51 results about "Chemical exchange" patented technology

The invention discloses a method for predicting brain glioma subtypes through magnetic resonance imaging based on deep learning, and relates to the technical field of chemical exchange saturation transfer magnetic resonance imaging. The method comprises the following steps: preprocessing a CEST magnetic resonance image of a patient; voxel Z spectrums and corresponding classification labels in tumor and opposite side normal tissue areas of the CEST magnetic resonance image are obtained; inputting the obtained voxel Z spectrum and the classification label into a convolutional network model for training; and performing classification prediction on test data by using the trained model. According to the method, a voxel Z-spectrum full-spectrum training convolutional network model is utilized to realize classification of tumor tissues and normal tissues and prediction of IDH and MGMT subtypes of glioma. According to the method, the whole voxel Z spectrum serves as network input, Z spectrum information can be better utilized, and the requirement for the training data size is lowered.

The embodiment of the invention provides a CEST image super-resolution reconstruction method, medium and equipment, and the method comprises the steps: obtaining an original image and a reference image of a target object, the original image being a molecular function image collected through a chemical exchange saturation transfer imaging technology, and the reference image being an anatomical structure image collected through a magnetic resonance imaging technology; through a high-frequency, intermediate-frequency and low-frequency fusion enhancement network, extraction and fusion enhancement of corresponding high-frequency, intermediate-frequency and low-frequency characteristics are carried out on an original image and a reference image. According to the method, anatomical edge details of a reference image are captured through a high-frequency fusion enhancement network to enhance image edge details, image texture features are captured through an intermediate-frequency fusion enhancement network to enhance image texture details, image background details are enhanced through a low-frequency fusion enhancement network, and then images with enhanced frequency band information are fused. A reconstructed image with high resolution and molecular function signals is obtained, and the reconstruction precision of super-resolution reconstruction is improved.

The embodiment of the invention discloses a magnetic resonance signal acquisition method and system based on chemical exchange saturation transfer. The method comprises the following steps: applying a pre-configured pulse sequence to a scanned object to acquire a magnetic resonance signal; wherein the pulse sequence comprises a saturation module, the saturation module is used for enabling chemical exchange in the scanning object to reach a steady state, the saturation module comprises a plurality of saturation pulses, and a time gap exists between each pair of adjacent saturation pulses in the plurality of saturation pulses; and each acquisition module is used for acquiring magnetic resonance signals corresponding to one or more k-space trajectories, and the application time of at least one acquisition module is in a time gap between a pair of adjacent saturation pulses. Therefore, the scanning time can be effectively shortened.

The invention discloses a magnetic resonance brown fat activity imaging method, system and equipment and a storage medium. The method comprises the following steps: acquiring a chemical exchange saturation transfer image of a shoulder and neck region of a human body; performing normalization processing on the acquired chemical exchange saturation transfer image to obtain an original Z-spectrum image, performing primary three-pool Lorentz curve fitting on the original Z-spectrum image, finding out the position of a water peak, and correcting the main magnetic field nonuniformity of the original Z-spectrum image; and carrying out two-pool Lorentz curve fitting on the Z-spectrum image after main magnetic field non-uniformity correction again, extracting a creatine signal contained in the Z-spectrum image, and taking the creatine signal as an image quantitative index for reflecting the brown fat activity level to realize brown fat activity imaging. The method is non-invasive, non-radiative and low in cost, can be used in women and children, and is suitable for large-queue and repeated observation research.

The present disclosure provides a chemical supply apparatus of a liquid processing apparatus. The chemical supply apparatus of a liquid processing apparatus may include: a first tank and a second tank storing liquid to be supplied to the substrate processing apparatus; a liquid supply source supplying a chemical to the first tank and the second tank; a main circulation line connected to the first tank and the second tank and supplying liquid to the substrate processing apparatus; and a control unit controlling the tanks and the main circulation line to perform a flushing mode that drains the liquid accommodated in the first tank and the second tank, supplies a flushing liquid to the first tank, collects the flushing liquid to the second tank from the main circulation line, and then drains the flushing liquid.

