16 results about "Chemical exchange" patented technology

The embodiment of the invention provides a CEST image super-resolution reconstruction method, medium and equipment, and the method comprises the steps: obtaining an original image and a reference image of a target object, the original image being a molecular function image collected through a chemical exchange saturation transfer imaging technology, and the reference image being an anatomical structure image collected through a magnetic resonance imaging technology; through a high-frequency, intermediate-frequency and low-frequency fusion enhancement network, extraction and fusion enhancement of corresponding high-frequency, intermediate-frequency and low-frequency characteristics are carried out on an original image and a reference image. According to the method, anatomical edge details of a reference image are captured through a high-frequency fusion enhancement network to enhance image edge details, image texture features are captured through an intermediate-frequency fusion enhancement network to enhance image texture details, image background details are enhanced through a low-frequency fusion enhancement network, and then images with enhanced frequency band information are fused. A reconstructed image with high resolution and molecular function signals is obtained, and the reconstruction precision of super-resolution reconstruction is improved.

The invention provides a system for producing deuterium-rich water by combining chemical exchange and liquid ammonia rectification, which comprises an ammonia A2 storage unit, an ammonia water exchange device, a liquid ammonia rectification device and a water ammonia exchange device, and three processes of ammonia water exchange, liquid ammonia rectification and water ammonia exchange are coupled and connected in series to construct a complete hydrogen isotope (deuterium) enrichment path. According to the path, deuterium is efficiently transferred from high-boiling-point raw water to a low-boiling-point ammonia medium through ammonia water exchange, low-energy-consumption and high-magnification deuterium enrichment is achieved in an N-stage rectifying tower through liquid ammonia rectification by means of the low-boiling-point characteristic of liquid ammonia, and finally high-deuteration-degree ammonia is efficiently converted back to high-deuteration-degree deuterium-enriched water through reverse water ammonia exchange. Cooperative transmission of the material flow and the isotope flow is obviously optimized, and directional and step-by-step enrichment of deuterium in the material flow process is achieved.

The invention is suitable for the technical field of magnetic resonance chemical exchange saturation transfer imaging, and provides a magnetic resonance chemical exchange saturation transfer imaging method, device, equipment, product and storage medium. A gradient echo sequence is adopted to collect saturated water molecule signals, and the collected water molecule signals are stored in a K space; and wave control coding is introduced in the acquisition process, and a CEST image is reconstructed based on a water molecule signal of a K space. The introduction of wave control coding can reduce the scanning time. Due to the fact that the wave control coding sampling efficiency is high, a larger matrix size can be supported within the same time, high-resolution imaging is achieved, the partial volume effect can be relieved, and CEST quantitative accuracy is improved.

This application discloses a magnetic resonance chemical exchange saturation transfer imaging method, system, device, and storage medium. The method includes: applying a radio frequency saturation pulse for a first preset time to a region to be detected; applying a radio frequency echo pulse to the region to be detected and acquiring several gradient echo signals generated after activation by the radio frequency echo pulse; and using radial sampling to read the gradient echo signals along a preset direction to generate a magnetic resonance image. Through this method, this application effectively shortens the signal acquisition time by using gradient echo readings, effectively suppresses motion artifacts by using radial acquisition, and applies post-processing methods such as fitting to the acquired chemical exchange saturation transfer imaging spectral data to achieve water-lipid signal separation and extract and analyze the target signal.

The application discloses a flexible echo time water-fat separation method and system based on a main magnetic field map (B0map) and equipment, and belongs to the technical field of magnetic resonance imaging. The application combines a B0map which needs to be collected in chemical exchange saturation transfer (CEST) imaging, and proposes a new seed point selection and seed point error phase determination method. The seed point error phase determined by the method can grow a relatively accurate error vector map in space, thereby ensuring the final water-fat accurate separation. In the embodiment of the application, the proposed method is verified on a water model and pork, and ideal water-fat separation results are obtained.

The invention relates to a germanium isotope separation method, device and system. According to the germanium isotope separation method, device and / or system, the problems that in the prior art, a germanium isotope separation method is small in scale, low in production efficiency, incapable of achieving continuous production, not suitable for industrial application and the like are solved through a chemical exchange method.

An evaluation method is performed by an arithmetic circuit and includes obtainment processing (S1), evaluation processing (S2), and presentation processing (S3). The obtainment processing (S1) obtains: image information on a sectional image representing an interested section of an organism including a target section of a testis of the organism generated by use of magnetic resonance of hydrogen atoms; and concentration information on a creatine concentration in the interested section measured by use of magnetic resonance based on chemical exchange saturation transfer. The evaluation processing (S2) generates an evaluation image representing a distribution of evaluation results of a testicular function in the target section based on the concentration information. The presentation processing (S3) presents the sectional image and the evaluation image.

