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Q: How to Satisfactory yield?

Immunoglobulin purification using pre-cleaning steps,Process for the manufacture of peptide compounds,Immunoglobulin purification using pre-cleaning steps,Immunoglobulin purification using pre-cleaning steps

Immunoglobulin purification using pre-cleaning steps

ActivePT3674310Treducing technical complexity of purification processefficient and cost-effective

The present invention relates to the purification of immunoglobulins and the problem of providing a method for purifying an immunoglobulin in an efficient and cost-effective manner and with satisfactory purity and yield. In particular, the present invention addresses the aspect of the re-use of the rather cost-intensive chromatography materials, in particular the lifetime of the chromatography materials used in the capture step of the downstream process, and how this can be increased while reducing the technical complexity of the purification process.

Owner:RICHTER GEDEON NYRT

Process for the manufacture of peptide compounds

ActiveCN113614061BSatisfactory yield

Provided is a method for producing a peptide containing an N-alkyl amino acid, comprising the following steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or an alkyl haloformate; Step (2): a step of mixing an amino acid or a peptide that is not protected at the N- and C-termini with a trialkylsilylating agent; and a step of mixing the product obtained in Step (1) with the product obtained in Step (2).