The present disclosure provides a chemical supply apparatus of a liquid treatment apparatus. A chemical supply apparatus of a liquid processing apparatus may include: a first tank and a second tank that store a liquid to be supplied to a substrate processing apparatus; a liquid supply source that supplies a chemical to the first tank and the second tank; a main circulation line that is connected to the first tank and the second tank, and supplies a liquid to the substrate processing apparatus; and a control unit that controls the tanks and the main circulation line to execute a flushing mode that discharges the liquid contained in the first tank and the second tank, supplies flushing liquid to the first tank, and collects the flushing liquid from the main circulation line to the second tank, and then discharging the flushing fluid.

The devices, systems, and methods can improve magnetic resonance imaging (MRI), MR spectroscopy (MRS), MR spectroscopic imaging (MRSI) measurement(s), thereby providing more reliable quantification. The method may include a method for correcting MR image(s) / spectrum. The method may include providing an inhomogeneity field / response map of a region of interest; and providing MR image(s) / spectrum of the region of interest. The method may include determining an intravoxel / voxel inhomogeneity correction coefficient for each voxel of at least one subregion of the region of the interest using the inhomogeneity field / response map. The method may include correcting each voxel of the MR image(s) / spectrum of the region of interest using the intravoxel / voxel inhomogeneity correction coefficient. The MR image(s) / spectrum may include chemical exchange saturation transfer (CEST) / magnetization transfer (MT) imaging with Z-spectrum, CEST / MT imaging without Z-spectrum, CEST spectroscopy, CEST MRS, MRS, MRSI, or any combination thereof.

The invention provides a respiratory-gating-free free-breathing liver glycogen quantitative magnetic resonance imaging method and system, and the method comprises the steps: applying a chemical exchange saturation transfer imaging sequence to a liver region of a subject, and the imaging sequence comprises saturation pulses of a plurality of saturation frequency deviation points; a radial blade type k-space acquisition strategy is adopted to acquire magnetic resonance signal data, the radial blade type k-space acquisition strategy comprises a plurality of blades, each blade is composed of a group of parallel k-space lines, and different blades are rotationally distributed by taking the k-space center as a rotating shaft; performing image reconstruction on the acquired k space data to obtain magnetic resonance images under different saturation frequency deviations; and performing fitting analysis on the magnetic resonance image by adopting a multi-pool Lorentz model to obtain quantitative information of the liver glycogen. According to the method, the interference of respiratory movement on the CESTMRI data acquisition process can be eliminated, so that the accurate quantification of the liver glycogen in the free respiration state is realized.

The invention discloses a non-contrast agent injection tumor glucose CEST weighted imaging acquisition and post-processing method, and relates to the technical field of magnetic resonance imaging, and the method is characterized in that a 16-channel phased array coil is used on a 3.0 T MR scanner to obtain MRI; by means of the obtained MRI, a 3D glucose CEST (glucoCEST) image is obtained by means of a 3D single TSE-mDixon sequence and SPIR fat suppression; post-processing is carried out on the 3D (three-dimensional) glucoCEST image, and an MTRasym image is obtained; the change of the glucose CEST weighted signal is analyzed through MTRasym imaging, the change of the in-vivo glucose concentration is obtained, and the detection of the in-vivo glucose signal is completed. According to the magnetic resonance imaging technology based on chemical exchange saturation transfer, the contrast agent is replaced with the magnetic resonance saturation pulse for specifically inhibiting the glucose signal, in-vivo glucose signal detection can be achieved, meanwhile, the obtained image is high in resolution and low in cost, and repeated detection and clinical popularization are facilitated.

Methods and systems for performing the methods of imaging at least a part of a body are presented. The method comprises: acquiring signals by subjecting the portion of the body (10) to a chemical exchange saturation transfer (CEST) imaging protocol including radiofrequency (RF) saturation at a number of different saturation frequency offsets; defining local sets of voxels, each containing at least one voxel, which cover the anatomical portions of the imaged part of the body; generating a Z-spectrum for each set of voxels based on the combined acquired signals of the voxels for a magnetic resonance image; using a fitting model to capture the shape of the Z-spectrum and derive a basic CEST signal within each set of voxels; deriving a scaling quantity based on a selected shape parameter of the fitting model, wherein the scaling quantity decreases with increasing fluid content within local set of voxels depending on its location in the anatomical portions of the imaged part of the body; deriving a fluid- suppressed CEST contrast signal for each set of voxels based on the basic CEST signal and the scaling quantity for each set of voxels; outputting the fluid-suppressed CEST contrast signal.

