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Artificial cornea containing biological materials

A technology of artificial cornea and biological material, applied in the field of medicine, to achieve the effect of reducing foreign body reaction, eliminating gaps and slight inflammatory reaction

Active Publication Date: 2019-07-19
THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main purpose of the present invention is to overcome the above-mentioned defects in the existing artificial cornea, and provide an artificial cornea containing biomaterials and an implantation method to enhance the biointegration of the artificial cornea and reduce the artificial cornea during use. discharge and reduce the incidence of infection

Method used

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  • Artificial cornea containing biological materials
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  • Artificial cornea containing biological materials

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Experimental program
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Embodiment

[0067] The present invention uses the exposure rate of the artificial corneal stent to evaluate the implementation effect of the artificial cornea of ​​the present invention, and the exposure rate is also the rejection rate. According to the applicant's experience of using MICOF and Boston type II artificial corneas, the exposure rate (rejection rate) of patients implanted with existing PMMA artificial corneas without biomaterial components is 60% 5 years after the operation. However, the applicant performed a total of 156 cases of artificial cornea implantation operations containing autologous ear cartilage. As a result, only 6 cases were exposed after 5 years, and the exposure rate dropped to 3.8%.

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Abstract

The present invention discloses an artificial cornea containing biological materials. The artificial cornea comprises an optical part and a biological material component, the biological material component is composed of the biological materials, the biological materials comprise autogenous materials and / or non-autogenous materials. The novel artificial cornea has good biocompatibility, optical properties and mechanical strength properties, is suitable for recovery treatments of various complex and severe corneal blindness, can use patient's autologous cornea and also donor's cornea as a carrier, and is convenient for large-scale promotion and use.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a novel artificial cornea containing biomaterials. Background technique [0002] According to the World Health Organization (WHO) report in 2009, there are about 8 million patients with corneal blindness in the world. There are about 3 million corneal blind patients in my country. Penetrating keratoplasty is currently the main means of vision recovery for corneal blindness, and the 5-year success rate for low-risk lesions can reach 70%. However, for high-risk cases with a large number of corneal neovascularization, etc., the success rate is less than 50%, especially for severe corneal scars, vascularization, infection or immune diseases caused by severe acid-base chemical burns or eyelids that cannot be restored. Conjunctival sac dysfunction, such as complete obliterated symblephane, Steven-Johnson syndrome (SJS), ocular cicatricial pemphigoid (OCP), and multiple keratoplasty ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/14A61L27/50
CPCA61F2/142A61F2210/00A61F2210/0004A61L27/50A61L2430/16
Inventor 王丽强黄一飞
Owner THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL