58results about How to "Improve slack" patented technology

The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability of a nanoparticle or liposomal delivery system, and inherent degradability or disruption of barrier integrity upon endocytosis. The invention also provides for liposomes having combined therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents, in one embodiment, by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. The invention provides for imaging of therapeutic liposomes by inserting a lipopolymer anchored, remotely sensing reporter molecules into liposomal lipid layer. The invention allows for an integrated delivery system capable of imaging molecular fingerprints in diseased tissues, treatment, and treatment monitoring.

In some embodiments, the present invention is directed to novel targeted contrast agents for magnetic resonance imaging (MRI). The present invention is also directed to methods of making such targeted MRI contrast agents, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically afford enhanced blood clearance rates and biodistribution.

Superparamagnetic nanoscale particles are disclosed which are useful for providing a contrast agent with high signal intensity, high relaxivity and high intrinsic magnetism. The disclosed contrast agents will have utility and magnetic resonance imaging (MRI) and associated techniques.

The invention discloses a production process of rebar for concrete. The production process comprises the following steps of: removing scales on a hot rolling steel wire rod; straightening the hot rolling steel wire rod after forming with die drawing or roller die drawing, or directly straightening the hot rolling steel wire rod without drawing; leading the hot rolling steel wire rod to continuously pass through a heating ring and a cooling water ring by a high-medium frequency induction furnace; heating the rebar to Ac1 above so as to carry out austenization; quenching and cooling the rebar by spraying water; executing drawing temper, and applying tension on the rebar when tempering; and cooling the rebar by spraying water to obtain the rebar for the concrete.

A contrast agent for magnetic resonance imaging comprising a complex of a paramagnetic cation, preferably Gd+3, Dy+3, and Fe+3 with three equivalents of a charge neutralizing chelator that provides a lipid soluble complex of the paramagnetic cation is described. The complex is retained intracellularly when introduced into a mammalian cell. A method of providing an image of an internal pathology of a patient by magnetic resonance imaging (MRI) by administering the MRI contrast agent or tagged cells to the patient and scanning the patient using magnetic resonance imaging to obtain visible images of the internal pathology of the patient is also set forth.

The invention provides a core wire supply apparatus capable of utilizing a core wire send-out portion to send out core wire and a spinning machine having the core wire supply apparatus. The core wire supply apparatus comprises a core wire send-out portion (13) for sending out the core wire (C) pulled out from a core wire bobbin (15), a tension giving portion (11) which is arranged between the core wire bobbin (15) and the core wire send-out portion (13) for giving tension to the above mentioned core wire (C), and a tension relaxing portion (12) which is arranged between the tension giving portion (11) and the core wire send-out portion (13) for making the tension of the above mentioned core wire (C) relaxed.

The invention relates to anti-skin aging skin care compound essential oil which is prepared by uniformly mixing alpinia oxyphylla oil, peppermint oil, lavender oil, tea tree oil and jojoba oil, wherein the alpinia oxyphylla oil is prepared by the steps of: grinding the fruit of alpinia oxyphylla into coarse powder, adding water for digestion and separating oil from water; the peppermint oil is prepared by the steps of: performing coarse grinding of the whole plant of peppermint, adding water for digestion and separating oil from water; the lavender oil is prepared by the steps of: grinding the whole plant of lavender into coarse powder, adding water for digestion and separating oil from water; and the tea tree oil is prepared by the steps of: mashing the cajeput leaves, adding water for digestion and separating oil from water. In the invention, the technology is simple, and multiple kinds of natural essential oil are scientifically matched for synergistic effect, so that the active ingredients can quickly permeate to be absorbed by the skin and the cell proliferation and metabolic capability are enhanced; the anti-skin aging skin care compound essential oil has a perfect effect onimproving the skin aging symptom, prevents toxic side effect, is simple to use, and is suitable for various skin aging symptoms.

A coil processor is provided for performing processing operations on coiled sheet-like material, such as sheet metal, plastics or other materials. The coil processor uncoils and straightens the material before performing desired operations on the material and transferring it for packaging, shipping or further processing. Various features improve the overall efficiency of the coil processor, including its ability to move material forward and backward through the unit without slowing down the overall operation, as well as the versatility of its mobile tool carriers, which can perform multiple complex processing applications, including cutting, punching, stamping, bending or others. Additionally, processing efficiency may be further enhanced by the use of a computer, which determines the most efficient sequence for performing processing operations, and controls the coil processor's various features to process material in that sequence.

