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60 results about "Polymersome" patented technology
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In biotechnology, polymersomes are a class of artificial vesicles, tiny hollow spheres that enclose a solution. Polymersomes are made using amphiphilic synthetic block copolymers to form the vesicle membrane, and have radii ranging from 50 nm to 5 µm or more. Most reported polymersomes contain an aqueous solution in their core and are useful for encapsulating and protecting sensitive molecules, such as drugs, enzymes, other proteins and peptides, and DNA and RNA fragments. The polymersome membrane provides a physical barrier that isolates the encapsulated material from external materials, such as those found in biological systems.
Polymersomes incorporating highly emissive probes
The instant invention concerns compositions comprising polymersomes, visible or near infrared emissive agents, and optionally a targeting moiety associated with a surface of the polymersome. The invention also relates to use of these compositions in the treatment of disease and in imaging methodology.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Polymersome compositions and associated methods of use
The present invention relates to methods and compositions for treating subterranean formations. More particularly, the present invention relates to polymersomes, viscosifying agents that comprise polymersomes, and associated methods of use. In some embodiments, the present invention discloses methods of treating a section of a subterranean formation that comprises the steps of providing a viscosified treatment fluid that comprises an aqueous-based component, and a viscosifying agent that comprises a polymersome; and treating the section of the subterranean formation. In other embodiments, the present invention discloses methods of viscosifying a treatment fluid, suspending particulates in a treatment fluid, fracturing a subterranean formation, providing sand control in a section of a subterranean formation, and encapsulating treatment fluid additives. In yet other embodiments, the present invention discloses viscosified treatment fluids, fracturing fluids, gravel pack fluids, polymersomes, and encapsulated treatment fluid additives.
Owner:PRINCETON UNIV +1
Polymersomes and related encapsulating membranes
InactiveUS7217427B2Easy to measureMaintaining semi-permeabilityUltrasonic/sonic/infrasonic diagnosticsBiocideAqueous solutionMembrane configuration
Owner:RGT UNIV OF MINNESOTA
Polymersomes and related encapsulating membranes
InactiveUS20050048110A1Easy to measureUltrasonic/sonic/infrasonic diagnosticsPowder deliveryAqueous solutionStructural unit
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.
Owner:RGT UNIV OF MINNESOTA
Polymersomes and related encapsulating membranes
InactiveUS20080181939A1Easy to measureBiocideCarbohydrate active ingredientsExocytic vesiclePolyethylene oxide
Provided are methods for preparing and delivering stable, purely synthetic, self-assembling, controlled release, polyethylene oxide (PEO)-based polymersome vesicles, and the resulting PEO-based polymersomes capable of such controlled release, and methods of use therefor for the controlled transport and delivery of encapsulatable, cytotoxic, anticancer active agents contained therein. Further provided are methods for controlling destabilization of the vesicle membrane and the resulting hydrolysis-triggered, controlled release of active agent(s) encapsulated in the vesicle by controlling the blend ratio (mol %) of hydrolysable PEO-block copolymer of the hydrophilic component(s) and of the more hydrophobic PEO-block copolymer component(s) to produce amphiphilic high molecular weight PEO-based polymersomes, wherein the PEO volume fraction (fEO) and chain chemistry control encapsulant release kinetics from the copolymer vesicles and the polymersome carrier membrane destabilization.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Polymersome compositions and associated methods of use
The present invention relates to methods and compositions for treating subterranean formations. More particularly, the present invention relates to polymersomes, viscosifying agents that comprise polymersomes, and associated methods of use. In some embodiments, the present invention discloses methods of treating a section of a subterranean formation that comprises the steps of providing a viscosified treatment fluid that comprises an aqueous-based component, and a viscosifying agent that comprises a polymersome; and treating the section of the subterranean formation. In other embodiments, the present invention discloses methods of viscosifying a treatment fluid, suspending particulates in a treatment fluid, fracturing a subterranean formation, providing sand control in a section of a subterranean formation, and encapsulating treatment fluid additives. In yet other embodiments, the present invention discloses viscosified treatment fluids, fracturing fluids, gravel pack fluids, polymersomes, and encapsulated treatment fluid additives.
