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88results about How to "Satisfactory yield" patented technology

Solid phase synthesis method of ziconotide

The invention relates to a solid phase synthesis method for ziconotide, which comprises the following steps: an Fmoc-Rink Amide-MBHA resin is taken as a solid phase carrier for program reaction; condensation reactions are orderly performed to link 25 amino acids with protecting groups to obtain a linear peptide complete-protection resin of the 25 amino acids,wherein in three groups of Cyses which form a disulfide bond, the Cyses in the same group are simultaneously linked with one of a Trt, Acm or Mob protecting group, and different groups of the Cyses are linked with different protecting groups; the protecting groups of the three groups of the Cyses are orderly removed; a cyclization reaction is performed to form a disulfide ring bond; a side chain protecting group is removed; and the resin is cut to obtain the ziconotide containing three disulfide rings. The method has the main advantages of few side products, high directive efficiency, simplicity, convenience, high yield of products, and favorability for the purification of the products.
Owner:ADLAI NORTYE BIOPHARMA CO LTD

Horizontal cavity surface emitting laser diodes, vertical illuminated photodiodes, and methods of their fabrication

The horizontal cavity surface emitting laser includes a cavity structure portion including a stacked structure of a first conduction type clad layer, an active layer and a second conduction type clad layer stacked over a semiconductor substrate and causing light generated by the active layer to be reflected or resonated, an optical waveguide layer provided at part of the semiconductor substrate and guiding the light, a reflector provided in the optical waveguide layer, for reflecting the light and emitting the light from the back surface of the semiconductor substrate, and a condensing lens provided at the back surface thereof and focusing the reflected light. The back surface thereof has a groove provided with the condensing lens and a terrace-like portion disposed below the cavity structure portion and has a terrace shape with the cleavage direction along a longitudinal direction thereof provided along a cleavage direction of the semiconductor substrate.
Owner:HITACHI LTD

Perylene derivative synthesis process, perylene derivative and organic EL device

The invention aims to provide a perylene derivative preparation process featuring satisfactory yields and improved preparation efficiency, a perylene derivative obtained by the process, and an organic EL device using the same.
Owner:FUTABA CORPORATION

Organic electroluminescence display apparatus

An organic EL display apparatus is disclosed that includes a substrate, a thin film transistor formed on the substrate, an insulation film formed on the substrate in a manner covering the thin film transistor, and an organic EL element formed on the insulation film. The insulation film is formed with a recess portion. The organic EL element is formed in a manner contacting the thin film transistor via the recess portion formed in the insulation film.
Owner:UDC IRELAND +1

Method for increasing crop yield

The method for increasing yield of crop plants uses foliar application to the plants during the plant growth stage of a granular fertilizer consisting essentially of urea, ammonium sulfate and a fertilizer stabilizing agent. The stabilizing agent regulates and slows down decomposition nitrogen in urea and / or ammonium sulfate to maximize use thereof. The granular fertilizer has a urea / ammonium sulfate weight ratio of about 4 / 1 and contains at least 40% nitrogen and at least 4% sulfur. The relatively high N—S fertilizer is applied at relatively high rates of about 100 to 150 pounds per acre to ensure that the fertilizer nutrients are always available to the plants at several stages of growth.
Owner:RIZZO JOHN M

Process for the manufacture of a starch hydrolysate with high dextrose content

The invention concerns a process for the manufacture of a starch hydrolysate with high dextrose content comprising the stages of: (a) liquefying starch milk with the aid of an alpha -amylase so as to obtain a liquefied starch milk; (b) saccharifying the liquefied starch milk, with the aid of a glucogenic enzyme, to obtain a raw saccharified hydrolysate; (c) separating the raw saccharified hydrolysate by nanofiltration over membranes so as to collect a nanofiltration permeate constituting said starch hydrolysate with high dextrose content and a nanofiltration retentate.
Owner:ROQUETTE FRERES SA

Drying method of formed ceramic article

There is disclosed formed ceramic article drying means capable of evenly and uniformly drying even a large formed ceramic article containing much moisture as a drying target for a short time without causing any crack or deformation, to efficiently obtain a dry formed ceramic article having a high quality with a satisfactory yield. There is provided a drying method of a formed ceramic article including the steps of subjecting an unfired formed ceramic article formed of a ceramic material as a main material to dielectric drying and then microwave drying.
Owner:NGK INSULATORS LTD

Process for manufacturing ophthalmic oil-in-water emulsions

The present invention relates to new processes for the preparation of oil-in-water emulsions useful in ophthalmic applications. In particular, processes are provided that include preparing a pre-concentrate of the oil-in-water emulsion, and diluting the pre-concentrate obtained to form the desired oil-in-water emulsion. The present invention also provides pharmaceutical compositions comprising an oil-in-water emulsion prepared by an inventive process, and methods of using these compositions for the treatment of an eye disease or condition.
Owner:SANTEN SAS

