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24results about How to "Improve patency" patented technology

Urethral administration device

The invention relates to the technical field of medical instruments, and particularly discloses a urethra dosing device which comprises an external reserving part, a tube body and a tube head which are connected in sequence, and further comprises an external lubricating mechanism, the external lubricating mechanism is slidably mounted on the outer side of the pipe body and can lubricate the outer wall of the pipe body; an internal lubrication mechanism; the internal lubricating mechanism is mounted on the external part, the internal lubricating mechanism can lubricate the urethra of the patient, the external lubricating mechanism can uniformly lubricate the outer wall of the catheter body, the catheter body entering smoothness is improved, the pain of the patient is reduced, and the external lubricating mechanism can lubricate the urethra of the patient; furthermore, the pain of the patient in the administration process can be further relieved.
Owner:西安国际医学中心有限公司

Electricity-saving furnace for seven-hole wobbler tube extrusion molding with adjustable extrusion tube

The application relates to the technical field of pipe extrusion, in particular to a power-saving furnace for seven-hole plum-blossom pipe extrusion forming with adjustable extrusion pipes, which comprises an extrusion furnace for melting materials and a pipe die set coaxially connected to the discharge end of the extrusion furnace, a storage rack is arranged outside the discharge end of the extrusion furnace, and a plurality of pipe die sets with different specifications are arranged for staggered sliding switching; the pipe die set is coaxially composed of an extrusion pipe, a pipe sleeve die and a plurality of pipe hole dies from outside to inside, a central shaft die is sleeved on the central shaft of the extrusion pipe, and a pipe material channel is formed between the extrusion pipe and the plurality of pipe hole dies and the central shaft die; and the plurality of pipe die sets are slidingly clamped on the storage shaft. The application can complete the quick disassembly of old dies and the accurate positioning and installation of new dies by suspending a plurality of pipe die sets with different specifications on the storage rack in a staggered mode; the technical effect that only the screw extrusion function needs to be stopped when plum-blossom pipes with different aperture specifications are replaced, and the extrusion furnace heating function does not need to be stopped is achieved; and the power-saving benefit is realized.
Owner:QINGTIAN ZHENHONG POWER COMPOUND PIPE CO LTD

Extrusion feeding device for cable insulation material production

The utility model relates to the technical field of cable insulation material production, and discloses an extrusion feeding device for cable insulation material production, which comprises an extruder body, the bottom of the extruder body is fixedly connected with a bottom frame, a feeding port of the extruder body is fixedly connected with a feeding hopper, the feeding hopper is provided with a feeding mechanism, and the feeding mechanism is fixedly connected with the bottom frame. The feeding mechanism comprises a fixing plate and a motor, and the motor is fixedly connected to the fixing plate. After materials are poured into the feeding hopper, the motor is started to drive the first rotating shaft to rotate, the rotating plate of the first rotating shaft rotates, the gear of the rotating plate drives the second rotating shaft to rotate along the inner gear ring in the rotating process of the rotating plate, and the stirring blades at the lower end of the second rotating shaft stir and discharge the materials in the feeding opening. And the second rotating shaft can do circular motion in the feeding port, so that the problem that the feeding port is blocked due to the fact that more materials are stacked at a time can be avoided, and the materials can be discharged more smoothly.
Owner:FUJIAN SANKAI ELECTRIC CO LTD

Wheat grain impurity removing device with impurity discharging auxiliary structure

The utility model discloses a wheat grain impurity removing device with an impurity discharging auxiliary structure, which comprises a screening frame, the inner wall of the screening frame is connected with a screening plate in a sliding mode, the surface of the screening frame is communicated with a wheat discharging hopper and an impurity discharging hopper, the outer side of the screening frame is provided with a discharging hopper and a conveying belt which are fixedly installed on the ground through bolts, and the conveying belt is connected with the screening frame. And the surface of the screening frame is fixedly connected with a fan through bolts. External air is blown into the blowing head through the fan via the hard pipe and the rotating pipe, then the blowing head blows impurities in the impurity discharging hopper, the blowing angle of the blowing head can be changed through the rotating arrangement of the rotating pipe, and then the discharging smoothness of the blowing head to the rotating pipe is improved; according to the wheat grain impurity removing device, air blowing can be carried out when impurities and chippings screened out from wheat are discharged, so that stress is assisted when the impurities are discharged out, the discharging smoothness after the impurities are screened out is guaranteed, and the purpose of improving the convenience of the wheat grain impurity removing device in the using process is achieved.
Owner:SHIYAN WUDANG FARMER AGRI DEV CO LTD