The invention provides a system for producing deuterium-rich water by combining chemical exchange and liquid ammonia rectification, which comprises an ammonia A2 storage unit, an ammonia water exchange device, a liquid ammonia rectification device and a water ammonia exchange device, and three processes of ammonia water exchange, liquid ammonia rectification and water ammonia exchange are coupled and connected in series to construct a complete hydrogen isotope (deuterium) enrichment path. According to the path, deuterium is efficiently transferred from high-boiling-point raw water to a low-boiling-point ammonia medium through ammonia water exchange, low-energy-consumption and high-magnification deuterium enrichment is achieved in an N-stage rectifying tower through liquid ammonia rectification by means of the low-boiling-point characteristic of liquid ammonia, and finally high-deuteration-degree ammonia is efficiently converted back to high-deuteration-degree deuterium-enriched water through reverse water ammonia exchange. Cooperative transmission of the material flow and the isotope flow is obviously optimized, and directional and step-by-step enrichment of deuterium in the material flow process is achieved.

The invention discloses an application of lanthanide metal complexes as a 31P CEST high-field contrast agent in ATP (adenosine triphosphate) recognition, which is characterized in that a chemical exchange saturation transfer (CEST) technology is utilized, the lanthanide metal complexes (such as Eu-DO3A, Tb-DO3A, Pr-DO3A and Yb-DO3A) are used as the 31P CEST high-field contrast agent, phosphate radicals of ATP are used as large-cell signals of CEST, and the chemical exchange saturation transfer (CEST) technology is utilized to identify the ATP. According to the present invention, the phosphate radical of ATP coordinated with the lanthanide series metal complex is adopted as the CEST small pool signal, such that the 31P CEST signals of the alpha-P, the beta-P and the gamma-P three exchange sites of ATP can be obtained, the 31P CEST signals of the ATP analogues ADP (alpha-P and beta-P) and AMP can be significantly distinguished, and the problem that the ATP and the ATP analogues are difficult to distinguish by using the traditional optical and electrochemical means is solved.

The invention discloses chemical supply equipment and a chemical exchange method. Specifically disclosed is a chemical exchange method in a liquid treatment apparatus, the liquid treatment apparatus comprising a first tank, a second tank and a third tank, the method includes: a flushing operation of discharging chemicals in a first tank, a second tank, and a third tank, injecting a flushing chemical into each tank and then circulating the flushing chemical, and then discharging the flushing chemical; and supplying a new chemical to at least one of the first tank, the second tank, and the third tank to perform a liquid exchange operation of liquid exchange.

The invention is suitable for the technical field of magnetic resonance chemical exchange saturation transfer imaging, and provides a magnetic resonance chemical exchange saturation transfer imaging method, device, equipment, product and storage medium. A gradient echo sequence is adopted to collect saturated water molecule signals, and the collected water molecule signals are stored in a K space; and wave control coding is introduced in the acquisition process, and a CEST image is reconstructed based on a water molecule signal of a K space. The introduction of wave control coding can reduce the scanning time. Due to the fact that the wave control coding sampling efficiency is high, a larger matrix size can be supported within the same time, high-resolution imaging is achieved, the partial volume effect can be relieved, and CEST quantitative accuracy is improved.

Various examples are provided related to MRI non-invasive mapping of brown adipose tissue activity. Brown adipose tissue (BAT), when activated, induces thermogenesis that may counteract metabolic syndrome and obesity. A non-invasive metabolic MRI approach based on creatine chemical exchange saturation transfer (CrCEST) contrast was developed to assess BAT activity in animals and humans. In one example, a method includes acquiring z-spectrum data from a MR image of biological tissues of a subject; normalizing the z-spectrum data; reversing the normalized z-spectrum data to 1-z; fitting multi-Lorentzian functions to the reversed z-spectrum data; determining components of the z-spectrum data associated with CrCEST and amide proton transfer (APT); and providing indications of BAT on the magnetic resonance image based at least in part upon the determined components. As set forth herein, CrCEST MRI is an endogenous, noninvasive, and radiation-free method for in vivo mapping of BAT activity.

