86results about How to "Satisfactory yield" patented technology

The invention relates to a solid phase synthesis method for ziconotide, which comprises the following steps: an Fmoc-Rink Amide-MBHA resin is taken as a solid phase carrier for program reaction; condensation reactions are orderly performed to link 25 amino acids with protecting groups to obtain a linear peptide complete-protection resin of the 25 amino acids,wherein in three groups of Cyses which form a disulfide bond, the Cyses in the same group are simultaneously linked with one of a Trt, Acm or Mob protecting group, and different groups of the Cyses are linked with different protecting groups; the protecting groups of the three groups of the Cyses are orderly removed; a cyclization reaction is performed to form a disulfide ring bond; a side chain protecting group is removed; and the resin is cut to obtain the ziconotide containing three disulfide rings. The method has the main advantages of few side products, high directive efficiency, simplicity, convenience, high yield of products, and favorability for the purification of the products.

The horizontal cavity surface emitting laser includes a cavity structure portion including a stacked structure of a first conduction type clad layer, an active layer and a second conduction type clad layer stacked over a semiconductor substrate and causing light generated by the active layer to be reflected or resonated, an optical waveguide layer provided at part of the semiconductor substrate and guiding the light, a reflector provided in the optical waveguide layer, for reflecting the light and emitting the light from the back surface of the semiconductor substrate, and a condensing lens provided at the back surface thereof and focusing the reflected light. The back surface thereof has a groove provided with the condensing lens and a terrace-like portion disposed below the cavity structure portion and has a terrace shape with the cleavage direction along a longitudinal direction thereof provided along a cleavage direction of the semiconductor substrate.

The invention aims to provide a perylene derivative preparation process featuring satisfactory yields and improved preparation efficiency, a perylene derivative obtained by the process, and an organic EL device using the same.

An organic EL display apparatus is disclosed that includes a substrate, a thin film transistor formed on the substrate, an insulation film formed on the substrate in a manner covering the thin film transistor, and an organic EL element formed on the insulation film. The insulation film is formed with a recess portion. The organic EL element is formed in a manner contacting the thin film transistor via the recess portion formed in the insulation film.

The method for increasing yield of crop plants uses foliar application to the plants during the plant growth stage of a granular fertilizer consisting essentially of urea, ammonium sulfate and a fertilizer stabilizing agent. The stabilizing agent regulates and slows down decomposition nitrogen in urea and/or ammonium sulfate to maximize use thereof. The granular fertilizer has a urea/ammonium sulfate weight ratio of about 4/1 and contains at least 40% nitrogen and at least 4% sulfur. The relatively high N—S fertilizer is applied at relatively high rates of about 100 to 150 pounds per acre to ensure that the fertilizer nutrients are always available to the plants at several stages of growth.

The invention concerns a process for the manufacture of a starch hydrolysate with high dextrose content comprising the stages of: (a) liquefying starch milk with the aid of an alpha -amylase so as to obtain a liquefied starch milk; (b) saccharifying the liquefied starch milk, with the aid of a glucogenic enzyme, to obtain a raw saccharified hydrolysate; (c) separating the raw saccharified hydrolysate by nanofiltration over membranes so as to collect a nanofiltration permeate constituting said starch hydrolysate with high dextrose content and a nanofiltration retentate.

There is disclosed formed ceramic article drying means capable of evenly and uniformly drying even a large formed ceramic article containing much moisture as a drying target for a short time without causing any crack or deformation, to efficiently obtain a dry formed ceramic article having a high quality with a satisfactory yield. There is provided a drying method of a formed ceramic article including the steps of subjecting an unfired formed ceramic article formed of a ceramic material as a main material to dielectric drying and then microwave drying.

The invention discloses a linaclotide solid-phase synthesis method, and belongs to the biochemical technical field. The method includes the following steps: (1) preparation of linaclotide resin; (2) cutting the linaclotide linear peptide resin obtained in the step (1), to obtain a protection group linear peptide containing Cys(Acm) and Cys(tBu); (3) oxidizing to form a first disulfide bond, to obtain a monodisulfide cyclopeptide; (4) removing an Acm protection group in the monodisulfide cyclopeptide, to obtain a dual disulfide cyclopeptide; (5) removing a tBu protection group of the dual disulfide cyclopeptide, to obtain a trisdisulfide cyclopeptide; and (6) purifying the trisdisulfide cyclopeptide by HPLC, and freeze-drying to obtain linaclotide. The process has the characteristics of simple reaction operation, easy post-processing, low cost, high yield, and considerable economic and practical values, and besides, has wide application prospect in the polypeptide drug design and synthesis field.

A copper alloy for electronic machinery and tools, having a surface layer of a work affected layer whose thickness is 0.2 μm or below; and a method of producing the same.

An object of the present invention is to provide a molding and a method for producing the same; a catalyst for the production of an unsaturated aldehyde and an unsaturated carboxylic acid, and a method for producing the same; and a catalyst for the production of methacrylic acid, and a method for producing the same.

The molding of the present invention shows a shape including a plurality of columnar portions disposed with a predetermined gap; and bridge portions which are provided at both ends in longitudinal directions of two adjacent columnar portions and join adjacent columnar portions each other; and including through holes surrounded by a plurality of columnar portions in the longitudinal directions of the columnar portions, and openings formed on a peripheral surface by a gap between the plurality of adjacent columnar portions. This molding can be formed by using an extrusion molding machine including a first die which has a plurality of grooves on an outer peripheral surface, and a ring-shaped or cylindrical second die fitted in the first die which has a plurality of grooves on a peripheral surface, and repeatedly rotating and stopping at least one of the first and second dies.

