541results about How to "Increased longevity" patented technology

A method for treatment of obesity, especially morbid obesity, gastroparesis and other syndromes related to motor disorders of the stomach. The method of this invention utilizes a sensor to detect food entering the patient's stomach, thereby the sensor communicates with and activates at least one electrical stimulation device attached to either the stomach or the small intestine.

The present invention provides a flash memory management system and method with increased performance. The flash memory management system provides the ability to efficiently manage and allocate flash memory use in a way that improves reliability and longevity, while maintaining good performance levels. The flash memory management system includes a free block mechanism, a disk maintenance mechanism, and a bad block detection mechanism. The free block mechanism provides efficient sorting of free blocks to facilitate selecting low use blocks for writing. The disk maintenance mechanism provides for the ability to efficiently clean flash memory blocks during processor idle times. The bad block detection mechanism provides the ability to better detect when a block of flash memory is likely to go bad. The flash status mechanism stores information in fast access memory that describes the content and status of the data in the flash disk. The new bank detection mechanism provides the ability to automatically detect when new banks of flash memory are added to the system. Together, these mechanisms provide a flash memory management system that can improve the operational efficiency of systems that utilize flash memory.

A surgical staple for use in creating an everted anastomosis of at least two anatomical structures includes a bendable staple body. At least two evening elements protrude from the staple body. Spacing elements and a penetrating element also are provided. In use, the evening elements and spacing elements are apposed, and inner layers of the anatomical structures are held together to form an evened anastomosis. The evening platforms are disposed on an outer radius of the closed staple, and the penetrating element is disposed on a different, inner radius, to ensure that the penetrating element is excluded from the lumen of the anastomosis. Embodiments of the invention substantially ensure intima-to-intima approximation completely circumferentially at the anastomotic site, with no portion of cut tissue edges, suture or staple exposed to the lumen of the anastomosis. Cut tissue edges, as well as the staple, are completely extra-lumenal. Related methods provide similar advantages.

According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and / or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and / or vagal nerve stimulation therapy or the like.

Priority-based garbage collection utilizes attributes of data stored in the non-volatile memory array in order to improve efficiency of garbage collection and of the overall data storage system. A set of low priority data can be selectively evicted from a non-volatile memory array. This can, for example, reduce write amplification associated with garbage collection. Another set of low priority data can be regrouped or consolidated in a different region of the non-volatile memory array. In addition, flushing of data can be performed in order to enhance or optimize garbage collection. Performance and endurance can thereby be improved.

A device 10 and method for replacing or restoring competence to incompetent valves. The device 10 is inserted percutaneously or surgically and is preferably constructed of a material capable of promoting cellular ingrowth such that, eventually, native biologic tissue completely covers the device 10 insulating the blood flow therefrom. The material is preferably bioabsorbable over time, allowing the device to harbor the regeneration of a valve structure and to later become absorbed by the body. The device is sized and arranged to mimic the valve it is replacing or repairing.

An elongated perimeter light is disclosed, which comprises a linear array of light sources (LEDs) that are electrically illuminated. The array of light sources is disposed within an elongated transparent tube, with the tube transmitting and dispersing the light from the array giving the appearance that said array of light sources is a continuous light source. The array of light sources is capable of being cut at intervals down its length to shorten it. The light sources that remain in the array continue to emit light and the tube can be cut to match the length of said array. The present invention also discloses systems for lighting structural features, with one system according to the present invention comprising a plurality of elongated perimeter lights. The perimeter lights are electrically coupled in a daisy chain with the electrical power at each of the perimeter lights being transmitted to the successive light. A mechanism is included for anchoring the plurality of perimeter lights to a structure to illuminate it. Each of the perimeter lights can be cut at intervals down its length while not interfering with its ability to transmit its electrical power to successive lights.

This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and / or using the unsupplemented or supplemented fibrin sealant bandage.

Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transfection under serum-free conditions. In preferred embodiments, the cells of use are SpESF or SpESF-X cells.