A simplified shield tail for a tunnel rescue shield machine and method of use thereof

PendingCN122428922AUnobstructed spacesmooth traffic
The application provides a simplified shield tail for a tunnel rescue shield machine and a use method thereof, and belongs to the field of collapsed body drilling rescue. The simplified shield tail comprises an annular shield tail body, a limiting part fixing base arranged on the outer wall of the annular shield tail body in a circumferential direction, and a limiting part arranged on the limiting part fixing base. The limiting part is arranged on the limiting part fixing base in a circumferential direction of the annular shield tail body, and one end of the limiting part extends to the inner side of the annular shield tail body through the tail end of the annular shield tail body to limit the segment in the annular shield tail body. A bottom rail is arranged on the bottom of the tunnel rescue shield machine and the annular shield tail body in the length direction of the tunnel rescue shield machine, and the annular shield tail body is fixedly connected with the bottom rail. The problems of the bulky structure design of the conventional shield tail of the shield machine and the certain obstruction to the smoothness of the tail of the shield machine are solved, and rescue is affected.
Owner:CHINA RAILWAY SECOND BUREAU GROUP CO LTD RESCUE BRANCH

Crown cap sorting device

The invention discloses a crown cap sorting device, and relates to the field of crown cap sorting, the crown cap sorting device comprises a bottom plate, a driving motor is mounted on the bottom plate, the output end of the driving motor is connected with a transmission part, and the side, away from the driving motor, of the transmission part is connected with a rotating disc to drive the rotating disc to rotate; according to the device, the driving motor drives the transmission part and the rotating disc to continuously rotate, the crown caps uniformly slide to the outlet of the material guide channel on the panel by utilizing centrifugal force, centrifugal blanking is stable and continuous, the crown caps are uniformly stressed and regularly arranged, and hard friction and direct impact are reduced, so that the coating scratch and rusting risk is reduced, and the service life of the crown caps is prolonged. The guide wheel arranged in the material guide channel and the rotating disc rotate in the opposite direction, the crown caps clamped at the material guide channel can be rapidly thrown away, the smoothness of an outlet is improved, the auxiliary cleaning assembly can collect and discharge cleaning liquid, continuous and low-damage cap sorting and outputting of the crown caps are achieved under the condition that magnetic force or vibration intervention is not needed, and the working efficiency is improved. And the cleaning preparation of the interior of the equipment is synchronously completed.
Owner:HEFEI ZHONGCHEN LIGHT IND MACHINERY

A gas-liquid mixing injector for ethyl vanillin oxidation column

ActiveCN224599232Uincrease diversityimprove patency
The utility model relates to the field of chemical equipment for spice production discloses a gas -liquid mixing injector for ethyl vanillin oxidation tower, including work main stream import pipe, the outside fixed connection of work main stream import pipe has the mixing chamber, the upper surface of mixing chamber is connected with work secondary flow import pipe, one end of work main stream import pipe is connected with the nozzle, one side of mixing chamber is provided with the connecting shell, one side of connecting shell is connected with the connecting pipe, one end of connecting pipe is provided with the throat pipe, one end of throat pipe is provided with the diffusion pipe. The utility model is convenient for the wall scraping of throat pipe inner wall, and the scraping rod is scraped comprehensively by the connecting effect of the rotating ring, and the deposits of throat pipe inner wall are effectively removed, and at the same time, the convenient disassembly separation of the injection pipe and the nozzle in the injector is convenient, not only convenient for the separate replacement of the nozzle or injection pipe to reduce the maintenance cost, but also allows the replacement of the nozzle or injection pipe of different geometric shapes according to the actual demand.
Owner:LIAONING SHIXING PHARMA & CHEM

A tire mold

PendingCN122500984AEnsure vulcanization molding qualityReduce development costsMechanical engineeringTread
This application discloses a tire mold, belonging to the field of tire mold technology. The tire mold includes: a base and a tread pattern shell. The base is provided with multiple positioning elements; the tread pattern shell is provided with a positioning groove, and the tread pattern shell is installed on the positioning elements. A flow guiding gap is formed between the tread pattern shell, the positioning elements, and the base. The flow guiding gap includes a first gap. The top surface of the positioning element abuts against the bottom wall of the positioning groove, and a first gap is formed between the tread pattern shell and the mounting surface. The base is provided with a first exhaust channel, and the positioning elements are provided with a second exhaust channel. The first exhaust channel and the second exhaust channel are connected, and the flow guiding gap is connected to the second exhaust channel. The tread pattern shell includes an arc-shaped transition section, which extends from the starting position to the side where the positioning groove is located. The tangent of the arc-shaped transition section at the starting position has an angle α with a preset direction, and the value range of α is: 0°≤α≤60°. This solves the technical problems of inconvenient tread pattern replacement and easy clogging of the exhaust structure in existing tire molds.
Owner:HIMILE MECHANICAL SCI & TECH (SHANDONG) CO LTD

