14 results about "Neovascularization" patented technology

Provided herein are novel reprogrammed smooth muscle cells (rSMCs) and methods of making and using the cells for the treatment of ischemia. The rSMCs are produced by culturing a fibroblast with an all-trans-retinoic acid (ATRA) under conditions that produce the rSMC from the fibroblast, wherein the fibroblasts are genetically modified to overexpress myocardin. The rSMCs offer advantages over currently available regenerative vascular therapies by promoting vascular perfusion in a recipient subject. In particular, the rSMCs can increase neovascularization of both small and large vessels.

This invention provides a method for treating ocular indications involving abnormal neovascularization. [Solution] The present invention provides a method comprising the step of administering an effective amount of nintedanib or a pharmaceutically acceptable salt thereof in the form of a topical eye drop or implant to the eye of a subject.

This invention relates to a self-assembling polypeptide for regulating the permeability of retinal pigment epithelium (RPE), its preparation method, and its applications. The self-assembling polypeptide comprises an integrin receptor-targeting peptide, a self-assembling polypeptide, and a hydrophobic molecule sequentially linked. The self-assembling polypeptide designed in this invention can self-assemble into nanoparticles and specifically target RPE cells. After interacting with receptors on the cell membrane, the nanoparticles transform into nanofibers, achieving rapid targeted enrichment of RPE tissue. Furthermore, by regulating the permeability of RPE tissue, it can enhance the transcellular drug transport capacity, providing a new clinical application strategy for the treatment of macular neovascularization, especially polypoid choroidal vascular lesions.

The application discloses application of harman alkaline in preparation of a medicine for treating and / or preventing myocardial infarction; the application firstly finds that the harman alkaline can be used for treating and / or preventing myocardial infarction. Meanwhile, the harman alkaline can significantly reduce a myocardial infarction area, improve heart function, and promote blood vessel neogenesis in an infarction edge area; and the harman alkaline can also up-regulate protein expression of CD31. In a cell experiment, the harman alkaline can promote HUVEC cell migration and proliferation after H2O2 injury. The application discloses the anti-myocardial infarction effect of the harman alkaline, provides a new medicine for myocardial infarction treatment, and has important clinical application value.

The present invention relates to a composition for inhibiting angiogenesis containing yohimbine, and more specifically, to a pharmaceutical preparation and a functional food containing a composition capable of exhibiting preventive, improving, and therapeutic effects on angiogenesis-related diseases such as hemangioma, vascular adhesion, neovascular glaucoma, diabetic retinopathy, macular degeneration, corneal disease caused by neovascularization, or telangiectasia by containing yohimbine capable of inhibiting PDGF-induced vascular smooth muscle cell proliferation and migration through the factor FOXO3a.

To provide a method for treating ocular indications involving abnormal neovascularization.SOLUTION: There is provided a method comprising administering to an eye of a subject an effective amount of nintedanib or a pharmaceutically acceptable salt thereof in a form of topical eye drop or an implant.SELECTED DRAWING: None

The present invention relates to a method for preparing a mixture of DNA fragments of high functionality derived from mushrooms, and a functional composition comprising the mixture of DNA fragments prepared by the method. Specifically, the present invention relates to a method for preparing a mixture of DNA fragments having uniform sizes within a prescribed range using specific restriction enzymes in mushrooms. According to the present invention, a functional composition having excellent effects of tissue interstitial support filling, skin condition improvement, tissue regeneration, wound healing, moisturizing, promotion of ECM synthesis, inhibition of cell aging, neovascularization, relief of inflammation, relief of pain, treatment of dermatitis such as atopic dermatitis, inhibition of hair loss, promotion of hair growth, and promotion of stem cell activity can be provided, using the mixture of DNA fragments as a main ingredient.

The application discloses a kind of polydopamine / drug nano composite particles and preparation method and application thereof.The polydopamine / drug nano composite particles in aqueous solution, using the synchronous process of alkaline drug molecule crystallization and dopamine oxidative polymerization, green synthesis nano drug.The polydopamine / drug nano composite particles of the application have: (1) high drug loading efficiency, simple preparation method; (2) have excellent active oxygen scavenging capacity; (3) response active oxygen controlled release drug; (4) the active oxygen of synthesis nano drug retains the activity of drug, such as nanofasudil nano drug can inhibit ROCK signal pathway; (5) good biocompatibility; can significantly reduce the ROS level in diabetic retinopathy model, reduce the expression of inflammatory factors, improve vascular leakage and inhibit neovascularization.The preparation process of the application is simple, the reaction condition is mild, and the biocompatibility is good, which provides a new nano drug delivery strategy for the treatment of diabetic retinopathy.