The invention relates to a temperature measurement method and device based on phosphocreatine chemical exchange saturation transfer imaging. The method comprises the following steps: (1) carrying out chemical exchange saturation transfer imaging on creatine phosphate phantom at different temperatures, and calculating apparent chemical shift of creatine phosphate in the creatine phosphate phantom at different temperatures; (2) fitting the mathematical relationship between the apparent chemical shift of the creatine phosphate and the temperature of the creatine phosphate phantom; and (3) carrying out in-vivo phosphocreatine chemical exchange saturation transfer imaging on the individual to be detected, calculating the apparent chemical shift of phosphocreatine in the individual to be detected, and generating a temperature map of the biological tissue of the individual to be detected according to the mathematical relationship. The absolute temperature imaging technology based on the CEST effect of endogenous phosphocreatine and the temperature dependence of the endogenous phosphocreatine is developed, and the method has the advantages of being high in spatial resolution, high in sensitivity, non-invasive, capable of being repeated for multiple times and the like, and has good clinical conversion application and popularization prospects.

The invention discloses a device and a method for separating boron isotopes through direct refrigeration and low-temperature rectification, and relates to the technical field of separation. The device comprises rectifying towers, a reboiler and a compressor, a liquid-phase material is discharged to the tower top of the next-stage rectifying tower through a tower kettle of each-stage rectifying tower, and a gas-phase material is discharged to the tower kettle of the previous-stage rectifying tower through the tower top of each-stage rectifying tower. Extra heat source heat supply and cold source cooling are not needed, a large amount of cooling capacity can be obtained with a small amount of power consumption, the power consumption is only about 1 / 10 of the cooling capacity required by rectification, a large amount of low-grade cooling capacity is recycled through a circulating working medium, energy is efficiently utilized, and the energy consumption of the device is reduced; and compared with other chemical exchange rectification methods, the design of a complexing process and a cracking process is omitted, further impurity removal treatment is not needed subsequently, and the technological process is simplified.

The invention discloses a method and a system for detecting BPA based on CEST. The method comprises the following steps: acquiring an improved continuous wave-planar echo chemical exchange saturation transfer sequence; scanning the test tube model of the BPA according to the improved continuous wave-planar echo chemical exchange saturation transfer sequence, and collecting chemical exchange saturation transfer data; and analyzing the signal intensity and distribution of the BPA according to the chemical exchange saturation transfer data. In view of the fact that most human tumor microenvironments are weakly acidic or acidic, a boron drug BPA signal is difficult to directly detect by a conventional method. Meanwhile, compared with a PET method, radioactive element labeling does not need to be introduced, and efficient and accurate quantitative detection and visual expression of BPA can be achieved. The method has the advantages of being simple and convenient to operate, noninvasive, high in sensitivity and specificity and the like, and a new strategy is provided for establishment of a precise boron drug concentration measurement system.

The application provides a motion self-correcting kidney chemical exchange saturation transfer imaging method and system, belongs to the CEST imaging technical field, and the imaging method comprises the following steps: collecting an original image, dividing a respiratory state, reconstructing an image, image registration and fusion, data post-processing and signal quantification, and the imaging system comprises various modules for realizing the imaging method; through CEST sequence design of 112.5° radial sampling, k-space reading of fast field echo (TFE) is utilized, the signal of 0.1-0.5 Hz at the center of k-line is extracted as a respiratory signal, the respiratory state is divided by using the respiratory signal and k-space data is split, the images corresponding to different respiratory states are reconstructed, finally, the final CEST-MRI image is obtained through image registration and average fusion of the images of different respiratory states, the signal-to-noise ratio, saturation efficiency and signal accuracy are ensured, and the problem that the respiratory motion influences CEST signal quantification when chemical exchange saturation transfer imaging (CEST-MRI) of the kidney is performed under free breathing is solved.