Multi-layer composite masonry structure for upper groove of RH furnace and precise construction method of multi-layer composite masonry structure

The invention discloses an RH furnace upper groove multi-layer composite masonry structure and a precise construction method thereof, and relates to the technical field, the RH furnace upper groove multi-layer composite masonry structure comprises an RH furnace upper groove body, the RH furnace upper groove body is sequentially provided with a brick supporting plate, a heat preservation layer, light bricks, a permanent layer and a working layer from outside to inside, and the top of the RH furnace upper groove body is provided with an upper groove flange; filling fiber felt is arranged outside the upper groove flange, and a discharging pipe is arranged at the top of one side of the RH furnace upper groove body. The service life of the alloy feeding port is prolonged to 12 months from 3 months, so that the service life of the alloy feeding port is prolonged, the temperature of a furnace shell is reduced to 120 DEG C or below, energy is saved by 15%, the heat efficiency of the alloy feeding port is better, heat can be fully reserved, the center offset is smaller than or equal to 1 mm, molten steel splashing can be effectively eradicated, the safety of the alloy feeding port is controllable, the local replacement efficiency is improved by 50%, and the maintenance cost is reduced.
Owner:BAOTOU IRON & STEEL (GROUP) CO LTD

A rubber particle screening mechanism

ActiveCN224527683Uquality improvementEasy to shake and sieve
The application relates to a rubber particle screening mechanism, which comprises a screening box, the inside of the screening box is provided with a first screening frame and a second screening frame from top to bottom, the inner bottom of the screening box is provided with a collecting box, the side wall of one end of the screening box is provided with a first discharge port and a second discharge port, the outer side of the first discharge port and the second discharge port is provided with a first material guide hopper and a second material guide hopper, and the top of the screening box is further provided with a feeding hopper. Through the work of a driving motor, the shaft rod drives the cam to vibrate the first screening frame and the second screening frame under the action of a first transmission wheel, a second transmission wheel and a transmission belt, and under the action of a spring rod, the first screening frame and the second screening frame can well vibrate and screen rubber particles, so that the screening of the rubber particles is more sufficient, and the screening quality is improved.
Owner:SUZHOU YIFENG INSULATION MATERIAL TECHNOLOGY CO LTD

Protective structure of a stamping jig

ActiveCN224333320UPrevent punching injuriesimprove patencyShaping toolsShaping safety devicesStampingStructural engineering
The utility model provides a kind of protection structure of stamping fixture, comprising: mounting bracket, the mounting bracket is provided with the protection mechanism for preventing operator from being hurt by stamping, the protection mechanism is provided with lubricating mechanism, compared with prior art, the utility model has the beneficial effects as follows: by setting protection mechanism, first, the installation rod is fixedly installed with the stamping module of external stamping equipment, the stamping module is first driven to displace downward in the process of descending stamping, while the protective window is displaced downward and contacts with the body of operator, prompting the body of operator to first separate from stamping area and then complete die stamping, to prevent the body of operator from failing to separate from stamping area, to cause stamping injury to the body, another by setting lubricating mechanism, lubricating oil is stored by using oil storage cavity and oil storage cotton and continuously oiling the contact surface of sliding sleeve and sliding rod through oil hole, improve the smoothness of sliding sleeve displacement.
Owner:SUZHOU KUNNIU MASCH TECH CO LTD

Filter and dishwasher

The utility model provides a filter and dish washer belong to kitchen equipment technical field. The filter includes main frame, tubular filter part and cup, main frame includes upper frame and lower frame, upper frame and lower frame clamping, tubular filter part's axial both ends are rotatable connection with upper frame and lower frame respectively, cup sets up in tubular filter part, and cup and main frame are detachable connection. The cup carries out first course rough filtration to the residue, to leave the big piece residue in the cup, prevent the mesh hole from being blocked, tubular filter part carries out second course filtration to prevent small residue from being inhaled in the washing pump. When the cup gathers too much residue, can pour down the residue just can with cup, realize convenient cleaning. Because tubular filter part can rotate, when tubular filter part and water suction mouth opposite side is full of residue and water suction is not smooth, can rotate tubular filter part, make residue not gather in one place, improve washing water through mesh hole's unobstructed nature.
Owner:VATTI CORP LTD