The present invention relates to the purification of immunoglobulins and the problem of providing a method for purifying an immunoglobulin in an efficient and cost-effective manner and with satisfactory purity and yield. In particular, the present invention addresses the aspect of the re-use of the rather cost-intensive chromatography materials, in particular the lifetime of the chromatography materials used in the capture step of the downstream process, and how this can be increased while reducing the technical complexity of the purification process.

The invention concerns a process for the manufacture of a starch hydrolysate with high dextrose content comprising the stages of: (a) liquefying a starch milk with the aid of an .alpha.-amylase so as to obtain a liquefied starch milk; (b) saccharifying the liquefied starch milk, with the aid of a glucogenic enzyme, to obtain a raw saccharified hydrolysate having a maximum content of 80% by weight, and preferably 75% by weight; (c) microfiltering the raw saccharified hydrolysate so as to collect a microfiltration permeate and a microfiltration retentate; (d) separating the microfiltration permeate by nanofiltration over membranes so as to collect a nanofiltration permeate constituting said starch hydrolysate with high dextrose content and a nanofiltration retentate.

A method for producing a coumarin compound represented by Formula 1, which comprises a step of reacting a coumarin compound represented by Formula 1 with a compound having an aldehyde group and an activated methylene group; luminous agents for organic EL elements and organic EL elements which all comprise the coumarin compound; and displaying panels and information displaying apparatuses using the organic EL elements:

ø(Z)m  Formula 1

wherein in Formula 1, ø is an aromatic ring, heterocycle, or a combination thereof, each Z is the same or a different coumarin group represented by Formula 2; and m is an integer of two or more; Formula 2:

There is disclosed a manufacturing method of a phase shift mask blank in which dispersions of phase angle and transmittance among blanks can be reduced as much as possible and yield is satisfactory. In the manufacturing method of the phase shift mask blank, a process of using a sputtering method to continuously form a thin film on a transparent substrate comprises: successively subjecting a plurality of substrates to a series of process of supplying the transparent substrate into a sputtering chamber, forming the thin film for forming a pattern in the sputtering chamber, and discharging the transparent substrate with the film formed thereon from the sputtering chamber; supplying and discharging the transparent substrate substantially at a constant interval; and setting a film formation time to be constant among a plurality of blanks.

A preparation method of a compound of formula I is characterized in that the compound of formula I is obtained through one step direct condensation ether formation on a raw material of formula II and a raw material of formula III. The protection of reactive hydrogen on the nitrogen atom of the compound of the formula III is not needed in the invention, and a sulfonic acid compound is adopted as a reaction assistant, so the side reaction is reduced, reaction steps are simplified, and a satisfactory product yield can be realized. The compound of formula I having a single optical isomer can be obtained when the raw material of formula II having different isomers is selected.

According to a method of producing a key top for a pushbutton switch of the present invention, a base layer made of an insulating resin that can be plated with metal, an electroless plating layer to be formed on the surface of the base layer, and a polymer coating layer, if required, are stacked on the surface of a key top body. Alternatively, an electroplating layer formed by electroplating is further formed on the electroless plating layer. Therefore, a plating layer can be directly and easily formed on the insulating resin, whereby a key top for a pushbutton switch having a sensation of metal and being rich in design is obtained.

A method for the separation of multiple dies during semiconductor fabrication is described. On an upper surface of a semiconductor wafer containing multiple dies, a seed metal layer may be used to grow hard metal layers above it for handling. Metal may be plated above these metal layers everywhere except where a block of stop electroplating (EP) material exists. The stop EP material may be obliterated, and a barrier layer may be formed above the entire remaining structure. The substrate may be removed, and the individual dies may have any desired bonding pads and/or patterned circuitry added to the semiconductor surface. The remerged hard metal after laser cutting and heating should be strong enough for handling. Tape may be added to the wafer, and a breaker may be used to break the dies apart. The resulting structure may be flipped over, and the tape may be expanded to separate the individual dies.

An arc melting high-purity carbon electrode is capable of forming stable arc at the time of arc discharge, and it is possible to produce a vitreous silica crucible with good properties, which does not cause local lack of the electrode and does not create black foreign materials or concave portions on the inner surface of the crucible. The arc melting high-purity carbon electrode is a carbon electrode used to heat and melt silica powder by arc discharge, in which the density of the carbon electrode is equal to or more than 1.60 g/cm³ and equal to or less than 1.80 g/cm³, and is formed of high-purity carbon particles having a diameter of 0.05 mm or less.

A polythiol composition according to the present invention includes a polythiol compound (A) having three or more mercapto groups and a nitrogen-containing compound (B) in which one of a mercapto group of the polythiol compound (A) is replaced with a group represented by the following formula (a) and other one of a mercapto group of the polythiol compound (A) is replaced with a hydroxyl group, in which the peak area of the nitrogen-containing compound (B) is equal to or less than 3.0 with respect to the peak area of 100 of the polythiol compound (A) in a high performance liquid chromatography measurement.

A process for preparing substituted or non-substituted aminoalkyl acrylate is characterized by that in the presence of catalyst (alkali-earth metal) the acrylate or substituted acrylate and alkylamino alcohol are subjected to ester exchange reaction to obtain said product.