The invention discloses a composite gel for promoting wound healing. The composite gel comprises at least one growth factor and at least one therapeutic gas. The composite gel can maximize the synergistic effect of the gas and the growth factors by selectively adjusting the combination of the gas and the growth factors, so as to meet the treatment requirements of different types of wounds and different healing stages. The therapeutic gases can be selected from oxygen, hydrogen, nitric oxide, hydrogen sulfide and the like, are distributed in the gel in the form of microbubbles and are slowly released to improve the local microenvironment of the wound. In addition, the growth factors can comprise epidermal growth factors (EGF), fibroblast growth factors (FGF), vascular endothelial growth factors (VEGF) and the like, and cell proliferation, migration and new angiogenesis are promoted. The preparation method of the composite gel comprises the following steps: selecting a proper matrix material, dissolving the matrix material with growth factors, and then injecting therapeutic gas to form gel containing bubbles. The composite gel can effectively improve the wound healing speed, and is especially suitable for chronic or refractory wounds such as diabetic ulcers, burns, surgical incisions and the like.

This application discloses the fusion polypeptide AJ007 and its use, and belongs to the art of ophthalmic drugs. This fusion polypeptide AJ007 is formed by linking a TAT membrane-permeable peptide to the tip of a polypeptide HM-1 molecule that inhibits neovascularization. The fusion polypeptide AJ007 was used in the preparation of polypeptide eye drops, and by selecting the formulation of this application, the fusion polypeptide AJ007 was prepared as an eye drop. In the prevention or treatment of wet age-related macular degeneration, the method of administering eye drops effectively avoids various serious side effects and low patient tolerance problems associated with intravitreal injection in clinical practice, and has the advantage of non-invasive treatment. Furthermore, in a laser-induced mouse wAMD model, it showed extremely good efficacy in improving abnormal hyperplasia of choroidal neovascularization, and possesses high clinical therapeutic potential.

Ensuring cell survival and promoting rapid vascularization after transplantation is an important for achieving successful tissue regeneration. Disclosed herein are methods designed to enhance cell survival and stimulate neovascularization and / or vascularized tissue regeneration after transplantation in a subject. The disclosed approach involves using a compound to pre-treat cells, stabilizing or activating HIF-1α under normal oxygen conditions, thereby increasing the therapeutic potential of the treated cells and triggering an angiogenic / vasculogenic response, particularly for dental pulp regeneration.

The application belongs to the technical field of medical devices, and discloses a tibial periosteum embedded air bag stimulation device and method, which comprises a stimulation air bag, a gas storage and driving assembly and a power supply assembly. The stimulation air bag is implanted between the tibia and the periosteum, and the surface of the stimulation air bag is provided with ribs in the same direction as the long axis of the stimulation air bag. The stimulation air bag is respectively provided with an air inlet pipe and an air outlet pipe for air intake and exhaust. The gas storage and driving assembly comprises a gas storage bag and a gas pump. The gas storage bag is in communication with the air inlet pipe and the air outlet pipe. The air inlet pipe is connected in series with the gas pump and a first electromagnetic valve. The air outlet pipe is provided with a second electromagnetic valve. The power supply assembly, the gas pump, the first electromagnetic valve and the second electromagnetic valve are electrically connected with a main control board and are all packaged in a packaging assembly. The stimulation air bag is placed between the tibia and the periosteum to directly stimulate the inner layer of the periosteum rich in vascular endothelial progenitor cells and activate the potential of neovascularization through mechanical stimulation. The mechanical stimulation effect is enhanced through the convex ribs. The main control board is used for control without the intervention of the patient.

The application discloses a traditional Chinese medicine for preventing and treating retinal fibrous membrane or neovascularization proliferative disease, which is composed of leech, zedoary, panax notoginseng, earthworm, kelp and turtle shell. Compared with the prior art, the medicine has wide sources, small toxic and side effects and high safety. The application provides a new method, a new idea and a new prospect for clinical application for the traditional Chinese medicine for preventing and treating retinal fibrous membrane or neovascularization proliferative disease.