The present invention provides a class of biochemically-activated MRI contrast agents. The agents include a paramagnetic chelate attached via a linker arm to a relaxivity-modulating group. When the relaxivity-modulating group is removed or otherwise interacts with a targeted substance, the agents are activated by various mechanisms. The activation is detectable by an increase or decrease in the relaxivity of the metal chelate. The agents are useful in the detection of biochemical parameters in cells, tissues and subjects. Exemplary biochemical parameters are markers that are associated with disease states.

Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula wherein R13, A1, R1 and R2 are as defined herein, are disclosed.

The invention supplies new type combined type film component that is alternate installing board frame film component and hollow fiber film component. The hollow fiber film component is made up of film thread, pumping collector pipe, and washing aerator pipe. The feature is that the invention combines the advantage of flat film component and hollow fiber film component to make the installation easy and filling density and area effectively increase. The invention realizes the control of film pollution, and the function for mechanically washing the film, and improves the running flux of flat film component, etc.

Disclosed is a movable type back massage robot. A percussion massage mechanism is located on the upper surface of the middle of a chassis, rolling and rubbing massage mechanisms are located at the four corners of the lower surface of the chassis, far infrared therapy lamps are located at the two ends of the lower surfaces at the two ends of the chassis, and four laser distance measuring sensors are distributed at the four corners of the upper surface of the chassis. Massage under three modes can be performed, and the percussion frequency can be regulated. The far infrared therapy lamps can achieve large-range far infrared physiotherapy, blood material circulation can be accelerated, metabolism is improved, pain is lowered, muscle relaxation is improved, and the physiotherapy effect is achieved. The robot is small in size, convenient to carry, capable of achieving the elastic percussion massage, rolling and rubbing massage and far infrared physiotherapy effects, massage motion can be performed on the back of the human body according to the path planned by a program, car body vibration is low, and the massage intensity is high.

The invention discloses a recyclable putty plastering machine. The structure of the recyclable putty plastering machine comprises a ceiling beam, an upright rod, a conveying belt, a plastering machine, a control panel, a power cord, casters, a feeding hose, a putty recycling device, a putty receiving plate, a plastering plate and a steel wire rope. The putty falling off while a wall is plastered can be collected through the putty recycling device, the putty condensed into clumps is crushed and stirred by a putty collecting and stirring box, and then the putty is introduced into a putty temperature control heating box to maintain a certain viscosity of the putty through heating so as not to condense into clumps. When the putty stored in the putty temperature control heating box reaches a certain capacity, a spring stop plate is opened, an upper closed valve stem and is separated from a lower closed valve stem, the putty flows into a material collecting box and is output through a rightconveying mechanism and a left conveying mechanism so as to be utilized, and thus the reuse of putty surplus materials is realized and the waste of materials is reduced.

The invention relates to a rose compound essential oil for resisting skin aging. The rose compound essential oil for resisting skin aging is prepared by uniform mixing of rose essential oil, citronella essential oil, cananga odorata essential oil, lavender essential oil and grape seed oil. The rose essential oil is prepared as follows: taking fresh rose petals, adding water for extraction, and separating oil and water, thus obtaining the rose essential oil. The citronella essential oil is prepared as follows: taking whole herb of citronella, coarsely crushing, adding the water for extraction, and separating oil and water, thus obtaining the citronella essential oil. The cananga odorata essential oil is prepared as follows: taking fresh cananga odorata petals, adding the water for extraction, and separating oil and water, thus obtaining the cananga odorata essential oil. The lavender essential oil is prepared as follows: taking whole herb of lavender, coarsely crushing to obtain coarse powder, adding the water for extraction, and separating oil and water, thus obtaining the lavender essential oil. The rose compound essential oil for resisting the skin aging has the advantages of simple processes; through scientific compatibility and synergistic effects of the natural plant essential oils, active ingredients can quickly penetrate into skins for absorption, and the anti-aging, skin protection and other purposes can be achieved; and the rose compound essential oil for resisting the skin aging has good improvement effects on skin aging symptoms such as stains, wrinkles, laxity and the like, and is applicable to the skin aging symptoms of all kinds of characteristics.