Linaclotide solid-phase synthesis method

The invention discloses a linaclotide solid-phase synthesis method, and belongs to the biochemical technical field. The method includes the following steps: (1) preparation of linaclotide resin; (2) cutting the linaclotide linear peptide resin obtained in the step (1), to obtain a protection group linear peptide containing Cys(Acm) and Cys(tBu); (3) oxidizing to form a first disulfide bond, to obtain a monodisulfide cyclopeptide; (4) removing an Acm protection group in the monodisulfide cyclopeptide, to obtain a dual disulfide cyclopeptide; (5) removing a tBu protection group of the dual disulfide cyclopeptide, to obtain a trisdisulfide cyclopeptide; and (6) purifying the trisdisulfide cyclopeptide by HPLC, and freeze-drying to obtain linaclotide. The process has the characteristics of simple reaction operation, easy post-processing, low cost, high yield, and considerable economic and practical values, and besides, has wide application prospect in the polypeptide drug design and synthesis field.
Owner:NANTONG SHIMEIKANG PHARMA CHEM

Copper alloy for electronic machinery and tools and method of producing the same

A copper alloy for electronic machinery and tools, having a surface layer of a work affected layer whose thickness is 0.2 μm or below; and a method of producing the same.
Owner:FURUKAWA ELECTRIC CO LTD

Molding and method for producing the same, and catalyst and method for producing the same

An object of the present invention is to provide a molding and a method for producing the same; a catalyst for the production of an unsaturated aldehyde and an unsaturated carboxylic acid, and a method for producing the same; and a catalyst for the production of methacrylic acid, and a method for producing the same.The molding of the present invention shows a shape including a plurality of columnar portions disposed with a predetermined gap; and bridge portions which are provided at both ends in longitudinal directions of two adjacent columnar portions and join adjacent columnar portions each other; and including through holes surrounded by a plurality of columnar portions in the longitudinal directions of the columnar portions, and openings formed on a peripheral surface by a gap between the plurality of adjacent columnar portions. This molding can be formed by using an extrusion molding machine including a first die which has a plurality of grooves on an outer peripheral surface, and a ring-shaped or cylindrical second die fitted in the first die which has a plurality of grooves on a peripheral surface, and repeatedly rotating and stopping at least one of the first and second dies.
Owner:SUMITOMO CHEM CO LTD

Perylene derivative synthesis process, perylene derivative and organic EL device

The invention aims to provide a perylene derivative preparation process featuring satisfactory yields and improved preparation efficiency, a perylene derivative obtained by the process, and an organic EL device using the same. The object is achieved by a perylene derivative preparation process comprising subjecting to coupling reaction a 1,8-dihalogenated naphthalene derivative of the formula (1): wherein X is Cl, Br or I, R1 to R4, R11 and R12 each are hydrogen, alkyl, alkoxy, alkylthio, alkenyl, alkenyloxy, alkenylthio, aralkyl, aralkyloxy, aralkylthio, aryl, aryloxy, and arylthio radicals which may be substituted, amino radical, cyano radical, hydroxyl radical, —COOM1 radical (wherein M1 is hydrogen, alkyl, alkenyl, aralkyl or aryl), —COM2 radical (wherein M2 is hydrogen, alkyl, alkenyl, aralkyl, aryl or amino), or —OCOM3 radical (wherein M3 is alkyl, alkenyl, aralkyl or aryl), and at least two adjoining radicals selected from among R1 to R4, R11 and R12 may bond or fuse together to form a substituted or unsubstituted carbocyclic aliphatic ring, aromatic ring or fused aromatic ring with the carbon atoms on which they substitute, with the proviso that when the carbocyclic aliphatic ring, aromatic ring or fused aromatic ring has substituent radicals, the substituent radicals are the same as R1 to R4, R11 and R12, to thereby synthesize a perylene derivative of the formula (2): wherein R1′ to R4′, R11′ and R12′ are as defined for R1 to R4, R11 and R12 in formula (1), and R1 to R4, R11 and R12 and R1′ to R4′, R11′ and R12′ may be the same or different.
Owner:FUTABA CORPORATION

Process for the manufacture of a starch hydrolysate with high content

InactiveUS6177265B1Accelerates hydrolysis reactionReduce in quantityNanotechFermentationHydrolysateAlpha-amylase
The invention concerns a process for the manufacture of a starch hydrolysate with high dextrose content comprising the stages of: (a) liquefying a starch milk with the aid of an .alpha.-amylase so as to obtain a liquefied starch milk; (b) saccharifying the liquefied starch milk, with the aid of a glucogenic enzyme, to obtain a raw saccharified hydrolysate having a maximum content of 80% by weight, and preferably 75% by weight; (c) microfiltering the raw saccharified hydrolysate so as to collect a microfiltration permeate and a microfiltration retentate; (d) separating the microfiltration permeate by nanofiltration over membranes so as to collect a nanofiltration permeate constituting said starch hydrolysate with high dextrose content and a nanofiltration retentate.
Owner:ROQUETTE FRERES SA