This application discloses a magnetic resonance chemical exchange saturation transfer imaging method, system, device, and storage medium. The method includes: applying a radio frequency saturation pulse for a first preset time to a region to be detected; applying a radio frequency echo pulse to the region to be detected and acquiring several gradient echo signals generated after activation by the radio frequency echo pulse; and using radial sampling to read the gradient echo signals along a preset direction to generate a magnetic resonance image. Through this method, this application effectively shortens the signal acquisition time by using gradient echo readings, effectively suppresses motion artifacts by using radial acquisition, and applies post-processing methods such as fitting to the acquired chemical exchange saturation transfer imaging spectral data to achieve water-lipid signal separation and extract and analyze the target signal.

A temperature measuring method and apparatus based on creatine chemical exchange saturation transfer (CEST) imaging. The method comprises the following steps: (1) performing creatine CEST imaging on a creatine phantom, and analyzing a chemical shift of creatine relative to water in the creatine phantom; (2) fitting a mathematical relation between the chemical shift of the creatine relative to water and the temperature; and (3) performing CEST imaging on creatine in a sample, and calculating the temperature according to the mathematical relation, fitted in step (2), between the chemical shift of the creatine relative to water and the temperature. In the temperature measuring method, the creatine is taken as an endogenous reference, and highly-spatial-resolution, highly-sensitive, and non-invasive absolute temperature measurement can be implemented by means of temperature dependence of a CEST effect of Cr and water.

The application discloses a flexible echo time water-fat separation method and system based on a main magnetic field map (B0map) and equipment, and belongs to the technical field of magnetic resonance imaging. The application combines a B0map which needs to be collected in chemical exchange saturation transfer (CEST) imaging, and proposes a new seed point selection and seed point error phase determination method. The seed point error phase determined by the method can grow a relatively accurate error vector map in space, thereby ensuring the final water-fat accurate separation. In the embodiment of the application, the proposed method is verified on a water model and pork, and ideal water-fat separation results are obtained.

The invention provides an enzyme heuristic magnetic nanoprobe and a preparation method and application thereof.The preparation method comprises the steps that gold tetrachlorate trihydrate and gadolinium acetylacetonate hydrate are dissolved in a mixed solvent of tetrahydronaphthalene and oleylamine, a reducing agent is rapidly injected under the inert atmosphere condition of 4-50 DEG C, a reaction is conducted for 30-60 min, a first non-polar solvent is used for washing, precipitation and centrifugation, and an enzyme heuristic magnetic nanoprobe is obtained; the oil-phase enzyme heuristic magnetic nanoparticles are obtained; carrying out surface hydrophilic modification on the obtained oil-phase enzyme heuristic magnetic nanoparticles in a mixed solvent system consisting of polar solvents by using hydrophilic molecules through a ligand exchange method to obtain aqueous-phase enzyme heuristic magnetic nanoparticles; the preparation method comprises the following steps: carrying out chemical amide connection reaction on aqueous-phase enzyme heuristic magnetic nanoparticles, and coupling the aqueous-phase enzyme heuristic magnetic nanoparticles with a high-specificity ligand to finish surface targeted modification, thereby obtaining the enzyme heuristic magnetic nanoprobe. According to the invention, efficient chemical exchange of water protons can be promoted, so that the magnetic resonance T1 imaging effect is obviously enhanced.

The invention relates to a germanium isotope separation method, device and system. According to the germanium isotope separation method, device and / or system, the problems that in the prior art, a germanium isotope separation method is small in scale, low in production efficiency, incapable of achieving continuous production, not suitable for industrial application and the like are solved through a chemical exchange method.