A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperproliferative tissue. The preferred compounds have the structural formula:where R1, R2, R2a R3, R3a R4, R5, R5a R6, R7, R7a, and R8 cumulatively contain at least two functional groups that will complex or combine with an MR imaging enhancing element or ion. The compound is intended to include such complexes and combinations and includes the use of such compounds for MR imaging and photodynamic therapy treatment of tumors and other hyperproliferative tissue.

The present invention relates to contrast agents for diagnostic magnetic resonance imaging. In particular, this invention relates to novel compounds which exhibit surprisingly improved relaxivity due to improved binding of an amino acid targeting group within the molecules to proteins following specific cleavage of the agent by a peptidase. This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement during magnetic resonance imaging.

The invention relates to cancer receptor-specific bioprobes for single photon emission computed tomography (SPECT) and computed tomography (CT) or magnetic resonance imaging (MRI) for dual modality molecular imaging. The base of the bioprobes is the self-assembled polyelectrolytes, which transport gold nanoparticles as CT contrast agents, or SPION or Gd(III) ions as MR active ligands, and are labeled using complexing agent with technetium-99m as SPECT radiopharmacon. Furthermore these dual modality SPECT / CT and SPECT / MR contrast agents are labeled with targeting moieties to realize the tumorspecificity.

The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.

Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. The compounds are conveniently prepared from achiral derivatives of chelating moieties.

Immunomagnetic nanoparticles are used as a contrast agent for enhancing medical diagnostic imaging such as magnetic resonance imaging (MRI). The present invention is directed to methods of making targeted MRI contrast agents from immunomagnetic particles, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically can afford enhanced blood clearance rates and distribution. The ability to use the contrast agents im MRI provides a tool in the diagnosis and treatment of several disease states.

Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mn2+ and Mn3+ oxidation states. In the presence of a reductant such as glutathione, low relaxivity MnIII-HBET is rapidly converted to high relaxivity MnII-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.

The embodiment of the invention discloses a beautifying hexapeptide stock solution, which is prepared from water, propylene glycol, butanediol, glycerol, sodium hyaluronate, hexapeptide-9, palmitoyl hexapeptide-12, bird's nest extract, snail secretion filtrate, PORTULACA OLERACEA extract and ethylhexylglycerin. Small molecules instantly permeate into the bottom layer of the skin, so that the skinis full and moist, and the mask has the functions of removing wrinkles, moisturizing, controlling water-oil balance of the skin and resisting aging.

The invention discloses pregnancy line massage lotion. The pregnancy line massage lotion comprises first components, second components, third components and fourth components. The first components comprise water, disodium EDTA (ethylene diamine tetraacetic acid) and humectants; the second components comprise PEG-60 dehydrated sorbitol stearate and softening and wetting agents; the third components comprise water and acrylic acid (ester) / C10-30 alkyl alcohol acrylate cross-linked polymers; the fourth components comprise acetyl hexapeptide-8, acetyl tripeptide-30 melon amino acid and pentapeptide. The pregnancy line massage lotion has the advantage of effects of reducing the quality difference of products.

The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

The present invention relates to a novel class of paramagnetic ion-based contrast i agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic i profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity. Formula (I): A(LR)v wherein: A is a linear or cyclic chelating backbone moiety; R is, independently, H or a C2-C70aminopolyol moiety comprising a ‘straight or branched alkyl chain substituted by from 2 to 30 hydroxyl groups, the said chain being optionally interrupted by one or more groups selected from -0-, —NH—, —N<, —CO—, —CONH—, —NHCO—, —CON< or >NCO—; and optionally substituted by one or more C4-C10 cyclic units; L is, independently, a direct bond or “a divalent straight or branched linker moiety between A and R, at most comprising 20 carbon atoms; V is a positive integer from 1 to 7; with the proviso that at least one of the R groups is other than H; or a physiologically acceptable salt of such ligand.

The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5