Coumarin compound

A method for producing a coumarin compound represented by Formula 1, which comprises a step of reacting a coumarin compound represented by Formula 1 with a compound having an aldehyde group and an activated methylene group; luminous agents for organic EL elements and organic EL elements which all comprise the coumarin compound; and displaying panels and information displaying apparatuses using the organic EL elements: ø(Z)m  Formula 1 wherein in Formula 1, ø is an aromatic ring, heterocycle, or a combination thereof, each Z is the same or a different coumarin group represented by Formula 2; and m is an integer of two or more; Formula 2:
Owner:HAYASHIBARA BIOCHEMICAL LAB INC

Thin film solid lithium ion secondary battery and manufacturing method thereof

The present invention discloses a high-performance and inexpensive thin-film solid-state lithium ion secondary battery and a method of manufacturing the battery, which can be charged and discharged in the air and can be stably manufactured with a satisfactory yield. The thin-film solid-state lithium ion secondary battery has: an electrically insulating substrate (10) formed of an organic resin; an insulating film (20) made of an inorganic material and formed on the surface of the substrate; a positive electrode side current collector A membrane (30); a cathode active material membrane (40); a solid electrolyte membrane (50); an anode active material membrane (60); and an anode-side current collector membrane (70). In this thin-film solid-state lithium ion secondary battery, the positive electrode side current collector film and / or the negative electrode side current collector film are formed on the face of the above-mentioned insulating film, and the film thickness of the above-mentioned insulating film is greater than or equal to 10 nm and less than Or equal to 200nm. The insulating film has an area larger than that of the positive electrode-side current collector film or the negative electrode-side current collector film, or larger than the total area of ​​the positive electrode-side current collector film and the negative electrode-side current collector film. The aforementioned inorganic material includes at least one of oxides, nitrides, and sulfides containing any one of Si, Al, Cr, Zr, Ta, Ti, Mn, Mg, and Zn.
Owner:SONY CORP

Manufacturing Method and Apparatus of Phase Shift Mask Blank

There is disclosed a manufacturing method of a phase shift mask blank in which dispersions of phase angle and transmittance among blanks can be reduced as much as possible and yield is satisfactory. In the manufacturing method of the phase shift mask blank, a process of using a sputtering method to continuously form a thin film on a transparent substrate comprises: successively subjecting a plurality of substrates to a series of process of supplying the transparent substrate into a sputtering chamber, forming the thin film for forming a pattern in the sputtering chamber, and discharging the transparent substrate with the film formed thereon from the sputtering chamber; supplying and discharging the transparent substrate substantially at a constant interval; and setting a film formation time to be constant among a plurality of blanks.
Owner:HOYA CORP

Multi-sulfonic acid funtionalized mesoporous polymeric solid acid catalyst and preparation method and application thereof

The invention discloses a multi-sulfonic acid funtionalized mesoporous polymeric solid acid catalyst and a preparation method thereof and an application of the catalyst in high-efficiency catalysis of an esterification reaction between free fatty acid and short-chain alcohols (ethanol and methanol) and catalysis of one-pot preparation of biodiesel from high acid-value grease and methanol. The preparation method of the catalyst comprises the following steps: mesoporous polydivinylbenzene is used as a carrier, and the carrier firstly reacts with chloromethyl methyl ether to introduce the carrier into chloromethylene; then, a product reacts with ethene diamine to make the carrier to be linked in the form of a covalent bond with ethene diamine; and finally, chlorosulfonic acid is used to carry out sulfonation so as to obtain the multi-sulfonic acid funtionalized mesoporous polymeric solid acid catalyst. The mesoporous polymeric solid acid catalyst obtained by the preparation method has a lot of mesoporous pore structures, large specific surface area and pore volume and high acid density. The catalyst is applied in catalysis of an esterification reaction between free fatty acid and short-chain alcohols (ethanol and methanol) and catalysis of one-pot preparation of biodiesel from high acid-value grease and methanol, and has a high catalytic activity. Thus, the catalyst has good industrial application value.
Owner:GUIZHOU UNIV

Synthesis method of 2-[(-4-chlorophenyl)(4-piperidinyl-oxy)methyl]pyridine having single optical isomer