A flat compact generator

The application provides a flat compact generator, and belongs to the technical field of generators, which solves the problems of large volume, complex structure and low heat dissipation efficiency of the existing generator. The generator comprises a front end cover, a casing, a rear end cover and a rear cover cover. The outer part of the front end cover is provided with an air outlet mesh cover. The outer part of the upper end of the casing is provided with a wiring board and a wire outlet box. The inner side of the wire outlet box is provided with an automatic voltage regulator. The inner part of the casing is fixedly provided with a main stator. The front end of the rear end cover is provided with an excitation stator. The rear cover cover is arranged at the rear end of the rear end cover. The inner part of the rear end cover is provided with a bearing. The inner ring of the bearing is fixedly provided with a main shaft. A plurality of closely arranged disc couplings and a locking plate are sequentially arranged on the front end surface of the main shaft from back to front by locking screws. A heat dissipation fan blade, a main rotor and an excitation rotor are sequentially arranged on the main shaft from front to back. The rear side end surface of the excitation rotor is provided with a rectifier bridge. The application realizes flat and compact design, and optimizes the smoothness of the internal cooling air duct to improve the heat dissipation efficiency.
Owner:FUAN SHENZHOU ELECTRIC CO LTD

Electrostatic dust collection equipment convenient to clean

The utility model relates to the technical field of air purifiers, and discloses electrostatic dust collection equipment convenient to clean, which comprises an air volume spray tower, a supply assembly for providing cleaning agents for subsequent workpieces is fixedly connected in the air volume spray tower, an air inlet pipe is fixedly connected to the top of the air volume spray tower, and an air outlet pipe is fixedly connected to the bottom of the air volume spray tower. A supporting sleeve is fixedly connected to the interior of the air inlet pipe, a motor is fixedly connected to the interior of the supporting sleeve, a rotating block is fixedly connected to the driving end of the motor, a rotating rod is fixedly connected to the end, away from the motor, of the rotating block, a guide groove is formed in the outer portion of the rotating rod, and a sliding block is slidably connected to the interior of the guide groove. According to the dust removal device, stubborn dust can be effectively removed, the smoothness of a pipeline is improved, normal conveying of airflow is ensured, the normal working efficiency of equipment is maintained, meanwhile, harmful substances such as bacteria and microorganisms in the dust can be killed through a cleaning agent, the risk of secondary pollution is reduced, and cleaner air can be provided.
Owner:QUANZHOU XINGYUE MASCH CO LTD

In-station track circuit system and method for calculating element parameters of a tuning zone

The application provides a station track circuit system and a tuning area element parameter calculation method, and relates to the technical field of track circuits.The system comprises: at least one tuning area;any one of the tuning areas comprises a first tuning unit, a second tuning unit, a first air coil and a two-end rail segment;the first tuning unit, the second tuning unit and the first air coil are connected in parallel through the rail segment;the first air coil is connected to a traction return line through a second air coil;the rail segments of any two adjacent tuning areas are extended and connected;the two tuning units in any one of the segments are the same, and the tuning unit at the first end of the segment is connected to track circuit sending side equipment, and the tuning unit at the second end of the segment is connected to track circuit receiving side equipment.The application can reduce the circuit failure rate, improve the smoothness of the traction current return flow, and improve the anti-interference ability to the traction current harmonic and the adjacent segment track circuit signal.
Owner:BEIJING RAILWAY SIGNAL

Improved fistulization and ostomy bag device

ActiveCN224141020Uimprove patencyReduce the risk of secondary infectionColostomy
The utility model relates to the field of medical auxiliary devices, in particular to an improved fistulization and ostomy bag device which comprises a waistband assembly, a steering tube assembly and an ostomy bag assembly, the waistband assembly is provided with a waistband body and a fixing piece, the steering tube assembly is provided with a bent tube body and a connecting piece, the bent tube body is provided with a rotating connector, and the connecting piece is provided with a connecting piece. The bent pipe body is connected to the fixing piece through a connecting piece, the ostomy bag assembly is provided with a bag body and an elastic film sleeve, and the bag body is connected to the other end of the bent pipe body. According to the ostomy bag, the bag body of the ostomy bag assembly is always consistent with the lower outlet of the bent pipe body of the steering pipe assembly in direction without blocking the outlet of the bent pipe body, so that natural excretion of a patient is not influenced when the ostomy bag assembly droops; the lower portions of the elastic film sleeves in the bag body of the ostomy bag assembly are attached to each other without external force, so that excretion of a patient can be discharged into the cavity in the lower portion of the bag body, splashing can be prevented through the elastic film sleeves, the excretion smoothness of the patient can be improved, and the risk of secondary infection can be reduced.
Owner:晋江市医院(上海市第六人民医院福建医院)

