69 results about "Conjunctival sac" patented technology

A tear replacement solution that contains at least one water-soluble fluorosurfactant, water and a non-polar component, preferably in gel form, and a method for the external treatment for the eye of an mammal by applying the tear replacement solution to the eye, preferably by placing in the conjunctival sac.

The invention relates to a method of instilling insulin ophthalmic drops in the conjunctival sac for treating retinitis pigmentosa due to any etiological factors both genetic and non genetic. The retinitis pigmentosa is treated with Insulin and / or IGF-I with or without known anti-retinitis pigmentosa therapeutic, pharmaceutical, biochemical, and biological agents or compounds. The invention furthermore uses this method as prophylactic on patients where the patients are predisposed to develop retinitis pigmentosa. The invention additionally treats other oculopathies associated with and / or contributing to retinitis pigmentosa.

A method for treating age related macular degeneration (AMD) using an insulin preparation applied topically to the conjunctival sac of the affected eye. Another aspect of this invention is using antiangiogenic adjuvant therapeutic agents such as bevacizumab, ranibizumab, pegaptanib, etanercept, instilled in to the afflicted eye conjunctival sac with insulin to prevent further formation of new blood vessels, and shrink the existing pathologically formed blood vessels and reduce the edema in wet AMD. This method incorporates putting the patients on low fat diet, aerobic exercise, ketamine-a NMDA blocker, reducing the blood cholesterol using adjuvant therapeutic agents selected from Statins, that are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A, (i.e. HMG-Co A) reductase which in turn reduce drusen formation that leads to AMD, combined with insulin ophthalmic drops.

The invention belongs to the field of medicinal preparations, and in particular relates to an intraocular drug delivery composition and a preparation method of the intraocular drug delivery composition. The composition is a nano-composite prepared from cell-penetrating peptide, a ramous cationic polymer and a bio-macromolecular medicine, wherein in appearance, the composition is nanoparticles withthe particle size being 100-500 nm; the bio-macromolecular medicine is the medicine such as genes, polypeptides and protein with negative charges under the condition that the pH is 7.4; the electriccharge ratio of the ramous cationic polymer to the pharmaceutical molecules is (1:3) to (10:1), and the electric charge ratio of the cell-penetrating peptide to the medicine is (1:1) to (50:1). The composition is administrated by adopting the manner of dropping the medicine into the conjunctival sac, the absorption of the bio-macromolecular medicine in the eyes is promoted, and the bio-macromolecular medicine is delivered to the retina part at the posterior eye segment; with the composition, the compliance in treating eye diseases by adopting the bio-macromolecular medicines such as genes, polypeptides or protein of patients can be improved, and the bioavailability of the eyes for the medicine is improved.

The invention discloses an amnioscope and a preservation method thereof and belongs to medical instruments. The amnioscope structurally comprises an amniotic membrane and a conjunctival sac supporting device, the conjunctival sac supporting device is of an annular structure with diameter gradually increased from top to bottom and is identical with an ocular surface in radian, a trapezoidal groove is formed in a position where the lower portion of the conjunctival sac supporting device contacts with a lower hole of the ocular surface, and the upper portion of the amniotic membrane is fitted with an inner cavity of the conjunctival sac supporting device while the lower portion of the same extends out of the inner cavity of the same and is fixed to the outer wall of the conjunctival sac supporting device. Compared with the prior art, the amnioscope and the preservation method have the advantages that the amniotic membrane and the conjunctival sac supporting device are integrally arranged, and the amnioscope is preserved in a specific preservation solution and put in certain low-temperature state, so that tissue activity of the amniotic membrane is maintained; the amniotic membrane can be taken for use at any time and is simple to operate, so that uncomfortable symptoms of a patient when wearing the amnioscope are avoided, and the amnioscope has high popularization and application value.

The invention discloses an eyedrop dropping assistance glasses frame which consists of a fixed glasses frame, a rotating device and a feedback device. The rotating device is arranged in the fixed glasses frame, and the feedback device is fixedly arranged at the front end of the fixed glasses frame. When the eyedrop dropping assistance glasses frame is used, the fixed glasses frame is fixed to the head of a patient, the patient can observe the eye situation through angles of a first plane mirror and a second plane mirror on the feedback device, a rotating mechanism required in the rotating device is operated as required, the eyelids are pushed aside to make conjunctival sacs exposed, eyedrops are dropped into lower conjunctival-fornix conjunctival sacs, the patient closes eyes, and the device is taken off after dropping is completed. The eyedrop dropping assistance glasses frame is simple in structure, low in cost, simple in operation and convenient to carry, a user can accurately master an eyedrop dropping usage method, the usage cost is low, the patient can independently complete dropping, an active role is played in eye disease treatment, and the eyedrop dropping assistance glasses frame is suitable for patients suffering from eye diseases and populations having eye health care demands to widely use.