The invention is a bladder formed of multiple layers of barrier film to provide multiple pressurized layers of cushioning fluid or gas when the bladder is filled. The sidewalls of the bladder can be constructed with an inverted seam construction to eliminate finishing steps in the manufacture of cushioning bladders and alternatively to provide a clean, seamless appearance along the side walls. The inverted seam can be formed by attaching the peripheral edges of inner barrier layers to the outer barrier layers adjacent a weld between inner barrier layers to provide an inside-out inverted seam appearance. An inverted seam can also be formed by providing separate sidewall elements attached to the barrier layers of the bladder to provide a seam displaced from the center of the sidewall.

This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, antiinflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and / or using the unsupplemented or supplemented fibrin sealant dressing.

A selected augment, shown as a tibial augment, is secured at an augmentation location on a prosthetic implant component, shown as a tibial implant component, by a securing element assembled with the body of the augment for displacement relative to the augment body to selectively engage an abutment located on a depending structure of the implant component, adjacent the augmentation location, so as to establish a securing force between the securing element and the depending structure for urging the augment against the implant component, and thereby secure the augment to the implant component at the augmentation location. In the tibial augment, a distal surface includes surface portions extending in anterior-posterior directions and oriented essentially normal to medial-lateral directions.

Hypoxic delivery apparatus producing from ambient air a product gas having a lower levels of oxygen concentration and delivering the product gas to a user of the apparatus in pulse doses. Alternatively, the apparatus may include a selector for alternately delivering either a nitrogen enriched gas or an oxygen enriched gas to the user.

Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transfection under serum-free conditions. In preferred embodiments, the cells of use are SpESF or SpESF-X cells.

A hemodialysis and vascular access system comprises a subcutaneous composite PTFE silastic arteriovenous fistula having an indwelling silastic venous end which is inserted percutaneously into a vein and a PTFE arterial end which is anastomosed to an artery. Access to a blood stream within the system is gained by direct puncture of needle(s) into a needle receiving site having a tubular passage within a metal or plastic frame and a silicone upper surface through which needle(s) are inserted. In an alternate embodiment of the invention, percutaneous access to a blood stream may be gained by placing needles directly into the system (i.e. into the PTFE arterial end). The invention also proposes an additional embodiment having an arterialized indwelling venous catheter where blood flows from an artery through a tube and a port into an arterial reservoir and is returned to a vein via a port and a venous outlet tube distinct and distant from the area where the blood from the artery enters the arterial reservoir. The site where blood is returned to the vein is not directly fixed to the venous wall but is free floating within the vein. This system provides a hemodialysis and venous access graft which has superior longevity and performance, is easier to implant and is much more user friendly.

The invention concerns a surface traversing apparatus that includes a frame, a seal having a seal perimeter that is mounted to the frame, and a drive configured to move the apparatus relative to the surface. The seal perimeter is adapted substantially for rolling contact with the surface to be traversed. The device is capable of suction adhering and moving along horizontal, vertical, inverted surfaces and the like, and overcoming obstacles or surface irregularities while maintaining suction adhesion to the surface. The device can be propelled along the surface with a locomoting rolling seal assembly, which provides both a seal to affect the vacuum adhesion and the locomotion to drive the device across the surface.

An intravascular prosthetic graft is provided which includes a flexible tubular body having a first end defining at least one opening and a second end defining at least one opening. The flexible tubular body may be elongated and define a longitudinal axis. A first ring member is connected to the first end adjacent to the at least one opening of the first end. A second ring member is connected to the second end adjacent to the at least one opening of the second end. The flexible tubular body can be fabricated from a flexible material, such as, for example, DACRON(R), TEFLON(R), or other suitable material. The first and second ring members may be fabricated from a rigid material, such as metals or polymerics. A method of repairing at least a portion of an arterial system, such as, for example, treatment of an aortic aneurysm is disclosed. The method includes the steps of providing an intravascular prosthetic graft; determining a placement position for the intravascular prosthetic graft at an aneurysm site of the arterial system; introducing the intravascular prosthetic graft to the arterial system; delivering the intravascular prosthetic graft to the aneurysm site; positioning the intravascular prosthetic graft for repairing a diseased portion of an aorta at the placement position; expanding the intravascular prosthetic graft to substantially conform to an inner surface of the aorta; and fixing the intravascular prosthetic graft at the placement position. The step of fixing may include tying a suture about the exterior of the aorta. The method may further include the step of suturing the aorta to the intravascular prosthetic graft from exterior to the aorta.

