Magnetic resonance chemical exchange saturation transfer imaging method and magnetic resonance chemical exchange saturation transfer imaging system

Abstract

The invention provides a magnetic resonance chemical exchange saturation transfer imaging method and a magnetic resonance chemical exchange saturation transfer imaging system. The magnetic resonance chemical exchange saturation transfer imaging method comprises a main RF pulse generating step, applying a short-time main RF saturation pulse which lasts for a first preset time for aiming at a specific RF point, thereby generating the contrast of a magnetic resonance imaging signal; an image acquisition step, segmentally acquiring image data in a reading-out direction or / and a phase encoding direction based on the applied main RF saturation pulse by means of a segmental planar echo acquisition method; and a sub-RF pulse generating step, after one-time image data acquisition by means of the segmental planar echo acquisition method, applying a sub-RF saturation pulse which lasts for a second preset time, thereby keeping the contrast of the magnetic resonance imaging signal. The magnetic resonance chemical exchange saturation transfer imaging method and the magnetic resonance chemical exchange saturation transfer imaging system settle problems of low signal sensitivity and low imaging efficiency in existing magnetic resonance chemical exchange saturation transfer imaging technology.

Description

technical field [0001] The invention relates to magnetic resonance CEST imaging technology, in particular to a magnetic resonance chemical exchange saturation transfer imaging method and system. Background technique [0002] Magnetic resonance CEST imaging method (Chemical exchange saturation transfer, CEST) research began in 2000, because of its new magnetic resonance contrast mechanism, it has quickly attracted widespread attention, and has become a new sensitive way to study chemical exchange and chemical dynamics of macromolecules. The principle is to selectively apply a radiofrequency (radiofrequency, RF) pulse signal of a special resonance frequency to saturate the corresponding protons (such as figure 1 (a), poolB), these protons will interact with surrounding water molecules (such as figure 1 (a), poolA) is chemically exchanged, and then part of the saturation is transferred to the water molecules, and the strength of the CEST effect is reflected by detecting the de...

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Problems solved by technology

[0007] Based on this, it is necessary to provide a magnetic resonance chemical exchange saturation transfer imaging method and system for the problems of limited signal sensitivity and low imaging efficiency in the existing magnetic resonance chemical exchange saturation transfer imaging technology

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