cycloalkyl, alkenyl, and aryl; R 4 Selected from alkyl, cycloalkyl, alkoxy, perfluoroalkyl, aryl, and fluorine atoms; R 5 Selected from hydrogen, alkyl, cycloalkyl, alkoxy, perfluoroalkyl, aryl, and fluorine atoms; R 6 The substituents are selected from hydrogen, alkyl, cycloalkyl, alkoxy, perfluoroalkyl, aryl, and fluorine atoms; n and m are the number of substituents, where n+m≤5. This invention also discloses a method for preparing phosphosoxazoline ligands and their application in catalytic allylation, bicyclization, intermolecular desymmetry, or intramolecular condensation reactions of nitrile derivatives.

The invention relates to a water-based self-crosslinking composition as well as a preparation method and application thereof, and belongs to the technical field of water-based compositions. The water-based self-crosslinking composition disclosed by the invention is prepared from blocked isocyanate A, an oxazoline polymer B and water, the blocked isocyanate A contains an isocyanate group with carboxyl and a blocked isocyanate group; the oxazoline polymer B contains an oxazoline group and a hydroxyl group; in the solid parts of the water-based self-crosslinking composition, the concentration of the carboxyl group is 0.2 to 1.0 mmol / g, the concentration of the blocked isocyanate group is 1.2 to 2.0 mmol / g, the concentration of the oxazoline group is 0.2 to 1.2 mmol / g, and the concentration of the hydroxyl group is 1.2 to 2.8 mmol / g. The water-based self-crosslinking composition is high in crosslinking density after being baked, has excellent impact resistance, pencil hardness, MEK wiping resistance and adhesive force after being boiled in boiling water, and is very suitable for being used for water-based single-component baking coatings.

To provide compounds and compositions for reducing most common opioid-induced hyperalgesia associated with microglial hyperactivation.SOLUTION: 2-pentadecyl-2-oxazoline (PEA-OXA) for use as an opioid adjuvant for preventing the development of or in the treatment of opioid-induced hyperalgesia (OIH), wherein the PEA-OXA is administered with or in combination with an opioid. Wherein the administration is separate, together or simultaneous.SELECTED DRAWING: None

The present invention discloses a chiral heteroleptic nine-coordinate rare earth complex and its preparation method and application, belonging to the field of organic luminescent materials. This chiral rare earth complex consists of three anionic coumarin-derived diketone ligands (Coum) ‑ The chiral bis-oxazoline-derived enantiomerically pure ligands 1R,2R-2,6-bis(4-phenyl-2-oxazoline-2-yl)pyridine (1R,2R-Ph-PyBox) or 1S,2S-2,6-bis(4-phenyl-2-oxazoline-2-yl)pyridine (1S,2S-Ph-PyBox) were self-assembled with rare earth ions in alcohol solution. Thanks to the combination of the excellent photophysical properties of the Coum ligand and the strong chiral induction ability of the chiral Chiral-Ph-PyBox ligand, the two Tb 3+ The enantiomers [Tb(Coum)3(1R,2R‑Ph‑PyBox)](2)and[Tb(Coum)3(1S,2S‑Ph‑PyBox)](5) not only achieve bright and high color purity characteristic green emission (Φ PL =74%), and also obtained a strong excited state CPL activity (|g lum |=0.097‑0.103) and significantly enhanced antenna ligand center absorption behavior (ε 320nm =47820-47940M ‑1 cm ‑1 ). Complexes 2 and 5 have magnetic dipoles 5 D4→ 7 The circular polarization brightness at the F5 transition position (B CPL ) can be as high as 1132.7-1205.8M ‑1 cm ‑1 .

