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Flushing fluid for external eye operation and preparation method thereof

A technique for surgical irrigating solution and extracting solution, which is applied to the field of external eye surgery irrigating solution and its preparation, can solve the problems of unfavorable corneal repair, tear film stability, high conjunctival sac flora, and oil is not easy to rinse, and achieves excellent bactericidal properties, inhibiting The effect of corneal neovascularization and improvement of cleanliness

Active Publication Date: 2020-04-14
AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides an external eye surgery flushing solution and a preparation method thereof, which solves the problem that the existing external eye surgery flushing solution is not easy to flush due to the presence of oil in the operation, which leads to unclear operation field, high number of conjunctival sac bacteria after operation, heavy inflammatory reaction, and no Facilitates corneal repair and tear film stabilization issues

Method used

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  • Flushing fluid for external eye operation and preparation method thereof
  • Flushing fluid for external eye operation and preparation method thereof
  • Flushing fluid for external eye operation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This embodiment provides a kind of flushing solution for external eye surgery, which contains the following components in terms of mass percentage: 0.64% NaCl, 0.075% KCL, 0.048% CaCl2 2H2O, 0.048% MgCl2 6H 2 O 0.03%, C2H3NaO2 3H2O 0.39%, C 6 h 5 Na 3 o 7 2H 2 O 0.17%, Cocamidopropyl Betaine 0.001%, Digigenin 0.005%, Aescin 0.01%, Amniotic Membrane Extract 1%, Trehalose 1%, Hyaluronic Acid 0.5%, and the balance is purified water.

[0029] Wherein, the preparation method of the amniotic membrane extract is as follows: take the cesarean section placenta, separate the amniotic membrane after washing, grind with liquid nitrogen, add medical physiological saline at a weight-to-volume ratio of 1:8, and homogenize to obtain a homogenate; the homogenate is 0-4 Place at ℃ for 3 days, heat at 100-120℃ for 45 minutes, filter, and take the filtrate; adjust the pH value of the filtrate to 3, let it stand, filter, and take the filtrate; adjust the pH value of the filtrate to 7.2,...

Embodiment 2

[0038] This embodiment provides a kind of flushing solution for external eye surgery, which contains the following components in terms of mass percentage: 0.64% NaCl, 0.075% KCL, 0.048% CaCl2 2H2O, 0.048% MgCl2 6H 2 O 0.03%, C2H3NaO2 3H2O 0.39%, C 6 h 5 Na 3 o 7 2H 2 O 0.17%, Cocamidopropyl Betaine 0.0005%, Digigenin 0.006%, Aescin 0.005%, Amniotic Membrane Extract 1%, Trehalose 0.01%, Hyaluronic Acid 2%, and the balance is purified water.

[0039] Wherein, the preparation method of the amniotic membrane extract is as follows: take the cesarean section placenta, separate the amniotic membrane after washing, grind with liquid nitrogen, add medical physiological saline according to the weight to volume ratio of 1:5, and homogenate to obtain a homogenate; the homogenate is 0-4 Place at ℃ for 7 days, heat at 100-120℃ for 30 minutes, filter, and take the filtrate; adjust the pH value of the filtrate to 3, let it stand, filter, and take the filtrate; adjust the pH value of the f...

Embodiment 3

[0048] This embodiment provides a kind of flushing solution for external eye surgery, which contains the following components in terms of mass percentage: 0.64% NaCl, 0.075% KCL, 0.048% CaCl2 2H2O, 0.048% MgCl2 6H 2 O 0.03%, C2H3NaO2 3H2O 0.39%, C 6 h 5 Na 3 o 7 2H 2 O 0.17%, Cocamidopropyl Betaine 0.005%, Digigenin 0.001%, Aescin 0.03%, Amniotic Membrane Extract 0.01%, Trehalose 1%, Hyaluronic Acid 0.01%, and the balance is purified water.

[0049] Wherein, the preparation method of the amniotic membrane extract is as follows: take the cesarean section placenta, separate the amniotic membrane after washing, grind with liquid nitrogen, add medical physiological saline at a weight-to-volume ratio of 1:10, and homogenize to obtain a homogenate; the homogenate is 0-4 Place at ℃ for 1 day, heat at 100-120℃ for 60 minutes, filter, and take the filtrate; adjust the pH value of the filtrate to 3, let it stand, filter, and take the filtrate; adjust the pH value of the filtrate to ...

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Abstract

The invention discloses a flushing fluid for an external eye operation and a preparation method of the flushing fluid, and belongs to the technical field of surgical flushing fluids. The flushing fluid contains the following components: NaCl, KCl, CaCl2H2O, MgCl2.6H2O, C2H3NaO2.3H2O, C6H5Na3O7.2H2O, cocamidopropyl betaine, digitalin, Esculin, an amnion extracting solution, trehalose and hyaluronicacid. Through combined application of all the components, grease in an operation area, tissue debris generated in an operation and the like can be cleaned more easily, the cleanliness of the operation area is improved, the number of flora of conjunctival sacs is reduced, tissue repair can be promoted, postoperative inflammatory response is relieved, and discomforts such as eye edema, hyperemia and dryness are relieved. Meanwhile, the solutions are less irritating, have no toxic or side effect, are low-cost, and are suitable for wide clinical application.

Description

technical field [0001] The invention relates to the technical field of surgical flushing liquid, in particular to an external eye surgical flushing liquid and a preparation method thereof. Background technique [0002] Ophthalmic surgery often requires the application of physiological irrigation fluids to protect and maintain the physiological integrity of intraocular tissues. Usually, there are many external eye surgery operations that require irrigation fluid, such as corneal refractive surgery, strabismus surgery, lamellar keratoplasty, and pterygium surgery, among which corneal refractive surgery is the most widely used. Ophthalmic refractive surgery refers to surgery to change the existing refractive state of the eye. According to different surgical target tissues, it can be divided into corneal refractive surgery, scleral refractive surgery, and crystal refractive surgery. The most widely used clinically is laser corneal refractive surgery, which cuts corneal tissue b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44A61K31/7048A61K35/50A61K31/734A61K31/728A61P27/02A61P41/00A61P31/02A61K33/14A61K33/06
CPCA61K47/44A61K31/7048A61K35/50A61K31/734A61K31/728A61P27/02A61P41/00A61P31/02A61K33/14A61K33/06A61K2300/00
Inventor 付心怡梁山于志龙高国红赵晓燕刘升升
Owner AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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