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Method for using CEST contrast agents in MRI

A contrast agent, entity technology, applied in the direction of using magnetic variable measurement, using nuclear magnetic resonance imaging system for measurement, magnetic resonance measurement, etc. CEST effect optimization, elimination of concentration-dependent effects

Inactive Publication Date: 2008-04-23
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Finally, since the concentration of exchangeable protons is not maximal, having two different pools of exchangeable protons always results in a non-optimal maximal CEST effect, since they have to be distributed between the two pools

Method used

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  • Method for using CEST contrast agents in MRI
  • Method for using CEST contrast agents in MRI
  • Method for using CEST contrast agents in MRI

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Embodiment Construction

[0086] The present invention has been described with respect to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. Any reference signs in the claims should not be construed as limiting the scope. The drawings described are only schematic and not restrictive. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes. The term "comprising" used in the present description and claims does not exclude other elements or steps. When using indefinite and definite articles such as "a" or "an," "the" to refer to a singular noun, a plural of that noun is included unless expressly stated otherwise.

[0087] Furthermore, the terms first, second, third and similar terms in the present specification and in the claims are used to distinguish similar elements and not necessarily used to describe a front-rear or chronological order. It is to be understood th...

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Abstract

The invention relates to a method for mapping of a physico-chemical parameter such as pH value, temperature, PO2 or metabolite concentration, using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging. This method may be used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.

Description

technical field [0001] The present invention relates to magnetic resonance imaging. More specifically, the present invention relates to methods of using contrast agents in magnetic resonance imaging (MRI). Background technique [0002] In the medical field, magnetic resonance imaging (MRI) is an important imaging technique and one of the main vehicles for molecular imaging. Images are obtained by applying strong magnetic fields, magnetic field gradients, and frequency-matched (RF) pulses to the patient. During the imaging process, atomic nuclei in the body are excited by RF irradiation, the nuclei have magnetic moments, which are mainly protons in water and lipid molecules. When the RF pulse ceases, the excited nuclei relax and emit an RF signal. Due to the applied magnetic field gradient, the frequency of this emitted RF signal contains spatial information and can be used to construct an image. [0003] Sometimes, the difference in MRI signal intensity between different...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/28G01R33/48
CPCG01R33/5601G01R33/4804
Inventor R·T·韦J·A·皮克马特N·P·威拉德
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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