The present invention relates to the field of nuclear magnetic resonance technology, and particularly relates to a method for amplifying the intensity of nuclear magnetic resonance signals, comprising the following steps: collecting the one-dimensional nuclear magnetic resonance 1 1H spectrum and 13 13C spectrum of a sample; measuring the pulse widths of the 90-degree hard pulses of 13 13C and 1 1H of the sample; setting the intensities and durations of the z-filter gradients G1, G3 and the coherence selection gradients G2, G4; setting the spectral widths of the direct dimension and the indirect dimension; setting the central frequency of the detected hydrogen nuclei in the one-dimensional spectrum as the central frequency of the new pulse; setting the central frequency of the carbon nuclei as the irradiation decoupling central frequency and setting the decoupling power and sampling time; determining the number of sampling points n i in the indirect dimension; setting the value of the chemical shift reduction factor λ in the indirect dimension; using the INEPT pulse module to generate polarization transfer and enhance the 13 13C magnetization vector; adding n echo trains in the indirect dimension; then using the reversed INEPT module to transfer the 13 13C magnetization vector back to 1 1H; starting to collect nuclear magnetic resonance signals; performing two-dimensional Fourier transform on the signals to obtain the result.

The invention relates to a continuous separation production device for 10B isotope, which comprises a complexing tower for complexing a complexing agent and boron trifluoride and providing tower top reflux for an exchange tower group; the falling film cracking reactor is used for cracking the boron trifluoride-anisole complex, separating to obtain enriched < 10 > BF3 and providing tower bottom reflux for the exchange tower group; the exchange tower group is used for exchanging, enriching and separating < 11 > B in boron trifluoride and < 10 > B in boron trifluoride in a complex; and the natural abundance boron trifluoride gas raw material channel is laterally communicated with the tower bottom of the first exchange tower. The connection of the exchange towers in the device is relatively special, the liquid phase of the device flows according to the cross flow of 1-3-2-4 of the exchange towers, the effect of increasing the abundance gradient of liquid-phase and gas-phase 10B isotopes between the exchange towers is achieved, the chemical exchange mass transfer driving force is improved, the separation efficiency is improved, the balance time is shortened, and the separation efficiency is improved. The abundance of the obtained 10B isotope is higher, and the maximum abundance reaches 97% or above.

The application discloses a chemical exchange method and system for silicon isotope separation, and belongs to the technical field of isotope separation. The chemical exchange method comprises the following steps: S1, carrying out a complexation reaction on natural-abundance silicon tetrafluoride and a complexing agent raw material, wherein an inert component which does not participate in the complexation reaction and does not react with any component in a reaction system is premixed in the complexing agent raw material, so as to reduce the dynamic viscosity of a liquid phase of the reaction system in the complexation reaction; S2, carrying out a multistage chemical exchange on the complex generated in the step S1 and silicon tetrafluoride gas; S3, carrying out heating decomposition on the liquid-phase complex out of the exchange system; S4, purifying the complexing agent liquid obtained from a cracking tower through a decontamination tower, and returning the complexing agent liquid to the complexation tower; and S5, when the silicon isotope abundance in the complexation product reaches a target abundance, corresponding silicon isotope products are obtained. According to the scheme, the dynamic viscosity of the whole reaction system can be significantly reduced by premixing the chemically inert component in the complexing agent raw material, and the silicon isotope separation efficiency is improved.

The present invention relates to a method and system for efficiently separating boron isotopes, and belongs to the technical field of boron isotope separation. The method comprises cyclically performing complexation reaction, chemical exchange reaction and cleavage reaction in sequence; complexation reaction: anisole and 11 BF3 enriched gas is subjected to complexation reaction to obtain boron trifluoride·anisole complex liquid and impurity-carrying inert gas, and the impurity-carrying inert gas is removed to obtain inert gas circulation gas; chemical exchange reaction: the complex liquid and the mixed gas are subjected to exchange reaction to obtain the 11 BF3 enriched gas and 10 BF3 enriched complex liquid; the mixed gas is composed of the inert gas circulating gas and 10 BF3 enriched gas composition; cracking reaction: 10 The BF3-enriched complex solution is cracked to obtain the 10 BF3 enriched gas and crude anisole; cyclic reaction until 11 BF3 and / or 10 The abundance of BF3 meets the requirements. The present invention improves the mass transfer efficiency of the reaction through the inert gas circulation gas, thereby achieving efficient separation of boron isotopes.