A preparation method of a compound of formula I is characterized in that the compound of formula I is obtained through one step direct condensation ether formation on a raw material of formula II and a raw material of formula III. The protection of reactive hydrogen on the nitrogen atom of the compound of the formula III is not needed in the invention, and a sulfonic acid compound is adopted as a reaction assistant, so the side reaction is reduced, reaction steps are simplified, and a satisfactory product yield can be realized. The compound of formula I having a single optical isomer can be obtained when the raw material of formula II having different isomers is selected.
Owner:CHONGQING HUAPONT PHARMA

Method of producing the keytop for pushbutton switch

According to a method of producing a key top for a pushbutton switch of the present invention, a base layer made of an insulating resin that can be plated with metal, an electroless plating layer to be formed on the surface of the base layer, and a polymer coating layer, if required, are stacked on the surface of a key top body. Alternatively, an electroplating layer formed by electroplating is further formed on the electroless plating layer. Therefore, a plating layer can be directly and easily formed on the insulating resin, whereby a key top for a pushbutton switch having a sensation of metal and being rich in design is obtained.
Owner:POLYMATECH CO LTD

Producing method for plastic lens and raw material storage/supply apparatus

InactiveUS20040178526A1Difficult to dissipateEasy to disassembleOptical articlesLensRoom temperatureEngineering
Provided is a producing method and apparatus for a plastic lens capable of hardening a hardenable composition including a compound having an episulfide group under suppression of generation of an optical strain, and a raw material storage / supply apparatus adapted for storage and supply of such hardenable composition. A raw material storage / supply apparatus is provided by supporting, on a movable base, a storage container capable of storing a liquid raw material. A temperature regulating pipe is included for regulating the temperature of the storage container. Also provided is a temperature regulating apparatus capable of regulating a fluid flowing in the temperature regulating pipe at a temperature less than the room temperature.
Owner:SEIKO EPSON CORP

Method of separating semiconductor dies

A method for the separation of multiple dies during semiconductor fabrication is described. On an upper surface of a semiconductor wafer containing multiple dies, a seed metal layer may be used to grow hard metal layers above it for handling. Metal may be plated above these metal layers everywhere except where a block of stop electroplating (EP) material exists. The stop EP material may be obliterated, and a barrier layer may be formed above the entire remaining structure. The substrate may be removed, and the individual dies may have any desired bonding pads and / or patterned circuitry added to the semiconductor surface. The remerged hard metal after laser cutting and heating should be strong enough for handling. Tape may be added to the wafer, and a breaker may be used to break the dies apart. The resulting structure may be flipped over, and the tape may be expanded to separate the individual dies.
Owner:SEMILEDS OPTOELECTRONICS CO LTD

Arc melting high-purity carbon electrode and application thereof

An arc melting high-purity carbon electrode is capable of forming stable arc at the time of arc discharge, and it is possible to produce a vitreous silica crucible with good properties, which does not cause local lack of the electrode and does not create black foreign materials or concave portions on the inner surface of the crucible. The arc melting high-purity carbon electrode is a carbon electrode used to heat and melt silica powder by arc discharge, in which the density of the carbon electrode is equal to or more than 1.60 g / cm3 and equal to or less than 1.80 g / cm3, and is formed of high-purity carbon particles having a diameter of 0.05 mm or less.
Owner:JAPAN SUPER QUARTZ CORP +1

Polythiol composition, polymerizable composition for optical material and use thereof

A polythiol composition according to the present invention includes a polythiol compound (A) having three or more mercapto groups and a nitrogen-containing compound (B) in which one of a mercapto group of the polythiol compound (A) is replaced with a group represented by the following formula (a) and other one of a mercapto group of the polythiol compound (A) is replaced with a hydroxyl group, in which the peak area of the nitrogen-containing compound (B) is equal to or less than 3.0 with respect to the peak area of 100 of the polythiol compound (A) in a high performance liquid chromatography measurement.
Owner:MITSUI CHEM INC

Synthetic method of phosphorothioate compound

The present invention relates to a synthetic method of phosphorothioate compound. The preparation method adopts phosphite and thiophenol or mercaptan to synthesize the phosphorothioate under the promotion of a chlorate agent 1,3-dichloro-5,5-dimethylhydantoin / trichloroisocyanuric acid. The method is mild in condition, quick in reaction, free of alkalization and a catalyst in the reaction process, and has wide adaptability to substrates of different functional groups. The phosphite framework which is efficiently constructed by the preparation method provided by the invention is an important framework for many medicines, pesticides, biological active molecules and natural products. The synthetic method provided by the invention provides a widely applied preparation method for synthesizing the compounds.
Owner:中国人民解放军63975部队

Process for preparing substd. (or unsubstd.) aminoalkyl acrylate

A process for preparing substituted or non-substituted aminoalkyl acrylate is characterized by that in the presence of catalyst (alkali-earth metal) the acrylate or substituted acrylate and alkylamino alcohol are subjected to ester exchange reaction to obtain said product.
Owner:SICHUAN NORMAL UNIVERSITY +1
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