7 results about "MRI contrast agent" patented technology

To provide macrocyclic compounds that can be complexed with Fe(III).SOLUTION: The macrocyclic complexes or macrocyclic compounds have a 1,4,7-triazacyclononane (TACN) moiety with one or more amine group(s) or an O- or S- substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(III) atom coordinated to the TACN moiety. The macrocyclic complexes can be used in imaging methods.SELECTED DRAWING: None

The application discloses a fluorinated monosaccharide derivative and a synthesis method and application thereof. The fluorinated monosaccharide derivative is composed of three parts, the first part is a 1-substituted monosaccharide group, the second part is a fluorine signal source perfluoro-t-butyl ether group, and the third part is a triazole ring connecting the two. The fluorinated monosaccharide derivative of the application retains the 2-hydroxyl and 6-hydroxyl of the monosaccharide, thereby not affecting the recognition of the monosaccharide in the body, and having good water solubility and biocompatibility. The derivative contains nine magnetically equivalent fluorine-19, can produce a single and strong fluorine signal, and avoids problems such as fluorine signal splitting or low fluorine atom utilization. The fluorine signal strength has a good linear relationship with the concentration of the compound, which provides a basis for in vivo quantification 19 F MRI. 19 F MRI imaging of HepG2 cells has the potential to be used as a tumor selective 19 F MRI contrast agent.

This invention discloses a magnetic resonance imaging (MRI) contrast agent for targeted detection of collagen molecular structural denaturation, its preparation method, and its application. The general chemical formula of this MRI contrast agent is: [X] m -L-(GfO) n Among them, (GfO) n [n] is a collagen hybrid peptide, where n is a positive integer between 6 and 12; L is a linker, comprising amino acids and / or amino acid derivatives; [X] is a paramagnetic metal complex, composed of a chelating agent and paramagnetic metal ions; m represents the number of paramagnetic metal complexes, where m is a positive integer between 1 and 12. The magnetic resonance contrast agent of this invention can target and detect degenerated collagen, exhibiting higher lesion specificity and detection sensitivity compared to conventional targeted contrast agents that rely on differences in collagen content for imaging. Furthermore, this magnetic resonance contrast agent can significantly enhance the magnetic resonance signal of damaged and degenerated cartilage, Achilles tendon, and abdominal aortic aneurysm, facilitating the early diagnosis of collagen degeneration-related diseases.

The application discloses an oxidation-responsive macrocycle compound, a macrocycle complex and application thereof. The macrocycle compound has the following characteristics: 1) more than one macrocycle nucleus, the macrocycle nucleus has a ring structure containing carbon atoms and at least one nitrogen atom; 2) at least one nitrogen-containing aromatic ring group, the nitrogen-containing aromatic ring group exists as a part of the macrocycle nucleus or as an auxiliary pendant group; 3) at least one oxygen atom or oxygen-containing group, the oxygen atom or oxygen-containing group exists as a part of the macrocycle nucleus or an auxiliary pendant group; 4) at least one auxiliary pendant group, the auxiliary pendant group is coordinated with or not coordinated with an iron ion; and 5) the auxiliary pendant group is covalently attached to a nitrogen atom of the macrocycle nucleus. The iron complex formed by coordination of the macrocycle compound with a divalent or trivalent iron ion is the macrocycle complex according to the application. The macrocycle compound according to the application can be used as a T1 MRI contrast agent. The macrocycle complex provided by the application can also be used as a T2 MRI contrast agent.