9 results about "Saturation transfer" patented technology

The invention provides a respiratory-gating-free free-breathing liver glycogen quantitative magnetic resonance imaging method and system, and the method comprises the steps: applying a chemical exchange saturation transfer imaging sequence to a liver region of a subject, and the imaging sequence comprises saturation pulses of a plurality of saturation frequency deviation points; a radial blade type k-space acquisition strategy is adopted to acquire magnetic resonance signal data, the radial blade type k-space acquisition strategy comprises a plurality of blades, each blade is composed of a group of parallel k-space lines, and different blades are rotationally distributed by taking the k-space center as a rotating shaft; performing image reconstruction on the acquired k space data to obtain magnetic resonance images under different saturation frequency deviations; and performing fitting analysis on the magnetic resonance image by adopting a multi-pool Lorentz model to obtain quantitative information of the liver glycogen. According to the method, the interference of respiratory movement on the CESTMRI data acquisition process can be eliminated, so that the accurate quantification of the liver glycogen in the free respiration state is realized.

The invention is suitable for the technical field of magnetic resonance chemical exchange saturation transfer imaging, and provides a magnetic resonance chemical exchange saturation transfer imaging method, device, equipment, product and storage medium. A gradient echo sequence is adopted to collect saturated water molecule signals, and the collected water molecule signals are stored in a K space; and wave control coding is introduced in the acquisition process, and a CEST image is reconstructed based on a water molecule signal of a K space. The introduction of wave control coding can reduce the scanning time. Due to the fact that the wave control coding sampling efficiency is high, a larger matrix size can be supported within the same time, high-resolution imaging is achieved, the partial volume effect can be relieved, and CEST quantitative accuracy is improved.

This application discloses a magnetic resonance chemical exchange saturation transfer imaging method, system, device, and storage medium. The method includes: applying a radio frequency saturation pulse for a first preset time to a region to be detected; applying a radio frequency echo pulse to the region to be detected and acquiring several gradient echo signals generated after activation by the radio frequency echo pulse; and using radial sampling to read the gradient echo signals along a preset direction to generate a magnetic resonance image. Through this method, this application effectively shortens the signal acquisition time by using gradient echo readings, effectively suppresses motion artifacts by using radial acquisition, and applies post-processing methods such as fitting to the acquired chemical exchange saturation transfer imaging spectral data to achieve water-lipid signal separation and extract and analyze the target signal.

The application discloses a flexible echo time water-fat separation method and system based on a main magnetic field map (B0map) and equipment, and belongs to the technical field of magnetic resonance imaging. The application combines a B0map which needs to be collected in chemical exchange saturation transfer (CEST) imaging, and proposes a new seed point selection and seed point error phase determination method. The seed point error phase determined by the method can grow a relatively accurate error vector map in space, thereby ensuring the final water-fat accurate separation. In the embodiment of the application, the proposed method is verified on a water model and pork, and ideal water-fat separation results are obtained.

An evaluation method is performed by an arithmetic circuit and includes obtainment processing (S1), evaluation processing (S2), and presentation processing (S3). The obtainment processing (S1) obtains: image information on a sectional image representing an interested section of an organism including a target section of a testis of the organism generated by use of magnetic resonance of hydrogen atoms; and concentration information on a creatine concentration in the interested section measured by use of magnetic resonance based on chemical exchange saturation transfer. The evaluation processing (S2) generates an evaluation image representing a distribution of evaluation results of a testicular function in the target section based on the concentration information. The presentation processing (S3) presents the sectional image and the evaluation image.

The invention relates to a temperature measurement method and device based on phosphocreatine chemical exchange saturation transfer imaging. The method comprises the following steps: (1) carrying out chemical exchange saturation transfer imaging on creatine phosphate phantom at different temperatures, and calculating apparent chemical shift of creatine phosphate in the creatine phosphate phantom at different temperatures; (2) fitting the mathematical relationship between the apparent chemical shift of the creatine phosphate and the temperature of the creatine phosphate phantom; and (3) carrying out in-vivo phosphocreatine chemical exchange saturation transfer imaging on the individual to be detected, calculating the apparent chemical shift of phosphocreatine in the individual to be detected, and generating a temperature map of the biological tissue of the individual to be detected according to the mathematical relationship. The absolute temperature imaging technology based on the CEST effect of endogenous phosphocreatine and the temperature dependence of the endogenous phosphocreatine is developed, and the method has the advantages of being high in spatial resolution, high in sensitivity, non-invasive, capable of being repeated for multiple times and the like, and has good clinical conversion application and popularization prospects.

The invention discloses a method and a system for detecting BPA based on CEST. The method comprises the following steps: acquiring an improved continuous wave-planar echo chemical exchange saturation transfer sequence; scanning the test tube model of the BPA according to the improved continuous wave-planar echo chemical exchange saturation transfer sequence, and collecting chemical exchange saturation transfer data; and analyzing the signal intensity and distribution of the BPA according to the chemical exchange saturation transfer data. In view of the fact that most human tumor microenvironments are weakly acidic or acidic, a boron drug BPA signal is difficult to directly detect by a conventional method. Meanwhile, compared with a PET method, radioactive element labeling does not need to be introduced, and efficient and accurate quantitative detection and visual expression of BPA can be achieved. The method has the advantages of being simple and convenient to operate, noninvasive, high in sensitivity and specificity and the like, and a new strategy is provided for establishment of a precise boron drug concentration measurement system.

The application provides a motion self-correcting kidney chemical exchange saturation transfer imaging method and system, belongs to the CEST imaging technical field, and the imaging method comprises the following steps: collecting an original image, dividing a respiratory state, reconstructing an image, image registration and fusion, data post-processing and signal quantification, and the imaging system comprises various modules for realizing the imaging method; through CEST sequence design of 112.5° radial sampling, k-space reading of fast field echo (TFE) is utilized, the signal of 0.1-0.5 Hz at the center of k-line is extracted as a respiratory signal, the respiratory state is divided by using the respiratory signal and k-space data is split, the images corresponding to different respiratory states are reconstructed, finally, the final CEST-MRI image is obtained through image registration and average fusion of the images of different respiratory states, the signal-to-noise ratio, saturation efficiency and signal accuracy are ensured, and the problem that the respiratory motion influences CEST signal quantification when chemical exchange saturation transfer imaging (CEST-MRI) of the kidney is performed under free breathing is solved.

The application discloses a chemical exchange saturation transfer image anomaly detection method, comprising the following steps: pre-processing CEST data obtained through scanning to obtain a spectrum data set of all pixels, and finally dividing the spectrum data into a training set and a test set; constructing a self-encoder model Mamba-AE based on a Mamba network; constructing a joint loss function of a feature space and a data space, which is used for Mamba-AE training; inputting the training set into the Mamba-AE and training the Mamba-AE by using the joint loss function; constructing an anomaly score calculation mechanism, which is used for judging the possibility of the pixel belonging to a lesion; inputting the divided test set into the trained Mamba-AE, outputting an anomaly score based on the anomaly score calculation mechanism pixel by pixel, returning all anomaly scores to each corresponding pixel, and forming an anomaly image as a lesion detection result.