601 results about "Oxazoline" patented technology

The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

A resin composition in which a polylactic acid resin (A) 95-5 wt %, an aromatic polycarbonate resin (B) 5-95 wt %, and, with respect to 100 wt parts of the total of the (A) and the (B), at least one compatibilizer selected from a polymer compound containing an acrylic resin or styrene resin unit as a graft (C), a polymer compound to which a glycidyl compound or an acid anhydride is grafted or copolymerized (D) and an oxazoline compound, an oxazine compound and a carbodiimide compound (E) are compounded.

The present invention features a multi-layer ink-jet recording medium, suitable for recording images with dye and pigmented inks and thereby providing light-emitting, reflective, glossy, metallic-looking or holographic images, comprising a substrate coated with at least two layers comprising: (a) a first transparent ink-receptive layer comprising a polymeric binder and a cross-linker and optionally having a plasticizer and pigment particles such as alumina and silica coated over the substrate, wherein the cross-linker comprises and azetidinium polymer or a salt thereof, and/or a polyfunctinal aziridine or a salt thereof or a polyfunctional oxazoline or a salt thereof; and (b) a second ink-receptive layer comprising an opaque or semi-opaque coating composition, wherein the opaque or semi-opaque coating composition is capable of accepting a printed image and thereby becoming semi transparent or clearly transparent from application of ink-jet printing ink or similar inks, while presenting a light-emitting, reflective, glossy, metallic-looking or holographic image of high clarity and quality, wherein said first layer is located between said second layer and the substrate in said recording medium and the first and second layers are chemically coupled.

The invention disclosed in this document is related to field of pesticides and their use in controlling pests.

A chemoenzymatic method for the preparation of a core-fucoslyated glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of a fucosylated GlcNAc-protein and fucosylated GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of an endoglycosidase (ENGase) selected from Endo;F1, Endo-F2, Endo-F3, Endo-D and related glycosynthase mutants to transfer the oligosaccharide moiety to the acceptor and yield the structure defined core-fucosylated glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of fucosylated glycoprotein or fucosylated glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody to include a predetermined sugar chain to replace a heterogeneous sugar chain, are also described.

To provide an adhesive composition which shows high adhesion with a glass substrate and has excellent heat resistance, moisture resistance and moist heat resistance, an adhesive optical film comprising an adhesive layer made of the adhesive composition, which shows high adhesion between the adhesive layer and an optical film and effectively suppresses the occurrence of adhesive residue and lack of adhesive and also has excellent heat resistance, moisture resistance and moist heat resistance, and an image display device comprising the adhesive optical film, the adhesive optical film comprises an optical film 1, an adhesive layer 3 made of a water dispersible adhesive composition comprising, as raw monomers, an alkyl(meth)acrylate ester whose alkyl group has 4 to 18 carbon atoms, a carboxyl group-containing vinyl monomer, a phosphoric acid group-containing vinyl monomer, and a copolymerizable vinyl monomer which is optionally copolymerizable with the above monomers, wherein a carboxyl group concentration is from 0.05 to 1.50 mmol/g and a phosphoric acid group concentration is from 0.01 to 0.45 mmol/g in the raw monomers, an under coat layer 2 containing an oxazoline group-containing polymer, and being interposed between the optical film 1 and the adhesive layer 3, and the adhesive optical film is applied onto an image display device.

The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgGl-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.

The invention discloses a 2-(2-(diphenyl phosphine) phenyl) oxazoline nickel halogenide series complex. Said invention provides the structure formula of said complex and its preparation method. Said invention also provides catalyst composition containing said complex and its application in ethylene oligopolymerization. Said catalyst composition has higher ethylene oligopolymerization activity, and the obtained oligomer takes ethylene dimmer and trimer as main components.

The present invention relates to polymer compositions containing polyphenylene sulfide, a polymeric grafting agent and an ethylene copolymer. The polymeric grafting agent is a copolymer of at least about 50% by weight ethylene, about 0.5% to about 15% by weight of a first reactive moiety selected from the group consisting of: (i) an unsaturated epoxide of 4-11 carbon atoms, (ii) an unsaturated isocyanate of 2-11 carbon atoms, (iii) an alkoxy or alkyl silane wherein the alkyl group is from 1-12 carbon atoms, and (iv) an oxazoline; and about 0 to about 49% by weight of a second moiety selected from at least one of an alkyl acrylate, alkyl methacrylate, vinyl ether, carbon monoxide, and sulfur dioxide, where the alkyl and ether groups are of 1-12 carbon atoms. The ethylene copolymer comprises about 1% to about 20% by weight of an ethylene copolymer which comprises at least about 50% by weight ethylene, about 1% to about 35% by weight of an acid-containing unsaturated mono-carboxylic acid, and about 0 to about 49% by weight of a moiety selected from at least one of alkyl acrylate, alkyl methacrylate, vinyl ether, carbon monoxide, and sulfur dioxide, and further wherein the acid groups are neutralized from 0-100% by a metal ion. The molar ratio of polymeric grafting agent to ethylene copolymer preferably ranges from about 1.0 to about 5.5.

A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.

The invention relates to an asymmetric synthesis method for botanical pesticide nicotine and anabasine. The low-cost and easily acquired 2,5-dibromopyridine is taken as an initial raw material and is processed in two steps, so that the hydrogenation precursor annular imine is acquired; under the induction of the chiral catalyst, iridium-phosphine oxazoline, an important hydrogenated product intermediate is acquired through high enantioselectivity; the intermediate is processed in two steps, so that L-nicotine is acquired; the intermediate is converted into L-anabasine in one step. The asymmetric hydrogenation of the annular imine containing pyridine gene is taken as the key step of the method. According to the invention, the chiral catalyst, iridium-phosphine oxazoline, is used for catalyzing the asymmetric hydrogenation and the key intermediate with ultrahigh ee value is acquired, and then the methylation and reduction bromine-removing two-step reaction is performed for converting, so that the target products, natural nicotine and anabasine, are acquired. According to the invention, the operation is stable, the purity is high and the cost is low.