Owner:PRINCETON UNIV +1
Polymersomes incorporating highly emissive probes
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Amphipathic block polymer, polymersome, and preparation method and application of polymersome
ActiveCN103588940AStimulus Modulation of Biocatalytic ActivityPharmaceutical non-active ingredientsOn/in organic carrierPolymer sciencePolyethylene glycol
The invention relates to an amphipathic block polymer, a polymersome consisting of the amphipathic block polymer, and a preparation method and application of the polymersome. More specifically, the amphipathic block polymer is obtained from a hydrophilic chain segment and a hydrophobic chain segment by a reversible addition-fragmentation chain transfer (RAFT) polymerization method, wherein the hydrophilic chain segment is polyethylene glycol with the terminal group modified by tri-thioester and the molecular weight of the hydrophilic chain segment is 1,000 to 20,000 Da; the constitution of the hydrophobic chain segment is as shown in the following formula, m is equal to 1 to 11 and n is equal to 1 to 11. By adoption of the amphipathic block polymer, controllable and synchronous release of polymersome-loaded hydrophilic and hydrophobic molecules is realized, and the biological catalytic activity of a polymersome-loaded enzyme reactor is regulated and controlled through stimulation. In addition, in the processing of triggering crosslinking by stimulation, the permeability of a sieve-shaped hydrophilic channel generated in a double-layer membrane of the polymersome and the membrane can be controlled by the duration time of stimulation.
Owner:UNIV OF SCI & TECH OF CHINA
Chelating amphiphilic polymers
Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 / T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
Reversibly crosslinked biodegradable polymersome with asymmetric membrane structure as well as preparation method and application thereof to nucleic acid medicines
ActiveCN106177975AImprove loading performanceAvoid stabilityOrganic active ingredientsGenetic material ingredientsCancer cellSide effect
The invention discloses a reversibly crosslinked biodegradable polymersome with an asymmetric membrane structure as well as a preparation method and application thereof to nucleic acid medicines. The polymersome and the preparation method have the advantages that a triblock polymer PEG-P(TMC-DTC)-PEI or PEG-P(DLLA-DTC)-PEI is synthesized and is self-assembled and self-crosslinked to obtain the polymersome with the asymmetric membrane structure or the triblock polymer is linked with a targeting molecule and is self-assembled to obtain targeting RCCPs; the inner shell of the polymersome is PEI and is used for compounding and loading nucleic acid through electrostatic interaction; a membrane is reversibly crosslinked biodegradable polyester / polycarbonate with good biocompatibility; dithiolane of a side chain is similar to a human body natural antioxidant lipoic acid; the outer shell of the polymersome takes PEG as the background and can target cancer cells; by studying that the carrier is compounded with functional siRNA and studying the gene silencing effects in vitro and vivo, in vivo blood circulation and bio-distribution, the condition of treating lung cancer in situ bearing mice and toxic and side effects of the polymersome, the polymersome is expected to become a nanosystem platform integrating the advantages of simplicity, stability, multifunction, and the like and is used for carrying out efficient and active targeting delivery on siRNA to tumors in situ.
Owner:SUZHOU UNIV
Polymer vesicles for selective electromagnetic energy-induced delivery
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
DCs vaccine based on phospholipid hybrid polymersome jointly encapsulating antigen and dual immunoagonists and preparation method and application thereof
ActiveCN108938568AMaximize Targeting EffectAchieving ImmunotherapyCancer antigen ingredientsPharmaceutical non-active ingredientsT lymphocyteBiological activation
The invention relates to a DCs vaccine based on phospholipid hybrid polymersome jointly encapsulating an antigen and dual immunoagonists, a preparation method and application thereof. The phospholipidhybrid polymersome which can jointly load a model antigen OVA and two types of TLR agonists (TLR7 / 8 and TLR4) is used for stimulation in vitro of the DCs so as to realize the effective phagocytosis of DCs cells. The rapid and long-term immunostimulatory effect on the DCs is achieved by the internal and external co-loading of the OVA antigen. The synergistic effect of the two types of TLR agonistssignificantly enhances the immune response after antigen stimulation; the phospholipid hybrid polymersome which jointly encapsulates the antigen and the dual immunoagonists can effectively promote the activation and maturation of the DCs, increases the level of cross-presentation, promotes the migration of the DC vaccine to secondary lymphoid organs, and produces a strong specific cytotoxic T lymphocytes (CTLs) killing effect, thereby effectively killing tumor cells and realizing the immunotherapy of the DCs vaccine on tumors.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Copolymers
The invention provides a block copolypeptide comprising a hydrophilic heteropolypeptide block (A) and a hydrophobic homopolypeptide block (B). There is also provided a polymersome comprising a block copolypeptide of the invention. The invention further provides a method for preparing a copolymer comprising ring-opening polymerisation (ROP) of an amino acid N-carboxyanhydride (NCA) initiated from a peptide.