The invention relates to an intraocular pressure real-time measuring apparatus and method based on conjunctival sac pressure detection. The apparatus comprises a detection head disposed inside the conjunctival sac of a patient, and a signal receiver. The detection head comprises an air bag, and an air pressure sensor and a flexible circuit board both disposed inside the air bag. The air pressure in the air bag is the standard atmospheric pressure, the air bag is in contact with an eyeball, and the air bag is in a pressed state. The flexible circuit board is used for sensing the air pressure in the air bag, converting the air pressure into electric signals, and sending the electric signals. The signal receiver is used for receiving the signals sent by the flexible circuit board. According to the method, the air pressure sensor in the air bag senses the air pressure signals generated as the air bag is subjected to the intraocular pressure, the air pressure signals are converted into the electric signals, then the electric signals are sent out, and the signal receiver processes the signals after receiving the electric signals so as to obtain the real-time intraocular pressure value of the patient. The apparatus and the method are simple in structure, can automatically detect the intraocular pressure value of the patient in a real-time manner, facilitates a doctor in timely making a treatment scheme, and improves the treatment efficiency.

The invention discloses a conjunctival sac flushing and collecting system. The invention provides the technical scheme points that the conjunctival sac flushing and collecting system comprises an eyewashing cover, a fluid storage device and a flushing pipe, wherein the eye washing cover comprises a top plate and a side wall; the side wall is arranged along the side edge of the top plate; the sidewall and the top plate form a holding cavity for holding an eye part of a human body; an elastic fixing band is arranged on one surface, back on to the holding cavity, of the side wall; one end of the water flushing pipe communicates with the inside of the fluid storage device; the other end of the water flushing pipe stretches into the holding cavity; a valve for controlling flushing fluid to flow is arranged on the water flushing pipe; and a drain outlet is formed in one end, close to an ear side of the human body, of the side wall. The conjunctival sac flushing and collecting system is further provided with an eyelid opener, wherein openings are formed in the parts, corresponding to an upper eyelid and a lower eyelid of the human body, of the side wall; the eyelid opener comprises twoeyelid opening arms stretching into the openings; an operation port is formed in the top plate; and a seal cover for covering the operation port is further hinged onto the top plate. In the use process of the conjunctival sac flushing and collecting system provided by the invention, the flushing fluid is ensured to be concentrated at a conjunctival sac part of a patient, and the upper eyelid and the lower eyelid are held apart through the two eyelid opening arms, so that the exposure area of the conjunctival sac is increased.

The invention belongs to the field of medicinal preparations, and relates to liposome for eyes and a preparation method thereof. In order to overcome the defects that common eye drops have short residence time in the conjunctival sac to cause low bioavailability at the eyes and the semi-solid dosage form has poor compliance and is not easy to be accepted by patients and the like in the prior art,the invention provides a biological adhesive liposome preparation for eyes. The biological adhesive liposome preparation for the eyes consists of the liposome, a liposome membrane modification material and a medicament wrapped in the liposome, wherein the surface of the liposome is modified with free mercapto, and a covalent binding disulfide bond can be formed by the free mercapto and a mucoprotein subdomain rich in cysteine on the surface of the eye to anchor the liposome on the surface of a mucous membrane and serve as a medicament store to slowly release the medicament in the conjunctivalsac and provide permanent driving force for the absorption of the medicament. The preparation is helpful for promoting the absorption of the medicament at the eyes, and can improve the bioavailabilityof the medicament.

The invention relates to a sutureless amniotic membrane fixing device applied in ocular surface amniotic membrane covering surgery, in particular to an ocular surface amniotic membrane coverer. The fixing device is in the shape of a fish mouth and is provided with an opening on the outer side, the general profile of the fish mouth is streamline according to forms of an ocular surface and a conjunctival sac, the opening is positioned at an outer canthus, and the fixing device has good supporting performance, can guarantee an amniotic membrane after being clamped by the device to be closely adhered on the ocular surface, and is high in adhesiveness. When the sutureless amniotic membrane fixing device is in use, the amniotic membrane reverses from the bottom of the fixing device to wrap the device, and is fixed in a groove on the surface of the device by means of shackling, and the bottom of the fixing device is completely wrapped in the amniotic membrane, so that friction damage to the ocular surface is reduced, and foreign body sensation is small. After the amniotic membrane is fixed in the device, an operator holds and gently squeeze an upper arm and a lower arm of the fish mouth to enable upper and lower diameters of the fish mouth to be reduced, simultaneously uses another hand to prop open upper and lower eyelids of a patient, disposes the upper arm and the lower arm of the device into upper and lower fornices and releases the arms, so that the device is positioned on the ocular surface after being propped open, thereby being less prone to shedding. The opening of the fixing device is positioned on a temporal side, so that effusion below the amniotic membrane is avoided, and the fixing device is least prone to shedding. By the sutureless amniotic membrane fixing device, the process of the amniotic membrane covering surgery can be simplified, and damage to the ocular surface due to surgical suturing can be avoided; the sutureless amniotic membrane fixing device can be reused, and the surgical process is greatly simplified.

