9 results about "Elastin like polypeptides" patented technology

The invention relates to the technical field of biological materials, in particular to composite hydrogel as well as a preparation method and application thereof. In particular to an ion response type ELPs-SA composite hydrogel constructed based on elastin-like polypeptides (ELPs) and sodium alginate (SA) as well as a preparation method and application of the ion response type ELPs-SA composite hydrogel. According to the hydrogel, elastic-like polypeptides ELP-Vs (such as adhesion promotion, angiogenesis, antibiosis and the like) with biological functions are introduced and react with SA, CaCO3 and gluconolactone (GDL) together, and the non-covalent cross-linked three-dimensional network hydrogel is formed under mild conditions. The obtained hydrogel has excellent mechanical strength (the energy storage modulus is 450-1773 Pa), a proper microporous structure (the pore diameter is 50-100 microns) and good biocompatibility, and can support three-dimensional culture of cells and promote angiogenesis and immunoregulation. The material has a wide application prospect in the biomedical fields of tissue engineering, wound repair, organoid construction and the like.

The invention provides a biological membrane fusion nano-micelle, a drug-loaded biological membrane fusion nano-micelle as well as a preparation method and application thereof, and belongs to the technical field of medicines. The biological membrane fusion nano-micelle comprises an elastin-like polypeptide nano-micelle, a cancer cell membrane coating the surface of the elastin-like polypeptide nano-micelle, L-arginine located between the elastin-like polypeptide nano-micelle and the cancer cell membrane, and a fat-soluble photosensitizer located between phospholipid bilayers of the cancer cell membrane. The biological membrane fusion nano-micelle can bypass a traditional endocytosis way, and the treatment effect can be improved; the hydrophilic and hydrophobic structure of the elastin-like polypeptide nano-micelle is utilized to facilitate encapsulation of fat-soluble chemotherapeutic drugs (such as rapamycin or adriamycin), and a fat-soluble photosensitizer (such as a photosensitizer IR780 or a photosensitizer ICG) can be embedded into a phospholipid bilayer of a cancer cell membrane by utilizing the hydrophobic effect of the elastin-like polypeptide nano-micelle. Cancer synergistic chemotherapy, photodynamic therapy and gas therapy can be realized.

A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and a therapeutic agent is provided.

Disclosed herein are methods, pharmaceutical compositions, and kits for image-guided brachytherapy. An example method includes navigating a hollow tube to a tumor in a subject using an imaging modality and administering a pharmaceutical composition through the hollow tube to the tumor. An example pharmaceutical composition includes a pharmaceutically acceptable excipient and a collection of self-assembling conjugates, each self-assembling conjugate including a radionuclide coupled to an elastin-like polypeptide, the collection of self-assembling conjugates being included in the pharmaceutical composition at a concentration of no more than 300 µM.

Disclosed herein are fusion proteins comprising a biologic and an elastin‑like polypeptide (ELP) attached to the biologic that is capable of being expressed and secreted from a eukaryotic cell. Also disclosed herein are methods for producing the biologic-based fusion protein.

A composition and method of using the composition to treat neurological disorders including Alzheimer's disease are disclosed wherein the composition includes an elastin-like polypeptide (ELP) and a drug. The ELP undergoes a transition from a solution phase to a gel phase as the temperature is raised above a transition temperature, and in doing so sequesters at least a portion of the drug into the gel phase. The composition is configured such that intranasal delivery of the composition results in gelation and sequestration of the drug by the ELP, thereby allowing the drug to traverse olfactory mucosa into brain tissue in order to treat neurological disorders, including Alzheimer's disease.

This invention provides a material that utilizes the self-healing properties and / or high bioadhesion of elastin-like peptides. A composition comprising: (Sequence No. 1: X) 1 GGX 2 G) n The G-sequence blocks formed (where X) 1 Same or different, indicating V or L, X 2 Same or different, representing V or L, n represents an integer greater than 4. ) and by (Sequence number 2: VPGX 3 G) m The P-sequence block formed (where X) 3 ) represents any amino acid that is the same or different, and m represents an integer greater than 5. ) elastin-like block peptide sequences and polypeptides having amino groups, and water-soluble polymers having aldehyde groups.

Methods and pharmaceutical compositions for delivering a therapeutic agent, treating a neovascularization disorder, and treating an ocular infection include make use of a compound that includes an elastin-like polypeptide (ELP) coupled to a therapeutic agent, wherein the ELP comprises at least one repeat of the amino acid sequence VPGXG (SEQ ID NO: 1), and where the composition is suitable for ocular administration.