A device for spreading de-icing agent uniformly

ActiveCN224351124UAdjust the splash rangeFacilitate contact areaThrowing machinesCleaning
This utility model provides a de-icing agent spreading device, relating to the field of highway maintenance technology, to solve the problems of de-icing agent easily agglomerating into large particles, causing blockage at the discharge port, affecting spreading efficiency and uniformity, and the inconvenience of adjusting the spreading range of the de-icing agent according to road conditions and vehicle traffic. The device includes a storage bin, a spreading bin, and a conveyor belt. Two sets of mounting plates are fixedly connected to the left end of the storage bin. A rotating shaft is fixedly installed on the top of the spreading disc. External baffles are rotatably mounted at both ends of the outer side of the spreading disc. Two sets of electrically operated telescopic devices are installed at the bottom of the spreading disc. This utility model facilitates the crushing of large de-icing agent particles. The inclined structure of the conveyor belt, combined with its own operation, effectively improves the smoothness of de-icing agent spreading. The device allows for easy adjustment of the spreading range of the de-icing agent according to road conditions and vehicle traffic, and can automatically clean the surface of the conveyor belt.
Owner:刘勇

Asphalt smoke waste gas condensation recovery device with cooling structure

The utility model discloses an asphalt smoke waste gas condensation recovery device with a cooling structure. The asphalt smoke waste gas condensation recovery device comprises a gas collection tank and a cooling tank. An air inlet pipe and an axial flow fan are arranged on the side wall of the air collecting tank, and high-temperature asphalt smoke is primarily cooled by using external cold air; a spiral condensing pipe and a cooling water jacket are arranged in the cooling tank, so that substances such as tar in the asphalt smoke are further condensed, the condensing efficiency is improved, and the thermal load of equipment is reduced. An intermittent vibration mechanism is arranged at the bottom of the cooling tank, a jacking block is driven by a rotating disc to interact with rollers of a collecting box, periodic up-down vibration of the collecting box is achieved, condensate accumulation and blockage are prevented, waste gas smoothness is improved, and manual maintenance frequency is reduced. The device is reasonable in structure, high in condensation efficiency, stable in operation and suitable for efficient recovery treatment of asphalt smoke waste gas.
Owner:ANHUI QINGZHI TECH DEV CO LTD

Ice breaking and thawing device for water delivery channel

ActiveCN117779698Bimprove patencyEfficient ice breakingWater cleaningArtificial water canalsThermodynamicsThermal water
The application discloses an ice breaking and melting device for a water delivery channel and relates to the field of ice breaking of water delivery channels. The device comprises longitudinal transmission mechanisms, a transverse transmission mechanism, an ice breaking mechanism and a winding and melting mechanism. The longitudinal transmission mechanisms are symmetrically installed on the banks on both sides of the water surface. The transverse transmission mechanism is vertically arranged between the two longitudinal transmission mechanisms. The ice breaking mechanism is fixedly installed on the transverse transmission mechanism. The up-and-down cutting movement of the ice cutter is controlled by a driving group. After the ice surface is broken by the ice breaking mechanism, the rope net body is turned up from the vertical state by the turning guide rod group of the winding mechanism to hold the ice blocks above the water surface. Then, the water pipe sprays hot water on the broken ice in the arms of the rope net body to melt the ice. The device has high operability and can realize the combined effect of ice breaking, ice blocking and ice melting. After the ice on the water surface is broken, the ice blocks are lifted to separate from the water surface. Then, heat exchange is carried out to accelerate the melting of the ice blocks, improve the heat exchange efficiency and prevent the ice from being re-frozen.
Owner:SHANDONG SURVEY & DESIGN INST OF WATER CONSERVANCY

