13 results about "Polymersome" patented technology

The present invention relates to nanoparticles or microparticles for binding to cell surfaces, said nanoparticles or microparticles comprising (i) a plurality of different ligand species on their outer surface capable of binding to different receptor species on the cell surface, and (ii) polymer brushes on their outer surface. The present invention further relates to pharmaceutical compositions comprising a plurality of nanoparticles or microparticles of the invention, medical uses of such nanoparticles or microparticles, and vaccines comprising such nanoparticles or microparticles.

Described herein are compositions that are suitable for use in analyte sensing in biological samples and in medical diagnostics. The compositions include an oxidase capable of oxidizing the analyte of interest to produce hydrogen peroxide, a peroxidase, and a chemical compound, such as a near-infrared fluorescent compound, that is a substrate for the peroxidase. The oxidase, the peroxidase, and the chemical compound are encapsulated by vesicle that includes a lipid or polymeric bilayer, such as liposome and polymersome. The peroxidase catalyzes the oxidation of the chemical compound by hydrogen peroxide. Methods of analyte sensing in biological samples using these compositions, and methods of preparing the compositions are also described.

The present invention relates to a composition comprising a composition comprising a liposome and / or a polymersome, wherein the liposome and / or the polymersome enclose an enzyme capable of degrading ethanol, wherein the enzyme capable of degrading ethanol is assisted (in the breakdown of ethanol) by a co-factor capable of diffusing through the cell-membrane of the liposome and / or the polymersome.

The present disclosure relates to a copolymer and a polymersome for targeted delivery of biomolecules to a living organism. The exemplary copolymer comprises an initiator block, a propagator block, and a linkage connecting the initiator block and the propagator block. The initiator block comprises a glycan head configured to provide a targeted delivery, and the propagator block comprises a functional moiety configured to provide desired properties for the polymersome.

The application discloses a method for accelerating bio-orthogonal catalysis in situ of tumors by using acid / reduction-sensitive polymer vesicles, and the method comprises the following steps: introducing hydrophilic / hydrophobic precursors and Cu 2+ into the polymer vesicles, and then injecting the polymer vesicles into the body of a patient. The polymer vesicles are separated into an inner aqueous phase, a hydrophobic layer and a hydrophilic surface, so that side reactions and early reactions between the precursors and the divalent copper can be effectively avoided. The polymer vesicles are composed of linear copolymers of hyaluronic acid-bisulfur bond-poly-caprolactone with specific molecular weights, and the structure of the polymer vesicles is stable under normal physiological environment; under the acid / reduction environment in tumor cells, the membrane of the vesicles is degraded to cause perforation, so that the hydrophilic precursors are preferentially released from the inner aqueous phase to the outside of the membrane, chelate with the Cu + on the surface layer, and stabilize the structure of the Cu + and shorten the distance between the azide group and the catalytic center, so as to improve the catalytic efficiency. The co-delivery of the three substances (Azide, Alkyne and Cu 2+ ) and the improved catalytic efficiency after the chelation of the precursors and copper significantly reduce the dosage of intravenous injection, so that the nano-vesicle therapy has high efficiency and biological safety.

The present invention relates to polymersomes comprising copolymers of poly(ethylene glycol) (PEG) and poly(lactic acid) (PLA) or poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) and PLA which have both enhanced stability and a narrow polydispersity. Specifically, the present invention is directed to polymersomes comprising PEG-PLA or POEGMA-PLA copolymers in which the PEG block has a weight-average molecular weight of from 1,500 to 2,500 Da or the POEGMA block has a weight-average molecular weight of from 1,500 to 5,000 Da (preferably from 1,500 to 3,000 Da), and the PLA block has a weight-average molecular weight of from 7,500 to 14,000 Da, and the polydispersity index of the polymersome is less than 0.15 as measured by dynamic light scattering. The present invention further relates to a specific solvent injection method for preparing such polymersomes, which imparts low polydispersity on the polymersomes. Specifically, this method comprises dissolving the PEG-PLA or POEGMA-PLA copolymers in an organic solvent having a polarity index of greater than 5.0 and then adding the resulting organic polymer solution to an aqueous solvent. The present invention is further directed to pharmaceutical compositions comprising such polymersomes, to uses of such polymersomes and pharmaceutical compositions in medicine, and to vaccines comprising such polymersomes.

The present invention relates to a composition comprising a composition comprising a liposome and / or a polymersome, wherein the liposome and / or the polymersome enclose an enzyme capable of degrading ethanol, wherein the enzyme capable of degrading ethanol is assisted (in the breakdown of ethanol) by a co-factor capable of diffusing through the cell-membrane of the liposome and / or the polymersome.

The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS / PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.

The present invention relates to polymersomes which have enhanced stability, and copolymer materials that are suitable for making such polymersomes. The polymersomes comprise a particular type of triblock copolymer which, under typical in vivo physiological conditions, is resistant to hydrolysis and which therefore allows the polymersomes to maintain a constant electrostatic potential (zeta potential) for a longer period of time. This allows for improved targeting of polymersomes to their site of action in vivo. Specifically, the present invention is directed to a triblock copolymer comprising a hydrophilic block, a linker moiety and a hydrophobic block, wherein the rate of hydrolysis of the linker moiety is lower under typical in vivo physiological conditions that the rate of hydrolysis of the hydrophobic block. The present invention is further directed to polymersomes comprising such a triblock copolymer, as well as pharmaceutical compositions comprising a plurality of such polymersomes and one or more pharmaceutically acceptable excipients or diluents. The present invention is further directed to uses of such polymersomes and pharmaceutical compositions in medicine, and to vaccines comprising such polymersomes.

Methotrexate-containing polymersomes and methods for treating ectopic pregnancy or for treating gestational choriocarcinoma using the methotrexate-containing polymersomes.

The present application relates to pH-sensitive polymersomes. The polymersomes are capable of degradation at endosomes' mild acidic pH into resorbable materials, which also allows avoiding liposome premature degradation of the payload once internalised inside the cells. The polymersomes can thus be used in methods for the treatment or prevention of diseases.

The present disclosure relates to copolymers and polymersomes for targeted delivery of biomolecules to living organisms. Exemplary copolymers include an initiator block, a propagator block, and a linker connecting the initiator block and the propagator block. The initiator block includes a glycan head configured to provide targeted delivery, and the propagator block includes a functional moiety configured to provide desired properties to the polymersome.

The present invention relates to polymersomes comprising a soluble encapsulated antigen, wherein said soluble encapsulated antigen is a polynucleotide selected from a DNA molecule or a mRNA molecule, and wherein the polymersome further comprises an ionizable lipid.