A pattern is formed by coating a first positive resist composition comprising a copolymer comprising lactone-containing recurring units and acid labile group-containing recurring units onto a substrate to form a first resist film, patternwise exposure, PEB, and development to form a first resist pattern, applying an amine or oxazoline compound to the first resist pattern for inactivation, coating a second positive resist composition comprising a C₃-C₈ alcohol and an optional C₆-C₁₂ ether onto the first resist pattern-bearing substrate to form a second resist film, patternwise exposure, PEB, and development to form a second resist pattern.

The invention discloses a chiral tridentate PNN ligand and application of the same in asymmetric hydrogenation and similar reactions. The tridentate nitrogen phosphine ligand disclosed in the invention has been the first reported nitrogen phosphine ligand containing chiral oxazoline so far and has been successfully applied to high-efficiency and high-selectivity hydrogenation and similar reactions of ketone and imine salts. Compared with other ligand, the ligand provided by the invention is simpler in synthetic route, higher in yield and environment-friendlier; moreover, the metal complex of the ligand shows better selectivity and a higher turn-over number in asymmetric hydrogenation. An iridium complex of the chiral tridentate PNN ligand has successfully realized asymmetric reduction of beta-ketone ester into beta-alcohol ester (which is a raw material for synthesis of molecular drugs duloxetine and atomoxetine), asymmetric hydrogenation of alpha-hydroxyacetophenone into alpha-hydroxyphenylethyl alcohol and asymmetric hydrogenation of acetophenone into phenylethyl alcohol, which is of important significance to production of the medical industry.

The invention discloses a preparation method and an application for phosphine-oxazoline ligand, and ionic metal complex, enantiomer or racemate thereof. The ligand and the ionic metal complex thereof have the following structural formulas. The phosphine ligand related by the invention employs biphenyl as a skeleton, and realizes completely transmission from planar chirality to axial chirality through an asymmetric desymmerization. The synthetic method is simple and economic, omits a common and complex chiral separation process in the preparation of the chiral ligand. The obtained chiral ligand has the advantages of high reactive activity, good enantiomorphous selectivity and the like in a model reaction.

The present invention is use of chiral oxazolinyl. The complex comprising 1-[2-(4S)-4-R-4.5-dihydro-2- oxazolinyl-ethyl]piperidine or 1-[2-(4S)-4-isopropyl-4.5- dihydro-2-oxazolinyl-ethyl] tetrahydropyrrole, and the chloride or diethylate of bivalent metal Zn, Cu, La or Sm is used as the chiral catalyst for the addition reaction between aromatic aldehyde, substituted aromatic aldehyde or butyl aldehyde and cyanide or nitrile to prepare chiral target product. In the addition reaction of para aromatic aldehyde, R-form as main target product may be obtained in the conversion rate higher than 80 %, and ee % greater than 97 %; and in other addition reaction, S-form as main target product may be obtained in the conversion rate higher than 80 %, and ee % greater than 99 %.

A catalyst of chiral bis-oxazolinylpyridine is provided, which comprises two parts including a 4-z-2, 6-bis [4'(s)-R oxazoline-2'-] pyridine as the chiral ligand of the bis-oxazolinylpyridine, and a Scandate, Yttrium and Lanthanide metal salt. The preparation method is to mix the metal salt, the ligand of bis-oxazolinylpyridin with the equal molar quantity, and a 4-molecular sieve together, the mixture is added with the needed solvent, and then stirred under the temperature of -78 to 25 DEG C to obtain the catalyst prepared in situ. The usual dosage of the catalyst used for catalyzing Diels-Alder reaction is 1percent to 5percent of the dosage of the substrate. The catalyst can catalyze Diels-Alder reaction of both alpha, beta-unsaturated N-acetyl oxazolidone and alpha, beta-unsaturated ester with high efficiency in high selectivity. Under condition of the normal pressure with the temperature of 0 to 25 DEG C, the catalyst can accomplish the conversion rate as high as 100 percent and the enantiomeric selectivity of 96 percent.

The invention discloses a synthetic compound comprising iminopyridyl oxazoline, a preparation method thereof, a metal complex of the compound and application of a prochiral organic compound which contains at least one carbon/carbon or carbon/heteroatomic double bond in hydroboration. According to the compound, the total yield of two steps of a high-efficiency synthetic route can reach 50%, and the metal complex is an excellent catalyst or a catalyst precursor which is used for asymmetric synthesis (such as asymmetric hydrogenation of prochiral, unsaturated and organic compounds). The invention also provides application of the metal complex as a homogeneous catalyst. The catalyst is used for preparing a chiral organic compound by being subjected to the hydroboration and hydrosilation asymmetric addition on the carbon or carbon heteroatomic double bond of the prochiral organic compound, and an ee value can be more than 90%.

A polymer is prepared from monomers containing at least one carbon to carbon double bond and at least one siloxane moiety and from monomers containing at least one carbon to carbon double bond and at least one moiety that imparts reactivity to the resulting polymer. Siloxane moieties impart permeability; reactivity is obtained from monomers containing epoxy, oxetane, oxazoline, benzoxazine, or episulfide functionality. Additional properties can be added to the polymer by the inclusion in the initial polymerization mix of monomers that impart low glass transition temperature, high glass transition temperature, and adhesion. The level of each functionality can be controlled by the practitioner by varying the amount of monomer containing that functionality added to the initial polymerization. These materials can be B-staged.