Systems and methods for deriving chemical exchange saturation transfer (CEST) contrast images are presented. In one aspect according to the invention, the method comprises: acquiring signals by subjecting a portion of the body (10) to a CEST imaging protocol, the CEST imaging protocol comprising RF saturation at several different saturation frequency shifts; generating a Z-spectrum from the acquired signal for each voxel in a set of voxels from the magnetic resonance image; modeling a Z-spectrum background, the Z-spectrum background comprising contributions from direct water saturation, magnetization transfer and one or more fat signal components, where parameters of the model are determined by fitting the modeled Z-spectrum background to the generated Z-spectrum for each voxel, thereby omitting regions of the Z-spectrum affected by the CEST effect; and deriving a CEST contrast image based on the modeled Z-spectrum background and the Z-spectrum generated for each voxel. The system includes a processor configured to perform the method.

An evaluation method is performed by an arithmetic circuit and includes obtainment processing (S1), evaluation processing (S2), and presentation processing (S3). The obtainment processing (S1) obtains: image information on a sectional image representing an interested section of an organism including a target section of a testis of the organism generated by use of magnetic resonance of hydrogen atoms; and concentration information on a creatine concentration in the interested section measured by use of magnetic resonance based on chemical exchange saturation transfer. The evaluation processing (S2) generates an evaluation image representing a distribution of evaluation results of a testicular function in the target section based on the concentration information. The presentation processing (S3) presents the sectional image and the evaluation image.

The application discloses a brain glioma recognition device based on a 5T multi-nuclear magnetic resonance imaging system, which comprises an amide proton imaging acquisition module for receiving a chemical exchange saturation transfer spectrum of amide protons and amide proton concentration; 1 H T2 weighted MRI images, 23 Na MRI images and total sodium concentration maps 23 Na MRI image acquisition module; for receiving 31 P MRS images and phosphorus-containing metabolite concentration of brain regions 31 P MRS image acquisition module; and a recognition module comprising a discrimination network and a segmentation network. The application inputs a sample group into the discrimination network and the segmentation network of the cross-modal data brain tumor, can recognize abnormal signals of different voxels of brain regions, and can outline the boundary of the brain glioma.

The invention belongs to the technical field of powder material preparation, and particularly relates to a method for synthesizing carbon-silicon and carbon-boron powder by using a carbon source. The heavy component mixture generated in the boron isotope separation process through a chemical exchange method is used as a novel carbon source, the problems that a traditional carbon source is high in cost and complex in technology are solved by optimizing the raw material ratio, the calcination technology and post-treatment parameters, industrial waste resource utilization is achieved, and meanwhile powder with the excellent structure and performance is prepared. The boron isotope separation heavy component mixture is used as a carbon source for the first time, waste is turned into wealth, the cost is reduced, industrial waste discharge is reduced, and the method conforms to the green chemistry concept. The invention provides an efficient, environment-friendly and controllable carbon silicon / carbon boron powder synthesis method through raw material innovation and process optimization, and has remarkable economic value and technical advantages.

Disclosed is a chemical exchange method in a liquid treating device including a first tank, a second tank, and a third tank, the method including: a flushing operation of draining chemicals received in the first tank, the second tank, and the third tank, injecting a flushing chemical into each tank and then circulating the flushing chemical, and then draining the flushing chemical; and a liquid exchange operation of supplying a new chemical to at least one of the first tank, the second tank, and the third tank to perform liquid exchange.

The invention discloses a chemical exchange saturation transfer image anomaly detection method, which comprises the following steps: preprocessing CEST data obtained by scanning to obtain a spectrum data set of all pixels, and finally dividing the spectrum data into a training set and a test set; the method comprises the following steps: constructing an auto-encoder model Mamb-AE based on a Mamb network; constructing a joint loss function of a feature space and a data space, wherein the joint loss function is used for Mamba-AE training; inputting the training set into the Mamb-AE, and training the Mamb-AE by using a joint loss function; an abnormal score calculation mechanism is constructed and used for judging the possibility that the pixel belongs to the focus; and inputting the divided test set into the trained Mamba-AE, outputting abnormal scores pixel by pixel based on an abnormal score calculation mechanism, and returning all the abnormal scores to each corresponding pixel to form an abnormal image as a focus detection result.