A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva.; The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

The invention discloses an iris rotating artificial eye and a manufacturing method thereof. The artificial eye is designed into a hollow thin layer, an interlayer structure is arranged in the artificial eye, and an iris membrane is arranged in the interlayer structure of the artificial eye, wherein a magnetic driving sheet similar to a cornea contact lens sample is placed into a conjunctival sac on the back of the artificial eye to drive the iris membrane to move. The contradiction problem in the prior artificial eye, namely the relation between the size and motion degree of the artificial eye, is solved, so the artificial eye can meet the requirements of eyelid plumpness and the simulated motion of the artificial eye at the same time.

The invention relates to eye drops for treating conjunctivitis, which have the effect of treating the conjunctivitis by washing eyes to achieve anti-inflammatory treatment. The eye drops for treating the conjunctivitis are the externally applied eye drops which are prepared from the following traditional Chinese medicine raw materials: 13-17 parts of common jujube bark, 13-17 parts of mulberry bark, 8-12 parts of herb of ramose scouring rush, 8-12 parts of swordlike atractylodes rhizome, 10-14 parts of chrysanthemum and 8-12 parts of feather cockscomb seed. According to the invention, 319 patients (408 eyes) with the acute conjunctivitis in a group are observed after being subjected to conjunctival sac washing treatment with the eye drops disclosed by the invention so that the eye drops are proved to have significant curative effects against acute bacterial conjunctivitis.

The invention discloses a breathable amnioscope, and relates to medical instruments. The breathable amnioscope comprises a conjunctival sac supporting device. The conjunctival sac supporting device isannular and attached to the radian of the ocular surface. A plurality of through holes are formed in the conjunctival sac supporting device. Compared with the prior art, the breathable amnioscope ofthe present invention can drain effusion generated by the ocular surface below the conjunctival sac supporting device, and can conduct ventilation and air exchange on the lower part of the conjunctival sac supporting device, thereby inhibiting breeding of anaerobic bacteria. The breathable amnioscope solves the problem that apocenosis and ventilation cannot be achieved in the prior art.

A method of treatment of retinitis pigmentosa using a medically effective dose of insulin, IGF-1, and chlorin e6 topically applied to the conjunctival sac of the afflicted eye. The combination of these is very effective in treating retinitis pigmentosa and may be repeated as directed by a medical practitioner. The method includes preparing the dosage and filling an eye dropper with the compound, then having the patient lie in a supine position while administering the dosage. The patient remains in this position for 5 minutes to ensure absorption of the compound. In one embodiment, single use eye droppers are provided to simplify treatment. The particular dosage is adjusted to take individual metabolisms into account. A thorough examination of the patient's eyes should be done prior to treatment.

The invention discloses a flushing fluid for an external eye operation and a preparation method of the flushing fluid, and belongs to the technical field of surgical flushing fluids. The flushing fluid contains the following components: NaCl, KCl, CaCl2H2O, MgCl2.6H2O, C2H3NaO2.3H2O, C6H5Na3O7.2H2O, cocamidopropyl betaine, digitalin, Esculin, an amnion extracting solution, trehalose and hyaluronicacid. Through combined application of all the components, grease in an operation area, tissue debris generated in an operation and the like can be cleaned more easily, the cleanliness of the operation area is improved, the number of flora of conjunctival sacs is reduced, tissue repair can be promoted, postoperative inflammatory response is relieved, and discomforts such as eye edema, hyperemia and dryness are relieved. Meanwhile, the solutions are less irritating, have no toxic or side effect, are low-cost, and are suitable for wide clinical application.