Owner:LEIDEN UNIVERSITY
Polymeric drug carrier for image-guided delivery
InactiveCN101888857AHigh strengthHigh fluorescence intensityDispersion deliveryEmulsion deliveryDrug releaseCest mri
Described are Chemical Exchange-dependent Saturation Transfer (CEST) contrast agents for Magnetic Resonance Imaging (MRI) comprising a polymersome provided with a paramagnetic agent. The polymersome preferably comprises a polymeric shell enclosing a cavity, wherein the cavity comprises a pool of proton analytes, and wherein the shell allows diffusion of the proton analytes. The polymersome-based CEST MRI contrast agents are suitable as drug carriers useful in MRI-guided drug release.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
Cosmetic composition for improving skin elasticity
ActiveCN103079541AImprove wrinklesIncrease elasticityCosmetic preparationsToilet preparationsWrinkly skinPhyllanthus urinaria
A cosmetic composition for improving skin elasticity is provided which contains an active ingredient in the form of a polymersome in which Phyllanthus urinaria extract and an anti-ageing peptide have been stabilised on the inside. The cosmetic composition of the present invention is efficacious in improving skin wrinkles, restoring skin elasticity and increasing the skin water content, and is effective in improving skin elasticity.
Owner:AMOREPACIFIC CORP
Efficient Nuclear Delivery of Antisense Oligonucleotides or siRNA In Vitro and In Vivo by Nano-Transforming Polymersomes
InactiveUS20100255112A1Effective therapyOrganic active ingredientsSpecial deliveryDiseasePolyethylene oxide
Provided is a biocompatible polyethylene oxide (PEO)-based polymersome system for the delivery of oligonucleotides, including antisense RNA, siRNA and RNAi, to a cell or tissue target, and method of use therefore, wherein the method comprises encapsulating the oligonucleotide in a biodegradable neutral, nano-transforming polymersome delivery vehicle and delivering the encapsulated oligonucleotide to the cell or tissue target in vitro or in vivo, particularly for treating a disease, such cancer or cellular hyperproliferation. The degradable polymersome, and the oligonucleotides stably encapsulated therein are taken up passively by cells and delivered into endolysosomes, wherein the polymersomes decompose at a known rate at a known pH, thereby releasing encapsulated oligonucleotides in a controlled manner within the cell and facilitating delivery of antisense oligonucleotide or siRNA or RNAi into the nucleus of the cell target.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Chelating amphiphilic polymers
Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 / T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
Application of reduction response polymersome nano-drug in preparation of brain tumor treatment drugs
ActiveCN107998082AHigh drug loading efficiencyImprove in vitro stabilityOrganic active ingredientsMacromolecular non-active ingredientsIn vivoGlioma cell
The invention discloses application of a reduction response polymersome nano-drug in preparation of brain tumor treatment drugs. Block copolymers PEG-P(TMC-DTC), PEG-P(LA-DTC), PEG-P(TMC-DTC)-PEI, PEG-P(LA-DTC)-PEI, PEG-P(TMC-DTC)-Sp, PEG-P(LA-DTC)-Sp and targeted polymers thereof are combined in different ratios, and dual-targeted reduction-sensitive reversible crosslinked vesicles of different targeted molecular proportions can be prepared. Through the hydrogen-bond interaction or other electrostatic interaction between great hydrophilic inner cavities of the crosslinked vesicles and / or PEI-spermine and protein drugs or gene drugs, efficient encapsulation of micromolecular chemotherapeutic drugs, the protein drugs and the gene drugs can be achieved. By means of the in-vivo dual-targeteddrug-carrying crosslinked vesicles, more efficient blood brain barrier crossing, higher tissue penetration depth and endocytosis of more glioma cells can be achieved, and the reduction response polymersome nano-drug is very potential in treating brain gliomas and efficient.
Owner:SUZHOU UNIV
Method of painting microvesicles
InactiveUS20150233800A1Sufficient reactionReduce the amount requiredMicrobiological testing/measurementPreparing sample for investigationMicrobubblesMembrane anchor
The present invention relates to a method to modify and / or to isolate exosomes and other naturally occurring plasma membrane derived microvesicles, by incubation with a reactant, consisting of at least a membrane anchor domain or moiety and a hydrophilic functional domain or moiety. The invention also relates to modification using the same of artificially-prepared lipid bilayer vesicles called liposomes (composed of natural phospholipids) and non-biological or “synthetic” block copolymer membrane mimics which also form vesicles in aqueous solution called polymersomes..