According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and / or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and / or vagal nerve stimulation therapy or the like.

An implantable medical device (IMD) including a nonhermetic battery is described. The IMD includes components and a power source module that includes the nonhermetic battery. The IMD also includes a barrier to substantially impede movement of substances from the nonhermetic battery to the components. The barrier may include a hermetic feedthrough, a gel, a polymer, or a solid electrolyte within the nonhermetic battery, and a seal member. The barrier may also be a material that encapsulates the nonhermetic battery and a getter within the IMD. In some embodiments, the IMD comprises a modular IMD including an interconnect member. In that case, the barrier may include a material that fills at least a portion of a void defined by the interconnect member. A length and a cross-sectional area of the interconnect member may also act as a barrier.

An Artificial Disc Replacement (ADR) includes a body and / or outer wall that is fortified, reinforced, stiffened or otherwise strengthened with a higher durometer, for example, where it rests against a weakened or deficient area of the annulus fibrosis (AF). The “less stiff” portions facilitate the transfer of load to the healthier portion of the AF. A hydrogel or other compressible and / or resilient material may be used within the center of the ADR to selectively transfer the forces to the outer wall. The outer wall may constructed of an elastomer, and may include a radial ply, bias ply, and / or belted construction. Methods of determining a properly sized ADR are also disclosed.

A cardiac stimulation device and method deliver independent stimulation pulses to right and left cardiac chambers, based on the capture thresholds of each chamber, and confirm capture in each chamber. A threshold test is performed in one chamber while stimulating the opposite chamber at increased pulse energy and adjusted interchamber delay.

An orthopedic tool for loosening the connection between orthopedic components. In one embodiment, the orthopedic tool includes a housing and a wedge. The housing has a head, an upper portion, a lower portion, and an opening between the upper and lower portions. The wedge is positioned at least partially between the upper portion and the lower portion of the housing and is actuatable to move toward the head of the housing. When at least a portion of the head of the housing is placed in mating engagement with the junction between two assembled orthopedic components, advancement of the wedge towards the head results in separation of the upper portion and lower portion of the housing. Thus, as the wedge is advanced toward the head, the upper and lower portions of the housing are separated, which results in corresponding separation of the assembled orthopedic components.

Apparatus and methods for applying treatment fluids, such as disinfectants, flavoring agents, and tenderizing agents, to foodstuff surfaces to, for example, reduce populations of microorganisms or fungi, alter taste, or alter texture. In representative embodiments, the apparatus includes a housing, a fluid delivery system, and a shaft with a protruding surface, the latter adapted to rotatably convey, while agitating and tumbling, the foodstuffs from an inlet to an outlet of the housing, as the fluid delivery system applies a treatment fluid to the foodstuffs. In more specific embodiments, the protruding surface may be paddles, or paddles interconnected by a solid web and having angled distal surfaces, or a spiral blade with radial protrusions, or such a spiral blade along a first longitudinal portion of the shaft and paddles along a second longitudinal portion of the shaft.

A rotary facial seal and a thrust bearing are adapted to be installed between inner and outer concentric relatively movable members, such as, the spindle housing and axle of a motor vehicle, the facial seal having an annular diaphragm made up of an inner seating portion mounted on the axle, an outer plastic or PTFE sealing ring with a lip tapering away from a hinged section in a seal body to engage a radial wall of the housing, and an intermediate resilient wall section between the seal lip and seating portion to yieldingly urge the sealing lip into a thin band of contact with the radial wall under the biasing action of the intermediate wall section; and the thrust bearing includes a bearing member which is installed at the inner bore of the spindle housing and is freely rotatable with respect to the spindle housing when engaged by the end of the shaft and inner seating portion of the facial seal.