Seat capable of switching moving modes

ActiveCN224235020USolve slidingeasy to moveStoolsChairsPulleyPhysics
The utility model relates to the technical field of furniture, and particularly discloses a seat with switchable moving modes, which comprises a seat body and switchable moving components respectively arranged on the outer sides of legs and feet of the seat body, each switchable moving component comprises a bending connecting piece, a screw rod, a connecting frame and a pulley, the bending connecting piece is fixed with the legs and feet of the seat body through a fastener, and the screw rod is connected with the connecting frame. A lead screw vertically penetrates through the upper portion of the bending connecting piece, the two ends of the lead screw extend out of the bending connecting piece, the lower end of the lead screw extends out and penetrates through the connecting frame to be provided with a first limiting nut in a screwed mode, the upper end of the lead screw extends out and is provided with a second limiting nut in a screwed mode, and the outer wall of the lead screw is sleeved with a pressure spring which is located between the bending connecting piece and the connecting frame. When the chair is placed, the bottoms of the pulleys protrude out of legs and feet of the chair body, and when the chair is pressed down under stress, the bottoms of the pulleys are flush with the bottoms of the legs and feet of the chair body. The folding and unfolding of the pulley can be realized by switching two states of the moving component, and the problem that the seat is difficult to move is solved.
Owner:AVERY DISPLAY (JIANGSU) CO LTD

Filter and dishwasher

The utility model provides a filter and dish washer belong to kitchen equipment technical field, the filter includes main frame, tubular filter part, a plurality of first ball, a plurality of second ball and take cup, and main frame includes upper frame and lower frame, and upper frame is detachably connected with lower frame, and the axial both ends of tubular filter part are rotatable and are connected with upper frame and lower frame respectively, and first ball is arranged between the axial upper end of tubular filter part and upper frame, and second ball is arranged between the axial lower end of tubular filter part and lower frame, and first ball and second ball are configured to be used for reducing the friction of tubular filter part and upper frame and lower frame, and take cup is arranged in tubular filter part and is connected with main frame.
Owner:VATTI CORP LTD

Pressure relief mechanism of pulverized coal system valve

ActiveCN224093907UEffectively cope with dynamic changes in stressavoid shockPipe elementsEqualizing valvesUltrasonic vibrationPressure reduction
The utility model relates to the technical field of pulverized coal system valves, and discloses a pressure relief mechanism of a pulverized coal system valve, which comprises a coal conveying pipe and a mechanical pressure relief valve, the bottom of the mechanical pressure relief valve is provided with a feed port, the feed port is fixedly connected to one side of the top of the coal conveying pipe, the middle of the mechanical pressure relief valve is provided with a pressure relief port, and the pressure relief port is fixedly connected to one side of the top of the coal conveying pipe. A circulating pipe is fixedly connected to the interior of the pressure relief opening, an anti-blocking assembly is arranged in the circulating pipe, and a secondary pressure relief assembly is installed on the other side of the top of the coal conveying pipe; the secondary pressure relief assembly comprises a main valve cylinder and a secondary valve cylinder, and one end of the secondary valve cylinder is obliquely installed on the side wall of the main valve cylinder. According to the multi-stage pressure relief device, firstly, the mechanical pressure relief valve is used for quickly reducing the pressure, and then the secondary pressure relief valve is used for stably releasing the pressure, so that the system safety is improved. The pressure relief opening is connected with the circulating pipe to recycle pulverized coal, loss is reduced, blockage is prevented through the ultrasonic vibration rod, pipeline smoothness is guaranteed, and the energy utilization efficiency is improved.
Owner:ANHUI MAANSHAN WANNENGDA POWER GENERATION CO LTD

Preparation method of a biomimetic vascular graft and its application in liver preservation

The application belongs to the technical field of biomedical materials, and provides a preparation method of a biomimetic vascular graft and application of the biomimetic vascular graft in liver preservation. The preparation method comprises the following steps: obtaining a decellularized blood vessel by removing connective tissue, freeze-thawing treatment and trypsin treatment on a normal blood vessel; incubating the decellularized blood vessel in a functional modification solution to obtain a heparinized blood vessel; and incubating the heparinized blood vessel in an IL-4 solution to obtain the biomimetic vascular graft. The application can remove cell components and retain extracellular matrix as much as possible. The preparation method of the biomimetic vascular graft is simple, has strong applicability and is easy to mass-produce. The application improves the blood compatibility and patency of the biomimetic vascular graft by functional modification of the decellularized blood vessel, realizes local release of IL-4 molecules, and the biomimetic vascular graft can be used as a vascular bridge to establish a 'living preservation chamber' in the abdominal cavity of a recipient, so that the donor liver can continuously perform physiological perfusion, thereby providing a new strategy for liver preservation.
Owner:NANJING DRUM TOWER HOSPITAL