The invention provides an eye drop bottle. The eye drop bottle comprises a bottle body used for storing medicine liquid, a bottle neck used for dropping the medicine liquid and a dropping cap used in cooperation with the bottle neck; a hollow pipe in the bottle neck is communicated with the bottle body; the medicine liquid drops out from a liquid outlet of the bottle neck through the hollow pipe by extruding the bottle body; the eye drop bottle is further provided with a positioning support; when the eye drop bottle is used, the positioning support abuts against the lower eyelid skin, a dropping head is naturally aligned with a downwards-turned conjunctival sac and is downwards moved by a certain distance, and the medicine liquid is dropped into the conjunctival sac by extruding the bottle body.

The invention relates to a glaucoma drainage device, which consists of a drainage pipe (a pipe for short) and a drainage sheet (a membrane sheet for short), wherein the pipe and the membrane sheet can be simultaneously or singly used, the pipe has the length of 0-15mm, the inner diameter of 1-1500[mu]m, and the outer diameter of 3-3000[mu]m, the membrane sheet has the thickness of 0-3mm, and the area of 0-500mm<2>, the aqueous water can smoothly flow in the inner side surface of the membrane sheet, the inner side surface of the membrane sheet is provided with 0-N dot-shaped or line-shaped grooves, and the depth and the width of each groove are respectively 0-5mm; the drainage sheet is in a shape of semicircle, ellipse, sector and triangle. As the equipment adopts the material, such as silica rubber, the easiness in direct pricking into the anterior chamber of eyes is avoided, a metal chip is assisted by the applicable shape of the silica rubber, and the metal chip is provided with a handle to assist the soft material (such as silica rubber) in pricking into the anterior chamber of eyes. The glaucoma drainage device has the advantages that the material of equipment adopts medical silica rubber, hydrogel or other metallic human body implantable materials; the size of equipment is small, the appearance design conforms to the anatomy principle of human eyes, and the device is suitable for being arranged in any position of conjunctival sac for a long time.

The invention discloses an adjustable conjunctival sac expander and a method for expanding a conjunctival sac through the adjustable conjunctival sac expander. The conjunctival sac expander comprises two supporting modules used for expanding the conjunctival sac, the two supporting modules are oppositely arranged, and the outer surfaces of the two oppositely-arranged supporting modules are the outer surfaces of protruding balls. The two oppositely-arranged supporting modules are fixed together through an adjusting device which is used for supporting and is capable of adjusting the distance between the two supporting modules. The length of an eye shaft is determined, the size of the conjunctival sac expander is determined, the conjunctival sac expander is placed in the conjunctival sac, the distance between the two supporting modules is expanded at regular intervals through the adjusting device, the conjunctival sac expander is taken out until the needed expansion degree of the conjunctival sac is reached, and an ocular prosthesis sheet is mounted. The adjustable conjunctival sac expander is used for expanding the conjunctival sac, the ideal expansion effect can be achieved, and the problem that the ocular prosthesis sheet cannot be mounted after the conjunctival sac is narrow can be effectively solved.

A visual eye-drops application assisting device with a display screen enables the opening of an eye-drops bottle to downward, an extruding part clamped in the opening and a camera, a coiled pipe and the display screen connected with the extruding part enable the display screen to synchronously display an image of an affected eye, and the affected eye can be clearly seen through the display screen with a healthy eye. In other words, the visual eye-drops application assisting device can be aligned to the image of the affected eye through the camera, enables the display screen to synchronously display the image of the affected eye and enables the healthy eye to clearly see the image of the lower eyelid, pushed aside by one hand, of the affected eye through the display screen, an image of a conjunctival sac is formed between the eyeball and the eyelid, an eye-drops bottle body is extruded with the other hand through the extruding part to accurately drop eye drops into the image of the conjunctival sac of the affected eye, the image of the inner canthus is accurately compressed after eye-drops application, and a user can very easily drop the eye drops into the image of the conjunctival sac according to the images to reduce side effect, improve treating effect, effectively prevent eye drops from dropping onto the eyeball and effectively reduce harm to the eye of a preservative.

The invention is for a safe and effective method of administering an opthalmological therapeutic agent for the treatment of night blindness and improving night vision, using insulin, and chlorin e6, preparations instilled into the conjunctival sac as ophthalmic drops. Night blindness and decreased night vision is associated with retinal diseases such as dry age related macular degeneration, retinitis pigmentosa and other such related eye diseases by using insulin, chlorin e6, ketamine, and monoclonal antibodies and IGF-1. The ophthalmic preparations may be supplemented with oral intake of various retinal photoreceptors vision supporting lutein, vitamin A, Zeaxanthin, Omega 3 Oils and other nurticeuticals. They may also be supplemented with cholesterol lowering statins in the elderly with high blood cholesterol to prevent eye diseases such as AMD contributing to night vision and night blindness.