Owner:VIN DE BONA TRADING CO
Polymersome with hydrophilic lumen carrying anthracene ring medicines as well as preparation method and application
InactiveCN104771382AHydrophilicFlexibleOrganic active ingredientsAntineoplastic agentsRotary evaporatorEvaporation
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Method for eliciting an immune response to an immunogen
ActiveCN104936579AEnhance immune responseExtend cycle timeSsRNA viruses negative-senseViral antigen ingredientsPolymersomeImmunogen
Owner:AGENCY FOR SCI TECH & RES
Polymersomes And Production Method Thereof
It is an object of the invention to provide a polymersome excellent in the safety and feeling in use; in particular, there is no sticky feeling but there is a good refreshing feeling; and with excellent base-agent stability. A polymersome of the present invention comprises a block-type alkylene oxide derivative represented by the following formula (I) as the membrane component:R1O-[(EO)I(AO)m(EO)n]-R2 (I)wherein AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, m and 1+n are the average addition mole numbers for the oxyalkylene group and the oxyethylene group, respectively, and 1≦m≦70, 1≦1+n≦70; the percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 80 mass %; the addition pattern of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is block-type; and R1 and R2 are identical or different hydrocarbon groups having 1 to 4 carbon atoms.
Owner:SHISEIDO CO LTD
Self-assembled particles for targeted delivery of immunomudulators to treat autoimmunity and cancer
ActiveUS20200078300A1Good curative effectHigh activityEmulsion deliveryImmunological disordersEngineeringAutoimmunity
The present invention provides for delivery of therapeutic drug in a polymeric delivery system comprising a PEG-bl-PPS di-block polymer formed in a micelle, filomicelle, or polymersome structure, wherein the structure effectively binds and / or interacts through shape-based targeting with a targeted cell type.
Owner:NORTHWESTERN UNIV +1
Nanoparticle- and Drug-Containing Polymersomes for Medical Applications
Provided are polymersomes for co-delivery of hydrophobic metallic nanoparticles and pharmaceutical agents and suspensions of such polymersomes. Also provided are methods of making such polymersomes and suspensions of polymersome and methods of using the same to treat diseases or conditions.
Owner:NORTHEASTERN UNIV
Preparation method and application of a polymer vesicle with sugar sponge function
ActiveCN105037755BImprove stabilityFixed shapeSurgeryBlood vessel filtersMANNITOL/SORBITOLConcanavalin A assay
The present invention relates to a polymer vesicle with the function of sugar sponge and its preparation method and application. Concanavalin on the above; its preparation method is: at first synthesizing the amphiphilic sugar-based polymer with at least initiator and polymerized monomer, then making the amphiphilic sugar-based polymer assemble into polymer vesicles, and finally Concanavalin is combined with polymer vesicles to form sugar-responsive polymer vesicles; the sugar-responsive polymer vesicles of the present invention can respond to changes in the concentration of glucose or mannose in the external environment and are not affected by the pH value. It has good stability and can be used as a buffer for glucose or mannose or a non-drug buffer for treating diabetes.
Owner:TONGJI UNIV
Polymersome with dual response to ultrasound and pH and method for preparing same
ActiveCN102977293BOptimal Control StructureEasy to operateEnergy modified materialsPharmaceutical non-active ingredientsDual responseDrug carrier
Owner:TONGJI UNIV
Polymer vesicles for selective electromagnetic energy-induced delivery
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Polymersomes and production method thereof
ActiveUS8603533B2Good effectFeel goodCosmetic preparationsPowder deliveryPolymer sciencePerylene derivatives
It is an object of the invention to provide a polymersome excellent in the safety and feeling in use; in particular, there is no sticky feeling but there is a good refreshing feeling; and with excellent base-agent stability. A polymersome of the present invention comprises a block-type alkylene oxide derivative represented by the following formula (I) as the membrane component:R1O-[(EO)l(AO)m(EO)n]—R2 (I)wherein AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, m and 1+n are the average addition mole numbers for the oxyalkylene group and the oxyethylene group, respectively, and 1≦m≦70, 1≦l+n≦70; the percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 80 mass %; the addition pattern of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is block-type; and R1 and R2 are identical or different hydrocarbon groups having 1 to 4 carbon atoms.
Owner:SHISEIDO CO LTD
Nanoparticle- and Drug-Containing Polymersomes for Medical Applications
InactiveUS20170181971A1Heavy metal active ingredientsAluminium/calcium/magnesium active ingredientsDiseaseNanoparticle
Owner:NORTHEASTERN UNIV
Transmembrane ph-gradient polymersomes for the quantification of ammonia in body fluids
ActiveUS20200283583A1High selectivityReduce needDisease diagnosisPharmaceutical non-active ingredientsPolymer sciencePolyethylene oxide
The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS / PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.
Owner:ETH ZZURICH
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