Poly(oxazoline)- and poly(oxazine)-based lipids, process for the preparation thereof, and use thereofDisclosed are polymers of formulae (I) or (II)or polymers containing, based on all structural units, 10 to 95 mol % of structural units of the formula (III), 5 to 90 mol % of structural units of the formula (IV) and 0 to 20 mol % of structural units of the formula (V)or containing 10 to 95 mol % of structural units of the formula (VI), 5 to 90 mol % of structural units of the formula (VII) and 0 to 20 mol % of structural units of the formula (VIII)wherein at least one of the structural units of formula (III), (IV) or (V) or of formula (VI), (VII) or (VIII) with the grouping —CHR4—, —CHR5— or CHR7— or with the grouping —CHR5—, —CHR7— or —CHR10— is covalently bonded to a radical R2, whereinIni is a radical derived from an initiator of the cationic polymerization,R1 is selected from the group consisting of hydrogen or C1-C4 alkyl,R2 is selected from the group consisting of —OR11, —OCO—R11, —OCO—R14—CO—OR11, —OCO—R14—CO—NR12R13, —NR12—R14—CO—NR13R15, —O—R16—(O—OC—R18)m andR3, R4, R5, R6, R7, R8, R9 and R10 independentlky of one another are hydrogen, methyl, ethyl, propyl or butyl,R11 is C6-C20 alkyl,R12 and R15 independently of one another are hydrogen or alkyl,R13 is C6-C20 alkyl,R14 is alkylene, cycloalkylene, arylene or aralkylene,R16 is an m+1-valent aliphatic hydrocarbon radical,m is an integer from 1 to 5,R18 is C6-C20 alkyl, with the proviso, that several residues R18 of a residue R16 may be different within the scope of the given definitions,R17 is a trivalent bicyclic residue, andw is an integer in the range from 1 to 5000.These polymers are amphiphilic and can be used as a replacement for polyethylene glykols, for example in formulations comprising active ingredients.

Provided is a thermally expandable microsphere-containing water-dispersed adhesive composition which is capable of forming an adhesive that has good releasability by heating. The water-dispersed adhesive composition contains an acrylic polymer that serves as a base polymer, thermally expandable microspheres, and a crosslinking agent. With respect to the water-dispersed adhesive composition, the crosslinking agent contains at least one selected from the group consisting of an epoxy-based crosslinking agent, an oxazoline-based crosslinking agent, a carbodiimide-based crosslinking agent, an isocyanate-based crosslinking agent, a hydrazide-based crosslinking agent, and an aziridine-based crosslinking agent.

The invention discloses PET (polyethylene terephthalate)-based plastic cloth with high barrier property and a preparation method thereof, belongs to the technical field of preparation of plastic cloth, and aims to solve the technical problem that the barrier property and the mechanical property of the PET-based plastic cloth in the prior art need to be further improved. A hydroxyacetamide body, diol oxazoline and isosorbide modified polyester are sequentially synthesized in a polyester system, two structural units are introduced in the polycondensation process, a modified polyester material with cyclic active sites and bicyclic steric hindrance is formed, an oxazoline group provides an interchain strong effect, and orientation locking and structural compactness are improved; the isosorbide skeleton limits chain segment retraction and prolongs a gas permeation path, and the isosorbide skeleton and the isosorbide skeleton have a synergistic effect, so that the obtained plastic cloth keeps relatively high tensile strength and elongation at break, the heating size change rate is remarkably reduced, excellent gas barrier performance is realized, and comprehensive improvement of the performance is embodied.

The invention provides a plastic packaging bag material and a preparation method thereof, and belongs to the field of polyethylene plastics. The plastic packaging bag material is prepared from the following raw materials in parts by weight: 40 to 50 parts of metallocene polyethylene, 20 to 30 parts of highly branched polyethylene, 5 to 10 parts of zinc ion type ethylene-acrylic acid copolymer, 2 to 5 parts of oxazolinyl-containing polymer, 2 to 5 parts of multifunctional star copolymer, 8 to 12 parts of titanate coupling agent coated nano calcium carbonate, 0.5 to 2 parts of hydroxylated graphene oxide, 1 to 2.5 parts of polyethylene glycol and 0.5 to 2 parts of polydimethylsiloxane, 0.1 to 0.5 part of a beta crystal form nucleating agent, 0.1 to 0.5 part of an antioxidant and 0.1 to 0.5 part of a lubricant. Through the synergistic effect of matrix skeleton strengthening, multi-scale strengthening, dynamic-static crosslinking toughening and interface buffering regulation, synchronous breakthrough of the strength, toughness, puncture resistance and tear resistance of the plastic packaging bag material is achieved.

The application discloses a preparation method of 1,2-propylenediamine, which comprises the following steps: (1) 2-phenyl-5-methyl-2-oxazoline, ZIF-8 catalyst and liquid ammonia are added into a high-pressure reaction kettle, and after temperature rising, stirring and filtration, benzoyl 1,2-propylenediamine is obtained; (2) the benzoyl 1,2-propylenediamine obtained in the step (1), methanol and an alkali metal catalyst are added into an atmospheric pressure reaction kettle with a reflux device, after temperature rising and stirring, sulfuric acid is added to neutralize the alkali metal catalyst, after neutralization, the mixture is filtered, and the filtrate is subjected to distillation to obtain a mixture of methyl benzoate and 1,2-propylenediamine; (3) the mixture obtained in the step (2) is separated by rectification to obtain 1,2-propylenediamine products. The preparation method can reduce the production cost, the process condition is relatively mild, hydrogen is not needed to participate in the amination reaction, the process safety is higher, the raw material conversion rate is high, close to 100% conversion, the synthesis yield is higher than 90%, the preparation process is efficient and safe.

The application discloses a kind of repeatedly injection moulding polyphenyl ether compositions and preparation method thereof, repeatedly injection moulding polyphenyl ether compositions include matrix resin, crosslinking agent and toughening agent;Matrix resin is the mixture of polyphenyl ether and polystyrene;Crosslinking agent is the mixture of low molecular weight oxazoline and polystyrene graft oxazoline;Toughening agent is SEBS-g-MAH;The mass fraction ratio of low molecular weight oxazoline and polystyrene graft oxazoline is 0.5-1.5:2-5, the mass fraction ratio of SEBS-g-MAH and polystyrene graft oxazoline is 5-10:2-5;Preparation method is melt blending method.The preparation method of the application is simple, and the polyphenyl ether composition prepared can be repeatedly injection moulding, which makes up for the shortcomings of prior art.

The invention provides a method for constructing a chiral axis-containing planar chiral cyclophane compound by activating intramolecular asymmetric carbon-hydrogen bonds under the catalysis of cobalt, which comprises the following steps of: under the action of a cobalt catalyst, a chiral auxiliary agent and an additive, carrying out intramolecular asymmetric C-H activation reaction on alkynyl benzamide, and after the reaction is finished, separating the chiral axis-containing planar chiral cyclophane compound from the alkynyl benzamide to obtain the chiral axis-containing planar chiral cyclophane compound. Separating to obtain a planar chiral cyclophane compound containing a chiral axis; the synthesis of the planar chiral cyclophane compound containing the chiral axis is realized by a transition metal catalyzed asymmetric C-H activation method, the research technology of cheap transition metal catalyzed C-H activation is further developed, and meanwhile, the synthesis strategy of the planar chiral cyclophane compound containing the chiral axis is expanded; according to the present invention, the reaction substrate has characteristics of wide adaptability and strong product stereoselectivity, and the chiral control is achieved through the salicyl oxazoline so as to provide the high enantioselectivity and the high diastereoselectivity of the product; various planar chiral cyclophane compounds containing chiral axes are synthesized, the synthesis method is simple and convenient, the atom economy is good, and the synthesis efficiency is high.

2-Pentadecyl-2-oxazoline (also known as palmitoylethanolamide oxazoline or PEA-OXA) is used to counteract hyperalgesia induced by the most common opioids (OIH) associated with microglial hyperactivation. In particular, PEA-OXA is administered to humans and animals to prevent or treat some of the adverse effects of opioids by controlling immune hyperactivation. The PEA-OXA is administered separately, sequentially or jointly with the opioid.