The present invention provides a drainage device for a glaucoma valve filtration bleb site. The drainage device is composed of a drainage tube and a pushing assembly, and the pushing assembly is composed of a pushing rod and a puncture needle. The pushing rod is arranged on the front inner side of the drainage tube, and a puncture needle is arranged on the front end of the pushing rod. The anterior end of the drainage tube is an inclined plane for oblique gradual transition to engage with the puncture needle, and the posterior part of the drainage tube is placed in the conjunctival sac or fascial sac. A barb inverse locking structure is arranged on the outer side of the proximal tube wall of the front part of the drainage tube. The device has the advantages that the operation of implantingthe glaucoma valve wrapping bubble with the drainage device is simple, the glaucoma valve wrapping bubble need not be opened, the damage to the eye tissue is small, the wrapping caused by the fibrosis is effective, the drainage aqueous humor has the function of lubricating the eye surface, and the eye surface treatment is effective for the patients with severe dry eye.

A tear replacement solution that contains at least one water-soluble fluorosurfactant, water and a non-polar component, preferably in gel form, and a method for the external treatment for the eye of an mammal by applying the tear replacement solution to the eye, preferably by placing in the conjunctival sac.

The invention relates to an usage method of an auxiliary self-service dual-purpose eyedropper, which comprises a plurality of steps: the opening degree of an eyedropper mouth is adjusted; an observation mirror is selected; the distance between two elastic claws is adjusted; a drop bottle is connected between the two elastic claws; the angle of the observation mirror is adjusted; the upper and thelower eyelids of an eye are propped up for realizing the rough positioning of the eyedropper mouth; a worm-gear case is adjusted for realizing the accurate positioning of the eyedropper mouth; the drop bottle is squeezed for dropping eye drops into the conjunctival sac of a patient; and the operation is switched to the other eye for finishing dropping. The usage method enables the patient to use the auxiliary self-service dual-purpose eyedropper in an auxiliary way or a self-service way, can prevent the patient from blinking during the dropping process, enables the eye drops to be accurately dropped into the conjunctival sac of the patient, avoids the eye drops to be dropped outside the eyes and shuns contact infection to the eyes, therefore the eye drops can be effectively dropped with high quality, and the experience of the patient is greatly improved.

Device for administering a fluid into a patient's conjunctival sac, which combines in a single product optimum characteristics in terms of stability, positioning and spacing of the fluid dispenser with respect to the surface of the eye, as well as guiding of the dispensed fluid towards the center of the eye. The device has the shape of a hollow truncated cone, the minor (top) base of which is adapted to house the dripper of a fluid dispenser and the major (bottom) base of which has a non-coplanar ovoid shape and is adapted to rest precisely on the periocular area. The device allows safe spacing of the tip of the dripper from the corneal surface, preventing accidental contact between dripper and cornea. The dispensed fluid is directed towards the center of the eye surface, without coming into contact with the device. The device is constructively simple, low-cost and suitable for possible disposable use.

The invention relates to the technical field of medical instruments, and particularly discloses a conjunctival sac drainage aqueous humor micro-irrigation device for treating dry eye lesion. The device comprises a drainage intubation tube, a compression soft body, a drainage body, a drainage catheter and a liquid outlet body which are connected in sequence, and the drainage intubation tube, the compression soft body, the drainage body, the drainage catheter and the liquid outlet body are connected in sequence. The front end of the drainage intubation tube is provided with a tip end which can be conveniently inserted into the anterior chamber, and the middle section of the drainage cannula is provided with an anti-backflow assembly; in the drainage irrigation process, sterile aqueous humor is drained to the eye surface to achieve the wetting effect, the effect is better than that of conventional manual operation, carrying is not needed, meanwhile, the problem that drainage irrigation cannot be conducted after an existing aqueous humor drainage device is blocked is effectively solved, the structural design is simple, and the using effect is excellent; in addition, the insertion process of the drainage cannula can be accurately and accurately carried out through the inserted guide wire, and the use effect is excellent.

The invention discloses an iris rotating artificial eye and a manufacturing method thereof. The artificial eye is designed into a hollow thin layer, an interlayer structure is arranged in the artificial eye, and an iris membrane is arranged in the interlayer structure of the artificial eye, wherein a magnetic driving sheet similar to a cornea contact lens sample is placed into a conjunctival sac on the back of the artificial eye to drive the iris membrane to move. The contradiction problem in the prior artificial eye, namely the relation between the size and motion degree of the artificial eye, is solved, so the artificial eye can meet the requirements of eyelid plumpness and the simulated motion of the artificial eye at the same time.