This invention belongs to the field of biomedical technology, specifically relating to a hyperpolarized... 129 Xe magnetic resonance molecular probe and its preparation method. This probe uses ZIF-8 as a template and 2-aminoimidazole as a ligand exchange component. The molecular probe is formed by the interaction of a monomer with a ligand in a methanol solution. The monomer is synthesized from 2-methylimidazole and zinc nitrate hexahydrate. 129 Xe molecular cage ZIF-8, wherein the monomer ZIF-8 is modified by post-synthetic modification with a 2-aminoimidazolium ligand. 129 Xe molecular cage, i.e., hyperpolarization 129 Xe magnetic resonance molecular probe. The principle of this molecular probe is as follows: ZIF-8 is a Zn... 2+ The metal-organic framework (MOF) formed by coordination with the N atom on the 2-methylimidazolium ring exhibits acid sensitivity and pH responsiveness. Through post-synthetic modification (PSM) of ZIF-8, ligand exchange between 2-aminoimidazolium and ZIF-8 is achieved, resulting in a novel ZIF-8-AIM molecular probe for hyperpolarization. 129 Xe chemical exchange saturation transfer will produce a new signal different from the original ZIF-8, which can be used for magnetic resonance molecular probes.

The application discloses a chemical exchange saturation transfer image anomaly detection method, comprising the following steps: pre-processing CEST data obtained through scanning to obtain a spectrum data set of all pixels, and finally dividing the spectrum data into a training set and a test set; constructing a self-encoder model Mamba-AE based on a Mamba network; constructing a joint loss function of a feature space and a data space, which is used for Mamba-AE training; inputting the training set into the Mamba-AE and training the Mamba-AE by using the joint loss function; constructing an anomaly score calculation mechanism, which is used for judging the possibility of the pixel belonging to a lesion; inputting the divided test set into the trained Mamba-AE, outputting an anomaly score based on the anomaly score calculation mechanism pixel by pixel, returning all anomaly scores to each corresponding pixel, and forming an anomaly image as a lesion detection result.

The present application relates to a kind of low-temperature rectification separation methods of high-abundance boron halide-10 in the field of chemical synthesis and separation, comprising: S1, boron halide gas is pumped into dry device and is dry handled;S2, the boron halide gas that is handled by step S1 dry is pumped into rectification pipe body from the bottom of low-temperature rectification tower, rectification tank body is filled with liquid nitrogen, and multiple trays are arranged in rectification tank body, and the filler in the tray is graphene aerogel, and the boron halide pumped from the bottom of rectification tank body rises to the top of tower after sequentially passing through graphene aerogel in each layer of tray from bottom to top;S3, multiple low-temperature rectification towers are sequentially connected to form multistage low-temperature rectification tower, and the abundance of boron halide-10 in the boron halide gas output from the top of last-stage rectification tower is greater than or equal to 99%.The present application solves the technical problems such as corrosion and blockage caused by cracking in the chemical exchange rectification method of boron fluoride-methyl ether complex.

The application belongs to the field of nanometer and solid light emitting materials, and particularly relates to a quantum dot / liquid crystal nanocomposite material and a preparation method and application thereof. A 3-mercapto propionic acid modified CdSe-ZnS green light quantum dot with a core-shell structure is prepared by a hot injection method; a thermotropic liquid crystal unit with a double sulfur end group is synthesized through an esterification reaction between thioctic acid and cholesterols; and then, the 3-mercapto propionic acid ligand on the CdSe-ZnS green light quantum dot is replaced by the thermotropic liquid crystal unit with the double sulfur end group through a chemical exchange reaction, so as to construct a liquid crystal functionalized CdSe-ZnS green light quantum dot material. The composite material provided by the application ingeniously combines the flexible tunable advantage of the liquid crystal itself and the controllable semiconductor fluorescent characteristics of the quantum dot, realizes the synergistic fluorescent regulation of the composite material in display application through the interaction between different components, and provides a new way for improving the structure and performance of a liquid crystal display panel.

This invention belongs to the field of isotope separation technology, specifically disclosing a method for lithium isotope separation. Addressing the significant risks to the ecological environment and occupational health posed by existing lithium amalgam methods due to the use of large quantities of highly toxic metallic mercury, and the limitation of insufficient mercury availability hindering large-scale production to meet the increasing demand for lithium isotope products, this invention proposes a safe, efficient, and industrially viable non-mercury-based lithium isotope separation method. This method is a liquid-liquid extraction method based on isotope exchange reactions between molten salt and liquid metal. The basic principle utilizes two stable isotopes of lithium. 6 Li and 7 The difference in the partition coefficient of Li between the liquid metal phase and the molten salt phase. The single-stage separation coefficient α of this method can meet the requirements of the single-stage separation factor for the industrialization of chemical exchange method (α≥1.02), and can be realized by laboratory heating furnace or scaled up by high-temperature extraction tower, providing a new technical route for lithium isotope separation.