32results about How to "Reduce foreign body reactions" patented technology

The present disclosure relates to surgical implants comprising a bioabsorbable incision reinforcement element, a long-term mesh, and a bioabsorbable coating disposed on the mesh. The surgical implants disclosed herein are useful in a variety of surgical procedures, particularly surgeries involving the pelvic floor. More particularly, the present disclosure relates to surgical implants, wherein an incision reinforcement element comprises a bioabsorbable material that degrades during a first time period, and the coating comprises a bioabsorbable material that degrades in a second time period, and the first time period is shorter than the second time period.

The invention relates to a nano magnesium/polylactic acid composite material for a completely degradable endovascular stent and a preparation method thereof. The preparation method comprises the following steps: blending and compositing nano magnesium which is used as a reinforcing material with polylactic acid so as to prepare the completely degradable endovascular stent. The stent has good compatibility with a human body, has less possibility of causing inflammatory reaction, can be completely degraded, and has the advantages of stable mechanical property, simple preparation method, low cost and the like.

A glucose sensor assembly useful in patient systems includes an oxygen sensor from which glucose levels in the vicinity of the peritoneal cavity may be inferred. The sensor assembly may be associated with electronics, such as any or all of a DC power supply, an LED source of blue light, a photoreceptor for red light, a CPU, and transceiver, by a direct percutaneous connection. Alternatively they may be associated transdermally with the sensor and some of the electronics being located subdurally. Insulin infusion means are contemplated to respond manually or mechanically to information from the sensors through the CPU. Mechanical response may be automatic. Infusion means may be located subdurally. It is contemplated that the present invention enable revitalization or replacement of fluorescing compounds and glucose oxidase within the sensor assembly.

The invention belongs to the field of biological materials. A medical implant material can generate a foreign body reaction when entering a human body, and a present, a drug coating for preventing andtreating the foreign body reaction is difficult to delay and control drug release in a drug release process. Aiming at the problems in the prior art, the invention discloses a preparation method of amultiple drug fiber membrane for reducing a foreign body reaction of an implant material. The preparation method comprises the following steps of: firstly, preparing a nano fiber membrane with a 'skin-core' layer structure through a coaxial electrostatic spinning technology; and then spraying polymer microspheres containing an anti-fibrosis drug on the surface of the fiber membrane through a high-voltage electrostatic spraying technology. The preparation method provided by the invention is simple; and the prepared multiple drug fiber membrane has a multiple drug release system, and can realize multiple controlled release of drugs and reduce the foreign body reaction of the implant material.

The invention discloses a composite polypropylene mesh. The composite polypropylene mesh is bonded by a polypropylene mesh and a fibroblast growth factor through polydopamine. In the premise condition of not changing the mechanical strength and the surface structure of the original polypropylene mesh, the fibroblast growth factor is grafted on the surface of the polydopamine after the polydopamine is grafted on the surface of the polypropylene mesh, and the composite mesh separation phenomenon cannot be generated. Simultaneously the fibroblast growth factor is hard to degrade in the body, the fibroblast growth can be induced and then the fascia reconstruction is induced.

Stents are used in combination with a paclitaxel derivative in order to inhibit scarring that may otherwise occur when the implant is placed within an animal. Suitable implants include vascular stents, esophageal stents, tracheal or bronchial stents, gastrointestinal stents, genital-urinary stents, nasal and sinus stents, and ENT stents.

A rotator cuff patch based on fibroin gel comprises a rotator cuff patch body, a fibroin electrostatic spinning membrane serving as a patch base layer, fibroin gel containing Mg < 2 + > ions serving as a load anti-inflammatory drug layer and fibroin gel containing Zn < 2 + > ions serving as a load healing promoting drug layer, and the rotator cuff patch has the full-degradation characteristic, inhibits inflammatory response in the early stage, promotes osteogenesis in the repair period, and has the advantages of being free of side effects, free of side effects and the like. The effect of promoting graft integration is achieved, and the biological safety is higher.

A rotator cuff patch based on a cellulose gelatin coating comprises a rotator cuff patch body, a cellulose electrostatic spinning membrane serving as a patch substrate layer, gelatin containing chondroitin sulfate serving as a load anti-inflammatory drug layer and gelatin containing astragalus extract serving as a load healing promoting drug layer, and the rotator cuff patch can inhibit inflammatory reaction in the early stage, promote tissue regeneration in the repair period and promote healing. The effect of promoting graft integration is achieved.

Zwitterionic microgels, zwitterionic microgel assemblies, their formulations and methods for their use.

The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.

The invention discloses a keratoprosthesis. The keratoprosthesis comprises a central opticator and a fixed portion arranged in the periphery, and the keratoprosthesis is characterized in that a hydroxylapatite coating (3) is smeared on a cylinder lateral outer surface of the central opticator and the inner surface of the fixed portion (2) in the keratoprosthesis, and average grain diameter of nanoparticle of the coating is 20 nm. The keratoprosthesis has the advantages that isolation of the coating and an anti-microbial property of the hydroxylapatite are made use of, after smearing the coating and the hydroxylapatite on the cylinder outer surface of the keratoprosthesis opticator and the inner surface of the fixed portion of the periphery of the opticator, a role of killing effect on microorganisms such as germs which are in contact with a cornea and aqueous humor of a patient is thus played by the coating and the hydroxylapatite; due to the fact that the hydroxylapatite can smear the periphery of the keratoprosthesis opticator for a long time, intrinsic characteristics of keratoprosthesis materials are not changed, intrinsic characteristics of the keratoprosthesis are still maintained so that treatment and nursing can reach optimal effects.

The invention discloses a multi-layer blood vessel stent. The blood vessel stent comprises a stent body, the stent body is provided with an inner tube, an outer tube and a plurality of supporting strips, the inner tube is sleeved with the outer tube, the supporting strips are radially disposed on the outer wall of the inner tube, one end of each supporting strip is connected to the outer wall of the inner tube, the other end of each supporting strip is connected to the inner wall of the outer tube, the inner wall of the inner tube is coated with a first coating, and the outer wall of the outertube is coated with a second coating. A method for preparing the multi-layered blood vessel stent comprises the steps of a, extruding polylactic acid into a tube material, conducting laser cutting, preparing the supporting strips on the outer wall of the inner tube, coating the outer surfaces of the supporting strips with rapamycin, conducting drying and preparing the outer tube at the ends, awayfrom the inner tube, of the supporting strips; b, coating the inner surface of the inner tube with heparin-based medicine and alumina water-soluble gel and then coating the surface of the first coating layer with the alumina water-soluble gel; c, conducting electrospinning on the outer surface of the outer tube for 1-2 hours to form the second coating of 5-10 micons.

Neurological implants whose surfaces have been chemically and covalently modified to impart beneficial properties to the neurological implants are described. The neurological implants possess improved biocompatibility compared to a corresponding neurological implant that lacks the chemical modification. Following implantation in a subject, the surface-modified neurological implants induce a lower-foreign body response, compared to a corresponding unmodified product.

Infusion sets for subcutaneous drug delivery are described herein. The infusion set integrates a bijel-templated material (BTM) into a cannula such that a portion of the BTM protrudes from the cannula tip into the host tissue. The BTM is a porous, polymeric sponge having a co-continuous architecture with consistent curvature throughout non-constricting, interpenetrating channels, which is critical in mitigation of the deleterious host tissue response, vascularization, and flow redistribution in the implant.