A
system and method of use includes (a) directing a magnetic
resonance (MR)
system to perform a pulse sequences block in which
radio frequency (RF) energy is applied to the subject to substantially saturate
magnetization corresponding to an exchangeable
proton. The method includes (b), following step (a), acquiring data from the subject with the MR
system and (c) repeating step (a) a plurality of times where parameters of the
pulse sequence sub-block differ in at least some
pulse sequence sub-blocks by at least an amount of RF energy applied to saturate the
magnetization. The method further includes (d), after each repetition of step (a), repeating step (b) to acquire data representing
signal evolutions from the subject. Additionally, the method includes (e) comparing the
signal evolutions with a dictionary
database comprising a plurality of different
signal evolution templates to determine quantitative
chemical exchange or exchangeable
proton information of the subject.